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1. 发明申请

WO2007119103A1 LABELED MACROPHAGES AND METHODS OF USE THEREOF 审中-公开
标题翻译：标签的广泛使用及其使用方法
公开(公告)号：WO2007119103A1
公开(公告)日：2007-10-25
申请号：PCT/IB2006/004007
申请日：2006-10-17
申请人： BENDER, Robert , GREEN, Allan, M. , KIM, Perry , KISILEVSKY, Robert , MCNAIR, Douglas, S. , TAM, Shui-Pang
发明人： BENDER, Robert , GREEN, Allan, M. , KIM, Perry , KISILEVSKY, Robert , MCNAIR, Douglas, S. , TAM, Shui-Pang
IPC分类号： C12N5/08 , A61K49/00 , A61K51/02 , A61K51/06 , C12Q1/60
CPC分类号： G01N33/92 , A61K51/0493 , A61K51/1203 , A61K51/1268 , B82Y5/00 , G01N33/5055 , G01N2405/00 , G01N2500/10
摘要： The present invention relates to labeled-cholesterol loaded macrophages. The loaded macrophages are useful for diagnostic purposes and in a modified in vivo assay in order to assess the effectiveness of a test drug to modulate the reverse cholesterol transport pathway in a subject.
摘要翻译：本发明涉及标记胆固醇的巨噬细胞。负载的巨噬细胞可用于诊断目的和改进的体内测定，以评估测试药物调节受试者中逆向胆固醇转运途径的有效性。

2. 发明申请

WO2003090710A1 LAPACHONE DELIVERY SYSTEMS, COMPOSITIONS AND USES RELATED THERETO 审中-公开
标题翻译： LAPACHONE交付系统，组合物和相关用途
公开(公告)号：WO2003090710A1
公开(公告)日：2003-11-06
申请号：PCT/US2003/012605
申请日：2003-04-23
申请人： CASE WESTERN RESERVE UNIVERSITY , BOOTHMAN, David , GAO, Jinming , NASONGKLA, Norased , PINK, John
发明人： BOOTHMAN, David , GAO, Jinming , NASONGKLA, Norased , PINK, John
IPC分类号： A61K9/00
CPC分类号： A61K9/0024 , A61K31/35 , A61K31/352 , A61K31/353 , A61K31/724 , A61K47/34 , A61K47/40 , A61K47/6951 , A61K51/1268 , A61K51/1282 , B82Y5/00
摘要： In part, the present invention is directed to a system comprising a lapachone or a prodrug thereof and a polymer, such as a biocompatible and optionally biodegradable polymer, methods for treatment using the subject polymer compositions, and methods of making and using the same. In another part, the present invention includes inclusion complexes of a lapachone or a prodrug thereof and a cyclodextrin, preferably a β-cyclodextrin, such as hydroxypropyl β-cyclodextrin, e.g., to improve the solubility of the lapachone or prodrug thereof.
摘要翻译：部分地，本发明涉及包含拉帕酮或其前药以及聚合物，例如生物相容性和任选可生物降解的聚合物的方法的系统，其使用本发明聚合物组合物进行处理的方法及其制备和使用方法。另一方面，本发明包括拉帕酮或其前药和环糊精，优选β-环糊精如羟丙基β-环糊精的包合物，例如改善拉布他酮或其前药的溶解度。

3. 发明申请

WO01007089A3 TECHNETIUM TC99M TEBOROXIME MYOKARDIAL-PERFUSION MITTEL 审中-公开
标题翻译： TECHNETIUM TC99M TEBOROXIME MYKARDIAL-PERFUSION MITTEL
公开(公告)号：WO01007089A3
公开(公告)日：2001-06-14
申请号：PCT/IB2000/001013
申请日：2000-07-21
IPC分类号： A61K51/00 , A61K51/04 , A61K51/12
CPC分类号： B82Y5/00 , A61K51/0474 , A61K51/1268 , A61K51/1282
摘要： A kit containing a solution of boronic acid adducts of technetium-99m dioxime complexes; and hydroxypropyl gamma cyclodextrin to maintain the solution free of particulate matter originating from the formulation.
摘要翻译：包含锝-99m二肟配合物的硼酸加合物溶液的试剂盒; 和羟丙基γ-环糊精以保持溶液不含来自制剂的颗粒物质。

