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11. 发明申请

WO2006093510A1 METHOD FOR PROTECTING AMINE-COATED SURFACES FROM DEGRADING GASES 审中-公开
标题翻译：从降解气体保护胺涂层表面的方法
公开(公告)号：WO2006093510A1
公开(公告)日：2006-09-08
申请号：PCT/US2005/020178
申请日：2005-06-08
申请人： CORNING INCORPORATED , LACARRIERE, Valerie , CARRE, Alain
发明人： LACARRIERE, Valerie , CARRE, Alain
IPC分类号： B01L9/00 , B65D81/26
CPC分类号： B65D81/266 , B01D53/62 , B01D2257/504 , B01J20/041 , B01J20/06 , B01J2219/00497 , B01J2219/00527 , B01J2219/00576 , B01J2219/00605 , B01J2219/00612 , B01J2219/00637 , B01J2219/00639 , B01J2219/00693 , B01J2219/00722 , B01J2219/00725 , B01J2220/42 , Y02C10/04 , Y02C10/08
摘要： A device and methods for either protecting or restoring the delicate surface chemistry of amine-coated substrates adapted for biological assay uses from the deleterious effects of exposure to carbon dioxide and/or organic chemical compounds, which may arise in packaging or storage containers is provided. The device encompasses an enclosure, preferably hermetically sealed, a component susceptible to degradation from either carbon dioxide or organic compounds, and a sorbent, having a composition made from either a single material or a combination of materials, said material is characterized as being reactive with CO 2 and having a high-surface energy of≥100 milli-joules /m 2 for removing organic compounds. The method can stabilize the surface chemistry and prolong the useful life of the coated substrate.
摘要翻译：提供了一种用于保护或恢复适用于生物测定用途的胺涂覆的底物的精细表面化学性质的装置和方法，其可能由于暴露于二氧化碳和/或有机化合物而产生的有害影响，这可能在包装或储存容器中产生。该装置包括优选密封的易受二氧化碳或有机化合物降解的组分的外壳和具有由单一材料或材料组合制成的组合物的吸附剂，所述材料的特征在于与 CO 2，具有用于除去有机化合物的= 100毫焦耳/平方米的高表面能。该方法可以稳定表面化学性质并延长涂覆基材的使用寿命。

12. 发明申请

WO2006062200A1 核酸ライブラリー及びタンパク質ライブラリー审中-公开
标题翻译：核酸图书馆和蛋白质图书馆
公开(公告)号：WO2006062200A1
公开(公告)日：2006-06-15
申请号：PCT/JP2005/022688
申请日：2005-12-09
申请人：ユニバーサル・バイオ・リサーチ株式会社 , 独立行政法人産業技術総合研究所 , 町田雅之 , 萩原央子 , 田島秀二
发明人：町田雅之 , 萩原央子 , 田島秀二
IPC分类号： C12N15/00 , C12M1/00 , G01N33/53 , G01N37/00
CPC分类号： C12N15/1093 , B01J19/0046 , B01J2219/00497 , B01J2219/00515 , B01J2219/0052 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00657 , B01J2219/00722 , B01J2219/00725 , C07K2319/21 , C07K2319/23 , C12N15/1034
摘要：　複数種類のタンパク質を、それをコードする核酸と対応付けて一度に供給することができるとともに、複数種類のタンパク質の供給後、直ちに当該複数種類のタンパク質の解析を並列して行なうことができ、しかも変性や失活を起こしたタンパク質を容易に再生することができる核酸ライブラリーであって、その作製の際に核酸とタンパク質捕獲体との位置関係を対応付ける必要がなく、効率的な作製が可能である核酸ライブラリーを提供することを目的とし、この目的を達成するために、第１の固体支持体２と、第１の固体支持体２の所定表面領域に互いに離反した状態で固定された複数の核酸群３と、第１の固体支持体２に螺旋状に巻装された第２の固体支持体４と、第２の固体支持体４の所定表面領域に高密度で固定された複数のタンパク質捕獲体５とを備えた核酸ライブラリー１を提供する。
摘要翻译：旨在提供一种核酸文库，通过该核酸文库可以与编码该核酸的核酸一起提供多种类型的蛋白质，可以在提供这些蛋白质之后立即并行分析多种类型的蛋白质，并且将变性或灭活蛋白质可以容易地再生，并且可以有效地制备，而不需要在制备过程中协调核酸和蛋白质捕获剂之间的位置关系。为了实现该目的，具有第一固体支持物（2），多个核酸（3）的核酸文库（1）已经被固定在彼此的表面的一定区域中彼此分离的状态第一固体支持物（2），围绕第一固体支持物（2）螺旋缠绕的第二固体支持物（4），以及多个蛋白质捕获剂（5）已经以高密度固定在第二固体表面的确定区域支持（4）。

