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1. 发明申请

WO2003000722A1 MULTI-COPPER OXIDASE PROTEIN ENZYMES FOR IRON(II) ACQUISITION IN PROKARYOTIC CELLS 审中-公开
标题翻译：用于铁的多铜氧化酶蛋白酶（II）原核细胞获得
公开(公告)号：WO2003000722A1
公开(公告)日：2003-01-03
申请号：PCT/AU2002/000828
申请日：2002-06-26
申请人： THE UNIVERSITY OF QUEENSLAND , JENNINGS, Michael , MCEWAN, Alastair , HUSTON, Wilhelmina
发明人： JENNINGS, Michael , MCEWAN, Alastair , HUSTON, Wilhelmina
IPC分类号： C07K14/21
CPC分类号： C12N9/0057 , C07K16/12 , C07K16/40
摘要： The present invention relates generally to a class of enzymes involved in metal ion acquisition by cells and agents useful in the modulation of same. More particularly, the present invention is directed to novel mechanisms of ferrous ion (Fe II ) acquisition in prokaryotic organisms mediated through a member of the multi-copper oxidase family. Recognition of multi-copper oxidase-mediated (Fe II ) acquisition in bacteria permits the rationale design of agonists and antagonists with specific or broad spectrum activity amongst one or a number of multi-copper oxidases. The present invention further contemplates a genetic sequence encoding a multi-copper oxidase and the use of the enzyme and/or its genetic sequence in development of diagnostic or detection assays as well as recombinant organisms and plants.
摘要翻译：本发明一般涉及参与用于其调制的细胞和试剂的金属离子获取的一类酶。更具体地，本发明涉及通过多铜氧化酶家族的成员介导的原核生物中亚铁离子（Fe II）获得的新机制。在细菌中识别多铜氧化酶介导的（Fe II））允许在一种或多种多铜氧化酶中具有特异性或广谱活性的激动剂和拮抗剂的理论设计。本发明进一步考虑了编码多铜氧化酶的遗传序列，以及在诊断或检测测定以及重组生物和植物的开发中使用酶和/或其遗传序列。

2. 发明申请

WO99049010A2 PHENOL OXIDIZING ENZYMES AND THEIR USE 审中-公开
标题翻译：酚醛氧化酶及其使用
公开(公告)号：WO99049010A2
公开(公告)日：1999-09-30
申请号：PCT/EP1999/002042
申请日：1999-03-23
IPC分类号： C11D3/386 , C12N9/02 , C12N15/53
CPC分类号： C12N9/0055 , C11D3/38636 , C12N9/0057 , C12R1/645
摘要： Disclosed herein are phenol oxidizing enzymes obtainable from species of Stachybotrys which are useful in modifying the color associated with dyes and colored compounds, as well as in anti-dye transfer applications. Also disclosed herein are biologically-pure cultures of strains of the genus Stachybotrys, designated herein Stachybotrys parvispora MUCL 38996 and Stachybotrys chartarum MUCL 38898, which are capable of naturally producing the novel phenol oxidizing enzymes. Disclosed herein is the amino acid and nucleic acid sequence for Stachybotrys phenol oxidizing enzymes as well as expression vectors and host cells comprising the nucleic acid. Disclosed herein are methods for producing the phenol oxidizing enzyme as well as methods for constructing expression hosts. Disclosed herein are detergent compositions comprising phenol oxidizing enzymes obtainable from species of Stachybotrys.
摘要翻译：本文公开了可从Stachybotrys的物种获得的酚氧化酶，其可用于改变与染料和着色化合物相关的颜色以及抗染料转移应用。本文还公开了Stachybotrys属（Stachybotrys parvispora MUCL 38996）和Stachybotrys chartarum MUCL 38898属的天然生产新型酚氧化酶的菌株的生物纯培养物。本文公开了Stachybotrys酚氧化酶的氨基酸和核酸序列以及包含该核酸的表达载体和宿主细胞。本文公开了生产酚氧化酶的方法以及构建表达宿主的方法。本文公开了包含可从Stachybotrys的物种获得的酚氧化酶的洗涤剂组合物。

