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21. 发明申请

WO2003018113A1 TREATMENT OF DISORDERS BY UNIDIRECTIONAL NERVE STIMULATION 审中-公开
标题翻译：通过非感染性神经刺激治疗疾病
公开(公告)号：WO2003018113A1
公开(公告)日：2003-03-06
申请号：PCT/IL2002/000068
申请日：2002-01-23
申请人： BIOCONTROL MEDICAL LTD. , COHEN, Ehud , GROSS, Yossi , AYAL, Shai
发明人： COHEN, Ehud , GROSS, Yossi , AYAL, Shai
IPC分类号： A61N1/08
CPC分类号： A61N1/36007 , A61N1/36114
摘要： Apparatus (18) for treating a condition of a subject is provided. An electrode device (100) is adapted to be coupled to longitudinal nervous tissue (40) of the subject, and a control unit (50) is adapted to drive the electrode device to apply to the nervous tissue a current which is capable of inducing action potentials that propagate in the nervous tissue in a first direction, so as to treat the condition. The control unit is further adapted to suppress action potentials from propagating in the nervous tissue in a second direction opposite to the first direction.
摘要翻译：提供了用于治疗受试者状况的装置（18）。电极装置（100）适于联接到受试者的纵向神经组织（40），并且控制单元（50）适于驱动电极装置向神经组织施加能够引起动作的电流在第一方向在神经组织中传播的电位，以便治疗病症。控制单元还适于抑制动作电位在与第一方向相反的第二方向上在神经组织中传播。

22. 发明申请

WO2023073692A1 ATRIAL-VENTRICULAR CARDIAC IMPLANT 审中-公开
公开(公告)号：WO2023073692A1
公开(公告)日：2023-05-04
申请号：PCT/IL2022/051121
申请日：2022-10-25
申请人： GROSS, Yossi
发明人： GROSS, Yossi
IPC分类号： A61F2/24 , A61B17/04 , A61B17/00
摘要： A cardiac implant (20, 120, 220, 320, 520, 620, 720, 820, 920) is provided for treating diastolic heart failure, the cardiac implant including a flexible tether (24, 124, 224A, 224B, 324); a superior anchor (26, 226A, 226B), which is coupled to a superior portion (28, 128) of the flexible tether and configured to anchor the flexible tether to a left- atrial site (46) of a wall (30) of a left atrium (32) of a heart (14); and an inferior anchor (34, 234A, 234B), which is coupled to an inferior portion (36, 236A, 236B) of the flexible tether and configured to anchor the flexible tether to a left-ventricular site (38) of a left ventricle (56) of the heart (14). The flexible tether (24, 124, 224A, 224B, 324) is configured such that when the flexible tether is anchored and has a length of 6 - 12 cm between the superior anchor (26, 226A, 226B) and the inferior anchor (34, 234A, 234B), the flexible tether reduces a volume of the left atrium (32) during at least a portion of ventricular diastole of each cardiac cycle, thereby enhancing ventricular filling. Other embodiments are also described.

23. 发明申请

WO2019150358A1 RETINAL IMPLANT WITH IMAGE REGISTRATION 审中-公开
公开(公告)号：WO2019150358A1
公开(公告)日：2019-08-08
申请号：PCT/IL2019/050059
申请日：2019-01-16
申请人： NANO-RETINA, INC. , GROSS, Yossi
发明人： GROSS, Yossi , MILSTAIN, Yaakov , YANOVITZ, Leonid , RIMER-COHEN, Ofir
IPC分类号： A61N1/378 , A61N1/36
摘要： Apparatus (20) is provided including an intraocular device (60) which is implanted entirely in an eye of a subject and includes a photosensor array (6050) which detect photons representing an image in a gaze direction of the subject, and stimulating electrodes (6060) which apply currents to the retina. The apparatus (20) further includes an extraocular device (40) including an imaging device (4080) which captures a wide-field image, and processing circuitry (6074) which (i) receives the wide-field image from the imaging device (4080) of the extraocular device (40), (ii) receives a signal from the photosensors of the intraocular device (60), (iii) based on the signal from the photosensors, process the wide-field image from the imaging device (4080) to generate image data representative of a sub-portion of the wide-field image, and (iv) cause the electrodes (6060) to apply currents to the retina based on the image data. Other applications are also described.

