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11. 发明申请

WO2009050667A1 TUMOR DEMARCATION USING TARGETED FLUORESCENT PROBE AND PHOTONIC NEEDLE 审中-公开
标题翻译：使用指定的荧光探针和光子针头进行肿瘤分解
公开(公告)号：WO2009050667A1
公开(公告)日：2009-04-23
申请号：PCT/IB2008/054253
申请日：2008-10-16
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , VAN DER MARK, Martinus, B. , HENDRIKS, Bernardus, H., W.
发明人： VAN DER MARK, Martinus, B. , HENDRIKS, Bernardus, H., W.
IPC分类号： A61B5/00
CPC分类号： A61B90/39 , A61B2090/306 , A61B2090/3908 , A61B2090/3941
摘要： The present invention refers to the field of image-guided percutaneous needle biopsies, in particular to a light guiding hook wire comprising a light-guiding optical fiber (LGM, LGHW) for transferring light from one end on which a beam of input light are incident to another end placed in a cancerous tissue region around the tip of the hookwire, thereby providing an output light assignable to the intensity of the input light; and a liquid guiding device for providing a liquid to the region of interest. The present invention further refers to a method for excising non-palpable pathological tissue regions in the interior of a patient's body, especially tissue regions indicative of breast or prostate cancer, by using such a hookwire. A targeted contrast agent fluorescent in the visible or near-infrared spectrum of light can be used to mark cancerous tissue anomalies, and a light-guiding optical fiber (LGM, LGHW) may provide the light needed for an excitation of this tissue.
摘要翻译：本发明涉及图像引导的经皮针活检领域，特别涉及一种导光钩线，其包括用于从输入光束入射的一端传输光的导光光纤（LGM，LGHW）到另一端放置在钩线尖端周围的癌组织区域中，从而提供可分配给输入光强度的输出光; 以及用于向感兴趣区域提供液体的液体引导装置。本发明还涉及通过使用这种钩线来切除患者身体内部，特别是指示乳腺癌或前列腺癌的组织区域中的不可触知的病理组织区域的方法。在可见光或近红外光谱中荧光的靶向对比剂可用于标记癌组织异常，并且导光光纤（LGM，LGHW）可提供激发该组织所需的光。

12. 发明申请

WO2009016548A3 METHOD AND SYSTEM FOR IMAGING SAMPLES 审中-公开
标题翻译：用于成像样本的方法和系统
公开(公告)号：WO2009016548A3
公开(公告)日：2009-03-26
申请号：PCT/IB2008052950
申请日：2008-07-23
申请人： KONINKL PHILIPS ELECTRONICS NV , DE BOER RUTH W I , HENDRIKS BERNARDUS H W
发明人： DE BOER RUTH W I , HENDRIKS BERNARDUS H W
IPC分类号： G01N21/64 , G02B21/00
CPC分类号： G01N21/6458 , G01N2021/6419 , G01N2021/6421 , G01N2021/6441 , G02B21/16 , G02B21/244
摘要： The invention provides a method for imaging samples, at least comprising: - staining of a sample with a first marker material and with a second marker material; - utilizing the first marker material in a focusing step for focusing an imaging device with respect to the sample; and - utilizing the second marker material and the imaging device, which has been focused in the focusing step, in an imaging step to acquire an image of the sample. The invention also relates to a system for imaging samples.
摘要翻译：本发明提供了一种用于成像样品的方法，至少包括： - 用第一标记材料和第二标记材料对样品进行染色; - 在聚焦步骤中利用第一标记物材料以使成像装置相对于样本聚焦; 以及 - 利用在聚焦步骤中聚焦的第二标记材料和成像装置在成像步骤中获取样本的图像。本发明还涉及一种用于成像样本的系统。

