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1. 发明申请

WO2017039822A1 METHOD, APPARATUS, AND SYSTEM FOR RADIATION THERAPY 审中-公开
标题翻译：辐射治疗方法，装置和系统
公开(公告)号：WO2017039822A1
公开(公告)日：2017-03-09
申请号：PCT/US2016/040599
申请日：2016-07-01
申请人： MEDICAL THERANOSTICS INC.
发明人： SRINIVAS, Shyam , DOKE, Aniruddha
IPC分类号： A61K51/12 , A61P35/00
CPC分类号： A61K51/1282 , A61K51/06 , A61K51/1244 , A61K51/1251 , G01T1/02
摘要： A device and method for radioembolization in the treatment of cancer cells in the body. In preferred embodiments, a radiomicrosphere is formed from a resin where an alpha emitting isotope is used for tumoricidal purposes. As the alpha emitter decays, daughters of the alpha decay are captured by the resin. In further embodiments, the device comprises at least two isotopes; wherein a first isotope is for therapeutic purposes and a second isotope is for dosimetric purposes. The second isotope is a positron emitter for PET based dosimetry. In preferred embodiments, a post-treatment radiation absorbed dose is determined using the present invention, allowing both treatment and treatment efficacy to be provided to a cancer patient.
摘要翻译：用于放射栓塞的装置和方法，用于治疗身体中的癌细胞。在优选的实施方案中，辐射微球由其中使用α发射同位素用于杀肿瘤目的的树脂形成。当α发射体衰变时，α衰变的女儿被树脂捕获。在另外的实施方案中，该装置包括至少两个同位素; 其中第一同位素用于治疗目的，第二同位素用于剂量目的。第二同位素是基于PET的剂量测定法的正电子发射体。在优选实施方案中，使用本发明确定后处理辐射吸收剂量，允许将治疗和治疗功效提供给癌症患者。

2. 发明申请

WO2015000012A1 RADIOLABELLED MATERIAL 审中-公开
标题翻译：无辐射材料
公开(公告)号：WO2015000012A1
公开(公告)日：2015-01-08
申请号：PCT/AU2013/001510
申请日：2013-12-20
申请人： THE AUSTRALIAN NATIONAL UNIVERSITY
发明人： STEPHENS, Ross, Wentworth , BELL, Jessica, Louise
IPC分类号： A61K51/06 , A61K103/00 , A61P35/00
CPC分类号： A61K51/065 , A61K51/1244 , A61K51/1251
摘要： The invention relates to a radiolabelled material comprising a polymer, a radioactive isotope, and an immobilizing agent, wherein the immobilizing agent is capable of immobilizing the radioactive isotope on or in the polymer, and wherein the immobilizing agent is a macromolecule comprising electron donating groups. The invention also relates to a process for making a radiolabelled material, to use of a radiolabelled material for the preparation of medicaments for treating cancer and/or for radiation imaging, and to use of a radiolabelled material in the treatment of cancer. There is further described use of an immobilizing agent to immobilize a radioactive isotope on or in a polymer.
摘要翻译：本发明涉及包含聚合物，放射性同位素和固定剂的放射性标记材料，其中固定剂能够将放射性同位素固定在聚合物上或聚合物中，并且其中固定剂是包含给电子基团的大分子。本发明还涉及制备放射性标记材料的方法，使用放射性标记的材料制备用于治疗癌症和/或放射线成像的药物，以及使用放射性标记物质治疗癌症。进一步描述了固定化剂将放射性同位素固定在聚合物上或聚合物中的用途。