24. 发明申请

WO2013164829A1 WIRELESS ENDOVASCULAR STENT-BASED ELECTRODES 审中-公开
标题翻译：无电极基底静脉电极
公开(公告)号：WO2013164829A1
公开(公告)日：2013-11-07
申请号：PCT/IL2013/050375
申请日：2013-05-02
申请人： ENOPACE BIOMEDICAL LTD. , ELAZAR, Moshe , DAGAN, Amir , BERNSHTEIN, Vadim , GROSS, Yossi , GOLAN, Saar , HANANI, Nitai , GINDIN, Igor , ARMONY, Nir
发明人： ELAZAR, Moshe , DAGAN, Amir , BERNSHTEIN, Vadim , GROSS, Yossi , GOLAN, Saar , HANANI, Nitai , GINDIN, Igor , ARMONY, Nir
IPC分类号： A61F2/82
CPC分类号： A61N1/05 , A61F2/856 , A61F2/88 , A61F2/915 , A61F2002/8483 , A61F2002/91558 , A61F2002/9505 , A61F2220/0016 , A61F2220/005 , A61F2220/0075 , A61F2230/0013 , A61F2230/0054 , A61F2250/0001 , A61N1/37205
摘要： Apparatus and methods are provided including a stent (20) configured to be placed in a blood vessel. The stent includes first (214) and second (216) strut portions at first and second ends of the stent, and a flexible central portion (210) of the stent. In the absence of any force being applied to the stent, the length of the central portion is more than 50 percent of a total length of the stent. At any given longitudinal location along the central portion, the central portion defines no struts around a continuous angular region of more than 180 degrees around a longitudinal axis of the stent. A control capsule (30), coupled to the second strut portion, drives a current into the blood vessel via an electrode (22), which is coupled to the stent. An antenna (28), coupled to the first strut portion, receives power and powers the control capsule.
摘要翻译：提供了包括构造成放置在血管中的支架（20）的装置和方法。支架在支架的第一端和第二端处以及支架的柔性中心部分（210）包括第一（214）和第二（216）支柱部分。在没有施加任何力的支架上，中心部分的长度大于支架总长度的50％。在沿着中心部分的任何给定的纵向位置处，中心部分围绕围绕支架的纵向轴线的大于180度的连续角度区域不限定支柱。耦合到第二支柱部分的控制盒（30）经由与支架相连的电极（22）将电流驱动到血管中。耦合到第一支柱部分的天线（28）接收功率并为控制盒提供电力。

25. 发明申请

WO2012120495A2 TISSUE TREATMENT AND MONITORING BY APPLICATION OF ENERGY 审中-公开
标题翻译：通过应用能源组织治疗和监测
公开(公告)号：WO2012120495A2
公开(公告)日：2012-09-13
申请号：PCT/IL2012/000100
申请日：2012-03-04
申请人： RAINBOW MEDICAL LTD. , GROSS, Yossi , KARDOSH, Michael , MEIRY, Gideon , TSOREF, Liat , KUSHKULEY, Leonid , ASSAF, Yaron
发明人： GROSS, Yossi , KARDOSH, Michael , MEIRY, Gideon , TSOREF, Liat , KUSHKULEY, Leonid , ASSAF, Yaron
IPC分类号： A61N7/00
CPC分类号： A61N7/022 , A61B5/4836 , A61B8/12 , A61B8/445 , A61B8/546 , A61B2017/22069 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00577 , A61N2007/0043 , A61N2007/0078 , A61N2007/0086 , A61N2007/0091
摘要： Apparatus is provided, which includes at least one ultrasound transducer. The ultrasound transducer is configured to be positioned within a lumen of a subject and to ablate tissue surrounding a wall of the lumen without ablating the wall of the lumen, by focusing ultrasound energy on a focal zone that is outside of the wall of the lumen. A transluminal delivery tool is configured to position the ultrasound transducer in the lumen, and a control unit is configured to drive the ultrasound transducer. Other embodiments are also described.
摘要翻译：提供了包括至少一个超声换能器的装置。超声换能器被配置为定位在受试者的内腔内，并且通过将超声能量聚焦在位于管腔壁外部的聚焦区域上而消融内腔壁周围的组织，而不会消融内腔壁。经腔递送工具被配置为将超声换能器定位在内腔中，并且控制单元被配置为驱动超声换能器。还描述了其它实施例。