3. 发明申请

WO2015100338A2 METHODS AND ORGANISMS WITH INCREASED CARBON FLUX EFFICIENCIES 审中-公开
标题翻译：具有增加碳通量效率的方法和有机体
公开(公告)号：WO2015100338A2
公开(公告)日：2015-07-02
申请号：PCT/US2014/072178
申请日：2014-12-23
申请人： GENOMATICA, INC.
发明人： BURGARD, Anthony, P. , OSTERHOUT, Robin, E. , VAN DIEN, Stephen, J. , PHARKYA, Priti , YANG, Tae, Hoon , CHOI, Jungik
IPC分类号： C12N1/21
CPC分类号： C12P7/18 , C07K14/245 , C12N1/20 , C12N9/0036 , C12N9/0057 , C12N9/1205 , C12N9/16 , C12N9/52 , C12N9/88 , C12N9/93 , C12N15/52 , C12P7/42 , C12Y106/01002 , C12Y110/03 , C12Y207/0104 , C12Y301/00 , C12Y301/02 , C12Y301/02002 , C12Y304/21092 , C12Y401/01031 , C12Y401/01032
摘要： The invention is directed to a non-naturally occurring microbial organism comprising a first attenuation of a succinyl-CoA synthetase or transferase and at least a second attenuation of a succinyl-CoA converting enzyme or a gene encoding a succinate producing enzyme within a multi-step pathway having a net conversion of succinyl-CoA to succinate.
摘要翻译：本发明涉及一种非天然存在的微生物生物体，其包含琥珀酰-CoA合成酶或转移酶的第一次衰减，以及琥珀酰-CoA转化酶或编码多步骤中产琥珀酸酶的基因的至少第二次衰减途径具有琥珀酰-CoA向琥珀酸盐的净转化。

4. 发明申请

WO2006084731A1 CYTOCHROME O UBIQUINOL OXIDASE SUBUNIT FROM GLUCONOBACTER OXYDANS 审中-公开
标题翻译：来自葡萄糖酸氧化酶的细胞色素O UBIQUINOL氧化酶亚基
公开(公告)号：WO2006084731A1
公开(公告)日：2006-08-17
申请号：PCT/EP2006/001226
申请日：2006-02-10
申请人： DSM IP ASSETS B.V. , CHEVREUX, Bastien , MAYER, Anne, Françoise , MEURY, Anja , MOUNCEY, Nigel, John , SHINJOH, Masako
发明人： CHEVREUX, Bastien , MAYER, Anne, Françoise , MEURY, Anja , MOUNCEY, Nigel, John , SHINJOH, Masako
IPC分类号： C12N9/02 , C12P17/04
CPC分类号： C12P17/04 , C12N9/0057
摘要： The present invention relates to a bo-type ubiquinol oxidase subunit Il that is involved in the synthesis of L-ascorbic acid (hereinafter, also referred to as Vitamin C). The invention also features polynucleotides comprising the full- length polynucleotide sequence of the novel gene and fragments thereof, the novel polypeptide encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to the use of said polynucleotides and polypeptides as biotechnological tools in the productio of Vitamin C from microorganisms, whereby a modification of said polynucleotides and/or encoded polypeptides has a direct or indirect impact on yield, production, and/or efficiency of production of the fermentation product in said microorganism. Also included are methods/processes of using the polynucleotides and modified polynucleotide sequences to transform host microorganisms. The invention also relates to genetically engineered microorganisms and their use for the direct production of Vitamin C.
摘要翻译：本发明涉及参与L-抗坏血酸合成（以下也称为维生素C）的bo型泛醇氧化酶亚单位II。本发明还涉及包含新基因的全长多核苷酸序列及其片段的多核苷酸，由多核苷酸及其片段编码的新多肽及其功能等同物。本发明还涉及所述多核苷酸和多肽在来自微生物的维生素C生产中作为生物技术工具的用途，其中所述多核苷酸和/或编码多肽的修饰对产量，产量和/或所述微生物中发酵产物的生产效率。还包括使用多核苷酸和修饰的多核苷酸序列转化宿主微生物的方法/方法。本发明还涉及基因工程微生物及其用于直接生产维生素C的用途。

5. 发明申请

WO1996037617A1 POLYPHENOL OXIDASE GENES FROM LETTUCE AND BANANA 审中-公开
标题翻译：来自LETTUCE和BANANA的聚苯酚氧化酶基因
公开(公告)号：WO1996037617A1
公开(公告)日：1996-11-28
申请号：PCT/AU1996000310
申请日：1996-05-22
申请人： COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION , ROBINSON, Simon, Piers
发明人： COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION
IPC分类号： C12N15/53
CPC分类号： C12N9/0059 , C12N9/0057 , C12N15/8241 , C12N15/8243 , C12N15/825 , C12Y110/03001
摘要： The present invention provides methods for preparing nucleic acids encoding polyphenol oxidase (PPO), fragments and derivatives thereof. The present invention also provides nucleic acids encoding banana or lettuce PPO, or antisense to banana or lettuce PPO, fragments and derivatives thereof. Vectors including such nucleic acids, methods of using such nucleic acids and transgenic plants are also provided.
摘要翻译：本发明提供了制备编码多酚氧化酶（PPO）的核酸的片段和衍生物的方法。本发明还提供编码香蕉或莴苣PPO的核酸，或对香蕉或莴苣PPO，其片段和衍生物的反义。还提供了包含这些核酸的载体，使用这种核酸的方法和转基因植物。