3. 发明申请

WO2014036470A1 PARTICLES, METHODS AND USES THEREOF 审中-公开
标题翻译：颗粒，方法及其用途
公开(公告)号：WO2014036470A1
公开(公告)日：2014-03-06
申请号：PCT/US2013/057636
申请日：2013-08-30
申请人： SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH
发明人： KIRCHER, Moritz , HARMSEN, Stefan , WALL, Matthew
IPC分类号： A01N61/00 , A01N25/34
CPC分类号： A61K49/0093 , A61K49/00 , A61K49/0002 , A61K49/1878 , A61K49/1881 , A61K51/1251
摘要： The present disclosure, among other things, provides a composition including a nanoscale core; a plurality of capping agent entities associated on the core; an outer encapsulant layer; and a plurality of dopant entities distributed at locations selected from the group consisting of: on or within the nanoscale core, on or between capping agent entities, on or within the encapsulating layer, and combinations thereof. Provided technologies can achieve unprecedented levels of dopant entity density and/or surface localization, which, for a SE(R)RS-active agent dopant, results in dramatically improved signal intensity and/or imaging sensitivity.
摘要翻译：本公开内容尤其提供了包括纳米尺度核心的组合物; 在核心上相关联的多个封盖代理实体; 外包封层; 以及分布在选自以下的位置处的多个掺杂剂实体以及其组合：在纳米级核心上或纳米级核心之上，覆盖剂实体之间或之上，在封装层上或封装层内。所提供的技术可以实现前所未有的掺杂剂实体密度和/或表面定位水平，对于SE（R）RS-活性剂掺杂剂，其导致显着改善的信号强度和/或成像灵敏度。

4. 发明申请

WO2013106824A1 EPHERIN RECEPTOR TARGETING AGENTS 审中-公开
标题翻译： EPHERIN受体靶向剂
公开(公告)号：WO2013106824A1
公开(公告)日：2013-07-18
申请号：PCT/US2013/021434
申请日：2013-01-14
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
发明人： XIONG, Chiyi , CAO, Qizhen , SOOD, Anil , LI, Chun
IPC分类号： A61K49/14 , A61K31/7042 , A61K47/48 , A61K9/16 , A61P35/00
CPC分类号： A61K45/06 , A61K31/155 , A61K41/0052 , A61K47/62 , A61K47/64 , A61K47/6923 , A61K47/6929 , A61K49/14 , A61K51/088 , A61K51/1251 , A61K2300/00
摘要： Peptide targeting agents are provided that may be used as imaging and/or therapeutic agents for tumor cells overexpressing Ephrin receptors. In particular, the agents can be used for targeting cells expressing EphB4 and/or EphA2 receptors. Methods for non-invasive imaging and anticancer therapy using the targeting agents are likewise provided.
摘要翻译：提供了可用作过表达Ephrin受体的肿瘤细胞的成像和/或治疗剂的肽靶向剂。特别地，所述试剂可用于靶向表达EphB4和/或EphA2受体的细胞。同样提供了使用靶向剂进行非侵入性成像和抗癌治疗的方法。

5. 发明申请

WO2011053940A3 TEMPLATED NANOCONJUGATES 审中-公开
标题翻译：模板纳米复合物
公开(公告)号：WO2011053940A3
公开(公告)日：2011-07-28
申请号：PCT/US2010055018
申请日：2010-11-01
申请人： UNIV NORTHWESTERN , MIRKIN CHAD A , GILJOHANN DAVID A , DANIEL WESTON L , CUTLER JOSHUA I , ZHANG KE , ZHENG DAN
发明人： MIRKIN CHAD A , GILJOHANN DAVID A , DANIEL WESTON L , CUTLER JOSHUA I , ZHANG KE , ZHENG DAN
IPC分类号： C12Q1/68
CPC分类号： A61K47/6923 , A61K47/489 , A61K47/6933 , A61K49/0002 , A61K49/0093 , A61K51/1251 , B82Y5/00 , B82Y15/00 , C12N15/88 , C12Q1/6876 , G01N33/588
摘要： The present disclosure is directed to compositions comprising templated nanoconjugates and methods of their use.
摘要翻译：本公开涉及包含模板化纳米缀合物的组合物及其使用方法。