26. 发明申请

WO2012081011A1 ULTRASOUND SKIN TREATMENT 审中-公开
标题翻译：超声皮肤治疗
公开(公告)号：WO2012081011A1
公开(公告)日：2012-06-21
申请号：PCT/IL2011/000942
申请日：2011-12-14
申请人： SLENDER MEDICAL LTD. , AZHARI, Haim , TSOREF, Liat , KRASNOV, Gregory , GROSS, Yossi
发明人： AZHARI, Haim , TSOREF, Liat , KRASNOV, Gregory , GROSS, Yossi
IPC分类号： A61N7/00
CPC分类号： A61N7/00 , A61B2017/00106 , A61B2018/00791 , A61N7/02 , A61N2007/0034 , A61N2007/0091
摘要： Apparatus (20) is provided comprising a skin-application portion (40), configured to move across skin of a subject. At least one acoustic element (50) is coupled to the skin-application portion (40) and configured to be placed in acoustic contact with the skin, and configured to apply ultrasound energy to the skin. The apparatus (20) additionally comprises circuitry configured to generate a current responsive to motion of the skin-application portion (40); and a control unit (10), which is configured to receive the current, to determine, responsive thereto, whether the skin-application portion (40) is moving with respect to the skin, and to drive the acoustic element (50) to apply the ultrasound energy to the skin responsive to determining that the skin-application portion (40) is moving with respect to the skin. Other embodiments are also described.
摘要翻译：提供了一种设备（20），其包括皮肤应用部分（40），其构造成移动穿过受试者的皮肤。至少一个声学元件（50）耦合到皮肤施加部分（40）并且被配置为与皮肤声学接触，并且被配置为向皮肤施加超声波能量。所述装置（20）还包括经配置以响应于皮肤施加部分（40）的运动产生电流的电路; 以及控制单元（10），其被配置为接收电流，以响应于此来确定皮肤应用部分（40）是否相对于皮肤移动，并且驱动声学元件（50）施加响应于确定皮肤应用部分（40）相对于皮肤移动，对皮肤的超声能量。还描述了其它实施例。

27. 发明申请

WO2012011108A2 TECHNIQUES FOR PERCUTANEOUS MITRAL VALVE REPLACEMENT AND SEALING 审中-公开
标题翻译：用于经皮麻醉阀更换和密封的技术
公开(公告)号：WO2012011108A2
公开(公告)日：2012-01-26
申请号：PCT/IL2011/000582
申请日：2011-07-21
申请人： MITRALTECH LTD. , GROSS, Yossi , HACOHEN, Gil , MILLER, Eran , ZIPORY, Yuval , REICH, Tal
发明人： GROSS, Yossi , HACOHEN, Gil , MILLER, Eran , ZIPORY, Yuval , REICH, Tal
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61B17/068 , A61B17/29 , A61B2017/00243 , A61B2017/0441 , A61B2017/0464 , A61B2017/0647 , A61B2017/0649 , A61F2/24 , A61F2/2409 , A61F2/2412 , A61F2/2427 , A61F2/243 , A61F2/2436 , A61F2/2439 , A61F2/2457 , A61F2220/0016 , A61F2220/0025 , A61F2230/005 , A61F2230/0054 , A61F2250/0039 , A61F2250/006 , A61F2250/0063
摘要： Apparatus and methods are described including a prosthetic valve support (40) configured to be placed at a patient's native atrioventricular valve annulus. The valve support defines an annular element (44) that defines an inner cross-sectional area thereof. An expandable prosthetic valve (80) is placed into the patient's ventricle, the prosthetic valve including an expandable frame (79) and prosthetic valve leaflets (82) coupled to the frame. When the frame is in a non-constrained state thereof, a cross-sectional area of the frame, along at least a given portion L of the frame's length, is greater than the cross-sectional area defined by the annular element. The prosthetic valve is couplable to the prosthetic valve support at any location along the portion, by the frame being expanded when the location along the portion is aligned with the annular element. Other applications are also described.
摘要翻译：描述的装置和方法包括构造成放置在患者的天然房室瓣膜环上的假体瓣膜支撑件（40）。阀支撑件限定了限定其内部横截面面积的环形元件（44）。将可扩张的假体瓣膜（80）放置在患者的心室中，所述人工瓣膜包括可耦合到框架的可扩张框架（79）和假体瓣膜（82）。当框架处于非约束状态时，沿着框架长度的给定部分L的框架的横截面面积大于由环形元件限定的横截面积。当沿着该部分的位置与环形元件对准时，假体瓣膜可以在沿着该部分的任何位置处联接到人工瓣膜支撑件。还描述了其它应用。

28. 发明申请

WO2011141918A2 REFLECTANCE-FACILITATED ULTRASOUND TREATMENT AND MONITORING 审中-公开
标题翻译：反射辅助超声治疗和监测
公开(公告)号：WO2011141918A2
公开(公告)日：2011-11-17
申请号：PCT/IL2011/000382
申请日：2011-05-12
申请人： TSOREF, Liat , GROSS, Yossi , KARDOSH, Michael
发明人： TSOREF, Liat , GROSS, Yossi , KARDOSH, Michael
IPC分类号： A61N7/00
CPC分类号： A61B34/20 , A61B8/0841 , A61B8/0883 , A61B8/12 , A61B8/445 , A61B8/481 , A61B8/5223 , A61B17/320016 , A61B17/320092 , A61B2017/00026 , A61B2017/00084 , A61B2017/00106 , A61B2017/00243 , A61B2017/320052 , A61B2018/00285 , A61B2034/2063 , A61B2090/3784 , A61N7/022 , A61N2007/0052 , A61N2007/0056 , A61N2007/0069 , A61N2007/0091
摘要： Apparatus comprising an ultrasound ablation system (10), which comprises a reflection-facilitation element (12), configured to be placed at an extramyocardial site of a subject, and to provide an extramyocardial reflective region; and an ultrasound tool (20), which comprises at least one ultrasound transducer (40) configured to be positioned within a heart chamber of the subject. The ultrasound transducer (40) is configured to ablate myocardial tissue by applying ultrasound energy to the myocardial tissue such that at least a portion of the transmitted energy is reflected by the reflective region onto the myocardial tissue. Other embodiments are also described.
摘要翻译：包括超声消融系统（10）的装置，其包括被配置为放置在受试者的心肌外部位置处的反射促进元件（12），并且提供心外膜反射区域; 和超声波工具（20），其包括构造成定位在受试者的心室内的至少一个超声换能器（40）。超声换能器（40）被配置为通过向心肌组织施加超声能量来消融心肌组织，使得至少一部分透射能量被反射区域反射到心肌组织上。还描述了其它实施例。