6. 发明申请

WO2012153791A1 染色剤及びその用途审中-公开
标题翻译：染色剂及其用途
公开(公告)号：WO2012153791A1
公开(公告)日：2012-11-15
申请号：PCT/JP2012/061937
申请日：2012-05-10
申请人：天野エンザイム株式会社 , 廣瀬芳彦 , 佐藤幸秀
发明人：廣瀬　芳彦 , 佐藤　幸秀
IPC分类号： A61K8/66 , A61Q5/10 , C12N9/04 , C12N9/06 , C12S3/00 , D06P1/32
CPC分类号： A61K8/99 , A61K8/66 , A61Q5/10 , C12N9/001 , C12N9/0057 , C12N9/0059 , C12N9/0061 , C12N9/0063 , C12N9/0071 , C12P13/00 , C12Y103/03005 , C12Y110/03001 , C12Y110/03002 , C12Y110/03003 , C12Y110/03004 , C12Y114/18001 , D06P1/32 , D06P3/14
摘要：　酸化酵素を利用しつつも優れた染色効果が得られる染色方法及びそれに用いられる染色剤を提供することを課題とする。EC 1.10.3.1で特定される酵素、EC 1.10.3.2で特定される酵素、EC 1.3.3.5で特定される酵素、EC 1.10.3.4で特定される酵素、EC 1.10.3.3で特定される酵素、及びEC 1.14.18.1で特定される酵素からなる群より選択される酵素に対して、アミン類の化学修飾により正電荷を付加して得られる修飾酵素を含む染色剤が提供される。また当該染色剤を用いた染色法が提供される。
摘要翻译：为了解决提供在使用氧化酶时获得优异染色结果的染色方法的染色方法以及使用氧化酶的染色剂的问题，提供了含有通过添加正电荷获得的修饰酶的染色剂，由胺的化学修饰方法，选自以下的酶：分类为EC 1.10.3.1的酶，分类为EC1.10.3.2的酶，归类为EC 1.3.3.5的酶，归类为EC的酶 1.10.3.4，分类为EC 1.10.3.3的酶和分类为EC 1.14.18.1的酶。还提供了使用染色剂的染色方法。

7. 发明申请

WO2006084749A2 NOVEL GENE RCS 02 审中-公开
标题翻译：新基因RCS 02
公开(公告)号：WO2006084749A2
公开(公告)日：2006-08-17
申请号：PCT/EP2006001257
申请日：2006-02-10
申请人： DSM IP ASSETS BV , CHEVREUX BASTIEN , MAYER ANNE FRANCOISE , MEURY ANJA , MOUNCEY NIGEL JOHN , SHINJOH MASAKO
发明人： CHEVREUX BASTIEN , MAYER ANNE FRANCOISE , MEURY ANJA , MOUNCEY NIGEL JOHN , SHINJOH MASAKO
IPC分类号： C12N9/02 , C07H21/00 , C12N15/00 , C12P17/04
CPC分类号： C12N9/0057 , C12P17/04
摘要： The present invention relates to newly identified genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to the use of said polynucleotides and polypeptides as biotechnological tools in the production of Vitamin C from microorganisms, whereby a modification of said polynucleotides and/or encoded polypeptides has a direct or indirect impact on yield, production, and/or efficiency of production of the fermentation product in said microorganism. Also included are methods/processes of using the polynucleotides and modified polynucleotide sequences to transform host microorganisms. The invention also relates to genetically engineered microorganisms and their use for the direct production of Vitamin C.
摘要翻译：本发明涉及编码参与L-抗坏血酸合成（以下也称为维生素C）的蛋白质的新鉴定的基因。本发明还涉及包含新基因及其片段的全长多核苷酸序列的多核苷酸，由多核苷酸及其片段编码的新多肽及其功能等同物。本发明还涉及所述多核苷酸和多肽在从微生物生产维生素C中作为生物技术工具的用途，其中所述多核苷酸和/或编码多肽的修饰对产量，产量和/或所述微生物中发酵产物的生产效率。还包括使用多核苷酸和修饰的多核苷酸序列转化宿主微生物的方法/方法。本发明还涉及基因工程微生物及其用于直接生产维生素C的用途。