13. 发明申请

WO2009001300A1 LENS SYSTEM 审中-公开
标题翻译：镜头系统
公开(公告)号：WO2009001300A1
公开(公告)日：2008-12-31
申请号：PCT/IB2008/052532
申请日：2008-06-25
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , HENDRIKS, Bernardus Hendrikus Wilhelmus , SHIMIZU, Jeff , KUIPER, Stein
发明人： HENDRIKS, Bernardus Hendrikus Wilhelmus , SHIMIZU, Jeff , KUIPER, Stein
IPC分类号： G02B23/24
CPC分类号： G02B23/243 , G02B26/103
摘要： A lens system comprises a first lens group and a second lens group, and is configured to form an image at a first magnification and at a second magnification. The lens system has a common optical axis in both magnifications. The lens system is further configured to form an intermediate image between the first lens group and the second lens group at the first magnification. The intermediate image formed in the first magnification is further imaged onto an optical detector. In the first magnification, the second lens group acts as a relay lens imaging the intermediate image onto the optical detector. In the second magnification, the first and second lens groups together form an image on the optical detector without forming an intermediate image.
摘要翻译：透镜系统包括第一透镜组和第二透镜组，并且被配置为以第一放大率和第二放大率形成图像。透镜系统具有两个放大倍率的共同光轴。透镜系统还被配置为在第一放大率下在第一透镜组和第二透镜组之间形成中间图像。在第一放大率中形成的中间图像进一步成像到光学检测器上。在第一放大率中，第二透镜组用作将中间图像成像到中间透镜到光学检测器上。在第二放大倍数中，第一和第二透镜组一起在光学检测器上形成图像，而不形成中间图像。

14. 发明申请

WO2008081374A2 REFLECTION OR SINGLE SCATTERING SPECTROSCOPY AND IMAGING 审中-公开
标题翻译：反射或单个散射光谱和成像
公开(公告)号：WO2008081374A2
公开(公告)日：2008-07-10
申请号：PCT/IB2007/055191
申请日：2007-12-18
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , VAN HERPEN, Maarten, M.J.W. , KALKMAN, Jeroen , HENDRIKS, Bernardus, H.W. , STALLINGA, Sjoerd
发明人： VAN HERPEN, Maarten, M.J.W. , KALKMAN, Jeroen , HENDRIKS, Bernardus, H.W. , STALLINGA, Sjoerd
IPC分类号： A61B5/103 , A61B5/00
CPC分类号： A61B5/0075 , A61B5/0062 , A61B5/0068 , A61B5/441 , G01N21/474 , G01N21/4795 , G01N2021/213 , G01N2021/4792 , G02B21/0068 , G02B27/286
摘要： The invention relates to a method for the analysis of a probe medium (4) by interaction between an incident light beam (3), having an intensity, and the probe medium (4), the incident light beam (3) also passing through a scattering medium, the method comprising: - modulating the amplitude of at least two polarization components of the incident light beam (3), while keeping the intensity of the incident light beam constant, - after interaction between the modulated incident light beam (3) and the probe medium (4) and scattering by the scattering medium, generating an outgoing interacted and backscattered light beam (5, 5'), collecting a collected interacted and backscattered light beam (5p, 5s) from the outgoing light beam (5, 5'), - demodulating the collected light beam (5), in order to measure a value related to the interaction, free from scattering which does not preserve modulation.
摘要翻译：本发明涉及一种通过具有强度的入射光束（3）和探测介质（4）之间的相互作用来分析探测介质（4）的方法，入射光所述方法包括： - 调制所述入射光束（3）的至少两个偏振分量的振幅，同时保持所述入射光束的强度恒定， - 在所述光束（3）调制入射光束（3）和探测介质（4）并且通过散射介质散射，产生输出相互作用和反向散射的光束（5,5'），从所收集的相互作用和背向散射的光束（5p，5s）出射光束（5,5'）， - 对收集的光束（5）进行解调，以便测量与相互作用有关的值，没有不保持调制的散射。