4. 发明申请

WO99024396A1 ION BINDING COMPOUNDS, RADIONUCLIDE COMPLEXES, METHODS OF MAKING RADIONUCLIDE COMPLEXES, METHODS OF EXTRACTING RADIONUCLIDES AND METHODS OF DELIVERING RADIONUCLIDES TO TARGET LOCATIONS 审中-公开
标题翻译：离子结合化合物，放射性核素复合物，制备放射性核素复合物的方法，提取放射性核素的方法和将放射性核素递送到目标位置的方法
公开(公告)号：WO99024396A1
公开(公告)日：1999-05-20
申请号：PCT/US1998/024074
申请日：1998-11-12
IPC分类号： A61K47/48 , A61K51/12 , C07C259/06 , C07C311/29 , C22B3/26 , C22B3/32 , C22B59/00 , C22B60/00 , G21F9/12 , A61K51/04 , C07C59/74
CPC分类号： B82Y5/00 , A61K47/6887 , A61K51/1268 , C07C259/06 , C07C311/29 , C07C2603/92 , C22B3/0006 , C22B3/0024 , C22B59/00 , C22B60/00 , G21F9/12 , Y02P10/234
摘要： The invention pertains to compounds for binding lanthanide ions and actinide ions. The invention further pertains to compounds for binding radionuclides, and to methods of making radionuclide complexes. Also, the invention pertains to methods of extracting radionuclides. Additionally, the invention pertains to methods of delivering radionuclides to target locations. In one aspect, the invention includes a compound comprising: a) a calix[n]arene group, wherein n is an integer greater than 3, the calix[n]arene group comprising an upper rim and a lower rim; b) at least one ionizable group attached to the lower rim; and c) an ion selected from the group consisting of lanthanide and actinide elements bound to the ionizable group. In another aspect, the invention includes a method of extracting a radionuclide, comprising: a) providing a sample comprising a radionuclide; b) providing a calix[n]arene compound in contact with the sample, wherein n is an integer greater than 3; and c) extracting radionuclide from the sample into the calix[n]arene compound. In yet another aspect, the invention includes a method of delivering a radionuclide to a target location, comprising: a) providing a calix[n]arene compound, wherein n is an integer greater than 3, the calix[n]arene compound comprising at least one ionizable group; b) providing a radionuclide bound to the calix[n]arene compound; and c) providing an antibody attached to the calix[n]arene compound, the antibody being specific for a material found at the target location.
摘要翻译：本发明涉及用于结合镧系离子和锕系离子的化合物。本发明还涉及用于结合放射性核素的化合物以及制备放射性核素复合物的方法。此外，本发明涉及提取放射性核素的方法。此外，本发明涉及将放射性核素递送到目标位置的方法。一方面，本发明包括一种化合物，其包含：a）杯[n]芳烃基，其中n是大于3的整数，所述杯[n]芳烃基包括上边缘和下边缘; b）连接到下边缘的至少一个可离子化基团; 和c）选自与可离子化基团结合的镧系元素和锕系元素的离子。另一方面，本发明包括一种提取放射性核素的方法，包括：a）提供包含放射性核素的样品; b）提供与样品接触的杯[n]芳烃化合物，其中n是大于3的整数; 和c）将样品中的放射性核素提取到杯[n]芳烃化合物中。在另一方面，本发明包括将放射性核素递送到目标位置的方法，包括：a）提供其中n为大于3的整数的杯[n]芳烃化合物，所述杯[n]芳烃化合物包含至少一个可离子化基团; b）提供与杯[n]芳烃化合物结合的放射性核素; 和c）提供连接到杯[n]芳烃化合物的抗体，所述抗体对于在目标位置处发现的材料是特异性的。

5. 发明申请

WO2014182804A1 THERAPEUTIC AND IMAGING COMPOSITIONS AND USES THEREOF 审中-公开
标题翻译：治疗和成像组合物及其用途
公开(公告)号：WO2014182804A1
公开(公告)日：2014-11-13
申请号：PCT/US2014/037134
申请日：2014-05-07
申请人： PURDUE RESEARCH FOUNDATION , THOMPSON, David, H. , KULKARNI, Aditya , COLLINS, Christopher , MONDJINOU, Yawo
发明人： THOMPSON, David, H. , KULKARNI, Aditya , COLLINS, Christopher , MONDJINOU, Yawo
IPC分类号： G01N33/566
CPC分类号： C08B37/0015 , A61K31/724 , A61K31/765 , A61K47/547 , A61K47/60 , A61K47/61 , A61K47/6951 , A61K51/065 , A61K51/1268 , C08G83/007 , G01N33/6893
摘要： Various embodiments of the present invention are directed to polyrotaxanes comprising a poloxamer core and at least one cyclodextrin and methods for treating Niemann-Pick type C (NPC) and imaging (e.g., MRI) using the polyrotaxanes various embodiments of the present invention.
摘要翻译：本发明的各种实施方案涉及包含泊洛沙姆核心和至少一种环糊精的聚轮烷和使用本发明的各种实施方案使用聚轮烷成像（例如，MRI）的尼曼 - 皮克C型（NPC）的方法。

