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1. 发明申请

WO2016004068A8 HYDROGEL COMPOSITIONS COMPRISING ENCAPSULATED CELLS AND METHODS OF USE THEREOF 审中-公开
标题翻译：包含封装细胞的水凝胶组合物及其使用方法
公开(公告)号：WO2016004068A8
公开(公告)日：2016-03-24
申请号：PCT/US2015038601
申请日：2015-06-30
申请人： SHIN JAE-WON , MAO ANGELO S , UTECH STEFANIE , WEITZ DAVID A , MOONEY DAVID J , UZUN OKTAY
发明人： SHIN JAE-WON , MAO ANGELO S , UTECH STEFANIE , WEITZ DAVID A , MOONEY DAVID J , UZUN OKTAY
IPC分类号： A61K35/12 , C12N11/10 , C12N11/12
CPC分类号： A61K9/4816 , A61K9/0019 , A61K9/5036 , A61K9/5052 , A61K35/12 , A61K35/28 , A61K2035/124 , C12N11/04 , C12N11/10
摘要： The present invention provides injectable compositions comprising cells encapsulated in hydrogel capsules and methods of preparing these compositons. The present invention also provides methods for using these compositions to promote hematopoiesis and to treat or prevent cardiovascular and immunological disorders in a subject.
摘要翻译：本发明提供了包含在水凝胶胶囊中的细胞的可注射组合物和制备这些组合物的方法。本发明还提供了使用这些组合物促进造血作用并治疗或预防受试者的心血管和免疫学障碍的方法。

2. 发明申请

WO2014107240A1 SYSTEM AND METHOD FOR A BIOMIMETIC FLUID PROCESSING 审中-公开
标题翻译：一种生物流体处理系统和方法
公开(公告)号：WO2014107240A1
公开(公告)日：2014-07-10
申请号：PCT/US2013/070910
申请日：2013-11-20
申请人： BRIGHAM AND WOMEN'S HOSPITAL, INC. , ITALIANO, Joseph , MAZUTIS, Linas , THON, Jonathan, N. , WEITZ, David, A.
发明人： ITALIANO, Joseph , MAZUTIS, Linas , THON, Jonathan, N. , WEITZ, David, A.
IPC分类号： G01N33/48 , G06F19/12
CPC分类号： B01L3/502753 , B01L3/502746 , B01L3/502776 , B01L2200/0647 , B01L2200/0668 , B01L2300/0681 , B01L2300/0816 , B01L2400/086 , C12M23/16 , C12M23/20 , C12M25/02 , C12M29/04 , C12M29/10 , C12M29/20 , C12M41/36 , C12M41/40 , G01N33/491 , G01N33/86 , G01N2800/222 , Y10T436/25375
摘要： A system and method are provided for harvesting target biological substances. The system includes a substrate and a first and second channel formed in the substrate. The channels longitudinally extending substantially parallel to each other. A series of gaps extend from the first channel to the second channel to create a fluid communication path passing between a series of columns with the columns being longitudinally separated by a predetermined separation distance. The system also includes a first source configured to selectively introduce into the first channel a first biological composition at a first channel flow rate and a second source configured to selectively introduce into the second channel a second biological composition at a second channel flow rate. The sources are configured to create a differential between the first and second channel flow rates to generate physiological shear rates along the second channel that are bounded within a predetermined range.
摘要翻译：提供了用于收集目标生物物质的系统和方法。该系统包括基板和形成在基板中的第一和第二通道。纵向延伸的通道彼此平行。一系列间隙从第一通道延伸到第二通道，以产生在一系列柱之间通过的流体连通路径，其中柱纵向间隔预定间隔距离。该系统还包括被配置为以第一通道流速选择性地将第一生物组合物引入第一通道的第一源和被配置为以第二通道流速选择性地将第二生物组合物引入第二通道的第二源。源被配置为在第一和第二通道流量之间产生差分，以产生沿着第二通道的限制在预定范围内的生理剪切速率。