6. 发明申请

WO2009129577A1 METHODS FOR RADIOLABELLING MACROMOLECULES 审中-公开
标题翻译：放射性大分子的方法
公开(公告)号：WO2009129577A1
公开(公告)日：2009-10-29
申请号：PCT/AU2009/000508
申请日：2009-04-23
申请人： THE AUSTRALIAN NATIONAL UNIVERSITY , STEPHENS, Ross, Wentworth , SENDEN, Timothy, John , KING, David, Wallace
发明人： STEPHENS, Ross, Wentworth , SENDEN, Timothy, John , KING, David, Wallace
IPC分类号： A61K51/06 , A61K49/12 , A61K49/14 , A61K49/16 , A61K51/08 , A61K51/10 , A61P35/00
CPC分类号： A61K51/1251 , A61K41/0095 , A61K51/06 , A61K51/08 , A61K51/081 , A61K51/10
摘要： The present invention relates to a method for preparing a radiolabeled macromolecule, the method comprising contacting a macromolecule with a carbon encapsulated nanoparticle composite having a radioactive particulate core in an aqueous medium comprising a pH selected to promote short-range attractive forces between the nanoparticles and the macromolecule by attenuating repulsive electrostatic forces.
摘要翻译：本发明涉及一种制备放射性标记的高分子的方法，该方法包括使高分子与含有放射性颗粒核的碳包覆的纳米颗粒复合物在水性介质中接触，所述水性介质包含选择的pH以促进纳米颗粒与所述纳米颗粒之间的短程吸引力大分子通过衰减排斥静电力。

7. 发明申请

WO2007099536A2 RADIOACTIVE METAL-BOUND BEADS 审中-公开
标题翻译：放射性金属结合珠
公开(公告)号：WO2007099536A2
公开(公告)日：2007-09-07
申请号：PCT/IL2007/000261
申请日：2007-02-27
申请人： SOREQ NUCLEAR RESEARCH CENTER , LAVIE, Efraim , VAKNIN, Dan , SAYAG, Eli , VEINGUER, Maya , ZAUBER, Hilel
发明人： LAVIE, Efraim , VAKNIN, Dan , SAYAG, Eli , VEINGUER, Maya , ZAUBER, Hilel
IPC分类号： C22B11/00 , C22B3/42 , A61K51/12 , H01M4/92 , G21F5/015
CPC分类号： C22B11/042 , A61K49/0002 , A61K51/1251 , A61K51/1282 , C22B3/42 , Y02P10/214 , Y02P10/234
摘要： An efficient process for purification of palladium from a palladium and rhodium mixture is described, which is based on the difference in uptake of the two metals into a strong anion exchanger polymer, e.g., a copolymer of polystyrene and divinylbenzene.
摘要翻译：描述了一种用于从钯和铑混合物中纯化钯的有效方法，其基于两种金属吸收到强阴离子交换剂聚合物中的差异，例如聚苯乙烯和二乙烯基苯。

8. 发明申请

WO2006072948A3 GASTRO-RETENTIVE DIAGNOSTIC ASSEMBLIES 审中-公开
标题翻译：胃气道诊断装置
公开(公告)号：WO2006072948A3
公开(公告)日：2006-11-02
申请号：PCT/IL2006000017
申请日：2006-01-05
申请人： INTEC PHARMA LTD , YISSUM RES DEV CO , AFARGAN MICHEL , KIRMAYER DAVID , LAPIDOT NOA , FRIEDMAN MICHAEL , HOFFMAN AMNON
发明人： AFARGAN MICHEL , KIRMAYER DAVID , LAPIDOT NOA , FRIEDMAN MICHAEL , HOFFMAN AMNON
IPC分类号： A61K9/48 , A61K49/18 , A61K51/12
CPC分类号： A61K49/1818 , A61K9/0065 , A61K49/0002 , A61K51/1251
摘要： The present invention provides a gastro-retentive diagnostic assembly (GRDA) for use in determining a condition of a subject's gastrointestinal tract (GI tract), comprising a folded single or multi-layered device comprising a diagnostic utility, such as a contrasting agent, the device prior to folding being essentially planar, and included in a delivery system for oral intake, the delivery system being adapted to release the device once in the stomach, whereupon release said device unfolds into an unfolded shape that results in the retention of the device in the stomach. Further provided are methods of determining a condition of a subject's GI tract by the use of the GRDA of the invention, as well as uses of a single or multi-layered device comprising a diagnostic utility when in a folded or unfolded shape, and method of preparing the GRDA of the invention.
摘要翻译：本发明提供了一种用于确定受试者的胃肠道（GI道）的状况的胃滞留诊断组件（GRDA），其包括折叠的单层或多层设备，其包括诊断实用程序，例如造影剂，折叠前的装置基本上是平面的，并且包括在用于口服进入的输送系统中，所述输送系统适于在胃中释放装置一次，于是释放所述装置展开成展开形状，导致装置保持在肚子还提供了通过使用本发明的GRDA来确定受试者的胃肠道状况的方法，以及当处于折叠或展开形状时包括诊断用途的单层或多层设备的使用，以及方法准备本发明的GRDA。