6. 发明申请

WO9924081A3 A RADIONUCLIDE-BINDING COMPOUND AND ITS DELIVERY SYSTEM 审中-公开
标题翻译：一种放射性核素结合体及其输送系统
公开(公告)号：WO9924081A3
公开(公告)日：1999-07-29
申请号：PCT/US9824169
申请日：1998-11-12
申请人： BATTELLE MEMORIAL INSTITUTE , IDAHO RES FOUND
发明人： FISHER DARRELL R , WAI CHIEN M , CHEN XIAOYUAN
IPC分类号： A61K51/10 , A61K51/12
CPC分类号： B82Y5/00 , A61K51/1093 , A61K51/1268
摘要： The invention pertains to compounds which specifically bind radionuclides, and to methods of making radionuclide complexing compounds. In one aspect, the invention includes a radionuclide delivery system comprising: a) a calix[n]arene-crown-[m]-ether compound, wherein n is an integer greater than 3, and wherein m is an integer greater than 3, the calix[n]arene-crown-[m]-ether compound comprising at least two ionizable groups; and b) an antibody attached to the calix[n]arene-crown-[m]-ether compound. In another aspect, the invention includes a method of making a radium complexing compound, comprising: a) providing a calix[n]arene compound, wherein n is an integer greater than 3, the calix[n]arene compound comprising n phenolic hydroxyl groups; b) providing a crown ether precursor, the crown ether precursor comprising a pair of tosylated ends; c) reacting the pair of tosylated ends with a pair of the phenolic hydroxyl groups to convert said pair of phenolic hydroxyl groups to ether linkages, the ether linkages connecting the crown ether precursor to the calix[n]arene to form a calix[n]arene-crown-[m]-ether compound, wherein m is an integer greater than 3; d) converting remaining phenolic hydroxyl groups to esters; e) converting the esters to acids, the acids being proximate a crown-[m]-ether portion of the calix[n]arene-crown-[m]-ether compound; and f) providing a Ra ion within the crown-[m]-ether portion of the calix[n]arene-crown-[m]-ether compound.
摘要翻译：本发明涉及特异性结合放射性核素的化合物，以及制备放射性核素络合化合物的方法。一方面，本发明包括放射性核素递送系统，其包括：a）杯[n]芳烃 - 冠 - [m] - 醚化合物，其中n是大于3的整数，并且其中m是大于3的整数，包含至少两个可离子化基团的杯[n]芳烃 - 冠 - [m] - 醚化合物; 和b）连接到杯[n]芳烃 - 冠 - [m] - 醚化合物的抗体。另一方面，本发明包括制备镭络合化合物的方法，包括：a）提供其中n为大于3的整数的杯[n]芳烃化合物，包含n个酚羟基的杯[n]芳烃化合物 ; b）提供冠醚前体，所述冠醚前体包含一对甲磺酰化的末端; c）使一对甲苯磺酰化的末端与一对酚羟基反应，将所述一对酚羟基转化为醚键，将冠醚前体连接到杯[n]芳烃上形成杯[n] 芳基 - 冠 - [m] - 醚化合物，其中m是大于3的整数; d）将剩余的酚羟基转化成酯; e）将酯转化为酸，酸接近杯[n]芳烃 - 冠 - [m] - 醚化合物的冠 - [m] - 醚部分; 和f）在杯[n]芳烃 - 冠 - [m] - 醚化合物的冠 - [m] - 醚部分内提供Ra 2+离子。

7. 发明申请

WO1997046098A1 CLUSTER CLEARING AGENTS 审中-公开
标题翻译：集群清除剂
公开(公告)号：WO1997046098A1
公开(公告)日：1997-12-11
申请号：PCT/US1997009394
申请日：1997-06-06
申请人： NEORX CORPORATION
发明人： NEORX CORPORATION , THEODORE, Louis, J. , AXWORTHY, Donald, B.
IPC分类号： A01N43/04
CPC分类号： B82Y5/00 , A61K47/557 , A61K47/6893 , A61K47/6898 , A61K51/1268
摘要： Cluster clearing agents (CCAs) and the use thereof are discussed. CCAs are composed of a hepatic clearance directing moiety which directs the biodistribution of a CCA-containing construct to hepatic clearance; and a binding moiety which mediates binding of the CCA to a compound for which rapid hepatic clearance is desired.
摘要翻译：讨论了群集清除代理（CCAs）及其使用。 CCA由肝间隙指导部分组成，其指导含CCA构建体的生物分布为肝脏清除; 以及结合部分，其介导CCA与需要快速肝清除的化合物的结合。

