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11. 发明申请

WO2012153325A3 RETINAL PROSTHESIS TECHNIQUES 审中-公开
标题翻译： RETINAL PROSTHESIS技术
公开(公告)号：WO2012153325A3
公开(公告)日：2014-03-06
申请号：PCT/IL2012000186
申请日：2012-05-09
申请人： NANO RETINA INC , GEFEN RA ANAN , GROSS YOSSI , LIRAN TUVIA , VAINGAST SHAI
发明人： GEFEN RA ANAN , GROSS YOSSI , LIRAN TUVIA , VAINGAST SHAI
IPC分类号： A61N1/36
CPC分类号： A61N1/36046 , A61F2/16 , A61F2250/0001 , A61N1/0543 , A61N1/3787
摘要： Apparatus for use with an external non-visible light source (24) is provided. The apparatus includes an intraocular device (60) configured for implantation in a human eye, and including an energy receiver (32). The energy receiver (32) is configured to receive light emitted from the external non-visible light source (24), and extract energy from the emitted light for powering the intraocular device (60). The intraocular device (60) is configured to regulate a parameter of operation of the intraocular device (60) based on a modulation of the light emitted by the external non-visible light source (24) and received by the energy receiver (32). Other embodiments are also described.
摘要翻译：提供了用于与外部不可见光源（24）一起使用的装置。该装置包括配置用于植入人眼中并包括能量接收器（32）的眼内装置（60）。能量接收器（32）被配置为接收从外部不可见光源（24）发射的光，并且从所发射的光中提取能量来为眼内装置（60）供电。眼内装置（60）被配置为基于由外部不可见光源（24）发射并由能量接收器（32）接收的光的调制来调节眼内装置（60）的操作参数。还描述了其它实施例。

12. 发明申请

WO2012058477A2 FLEXIBLE ARTIFICIAL RETINA DEVICES 审中-公开
标题翻译：灵活人造革命装置
公开(公告)号：WO2012058477A2
公开(公告)日：2012-05-03
申请号：PCT/US2011/058159
申请日：2011-10-27
申请人： NATIONAL TSING HUA UNIVERSITY , FAN, Long-Sheng
发明人： FAN, Long-Sheng
IPC分类号： A61F9/08 , A61N1/36 , H05K3/10
CPC分类号： H01L27/1446 , A61N1/0543 , A61N1/36046
摘要： An implant apparatus comprising a plurality of photo sensors, a plurality of micro electrodes and circuitry coupled to the photo sensors and the micro electrodes are described. The photo sensors may receive incoming light. The circuit may drive the micro electrodes to stimulate neuron cells for enabling perception of a vision of the light captured by the photo sensors. The apparatus may be implemented in a flexible material to conform to a shape of a human eyeball to allow the micro electrodes aligned with the neuron cells for the stimulation. In another embodiment, fabrication methods for a flexible device having an array of pixel units for retina prosthesis are described. The fabrication method may comprise forming layered structures including the array of pixel units over a substrate, each pixel unit comprising a processing circuitry, a micro electrode and a photo sensor. In another embodiment, methods and apparatuses for configuring an implantable device to interface with retina cells are described. The device may comprise an array of pixel units capable of stimulating the retina cells. The pixel units may operate in a mode of operation selected from a plurality of modes including a normal mode and a calibration mode.
摘要翻译：描述了包括多个光传感器，耦合到光传感器和微电极的多个微电极和电路的植入装置。光传感器可以接收入射光。电路可以驱动微电极来刺激神经元细胞，以使得能够感知由光传感器捕获的光的视觉。该装置可以以柔性材料实现以符合人眼球的形状，以允许微电极与神经元细胞对准用于刺激。在另一个实施例中，描述了具有用于视网膜假体的像素单元阵列的柔性装置的制造方法。制造方法可以包括在衬底上形成包括像素单元阵列的分层结构，每个像素单元包括处理电路，微电极和光传感器。在另一个实施例中，描述了用于配置可植入装置以与视网膜细胞相接的方法和装置。该装置可以包括能够刺激视网膜细胞的像素单元的阵列。像素单元可以在从包括正常模式和校准模式的多种模式中选择的操作模式中操作。