8. 发明申请

WO99049020A2 PHENOL OXIDIZING ENZYME ENZYMES 审中-公开
标题翻译：酚醛氧化酶
公开(公告)号：WO99049020A2
公开(公告)日：1999-09-30
申请号：PCT/US1999/006327
申请日：1999-03-23
IPC分类号： C12N15/09 , C07H21/04 , C11D3/386 , C12N1/15 , C12N1/16 , C12N1/18 , C12N1/19 , C12N1/21 , C12N9/02 , C12N15/53 , C12N15/74 , C12P21/00 , C12P21/06 , C12R1/07 , C12R1/645 , C12R1/66 , C12R1/85 , C12N15/80
CPC分类号： C11D3/38654 , C12N9/0057
摘要： Disclosed herein are phenol oxidizing enzymes obtainable from species of Stachybotrys which are useful in modifying the color associated with dyes and colored compounds, as well as in anti-dye transfer applications. Also disclosed herein are biologically-pure cultures of strains of the genus Stachybotrys, designated herein Stachybotrys parvispora MUCL 38996 and Stachybotrys chartarum MUCL 38898, which are capable of naturally-producing the novel phenol oxidizing enzymes. Disclosed herein is the amino acid and nucleic acid sequence for Stachybotrys phenol oxidizing enzymes as well as expression vectors and host cells comprising the nucleic acid. Disclosed herein are methods for producing the phenol oxidizing enzyme as well as methods for constructing expression hosts. Disclosed herein are enzyme compositions comprising phenol oxidizing enzymes obtainable from species of Stachybotrys.
摘要翻译：本文公开了可从Stachybotrys的物种获得的酚氧化酶，其可用于改变与染料和着色化合物相关的颜色以及抗染料转移应用。本文还公开了Stachybotrys属（Stachybotrys parporpora MUCL 38996）和Stachybotrys chartarum MUCL 38898属的能够天然产生新型酚氧化酶的菌株的生物纯培养物。本文公开了Stachybotrys酚氧化酶的氨基酸和核酸序列以及包含该核酸的表达载体和宿主细胞。本文公开了生产酚氧化酶的方法以及构建表达宿主的方法。本文公开了包含可从Stachybotrys物种获得的酚氧化酶的酶组合物。

9. 发明申请

WO2013102764A2 ALTERNATIVE OXIDASE 审中-公开
标题翻译：替代性氧化酶
公开(公告)号：WO2013102764A2
公开(公告)日：2013-07-11
申请号：PCT/GB2013/050007
申请日：2013-01-04
申请人： THE UNIVERSITY OF SUSSEX
发明人： MOORE, Anthony Lennox , ELLIOTT, Catherine , YOUNG, Luke Edward
IPC分类号： C12N9/02
CPC分类号： C12N9/0057 , C12Y110/03011
摘要： The invention provides genetic constructs comprising a coding sequence encoding alternative oxidase, and extends to methods of producing highly active and pure recombinant alternative oxidase.
摘要翻译：本发明提供了包含编码替代氧化酶的编码序列的遗传构建体，并且延伸至产生高活性和纯重组替代氧化酶的方法。

10. 发明申请

WO2006084729A1 GENE RCS O1 审中-公开
公开(公告)号：WO2006084729A1
公开(公告)日：2006-08-17
申请号：PCT/EP2006/001224
申请日：2006-02-10
申请人： DSM IP ASSETS B.V. , CHEVREUX, Bastien , MAYER, Anne Françoise , MEURY, Anja , MOUNCEY, Nigel John , SHINJOH, Masako
发明人： CHEVREUX, Bastien , MAYER, Anne Françoise , MEURY, Anja , MOUNCEY, Nigel John , SHINJOH, Masako
IPC分类号： C12N9/02 , C12P17/04
CPC分类号： C12N9/0055 , C12N9/0006 , C12N9/0057 , C12P17/04
摘要： The present invention relates to newly identified genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to the use of said polynucleotides and polypeptides as biotechnological tools in the production of Vitamin C from microorganisms, whereby a modification of said polynucleotides and/or encoded polypeptides has a direct or indirect impact on yield, production, and/or efficiency of production of the fermentation product in said microorganism. Also included are methods/processes of using the polynucleotides and modified polynucleotide sequences to transform host microorganisms. The invention also relates to genetically engineered microorganisms and their use for the direct production of Vitamin C.
摘要翻译：本发明涉及编码参与L-抗坏血酸合成（以下也称为维生素C）的蛋白质的新鉴定的基因。本发明还涉及包含新基因及其片段的全长多核苷酸序列的多核苷酸，由多核苷酸及其片段编码的新多肽及其功能等同物。本发明还涉及所述多核苷酸和多肽在从微生物生产维生素C中作为生物技术工具的用途，其中所述多核苷酸和/或编码多肽的修饰对产量，产量和/或所述微生物中发酵产物的生产效率。还包括使用多核苷酸和修饰的多核苷酸序列转化宿主微生物的方法/方法。本发明还涉及基因工程微生物及其用于直接生产维生素C的用途。

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