13. 发明申请

WO2006040554A1 COMPARTMENTALISED COMBINATORIAL CHEMISTRY BY MICROFLUIDIC CONTROL 审中-公开
标题翻译：通过微流控制进行组合化合物化学
公开(公告)号：WO2006040554A1
公开(公告)日：2006-04-20
申请号：PCT/GB2005/003927
申请日：2005-10-12
申请人： MEDICAL RESEARCH COUNCIL , PRESIDENT AND FELLOWS OF HARVARD COLLEGE , GRIFFITHS, Andrew , WEITZ, David , LINK, Darren , AHN, Keunho , BIBETTE, Jerome
发明人： GRIFFITHS, Andrew , WEITZ, David , LINK, Darren , AHN, Keunho , BIBETTE, Jerome
IPC分类号： B01J19/00
CPC分类号： B01F13/0071 , B01F3/0807 , B01F5/0646 , B01F5/0647 , B01F5/0655 , B01F13/0076 , B01J19/0046 , B01J2219/00497 , B01J2219/005 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00599 , B01J2219/00707 , B01J2219/00722 , B01J2219/00725 , B01J2219/00743 , B01J2219/00853 , B01J2219/0086 , B01J2219/00889 , B01L3/5025 , B01L3/50273 , B01L3/502746 , B01L3/502761 , B01L3/502784 , B01L2200/0605 , B01L2200/0673 , B01L2300/0864 , B01L2300/0867 , B01L2400/0406 , B01L2400/0415 , B01L2400/0487 , B01L2400/084 , B82Y10/00 , B82Y30/00 , C07K1/047 , C40B40/06 , C40B40/10 , C40B50/08 , G01N2035/1034
摘要： The invention describes a method for the synthesis of compounds comprising the steps of: (a) compartmentalising two or more sets of primary compounds into microcapsules; such that a proportion of the microcapsules contains two or more compounds; and (b) forming secondary compounds in the microcapsules by chemical reactions between primary compounds from different sets; wherein one or both of steps (a) and (b) is performed under microfluidic control; preferably electronic microfluid.ic control The invention further allows for the identification of compounds which bind to a target component of a biochemical system or modulate the activity of the target, and which is co-compartmentalised into the microcapsules.
摘要翻译：本发明描述了一种合成化合物的方法，包括以下步骤：（a）将两组或多组初级化合物分隔成微胶囊; 使得一部分微胶囊含有两种或更多种化合物; 和（b）通过来自不同组的主要化合物之间的化学反应在微胶囊中形成次级化合物; 其中步骤（a）和（b）中的一个或两个在微流控制下进行; 优选电子微流体控制本发明进一步允许鉴定与生物化学体系的靶组分结合或调节靶的活性并且共分隔成微胶囊的化合物。

14. 发明申请

WO2005110593A3 PROCESS AND AUTOMATED SYSTEM FOR THE SYNTHESIS OF POLYMERS 审中-公开
标题翻译：用于合成聚合物的工艺和自动化系统
公开(公告)号：WO2005110593A3
公开(公告)日：2006-04-20
申请号：PCT/EP2005005359
申请日：2005-05-17
申请人： APIBIO SAS , LAURENT ALAIN
发明人： LAURENT ALAIN
IPC分类号： B01J19/00 , C40B40/06 , C40B40/10 , C40B40/12 , C40B50/14 , C40B60/14
CPC分类号： B01J19/0046 , B01J2219/00378 , B01J2219/00497 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00637 , B01J2219/00653 , B01J2219/00659 , B01J2219/00675 , B01J2219/00686 , B01J2219/00713 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , B82Y30/00 , C40B40/06 , C40B40/10 , C40B40/12 , C40B50/14 , C40B60/14
摘要： The present invention relates to the process for the stepwise synthesis of polymers, especially biopolymers, on a solid support surface comprising the steps of providing a solid support surface having a binding site, applying a first microdroplet of a solution comprising a first polymer building block on said binding site to attach the first polymer building block to the binding site and applying to the modified binding site of the preceding step a second microdroplet of a solution comprising the same or a different polymer building block, wherein the solution comprises two different solvents wich have a different viscosity and its relative viscosity (? rel =? second solvent<
摘要翻译：本发明涉及在固体支持体表面上逐步合成聚合物，特别是生物聚合物的方法，包括以下步骤：提供具有结合位点的固体支持物表面，将包含第一聚合物结构单元的溶液的第一微滴所述结合位点将第一聚合物结构单元连接到结合位点并向前述步骤的修饰结合位点施加包含相同或不同聚合物结构单元的溶液的第二微滴，其中溶液包含两种不同的溶剂，其具有不同的粘度及其相对粘度（η3）