3. 发明申请

WO2013006661A3 MULTIPLE EMULSIONS AND TECHNIQUES FOR THE FORMATION OF MULTIPLE EMULSIONS 审中-公开
公开(公告)号：WO2013006661A3
公开(公告)日：2013-01-10
申请号：PCT/US2012/045481
申请日：2012-07-05
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , KIM, Shin-Hyn , ABBASPOURRAD, Alireza , WEITZ, David, A.
发明人： KIM, Shin-Hyn , ABBASPOURRAD, Alireza , WEITZ, David, A.
IPC分类号： B01F3/08 , B01F5/04 , B01F13/00
摘要： Multiple emulsions and techniques for the formation of multiple emulsions are generally described. A multiple emulsion, as used herein, describes larger droplets that contain one or more smaller droplets therein. In some embodiments, the larger droplet or droplets may be suspended in a carrying fluid containing the larger droplets that, in turn, contain the smaller droplets. As described below, multiple emulsions can be formed in one step in certain embodiments, with generally precise repeatability, and can be tailored in some embodiments to include a relatively thin layer of fluid separating two other fluids.

4. 发明申请

WO2012162296A3 CONTROL OF EMULSIONS, INCLUDING MULTIPLE EMULSIONS 审中-公开
公开(公告)号：WO2012162296A3
公开(公告)日：2012-11-29
申请号：PCT/US2012/038957
申请日：2012-05-22
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , BASF SE , ROTEM, Assaf , WEITZ, David A. , ABATE, Adam R. , HOLTZE, Christian
发明人： ROTEM, Assaf , WEITZ, David A. , ABATE, Adam R. , HOLTZE, Christian
IPC分类号： B01F13/00 , B01F3/08
摘要： The present invention generally relates to emulsions, and more particularly, to double and other multiple emulsions. Certain aspects of the present invention are generally directed to the creation of double emulsions and other multiple emulsions at a common junction of microfluidic channels. In some cases, the microfluidic channels at the common junction may have substantially the same hydrophobicity. In one set of embodiments, a device may include a common junction of six or more channels (11, 12, 13, 14, 15, 16), where a first fluid (21) flows through one channel (11), a second fluid (22) flows through two channels (12, 13), and a third or carrying fluid (23) flows through two more channels (14, 15), such that a double emulsion of a first droplet of the first fluid, contained in a second droplet of the second fluid, contained by the carrying fluid, flows away from the common junction through a sixth channel (16). Other aspects of the invention are generally directed to methods of making and using such systems, kits involving such systems, emulsions created using such systems, or the like.

5. 发明申请

WO2011116154A3 MELT EMULSIFICATION 审中-公开
公开(公告)号：WO2011116154A3
公开(公告)日：2012-06-07
申请号：PCT/US2011028754
申请日：2011-03-17
申请人： HARVARD COLLEGE , BASF SE , SHUM HO CHEUNG , SUN BINGJIE , WEITZ DAVID A , HOLTZE CHRISTIAN
发明人： SHUM HO CHEUNG , SUN BINGJIE , WEITZ DAVID A , HOLTZE CHRISTIAN
IPC分类号： B01J13/00 , A01N25/28 , A61K9/50 , B01J13/04 , C09B67/00 , C11D3/50 , C11D17/00
CPC分类号： B01J13/0086 , B01F3/0807 , B01F13/0062 , B01F2005/0034 , B01J13/04 , C09B67/0009 , C09B67/0097 , G01N2015/1413
摘要： The present invention generally relates to colloidal systems, which may include colloidal particles and/or other types of particles. One aspect of the invention is generally directed to a system comprising fluidic droplets that can be at least partially solidified, e.g., to form colloidal particles. In some embodiments, particles comprising an at least partially solid outer phase encapsulating an inner phase are formed. The inner phase may be any phase, e.g., a solid, a liquid, or a gas. In some cases, solidifying at least a portion of the outer phase of the droplets to form particles may increase the stability of the particles and/or the colloidal system containing the particles. In one set of embodiments, melting or liquefying the outer phase of the particles (for example, by heating the particle to a temperature above a threshold temperature) can allow release of an agent contained within the inner phase, and/or allow the inner phase to coalesce with a phase external to the particles. The melting temperature of the outer phase can be controlled in some embodiments such that the outer phase will melt above a predetermined temperature. In some embodiments, the particles may be formed to be essentially free of an auxiliary stabilizing agent. In some embodiments, an agent may be encapsulated within a particle with relatively high efficiency. Other aspects of the invention are generally directed to methods of making and using such colloidal systems, e.g., containing such particles, kits involving such colloidal systems, or the like.
摘要翻译：本发明一般涉及胶体体系，其可以包括胶体颗粒和/或其它类型的颗粒。本发明的一个方面通常涉及包含流体液滴的系统，其可以至少部分地固化，例如形成胶体颗粒。在一些实施方案中，形成包含至少部分固体外层的包封内相的颗粒。内相可以是任何相，例如固体，液体或气体。在一些情况下，固化液滴的外相的至少一部分以形成颗粒可以增加包含颗粒的颗粒和/或胶体体系的稳定性。在一组实施方案中，熔化或液化颗粒的外相（例如，通过将颗粒加热到高于阈值温度的温度）可以允许包含在内相内的试剂的释放和/或允许内相以颗粒外部的相合并。在一些实施方案中，可以控制外相的熔融温度，使得外相将在预定温度以上熔化。在一些实施方案中，颗粒可以形成为基本上不含辅助稳定剂。在一些实施方案中，试剂可以以相对高的效率封装在颗粒内。本发明的其它方面通常涉及制备和使用这种胶体体系的方法，例如含有这种颗粒，涉及这种胶体系的试剂盒等。