15. 发明申请

WO2008038198A3 TEMPERATURE CONTROL OF PATIENTS DURING SURGERY 审中-公开
公开(公告)号：WO2008038198A3
公开(公告)日：2008-04-03
申请号：PCT/IB2007/053825
申请日：2007-09-20
申请人： KONINKLIJKE PHILIPS ELECTRONICS, N.V. , U.S. PHILIPS CORPORATION , HENDRIKS, Bernardus Hendrikus Wilhelmus , VAN PIETERSON, Liesbeth , LUCASSEN, Gerhardus Wilhelmus
发明人： HENDRIKS, Bernardus Hendrikus Wilhelmus , VAN PIETERSON, Liesbeth , LUCASSEN, Gerhardus Wilhelmus
IPC分类号： A61N5/06
摘要： An infrared radiant heating system for raising or maintaining a uniform core temperature of the body of a patient during surgery, substantially without affecting the temperature of the area surrounding the patient's body, comprising: infrared radiant heating means which in use is located in an unobtrusive position near the patient to provide radiant heat to the entire body or one or more parts of the body of the patient; and control means in communication with the heating means for controlling the intensity level and distribution of intensity of the radiant heat on the patient's body such that in use the skin temperature of the patient's body is raised or maintained within a predetermined range resulting in the uniform core body temperature, substantially without affecting the temperature of the area surrounding the patient's body.

16. 发明申请

WO2008017967A1 DEVICE, SYSTEM AND METHOD FOR INTERACTING WITH A CELL OR TISSUE IN A BODY 审中-公开
标题翻译：用于与身体中的细胞或组织相互作用的装置，系统和方法
公开(公告)号：WO2008017967A1
公开(公告)日：2008-02-14
申请号：PCT/IB2007/051326
申请日：2007-04-12
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , ZOU, Hans , KUIPER, Stein , HENDRIKS, Bernardus Hendrikus Wilhelmus , SUIJVER, Jan Frederik , PIERIK, Anke , RENSEN, Judith Margreet , DIJKSMAN, Johan Frederik , SHIMIZU, Jeff , DEN TOONDER, Jacob Marinus Jan
发明人： ZOU, Hans , KUIPER, Stein , HENDRIKS, Bernardus Hendrikus Wilhelmus , SUIJVER, Jan Frederik , PIERIK, Anke , RENSEN, Judith Margreet , DIJKSMAN, Johan Frederik , SHIMIZU, Jeff , DEN TOONDER, Jacob Marinus Jan
IPC分类号： A61B5/00
CPC分类号： A61B5/6882 , A61B1/041 , A61B5/0031 , A61B5/073 , A61B5/4839
摘要： A device or support, system and method are provided for precisely targeted and/or highly controlled interaction with a targeted cell or tissue in a body, with the support providing an ergonomic connecting interface for selectively connecting the support to a cell or tissue with at least minimal adverse affect to such cell or tissue, the system providing a remote facility that may be operatively associated with the support, and the method providing steps for employing the support and/or system so as to, inter alia, improve treatment, diagnostic and/or monitoring techniques and increase sensitivity and specificity with respect to interacting with, for example, diseased or abnormal cells or tissue without adversely effecting surrounding healthy cells or tissue, and/or the body in general.
摘要翻译：提供了一种装置或支撑件，系统和方法，用于与身体中的靶细胞或组织精确地靶向和/或高度受控的相互作用，其中所述支持物提供符合人体工程学的连接界面，用于至少选择性地将支持物连接到细胞或组织对这种细胞或组织的最小的不利影响，该系统提供可能与支持物可操作地相关联的远程设施，以及提供使用支持和/或系统的方法，以便除其他外改善治疗，诊断和/ 或监测技术，并提高与例如患病或异常细胞或组织的相互作用的灵敏度和特异性，而不会不利地影响周围的健康细胞或组织和/或身体。

