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    • 14. 发明申请
    • ALTERNATIVE OXIDASE (AOX) PREVENTS SMOKING-ASSOCIATED LUNG DAMAGE
    • 替代性氧化酶(AOX)预防吸烟相关的肺损伤
    • WO2014096437A1
    • 2014-06-26
    • PCT/EP2013/077865
    • 2013-12-20
    • MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V.UNIVERSITY OF TAMPERE
    • SZIBOR, MartenBRAUN, ThomasVOSWINCKEL, RobertJACOBS, HowardDUFOUR, EricRUSTIN, Pierre
    • A61K38/44C12N9/02C12N15/63A61P39/00A61P39/06A61P9/04A61P9/10A61P11/00A61P19/10A61P13/12A61P31/06A61K48/00
    • A61K38/44A01K67/0275A01K2217/072A01K2227/105A01K2267/03A61K48/005C12N9/0006C12N9/0057C12Y110/03011
    • The present invention relates to a nucleic acid molecule encoding a polypeptide, the polypeptide having the activity of alternative oxidase (AOX), wherein said nucleic acid molecule is selected from the group consisting of (a) a nucleic acid molecule encoding a polypeptide comprising or consisting of the amino acid sequence of SEQ ID NO: 1; (b) a nucleic acid molecule encoding a polypeptide comprising or consisting of an amino acid sequence having at least 60% sequence similarity to the amino acid sequence of SEQ ID NO: 1; (c) a nucleic acid molecule comprising or consisting of the nucleotide sequence of SEQ ID NO: 2; (d) a nucleic acid molecule having at least 60% sequence similarity to the nucleic acid molecule of (c); and (e) a nucleic acid molecule degenerate with respect to the nucleic acid molecule of (c) or (d), for use in a method of treating or preventing a disease or condition associated caused by the inhalation of toxic smoke. Further, the present invention relates to a vector comprising said nucleic acid molecule for use in a method of treating or preventing a disease or condition caused by the inhalation of toxic smoke and to a polypeptide encoded by said nucleic acid molecule for use in a method of treating or preventing a disease or condition caused by the inhalation of toxic smoke. The present invention further relates to a non-toxic host cell carrying the nucleic acid molecule, the vector or the polypeptide of the invention for use in a method of treating or preventing a disease or condition caused by the inhalation of toxic smoke and to a product of the non-toxic host cell for use in a method of treating or preventing a disease or condition caused by the inhalation of toxic smoke.
    • 本发明涉及编码多肽的核酸分子,所述多肽具有替代氧化酶(AOX)的活性,其中所述核酸分子选自(a)编码多肽的核酸分子,所述多核苷酸包含或组成 的SEQ ID NO:1的氨基酸序列; (b)编码包含与SEQ ID NO:1的氨基酸序列具有至少60%序列相似性的氨基酸序列的多肽的核酸分子; (c)包含SEQ ID NO:2的核苷酸序列或由其组成的核酸分子; (d)与(c)的核酸分子具有至少60%的序列相似性的核酸分子; 和(e)相对于(c)或(d)的核酸分子简并的核酸分子,用于治疗或预防由吸入有毒烟雾引起的疾病或病症的方法。 此外,本发明涉及包含所述核酸分子的载体,所述载体用于治疗或预防由吸入毒性烟雾引起的疾病或病症的方法和由所述核酸分子编码的多肽,用于以下方法: 治疗或预防由吸入有毒烟雾引起的疾病或病症。 本发明还涉及携带本发明的核酸分子,载体或多肽的无毒宿主细胞,其用于治疗或预防由吸入有毒烟雾引起的疾病或病症的方法和产品 的无毒宿主细胞,用于治疗或预防由吸入有毒烟雾引起的疾病或病症的方法。
    • 19. 发明申请
    • COMPOSITION FOR TREATING POROUS ARTICLE, TREATMENT METHOD, AND USE THEREOF
    • 用于治疗多孔性物品的组合物,治疗方法及其用途
    • WO1998024890A1
    • 1998-06-11
    • PCT/JP1997003798
    • 1997-10-21
    • SHOWA DENKO K.K.ECHIGO, TakashiOHNO, Ritsuko
    • SHOWA DENKO K.K.
    • C12N09/02
    • B27K3/002B27K7/00C12N9/0057
    • A method for treating a porous article by efficiently increasing the molecular weights of an enzyme having a polyphenol oxidation activity in an alkaline pH region, a phenolic compound and/or an aromatic amine compound in a porous article; a composition for use in the above method, and a treated porous article having imparted or improved strength, abrasion resistance, weather resistance, rust resistance, flame retardancy, antimicrobial property, preservative property, germicidal property, insecticidal property, insect repellency, antiviral property, biological repellency, adhesion, sustained release of chemicals, coloring, dimensional stability, cracking resistance, deodorant property, deoxygenation, humidification, water absorption, water repellency, surface smoothness, biological affinity, ion exchange property, formaldehyde absorption, chemical leaching prevention, and prevention of an inorganic compound from migrating onto the surface of the porous article.
    • 一种通过在多孔制品中有效提高碱性pH值区域,酚类化合物和/或芳香胺化合物中具有多酚氧化活性的酶的分子量来处理多孔制品的方法; 具有赋予或改善的强度,耐磨性,耐候性,耐锈性,阻燃性,抗微生物性,防腐性,杀菌性,杀虫性,防虫性,抗病毒性等的处理过的多孔制品, 生物排斥性,粘附性,化学品的持续释放,着色,尺寸稳定性,抗开裂性,除臭性,脱氧,加湿,吸水性,拒水性,表面平滑性,生物亲和力,离子交换性,甲醛吸收,化学浸出预防和预防 的无机化合物迁移到多孔制品的表面上。