9. 发明申请

WO2005072781A3 METHOD AND KIT FOR THE PRODUCTION OF PARTICLES LABELLED WITH RHENIUM-188 审中-公开
标题翻译：方法和试剂盒用于制备铼-188标记粒子
公开(公告)号：WO2005072781A3
公开(公告)日：2005-10-27
申请号：PCT/DE2005000140
申请日：2005-01-27
申请人： ROTOP PHARMAKA GMBH , WUNDERLICH GERD , DREWS ANTJE
发明人： WUNDERLICH GERD , DREWS ANTJE
IPC分类号： A61K51/04 , A61K51/08 , A61K51/12
CPC分类号： A61K51/1251
摘要： The invention relates to a method for the production of particles labelled with the radioactive isotope Rhenium-188 (Re-188) and a kit for carrying out said method. Such radioactively-charged particles can be used in medicine, preferably in oncology and nuclear medicine, for the radiotherapy of tumours, or metastases of tumours. According to the method, the particles are suspended in a solution and heated, whereupon the solution firstly has a pH value of pH 1 to pH 3 and contains a tin-II salt and a Re-188 perrhenate salt. After 45 to 70 minutes of heating the pH value is increased. The suspension obtained after increasing the pH may be directly used for radiotherapy in patients. Radiation protection of the personnel is significantly improved as a result of the unnecessary washing step, along with a corresponding saving in time. Furthermore, the requirement of tin-II salt for the labelling is reduced and the labelling yield is increased.
摘要翻译：本发明涉及一种用于制备铼-188（重188）标记的粒子的放射性同位素，以及用于执行该方法的试剂盒。这种放射性负载的颗粒可用于肿瘤或在医学肿瘤转移的放射治疗，优选地在肿瘤学和核医学的领域。在该方法中，将颗粒悬浮在溶液中并加热，其中，所述第一溶液具有pH为1的pH值至pH 3和含有锡的盐II和Re188 Perrhenatsalz。 45分钟至70分钟加热该pH值后增大。通过提高pH值获得的悬浮液可直接用于放疗给患者。通过缺失辐射防护的洗涤步骤，除了节省时间的人员有很大的提高。此外，所必需的标记锡-II盐的量减少和增加的标记率。

10. 发明申请

WO2004019999A2 AGENT DELIVERY PARTICLE 审中-公开
标题翻译：代理交付粒子
公开(公告)号：WO2004019999A2
公开(公告)日：2004-03-11
申请号：PCT/US2003/027228
申请日：2003-08-29
申请人： SCIMED LIFE SYSTEMS, INC.
发明人： DIMATTEO, Kristian , CASEY, Thomas, V., II , RIOUX, Robert, F. , KEENAN, Steve , LANPHERE, Janel
IPC分类号： A61K51/00
CPC分类号： A61K9/1635 , A61K9/1652 , A61K49/0452 , A61K51/1251 , A61L24/0036 , A61L2430/36
摘要： Particles having agents are disclosed. The agents can be radioactive species. The agents can be therapeutic agents. The agents can be in and/or on the particles.
摘要翻译：公开了具有试剂的颗粒。这些药剂可以是放射性物质。这些药剂可以是治疗剂。试剂可以在颗粒中和/或颗粒上。

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