13. 发明申请

WO2012001454A1 ARTIFICIAL RETINA DEVICE 审中-公开
标题翻译：人造革命装置
公开(公告)号：WO2012001454A1
公开(公告)日：2012-01-05
申请号：PCT/IB2010/002170
申请日：2010-09-02
申请人： JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENTIFIC RESEARCH , KAVASSSERY, Narayan, Sureswaran , GAUTAM, Vini , BAG, Monojit
发明人： KAVASSSERY, Narayan, Sureswaran , GAUTAM, Vini , BAG, Monojit
IPC分类号： A61F9/08 , A61F2/14 , H01L51/42
CPC分类号： A61N1/36046 , A61N1/0543 , B82Y10/00 , H01L51/0036 , H01L51/0047 , H01L51/4253
摘要： The present technology provides an organic based artificial retina device that includes a substrate and an array of micro-electrodes formed on the substrate. The illustrative artificial retina device further includes a photoconducting polymer blend deposited on the array of micro-electrodes. The photoconducting polymer blend is configured to produce a photoelectric signal in response to receiving light.
摘要翻译：本技术提供了一种有机基人造视网膜装置，其包括基板和形成在基板上的微电极阵列。示例性人造视网膜装置还包括沉积在微电极阵列上的光导聚合物共混物。光导聚合物共混物被配置为响应于接收光产生光电信号。

14. 发明申请

WO2011137307A1 SELECTABLE FILTERS FOR A VISUAL PROSTHESIS 审中-公开
标题翻译：可选滤镜为视觉展现
公开(公告)号：WO2011137307A1
公开(公告)日：2011-11-03
申请号：PCT/US2011/034488
申请日：2011-04-29
申请人： SECOND SIGHT MEDICAL PRODUCTS, INC. , GREENBERG, Robert, J. , MCCLURE, Kelly, H. , KAIKWAD, Sanjay, R.
发明人： GREENBERG, Robert, J. , MCCLURE, Kelly, H. , KAIKWAD, Sanjay, R.
IPC分类号： A61N1/36 , G02C7/10 , A61F9/02 , G02B7/00 , G02B5/20
CPC分类号： A61N1/36046 , A61F9/022 , A61N1/0543
摘要： The present invention is a visual prosthesis including a visor with an embedded camera and changeable optical filters to limit light entering the lens of the camera. This invention will allow use of custom filters to limit light intensity or certain light frequencies sent to the camera of the visual prosthesis in a variety of brightness conditions which will remove glare. It will allow modification of the color of the light sent to camera of the visual prosthesis to respond to different environments. Users may choose the best filter to suit their needs in real time.
摘要翻译：本发明是一种视觉假体，其包括具有嵌入式照相机的遮阳板和可变光学滤光器，以限制进入照相机镜头的光。本发明将允许使用定制滤光器来限制在各种亮度条件下发送到视觉假体的照相机的光强度或某些光频率，这将消除眩光。它将允许修改发送到视觉假体的相机的光的颜色以响应不同的环境。用户可以根据自己的需要选择最佳的过滤器。

15. 发明申请

WO2011137298A2 IMPROVED BIOCOMPATIBLE BONDING METHOD 审中-公开
标题翻译：改进的生物化学键合方法
公开(公告)号：WO2011137298A2
公开(公告)日：2011-11-03
申请号：PCT/US2011034471
申请日：2011-04-29
申请人： SECOND SIGHT MEDICAL PROD INC , FARAJI BOOZARJOMEHR , ZHOU DAVID DAOMIN , GREENBERG ROBERT J , OK JERRY , TALBOT NEIL HAMILTON , LITTLE JAMES SINGLETON
发明人： FARAJI BOOZARJOMEHR , ZHOU DAVID DAOMIN , GREENBERG ROBERT J , OK JERRY , TALBOT NEIL HAMILTON , LITTLE JAMES SINGLETON
IPC分类号： A61N1/36 , A61B5/04 , A61N1/375 , H01L21/56 , H01L21/60
CPC分类号： H01L21/563 , A61B5/04001 , A61B2562/125 , A61N1/0543 , A61N1/36046 , A61N1/3752 , H01L24/29 , H01L24/32 , H01L24/83 , H01L2224/16225 , H01L2224/2919 , H01L2224/32225 , H01L2224/45169 , H01L2224/48091 , H01L2224/48465 , H01L2224/73203 , H01L2224/73204 , H01L2224/73265 , H01L2224/81193 , H01L2224/81801 , H01L2224/838 , H01L2224/92125 , H01L2924/01005 , H01L2924/01006 , H01L2924/01013 , H01L2924/01033 , H01L2924/01041 , H01L2924/01045 , H01L2924/01047 , H01L2924/01073 , H01L2924/01074 , H01L2924/01077 , H01L2924/01078 , H01L2924/01079 , H01L2924/01082 , H01L2924/014 , H01L2924/0665 , H01L2924/0781 , H01L2924/12042 , H01L2924/14 , H01L2924/15787 , H01L2924/19107 , H01L2924/3011 , Y10T156/10 , H01L2924/00014 , H01L2924/00 , H01L2924/3512
摘要： The invention is a device and method for connecting a hermetic package to a flexible circuit such as for an electrode array in an implantable device. Attaching metal pads on a flexible circuit to metal pads on a hermetic device by conductive adhesive is known. A smooth metal, such as platinum, does not bond well to conductive epoxy. The invention provides a roughened surface, such as etching or applying high surface area platinum gray, to improve adhesion to platinum or other metal pads.
摘要翻译：本发明是一种用于将密封包装连接到诸如用于可植入装置中的电极阵列的柔性电路的装置和方法。通过导电粘合剂将柔性电路上的金属焊盘连接到密封设备上的金属焊盘是已知的。光滑的金属，如铂，不能很好地粘结到导电环氧树脂上。本发明提供了粗糙化的表面，例如蚀刻或施加高表面积的白金灰，以改善与铂或其它金属垫的粘合性。