6. 发明申请

WO2010148106A1 SYSTEMS AND METHODS INVOLVING CALCIUM PHOSPHATE BASED MATERIALS 审中-公开
标题翻译：涉及磷酸钙的材料的系统和方法
公开(公告)号：WO2010148106A1
公开(公告)日：2010-12-23
申请号：PCT/US2010/038849
申请日：2010-06-16
申请人： WASHINGTON STATE UNIVERSITY RESEARCH FOUNDATION , PRESIDENT AND FELLOWS OF HARVARD COLLEGE , BOSE, Susmita , SHUM, Ho Cheung , BANDYOPADHYAY, Amit , WEITZ, David A.
发明人： BOSE, Susmita , SHUM, Ho Cheung , BANDYOPADHYAY, Amit , WEITZ, David A.
IPC分类号： A61K9/14 , C04B35/447
CPC分类号： C04B35/447 , A61K9/14 , A61K9/143 , A61K9/1611 , A61K9/2009 , A61K47/02
摘要： Provided are systems and methods for making materials (e.g., unique calcium phosphate based materials) using multiple emulsion microreactors. Certain aspects comprise surrounding a first fluid with a second fluid, surrounding the second fluid with a third fluid, wherein the first and third fluids are suitably immiscible with the second fluid, and wherein at least one of the fluids comprises a precursor(s) of the material, and forming, in at least one of the fluids, a desired material from the precursor(s). Certain aspects comprise surrounding a first fluid containing a calcium phosphate precursor with a second fluid, thus forming a droplet of the first fluid within the second fluid, and surrounding the second fluid with a third fluid, and wherein a unique calcium phosphate based material (e.g., having, portions with large aspect ratios, nanoscale porosity, relatively high BET surface area, relatively high pore volume, etc.) may be formed from the precursor(s).
摘要翻译：提供了使用多个乳液微反应器制造材料（例如，独特的磷酸钙基材料）的系统和方法。某些方面包括用第二流体围绕第一流体，用第三流体围绕第二流体，其中第一和第三流体与第二流体适合地不混溶，并且其中至少一种流体包含并且在至少一种流体中形成来自前体的所需材料。某些方面包括围绕含有磷酸钙前体的第一流体与第二流体，从而在第二流体内形成第一流体的液滴，并用第三流体包围第二流体，并且其中独特的基于磷酸钙的材料（例如具有大纵横比的部分，纳米孔隙率，相对高的BET表面积，相对较高的孔体积等）可由前体形成。