15. 发明申请

WO2006033972A2 PROTEIN ARRAYS AND METHODS OF USE THEREOF 审中-公开
标题翻译：蛋白质阵列及其使用方法
公开(公告)号：WO2006033972A2
公开(公告)日：2006-03-30
申请号：PCT/US2005/032981
申请日：2005-09-15
申请人： PROTOMETRIX, INC. , SCHWEITZER, Barry , BALL, James, A. , PREDKI, Paul , MICHAUD, Gregory, A. , ZHOU, Fang, X.
发明人： SCHWEITZER, Barry , BALL, James, A. , PREDKI, Paul , MICHAUD, Gregory, A. , ZHOU, Fang, X.
IPC分类号： G01N33/53
CPC分类号： C12Q1/00 , B01J2219/00387 , B01J2219/00497 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00693 , B01J2219/00725 , G01N33/552 , G01N33/6842 , G01N33/6845 , G06Q50/22 , Y02A90/22
摘要： The present invention provides human protein arrays that include at least (1000) human proteins. In another embodiment, the present invention provides a method for identifying a substrate of an enzyme, comprising contacting the enzyme with a positional addressable array comprising at least (100) proteins immobilized on functionalized glass surface, and identifying a protein on the positional addressable array that is bound and/or modified by the enzyme, wherein a binding or modifying of the protein by the enzyme indicates that the protein is a substrate for the enzyme. In additional embodiments, provided herein are methods for making an array of at least (1000) human proteins under non-denaturing conditions, including human proteins that are difficult to express and/or difficult to isolate in a non-denatured state.
摘要翻译：本发明提供了包含至少（1000）人蛋白质的人类蛋白质阵列。在另一个实施方案中，本发明提供了一种方法，

16. 发明申请

WO2005050207A3 DIFFRACTION GRATING-BASED ENCODED ARTICLES FOR MULTIPLEXED EXPERIMENTS 审中-公开
标题翻译：衍射光栅为基础的编码多重实验的文章
公开(公告)号：WO2005050207A3
公开(公告)日：2005-12-29
申请号：PCT/US2004038416
申请日：2004-11-15
申请人： CYVERA CORP
发明人： MOON JOHN A , PUTNAM MARTIN A , PERBOST MICHEL , QUINN JOHN JOSEPH , TROUNSTINE MARY CATHERINE
IPC分类号： G01N15/14 , G01N33/543 , G01N35/00 , G02B5/18 , G02B6/34
CPC分类号： G01N35/00732 , B01J2219/00497 , B01J2219/005 , B01J2219/00502 , B01J2219/00542 , B01J2219/0056 , B01J2219/00576 , B01J2219/00722 , B01J2219/00725 , G01N33/54313 , G01N2035/00772
摘要： The present invention provides methods and compositions directed toward assays of a broad range of analytes using specific targeting chemicals that bind to the analytes. The assays are founded on the use of coded assay articles to which the targeting chemicals are attached. Additionally the codes are such that they are interrogated and determined in real time. The target is analyzed as to identity, presence and quantity in real time. The methods and compositions of the invention are highly suitable for use in high-complexity multiplexed assay systems. All the methods and compositions are based on assay article that includes an optical substrate to which the chemical is bound, and in which is disposed at least one diffraction grating. The grating provides an output optical signal when illuminated by an incident light signal which is indicative of the code in the substrate. In general, coded assay article or sets thereof are employed in assay methods, including multiplexed assay methods, according to which a sample is contacted with an article or a set, and any analytes that bind to the attached chemical are identified according to the code, detected and/or quantitated.
摘要翻译：本发明提供了使用与分析物结合的特定靶向化学物质针对宽范围分析物的分析的方法和组合物。该测定基于使用附接有靶向化学物质的编码测定物品。此外，这些代码可以实时查询和确定。实时分析目标的身份，存在和数量。本发明的方法和组合物非常适合用于高度复杂的多路复用测定系统。所有的方法和组合物都基于化验物品，该化验物品包括化学物质结合到其上的光学基材，并且其中布置有至少一个衍射光栅。光栅在被指示衬底中的代码的入射光信号照射时提供输出光信号。一般而言，在测定方法中使用编码测定物品或其组合，所述测定方法包括多重测定方法，根据该方法使样品与物品或组相接触，并且根据代码识别与所附化学物质结合的任何分析物，检测和/或定量。

