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1. 发明申请

WO2014096437A1 ALTERNATIVE OXIDASE (AOX) PREVENTS SMOKING-ASSOCIATED LUNG DAMAGE 审中-公开
标题翻译：替代性氧化酶（AOX）预防吸烟相关的肺损伤
公开(公告)号：WO2014096437A1
公开(公告)日：2014-06-26
申请号：PCT/EP2013/077865
申请日：2013-12-20
申请人： MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. , UNIVERSITY OF TAMPERE
发明人： SZIBOR, Marten , BRAUN, Thomas , VOSWINCKEL, Robert , JACOBS, Howard , DUFOUR, Eric , RUSTIN, Pierre
IPC分类号： A61K38/44 , C12N9/02 , C12N15/63 , A61P39/00 , A61P39/06 , A61P9/04 , A61P9/10 , A61P11/00 , A61P19/10 , A61P13/12 , A61P31/06 , A61K48/00
CPC分类号： A61K38/44 , A01K67/0275 , A01K2217/072 , A01K2227/105 , A01K2267/03 , A61K48/005 , C12N9/0006 , C12N9/0057 , C12Y110/03011
摘要： The present invention relates to a nucleic acid molecule encoding a polypeptide, the polypeptide having the activity of alternative oxidase (AOX), wherein said nucleic acid molecule is selected from the group consisting of (a) a nucleic acid molecule encoding a polypeptide comprising or consisting of the amino acid sequence of SEQ ID NO: 1; (b) a nucleic acid molecule encoding a polypeptide comprising or consisting of an amino acid sequence having at least 60% sequence similarity to the amino acid sequence of SEQ ID NO: 1; (c) a nucleic acid molecule comprising or consisting of the nucleotide sequence of SEQ ID NO: 2; (d) a nucleic acid molecule having at least 60% sequence similarity to the nucleic acid molecule of (c); and (e) a nucleic acid molecule degenerate with respect to the nucleic acid molecule of (c) or (d), for use in a method of treating or preventing a disease or condition associated caused by the inhalation of toxic smoke. Further, the present invention relates to a vector comprising said nucleic acid molecule for use in a method of treating or preventing a disease or condition caused by the inhalation of toxic smoke and to a polypeptide encoded by said nucleic acid molecule for use in a method of treating or preventing a disease or condition caused by the inhalation of toxic smoke. The present invention further relates to a non-toxic host cell carrying the nucleic acid molecule, the vector or the polypeptide of the invention for use in a method of treating or preventing a disease or condition caused by the inhalation of toxic smoke and to a product of the non-toxic host cell for use in a method of treating or preventing a disease or condition caused by the inhalation of toxic smoke.
摘要翻译：本发明涉及编码多肽的核酸分子，所述多肽具有替代氧化酶（AOX）的活性，其中所述核酸分子选自（a）编码多肽的核酸分子，所述多核苷酸包含或组成的SEQ ID NO：1的氨基酸序列; （b）编码包含与SEQ ID NO：1的氨基酸序列具有至少60％序列相似性的氨基酸序列的多肽的核酸分子; （c）包含SEQ ID NO：2的核苷酸序列或由其组成的核酸分子; （d）与（c）的核酸分子具有至少60％的序列相似性的核酸分子; 和（e）相对于（c）或（d）的核酸分子简并的核酸分子，用于治疗或预防由吸入有毒烟雾引起的疾病或病症的方法。此外，本发明涉及包含所述核酸分子的载体，所述载体用于治疗或预防由吸入毒性烟雾引起的疾病或病症的方法和由所述核酸分子编码的多肽，用于以下方法：治疗或预防由吸入有毒烟雾引起的疾病或病症。本发明还涉及携带本发明的核酸分子，载体或多肽的无毒宿主细胞，其用于治疗或预防由吸入有毒烟雾引起的疾病或病症的方法和产品的无毒宿主细胞，用于治疗或预防由吸入有毒烟雾引起的疾病或病症的方法。

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