29. 发明申请

WO2011138780A3 DEVICES AND METHODS FOR CONTROL OF BLOOD PRESSURE 审中-公开
公开(公告)号：WO2011138780A3
公开(公告)日：2011-11-10
申请号：PCT/IL2011/000356
申请日：2011-05-05
申请人： VASCULAR DYNAMICS INC. , GROSS, Yossi , AVNERI, Itzik , WEISBERG, Ori , ESHKOL, Moshe
发明人： GROSS, Yossi , AVNERI, Itzik , WEISBERG, Ori , ESHKOL, Moshe
IPC分类号： A61B17/00
摘要： Apparatus and methods are described including an implantable device (140) shaped to define (a) at least two artery-contact regions (142), the artery-contact regions comprising struts (146) that are configured to stretch an arterial wall by applying pressure to the arterial wall, and (b) at least two crimping regions (144) that comprise locking mechanisms (149) configured to prevent the crimping regions from becoming crimped due to pressure from the wall of the artery on the artery-contact regions. The crimping regions are configured to be crimped during insertion of the device, via a catheter, by the locking mechanisms being unlocked during insertion of the device. Other embodiments are also described.

30. 发明申请

WO2011067770A1 DELIVERY TOOL FOR IMPLANTATION OF SPOOL ASSEMBLY COUPLED TO A HELICAL ANCHOR 审中-公开
标题翻译：用于植入与安装在一起的锚固装置的输送工具
公开(公告)号：WO2011067770A1
公开(公告)日：2011-06-09
申请号：PCT/IL2010/001024
申请日：2010-12-02
申请人： VALTECH CARDIO, LTD. , MILLER, Eran , POMERANTZ, Uriel Aba , MAISANO, Francesco , CABIRI, Oz , HERMAN, Yaron , WEITZMAN, Yoseph , GROSS, Yossi
发明人： MILLER, Eran , POMERANTZ, Uriel Aba , MAISANO, Francesco , CABIRI, Oz , HERMAN, Yaron , WEITZMAN, Yoseph , GROSS, Yossi
IPC分类号： A61B17/08
CPC分类号： A61F2/2466 , A61B17/0401 , A61B17/0469 , A61B2017/00243 , A61B2017/0409 , A61B2017/0414 , A61B2017/044 , A61B2017/0441 , A61B2017/0464 , A61B2017/048 , A61F2/2427 , A61F2/2457
摘要： Apparatus is provided, including a tissue-adjusting member (60) configured to be coupled to tissue of a patient, a rotatable structure (2900, 3046) that is configured to adjust a tension of the tissue-adjusting member (60), a tissue anchor (50) coupled to the tissue-adjusting member (60) and configured to screw into the tissue of the patient, and a delivery tool (3022) reversibly coupleable to the rotatable structure (2900, 3046). The delivery tool (3022) comprises a first actuating element (3202) configured to rotate the tissue anchor (50) so as to facilitate screwing of the tissue anchor (50) into the tissue of the patient while not facilitating rotation of the rotatable structure (2900, 3046), and a second actuating element (3090) configured to rotate the rotatable structure (2900, 3046) while not facilitating rotation of the tissue anchor (50). Other applications are also described.
摘要翻译：提供了一种装置，包括构造成联接到患者组织的组织调节构件（60），被配置为调节组织调节构件（60）的张力的可旋转结构（2900,3046），组织锚固器（50），其联接到所述组织调节构件（60）并且构造成螺旋进入患者的组织;以及递送工具（3022），其可逆地联接到所述可旋转结构（2900,3046）。输送工具（3022）包括构造成旋转组织锚固件（50）的第一致动元件（3202），以便于有助于组织锚固件（50）旋入患者的组织中而不利于旋转结构的旋转 2900,3046）和第二致动元件（3090），其构造成在不促进组织锚（50）的旋转的同时旋转可旋转结构（2900,3046）。还描述了其它应用。

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