8. 发明申请

WO9705904A3 USE OF METAL CLUSTERS AS A CONTRAST OR RADIOTHERAPY AGENT 审中-公开
标题翻译：作为对照或放射治疗剂的金属簇的使用
公开(公告)号：WO9705904A3
公开(公告)日：1997-08-14
申请号：PCT/DE9601436
申请日：1996-07-25
申请人： SCHERING AG , KRAUSE WERNER , MAIER FRANZ , NIEDBALLA ULRICH , RADUECHEL BERND
发明人： KRAUSE WERNER , MAIER FRANZ , NIEDBALLA ULRICH , RADUECHEL BERND
IPC分类号： A61K41/00 , A61K49/04 , A61K49/18 , A61K51/12 , A61K49/00
CPC分类号： A61K41/0095 , A61K49/04 , A61K49/1809 , A61K49/1836 , A61K51/1217 , A61K51/1268 , A61K2121/00 , A61K2123/00 , B82Y5/00
摘要： Metal clusters can be used as a contrast agent for magnetic resonance or X-ray diagnosis and as a therapeutic agent in radiation therapy for tumours.

9. 发明申请

WO1997005904A2 USE OF METAL CLUSTERS AS A CONTRAST OR RADIOTHERAPY AGENT 审中-公开
标题翻译：金属团簇作为造影剂或治疗辐射USE
公开(公告)号：WO1997005904A2
公开(公告)日：1997-02-20
申请号：PCT/DE1996001436
申请日：1996-07-25
申请人： SCHERING AKTIENGESELLSCHAFT , KRAUSE, Werner , MAIER, Franz , NIEDBALLA, Ulrich , RADÜCHEL, Bernd
发明人： SCHERING AKTIENGESELLSCHAFT
IPC分类号： A61K49/00
CPC分类号： A61K41/0095 , A61K49/04 , A61K49/1809 , A61K49/1836 , A61K51/1217 , A61K51/1268 , A61K2121/00 , A61K2123/00 , B82Y5/00
摘要： Metal clusters can be used as a contrast agent for magnetic resonance or X-ray diagnosis and as a therapeutic agent in radiation therapy for tumours.
摘要翻译：金属簇可以用作用于磁共振或X射线诊断的，造影剂和如在肿瘤的放射治疗的治疗剂。

10. 发明申请

WO2011087548A2 THERAPEUTIC COMPOSITIONS AND METHODS FOR TARGETED DELIVERY OF ACTIVE AGENTS 审中-公开
标题翻译：治疗组合物和方法，用于有针对性地递送活性药剂
公开(公告)号：WO2011087548A2
公开(公告)日：2011-07-21
申请号：PCT/US2010/054321
申请日：2010-10-27
申请人： WILLIAM MARSH RICE UNIVERSITY , BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM , TOUR, James, M. , BERLIN, Jacob , PHAM, Tam , MYERS, Jeffrey, N. , SANO, Daisuke
发明人： TOUR, James, M. , BERLIN, Jacob , PHAM, Tam , MYERS, Jeffrey, N. , SANO, Daisuke
IPC分类号： A61K48/00
CPC分类号： C07K16/2854 , A61K47/6929 , A61K47/6949 , A61K51/1268 , B82Y5/00 , Y10S977/746 , Y10S977/75 , Y10S977/842 , Y10S977/906
摘要： The present invention pertains to therapeutic compositions that comprise: (1) a nanovector; (2) an active agent; and (3) a targeting agent, wherein the active agent and the targeting agent are non-covalently associated with the nanovector. The present invention also pertains to methods of treating various conditions in a subject by utilizing the above-described therapeutic compositions. Methods of making the therapeutic compositions are also a subject matter the present invention.
摘要翻译：本发明涉及治疗组合物，其包含：（1）纳米体; （2）活性剂; 和（3）靶向剂，其中活性剂和靶向剂与纳米体非共价结合。本发明还涉及通过利用上述治疗组合物治疗受试者的各种病症的方法。制备治疗组合物的方法也是本发明的主题。

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