7. 发明申请

WO2010080134A1 PARTICLE-ASSISTED NUCLEIC ACID SEQUENCING 审中-公开
标题翻译：颗粒辅助核酸序列
公开(公告)号：WO2010080134A1
公开(公告)日：2010-07-15
申请号：PCT/US2009/006649
申请日：2009-12-18
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , WEITZ, David, A. , ABATE, Adam, R.
发明人： WEITZ, David, A. , ABATE, Adam, R.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6809 , B01L3/502761 , B01L2200/10 , C12Q1/6834 , C12Q1/6869 , C12Q1/6874 , C12Q2525/204 , C12Q2563/149 , C12Q2563/159 , C12Q2565/629
摘要： This invention generally relates to particle-assisted nucleic acid sequencing. In some embodiments, sequencing may be performed in a microfluidic device, which can offer desirable properties, for example, minimal use of reagents, facile scale-up, and/or high throughput. In one embodiment, a target nucleic acid may be exposed to particles having nucleic acid probes. By determining the binding of the particles to the target nucleic acid, the sequence of the target nucleic acid (or at least a portion of the target nucleic acid) can be determined. The target nucleic acid may be encapsulated within a fluidic droplet with the particles having nucleic acid probes, in certain instances. In some cases, the sequence of the target nucleic acid may be determined, based on binding of the particles, using sequencing by hybridization (SBH) algorithms or other known techniques.
摘要翻译：本发明一般涉及颗粒辅助核酸测序。在一些实施方案中，可以在微流体装置中进行测序，所述微流体装置可以提供期望的性质，例如，最少使用试剂，容易的放大和/或高通量。在一个实施方案中，靶核酸可以暴露于具有核酸探针的颗粒。通过确定颗粒与靶核酸的结合，可以确定靶核酸（或目标核酸的至少一部分）的序列。在某些情况下，靶核酸可以包封在具有核酸探针的颗粒的流体液滴内。在一些情况下，可以通过使用通过杂交（SBH）算法或其他已知技术的测序，基于颗粒的结合来确定靶核酸的序列。

8. 发明申请

WO2009134395A3 MICROFLUIDIC DEVICE FOR STORAGE AND WELL-DEFINED ARRANGEMENT OF DROPLETS 审中-公开
标题翻译：用于储存和定义错误布置的微流体装置
公开(公告)号：WO2009134395A3
公开(公告)日：2010-02-18
申请号：PCT/US2009002644
申请日：2009-04-28
申请人： HARVARD COLLEGE , SCHMITZ CHRISTIAN , ROWAT AMY , KOESTER SARAH , AGRESTI JEREMY , WEITZ DAVID A
发明人： SCHMITZ CHRISTIAN , ROWAT AMY , KOESTER SARAH , AGRESTI JEREMY , WEITZ DAVID A
IPC分类号： G01N35/00 , C12Q1/02 , G01N21/64 , G01N33/50
CPC分类号： G01N21/6452 , B01L3/502784 , B01L7/525 , B01L2200/0621 , B01L2300/0816 , B01L2300/0819 , B01L2300/087 , B01L2300/1827 , B01L2400/0487 , B01L2400/086 , G01N33/5008
摘要： The present invention relates to systems and methods for the arrangement of droplets in pre-determined locations. Many applications require the collection of time- resolved data. Examples include the screening of cells based on their growth characteristics or the observation of enzymatic reactions. The present invention provides a tool and related techniques which addresses this need, and which can be used in many other situations. The invention provides, in one aspect, a tool that allows for stable storage and indexing of individual droplets. The invention can interface not only with microfluidic/microscale equipment, but with macroscopic equipment to allow for the easy injection of liquids and extraction of sample droplets, etc.
摘要翻译：本发明涉及用于在预定位置中布置液滴的系统和方法。许多应用程序需要收集时间分辨数据。实例包括基于其生长特征或观察酶反应来筛选细胞。本发明提供了一种解决该需求的工具和相关技术，并且可以在许多其它情况下使用。本发明在一个方面提供一种允许单个液滴的稳定储存和分度的工具。本发明不仅可以与微流体/微型设备连接，而且可以与宏观设备接合，以便容易地注入液体和提取样品液滴等。