16. 发明申请

WO2011106783A2 RETINA PROSTHESIS 审中-公开
公开(公告)号：WO2011106783A2
公开(公告)日：2011-09-01
申请号：PCT/US2011026526
申请日：2011-02-28
申请人： UNIV CORNELL , NIRENBERG SHEILA , PANDARINATH CHETHAN , OHIOHENUAN IFIJE
发明人： NIRENBERG SHEILA , PANDARINATH CHETHAN , OHIOHENUAN IFIJE
IPC分类号： A61N1/04
CPC分类号： A61N1/36046 , A61F9/08 , A61N1/0543 , G06N3/049
摘要： The invention provides a retinal prosthetic method and device that mimics the responses of the retina to a broad range of stimuli, including natural stimuli. Ganglion cell firing patterns are generated in response to a stimulus using a set of encoders, interfaces, and transducers, where each transducer targets a single cell or a small number of cells. The conversion occurs on the same time scale as that carried out by the normal retina. In addition, aspects of the invention may be used with robotic or other mechanical devices, where processing of visual information is required. The encoders may be adjusted over time with aging or the progression of a disease.
摘要翻译：本发明提供了视网膜假体方法和装置，其模拟视网膜对广泛范围的刺激（包括天然刺激）的反应。响应于使用一组编码器，接口和换能器的刺激来产生神经节细胞发射模式，其中每个换能器靶向单个细胞或少量细胞。转换发生在与正常视网膜相同的时间尺度上。此外，本发明的方面可以与机器人或其他机械装置一起使用，其中需要视觉信息的处理。随着老化或疾病的进展，编码器可随时间而被调整。

17. 发明申请

WO2011011257A1 CYTOKINE PRODUCTION VIA ELECTRICAL STIMULATION TO TREAT GLAUCOMA 审中-公开
标题翻译：细胞因子生产通过电刺激治疗葡萄球菌
公开(公告)号：WO2011011257A1
公开(公告)日：2011-01-27
申请号：PCT/US2010/042113
申请日：2010-07-15
申请人： ALCON RESEARCH, LTD. , LIND, Casey , SANCHEZ, Robert J., Jr.
发明人： LIND, Casey , SANCHEZ, Robert J., Jr.
IPC分类号： A61N1/36 , A61N1/05 , A61F9/00
CPC分类号： A61N1/36046 , A61F9/00781 , A61N1/0543
摘要： The present invention is a method of treating glaucoma by electrically stimulating the ciliary muscle to produce shear stress on the trabecular meshwork sufficient for cytokine production. A device for electrically stimulating the ciliary muscle includes a pair of electrodes configured to provide a voltage to the ciliary muscle. The electrodes are coupled to a voltage source. A controller operates to apply the voltage to the ciliary muscle.
摘要翻译：本发明是通过电刺激睫状肌以在足以产生细胞因子的小梁网上产生剪切应力来治疗青光眼的方法。用于电刺激睫状肌的装置包括配置成向睫状肌提供电压的一对电极。电极耦合到电压源。控制器操作以将电压施加到睫状肌上。