17. 发明申请

WO2005118885A2 METHODS AND APPARATUS FOR DETECTION OF VIRAL INFECTION 审中-公开
标题翻译：用于检测病毒感染的方法和装置
公开(公告)号：WO2005118885A2
公开(公告)日：2005-12-15
申请号：PCT/US2005012019
申请日：2005-04-12
申请人： ALLIED BIOTECH INC , YU YONG YI , LI LINA , LI ZHUANGWU , BAO JUN
发明人： YU YONG YI , LI LINA , LI ZHUANGWU , BAO JUN
IPC分类号： C12Q1/70 , G01N33/543 , G01N33/569
CPC分类号： G01N33/543 , B01J2219/00315 , B01J2219/00367 , B01J2219/00378 , B01J2219/00387 , B01J2219/00432 , B01J2219/00497 , B01J2219/005 , B01J2219/00511 , B01J2219/00527 , B01J2219/00545 , B01J2219/00547 , B01J2219/00574 , B01J2219/00576 , B01J2219/00578 , B01J2219/00641 , B01J2219/00662 , B01J2219/00677 , B01J2219/00691 , B01J2219/00722 , B01J2219/00725 , B01J2219/00743 , G01N33/56983 , G01N2469/20
摘要： This invention generally relates to apparatus and methods for high-throughput, reproducible and inexpensive detection of virus infection using multiplexing technologies such as slide-based, microtiter plate-based and membrane-based microarrays and beads technologies. The apparatus and methods allow simultaneous detection of multiple viral infections in a plurality of test samples.
摘要翻译：本发明一般涉及使用诸如基于幻灯片，微量滴定板和基于膜的微阵列和珠粒技术的复用技术来高度通过，可再现和便宜地检测病毒感染的装置和方法。该装置和方法允许在多个测试样品中同时检测多个病毒感染。

18. 发明申请

WO2005108625A2 METHOD FOR PREPARING SUBSTRATES HAVING IMMOBILIZED MOLECULES AND SUBSTRATES 审中-公开
标题翻译：用于制备具有固定分子和基底的基底的方法
公开(公告)号：WO2005108625A2
公开(公告)日：2005-11-17
申请号：PCT/US2005/016134
申请日：2005-05-06
申请人： NANOSPHERE, INC. , GARIMELLA, Viswanadham , ZHUKOVYTSKYY, Vadym
发明人： GARIMELLA, Viswanadham , ZHUKOVYTSKYY, Vadym
IPC分类号： C12Q1/68
CPC分类号： C07F7/1836 , B01J19/0046 , B01J2219/00387 , B01J2219/00497 , B01J2219/00527 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00639 , B01J2219/00648 , B01J2219/00659 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , B01J2219/00731 , B01J2219/00734 , B82Y5/00 , C07B2200/11 , C12Q1/6834 , G01N33/54346 , G01N33/54353 , G01N33/552
摘要： A method for the efficient immobilization of molecules onto substrate surfaces that employs an isocyanate compound to form a reactive isocyanate surface, nanoparticles onto surfaces as well as silylated molecules such as silylated oligonucleotides or proteins onto unmodified surfaces such as a glass surface is provided. Also provided are compounds, devices, and kits for modifying surfaces such as glass surfaces.
摘要翻译：提供了一种使用异氰酸酯化合物形成活性异氰酸酯表面，将表面上的纳米颗粒以及甲硅烷基化的分子如甲硅烷基化的寡核苷酸或蛋白质高效地固定在基材表面上的方法，所述方法用于在未修饰的表面如玻璃表面上。还提供了用于改变诸如玻璃表面的表面的化合物，装置和试剂盒。