9. 发明申请

WO2009139898A2 VALVES AND OTHER FLOW CONTROL IN FLUIDIC SYSTEMS INCLUDING MICROFLUIDIC SYSTEMS 审中-公开
标题翻译：流体系统中的阀门和其他流量控制，包括微流体系统
公开(公告)号：WO2009139898A2
公开(公告)日：2009-11-19
申请号：PCT/US2009/003024
申请日：2009-05-15
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , ABATE, Adam, R. , WEITZ, David, A.
发明人： ABATE, Adam, R. , WEITZ, David, A.
IPC分类号： B01J14/00
CPC分类号： B01L3/502738 , B01L3/0268 , B01L3/502746 , B01L3/502784 , B01L2200/0605 , B01L2200/0636 , B01L2200/146 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2400/0487 , B01L2400/0655 , B01L2400/082 , F16K99/0017 , F16K99/0026 , F16K99/0055 , Y10T436/2575
摘要： Articles and methods for controlling flow in fluidic systems, especially in microfluidic systems, are provided. In one aspect, a microfluidic system described herein includes a configuration such that the actuation of a single valve can allow the switching of fluids from a first fluid path (e.g., a first channel section) to a second fluid path (e.g., a second channel section). This may be achieved, for example, by incorporating a valve with a first channel section, which may have a lower hydrodynamic resistance than a second channel section prior to actuation of the valve. Actuation of the valve can cause only the hydrodynamic resistance of the first channel section to increase, thereby redirecting fluid flow into the second channel section (which now has a relatively lower hydrodynamic resistance). In some embodiments, the valve comprises a control channel for introducing a positive or reduced pressure, and is adapted to modulate fluid flow in an adjacent channel section by constricting or expanding the channel section. For example, the valve and/or the channel section may be formed in a flexible material and actuation of the valve may be achieved by applying a positive or reduced pressure to the valve to cause deformation of both the valve and the channel section. Another aspect of the invention includes articles and methods associated with manipulation of multiphase materials (e.g., dispersions). For instance, one or more valves may be combined with a flow focusing system so as to form droplets of different volumes and/or frequencies without the need to vary flow rates of the fluids when they are introduced into the fluidic system.
摘要翻译：提供了用于控制流体系统流动的文章和方法，特别是在微流体系统中。在一个方面，本文描述的微流体系统包括使得单个阀的致动可以允许流体从第一流体路径（例如，第一通道部分）切换到第二流体路径（例如，第二通道部分）。这可以通过例如通过结合具有第一通道部分的阀来实现，该阀在致动阀之前可具有比第二通道部分更低的流体动力阻力。阀的致动可以仅使第一通道部分的流体动力阻力增加，从而将流体流转向第二通道部分（其现在具有相对较低的流体动力阻力）。在一些实施例中，阀包括用于引入正压或减压的控制通道，并且适于通过收缩或扩大通道部分来调制相邻通道部分中的流体流动。例如，阀和/或通道部分可以形成为柔性材料，并且可以通过向阀施加正压或减压以使阀和通道部分变形来实现阀的致动。本发明的另一方面包括与多相材料（例如分散体）的操作有关的制品和方法。例如，一个或多个阀可以与流动聚焦系统组合，以便形成不同体积和/或频率的液滴，而不需要在将流体引入流体系统时改变流体流速。

10. 发明申请

WO2009061372A9 SYSTEMS AND METHODS FOR CREATING MULTI-PHASE ENTITIES, INCLUDING PARTICLES AND/OR FLUIDS 审中-公开
标题翻译：用于创建多相实体（包括颗粒和/或流体）的系统和方法
公开(公告)号：WO2009061372A9
公开(公告)日：2009-06-25
申请号：PCT/US2008012384
申请日：2008-10-31
申请人： HARVARD COLLEGE , SHAH RHUTESH KISHORKANT , KIM JIN-WOONG , WEITZ DAVID A
发明人： SHAH RHUTESH KISHORKANT , KIM JIN-WOONG , WEITZ DAVID A
IPC分类号： A61K9/50 , B01J13/00
CPC分类号： B01F17/005 , B01F17/0028
摘要： The present invention generally relates to multi-phase entities, which may include one or more phases containing particles. The particles may be agglomerated in some cases. In one embodiments, the multi-phase entity contains one or more phases and/or regions, which each may independently be a solid or a liquid. For example, a multi-phase entity may contain a solid phase and a liquid phase, a first solid phase and a second solid phase, a first liquid phase and a second liquid phase, etc., and the phases may be present within one or more phases within the entity. In some aspects of the invention, the hydrophobicities/hydrophilicities of one or more phases of the multi- phase entity are sensitive to temperature, pH, and/or an analyte, etc. Still other aspects of the invention generally relate to systems and methods of making and using such multi-phase entities, kits involving such entities, or the like.
摘要翻译：本发明一般涉及多相实体，其可以包括一个或多个含有颗粒的相。在某些情况下，颗粒可能团聚。在一个实施方案中，多相实体包含一个或多个相和/或区域，其各自可以独立地为固体或液体。例如，多相实体可以包含固相和液相，第一固相和第二固相，第一液相和第二液相等，并且相可以存在于一个或多个相实体内的更多阶段。在本发明的一些方面，多相实体的一个或多个相的疏水性/亲水性对温度，pH和/或分析物等敏感。本发明的其它方面一般涉及系统和方法制作和使用这样的多阶段实体，涉及这些实体的工具包等。

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