18. 发明申请

WO2010105728A2 ACTIVE RETINAL IMPLANT 审中-公开
标题翻译：活性植入物
公开(公告)号：WO2010105728A2
公开(公告)日：2010-09-23
申请号：PCT/EP2010/001126
申请日：2010-02-24
申请人： RETINA IMPLANT AG , WROBEL, Walter-G , ZRENNER, Eberhart , ROTHERMEL, Albrecht
发明人： WROBEL, Walter-G , ZRENNER, Eberhart , ROTHERMEL, Albrecht
IPC分类号： A61N1/05
CPC分类号： A61N5/0601 , A61F9/0079 , A61F2009/00863 , A61N1/0543 , A61N5/0622 , A61N2005/0648 , A61N2005/0652 , A61N2005/0653 , A61N2005/0659 , A61N2005/0662
摘要： The invention relates to an active retinal implant (10) to be implanted into an eye, with an array (16) of stimulation elements (17) that emit stimulation signals to cells of the retina, wherein the stimulation elements (17) are designed as radiation-emitting elements.
摘要翻译：本发明涉及要植入眼睛的活动视网膜植入物（10），其具有将刺激信号发射到视网膜细胞的刺激元件（17）的阵列（16），其中刺激元件（17）被设计为辐射发射元件。

19. 发明申请

WO2010035173A1 VISUAL PROSTHESIS IMPLANT 审中-公开
标题翻译：可视化植入物
公开(公告)号：WO2010035173A1
公开(公告)日：2010-04-01
申请号：PCT/IB2009/054043
申请日：2009-09-16
申请人： NXP B.V. , MEIJER, Peter Bartus Leonard
发明人： MEIJER, Peter Bartus Leonard
IPC分类号： A61N1/36 , A61N1/05
CPC分类号： A61N1/36046 , A61N1/0543
摘要： A visual prosthesis implant (1) is provided which comprises an SIMD- based processor array (6) adapted for receiving image signals from an image sensor (5) and outputting processed signals, and a bio -compatible electrode implant (7) receiving the processed signals and adapted for coupling to neurons. Using the SIMD- based processor array (6) provides high performance at small power dissipation and small chip area such that a fully implantable is visual prosthesis is achieved.
摘要翻译：提供了一种视觉假体植入物（1），其包括适于从图像传感器（5）接收图像信号并输出处理的信号的基于SIMD的处理器阵列（6），以及生物相容的电极植入物（7）信号并适合与神经元耦合。使用基于SIMD的处理器阵列（6）在小功耗和小芯片面积方面提供高性能，从而实现完全可植入的视觉假体。

20. 发明申请

WO2006116625A3 BATCH-FABRICATED FLEXIBLE INTRAOCULAR RETINAL PROSTHESIS SYSTEMS AND METHODS FOR MANUFACTURING THE SAME 审中-公开
标题翻译：批量制作柔性肌内放射治疗系统及其制造方法
公开(公告)号：WO2006116625A3
公开(公告)日：2009-04-30
申请号：PCT/US2006016070
申请日：2006-04-28
申请人： CALIFORNIA INST OF TECHN , UNIV SOUTHERN CALIFORNIA , TAI YU-CHONG , RODGER DAMIEN C , LI WEN , HUMAYUN MARK , WEILAND JAMES D , AMERI HOSSEIN
发明人： TAI YU-CHONG , RODGER DAMIEN C , LI WEN , HUMAYUN MARK , WEILAND JAMES D , AMERI HOSSEIN
IPC分类号： A61F2/14 , A61F9/08 , A61N1/28 , A61N1/36
CPC分类号： A61N1/0543 , A61F9/08 , A61N1/36046 , Y10T29/49002 , Y10T29/49128 , Y10T29/4913 , Y10T29/49156 , Y10T29/49224
摘要： Intraocular retinal prosthesis systems and methods for fabricating the same are provided. In one aspect, fabrication of all or multiple components of a prosthesis device or system are combined into a single monolithic fabrication process. Also, many such entire systems can be fabricated simultaneously in a single microfabrication processing run. A prosthesis device includes a cable region that connects an electrode array region with a power and data management region. The electrode array region includes one or more arrays of exposed electrodes, and the power and data management region includes various power and control elements. The power and data management elements, in one aspect, include an RF coil or coils and circuit arrangements and/or chips configured to provide drive signals to the electrodes via a cable and receive power and signals from the RF coil or coils. Each region includes elements fabricated on or in a single polymer layer during the same fabrication process.
摘要翻译：提供了眼内视网膜假体系统及其制造方法。在一个方面，假体装置或系统的全部或多个部件的制造被组合成单个整体制造工艺。此外，许多这样的整个系统可以在单个微细加工处理运行中同时制造。假体装置包括将电极阵列区域与功率和数据管理区域连接的电缆区域。电极阵列区域包括一个或多个暴露电极阵列，功率和数据管理区域包括各种功率和控制元件。功率和数据管理元件在一个方面包括RF线圈或线圈以及经配置以通过电缆向电极提供驱动信号并且从RF线圈或线圈接收功率和信号的电路布置和/或芯片。每个区域包括在同一制造过程中在单个聚合物层上或其中制造的元件。

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