19. 发明申请

WO2005062866A2 OPTICALLY ENCODED PARTICLES, SYSTEM AND HIGH-THROUGHPUT SCREENING 审中-公开
标题翻译：光学编码的颗粒，系统和高通量筛选
公开(公告)号：WO2005062866A2
公开(公告)日：2005-07-14
申请号：PCT/US2004/043001
申请日：2004-12-21
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , SAILOR, Michael, J. , MEADE, Shawn, O.
发明人： SAILOR, Michael, J. , MEADE, Shawn, O.
CPC分类号： C40B20/08 , B01J19/0046 , B01J2219/00497 , B01J2219/005 , B01J2219/0054 , B01J2219/00547 , B01J2219/00554 , B01J2219/0056 , B01J2219/00565 , B01J2219/00576 , B01J2219/00596 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , B82Y20/00 , C40B20/04 , C40B30/04 , C40B40/06 , C40B40/10 , C40B40/12 , C40B40/18 , C40B50/14 , C40B70/00
摘要： The invention concerns a particle (10, 10a) having a code from a library of codes embedded in its physical structure by refractive index changes between different regions of the particle. In preferred embodiments, a thin film possesses porosity that varies in a manner to produce a code detectable in the reflectivity spectrum. An assay detection method uses such a particle and detects a spectral shift in the presence of an analyte. Additional embodiments are disclosed including additional features.
摘要翻译：本发明涉及一种具有通过嵌入其物理结构中的代码库的代码的粒子（10,10a），其通过颗粒的不同区域之间的折射率变化。在优选实施例中，薄膜具有以产生在反射率谱中可检测的代码的方式变化的孔隙率。测定检测方法使用这样的颗粒并在存在分析物的情况下检测光谱偏移。公开了另外的实施例，其包括附加特征。

20. 发明申请

WO2004067191A3 ALTERATION OF SURFACE AFFINITIES 审中-公开
标题翻译：表面活性物质的改变
公开(公告)号：WO2004067191A3
公开(公告)日：2004-12-23
申请号：PCT/US2004002498
申请日：2004-01-29
申请人： HARVARD COLLEGE , JIANG XINGYU , FERRIGNO ROSARIA , WHITESIDES GEORGE M
发明人： JIANG XINGYU , FERRIGNO ROSARIA , WHITESIDES GEORGE M
IPC分类号： B01J20/32 , B05D3/14
CPC分类号： B82Y30/00 , B01J20/3204 , B01J20/321 , B01J20/3212 , B01J20/3225 , B01J20/3227 , B01J20/3248 , B01J20/3251 , B01J20/3274 , B01J20/3285 , B01J2219/00497 , B01J2219/00527 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00653 , B01J2219/00659 , B01J2219/00677 , B01J2219/00722 , B01J2219/00725 , B01J2219/00743 , B05D3/14 , B05D3/207 , G01N33/54353 , G01N2610/00 , Y10S436/823 , Y10T436/118339
摘要： The present invention provides a series of methods, compositions, and articles for altering a property of a surface (for example, the cytophilicity and/or the hydrophilicity), by exposing at least a portion of the surface to a non-chemical, force-creating field and/or force, such as an electric field. The field/force may be created by any suitable technique. For instance, the field can be created by applying a voltage across the surface, by electrical induction, etc. In certain embodiments, the surface includes molecules attached thereto that can be detached when exposed to non-chemical, force-creating fields and/or forces, thereby altering the chemical composition of at least a portion of the surface. In one set of embodiments, the molecules attached to the surface may include molecules forming a self-assembled monolayer on the surface. In some embodiments, the molecules attached to the surface may include thiol moieties (e.g., as in an alkanethiol), by which the molecule can become attached to the surface. In certain cases, the molecules may be terminated at the unattached end with one or more hydrophilic groups, for example, unmodified ethylene glycol moieties. In some cases, the molecules attached to the surface may include one or more moieties that can bind to various entities such as proteins, peptides, nucleic acids, drugs, cells, etc. In certain embodiments, the techniques are used to enable novel assays for cell motility and/or spreading and screening tests for determining drugs and/or treatments effective in increasing or decreasing cell shape changes and/or motility on surfaces.
摘要翻译：本发明提供了一系列用于改变表面性质（例如，细胞毒性和/或亲水性）的方法，组合物和制品，通过将至少一部分表面暴露于非化学，产生场和/或力，例如电场。场/力可以通过任何合适的技术来产生。例如，可以通过在表面上施加电压，通过电感应等来产生该场。在某些实施例中，表面包括附着于其上的分子，当暴露于非化学，力产生场和/或从而改变表面的至少一部分的化学成分。在一组实施方案中，连接到表面的分子可以包括在表面上形成自组装单层的分子。在一些实施方案中，附着于表面的分子可以包括硫醇部分（例如，如在链烷硫醇中），通过该分子可以使分子附着于表面。在某些情况下，分子可以在一个或多个亲水基团例如未改性的乙二醇部分的非附着端封端。在一些情况下，附着于表面的分子可以包括可结合各种实体的一个或多个部分，例如蛋白质，肽，核酸，药物，细胞等。在某些实施方案中，该技术用于使用于确定有效增加或减少细胞形状变化和/或表面活力的药物和/或治疗的细胞运动性和/或扩散和筛选试验。

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