17. 发明申请

WO2007132378A3 IMAGING SYSTEM FOR THREE-DIMENSIONAL IMAGING OF THE INTERIOR OF AN OBJECT 审中-公开
标题翻译：用于对象内部三维成像的成像系统
公开(公告)号：WO2007132378A3
公开(公告)日：2008-01-24
申请号：PCT/IB2007051631
申请日：2007-05-02
申请人： KONINKL PHILIPS ELECTRONICS NV , SUIJVER JAN FREDERIK , HENDRIKS BERNARDUS HENDRIKUS W
发明人： SUIJVER JAN FREDERIK , HENDRIKS BERNARDUS HENDRIKUS W
IPC分类号： A61B1/00
CPC分类号： G02B6/06 , A61B1/00167 , A61B1/00193 , G02B6/0008 , G02B6/04 , G02B23/2469 , H04N5/2256 , H04N5/2257 , H04N5/372 , H04N2005/2255
摘要： The invention relates to an imaging system and a method for three- dimensional imaging of the interior of an object. The imaging system comprises illumination means (10), detection means (11) and reconstruction means. The illumination means is adapted to illuminate the interior of the object with light, wherein the illumination means (10) is capable of generating different spatial light intensity distributions on the interior of the object. The detection means (11) is adapted to detect the different spatial light intensity distributions, and the reconstruction means is adapted to reconstruct a three-dimensional image from the detected different spatial light intensity distributions. The invention relates further to an optical fiber system comprising a transfer mechanism to transfer the optical fiber system from a first condition, in which optical fibers diverge from each other, to a second condition, in which optical fibers are parallel to each other, and vice versa.
摘要翻译：本发明涉及一种用于物体内部的三维成像的成像系统和方法。成像系统包括照明装置（10），检测装置（11）和重建装置。照明装置适于用光照射物体的内部，其中照明装置（10）能够在物体的内部产生不同的空间光强度分布。检测装置（11）适于检测不同的空间光强度分布，并且重建装置适于从检测到的不同的空间光强度分布重建三维图像。本发明还涉及一种光纤系统，该光纤系统包括一个传输机构，用于将光纤系统从光纤彼此分离的第一状态转移到光纤彼此平行的第二状态，反之亦然。

18. 发明申请

WO2006131888A3 SWITCHABLE OPTICAL ELEMENT 审中-公开
标题翻译：可切换光学元件
公开(公告)号：WO2006131888A3
公开(公告)日：2007-03-29
申请号：PCT/IB2006051811
申请日：2006-06-07
申请人： KONINKL PHILIPS ELECTRONICS NV , KUIPER STEIN , HENDRIKS BERNARDUS H W
发明人： KUIPER STEIN , HENDRIKS BERNARDUS H W
IPC分类号： G02B6/26
CPC分类号： G02B26/02 , G02B6/3538 , G02B6/3552
摘要： A switchable optical element has an optical axis. The element includes a chamber, a wave front modifier having a face defining an interior surface of the chamber (the face extending transverse the optical axis), a first fluid and a second fluid. The fluids are immiscible and in contact over an interface. The optical element is switchable between a first discrete state in which the first fluid substantially covers the face of the wave front modifier, and a second discrete state in which the second fluid substantially covers the face of the wave front modifier, wherein the chamber encloses both fluids in both discrete states, and the interlace extends transverse the optical axis in the first discrete state.
摘要翻译：可切换光学元件具有光轴。元件包括腔室，波前修改器，其具有限定腔室的内表面的面（横向于光轴延伸的面），第一流体和第二流体。流体是不混溶的并且通过界面接触。光学元件可在第一离散状态（其中第一流体基本上覆盖波前修改器的表面）和第二离散状态之间切换，其中第二流体基本上覆盖波前修改器的表面，其中，腔室包围两者在离散状态下的流体，并且交错在第一离散状态下横向于光轴延伸。

19. 发明申请

WO2006013526A3 DIFFRACTIVE PART 审中-公开
公开(公告)号：WO2006013526A3
公开(公告)日：2006-06-22
申请号：PCT/IB2005052460
申请日：2005-07-21
申请人： KONINKL PHILIPS ELECTRONICS NV , HENDRIKS BERNARDUS , TUKKER TEUNIS WILLEM
发明人： HENDRIKS BERNARDUS , TUKKER TEUNIS WILLEM
IPC分类号： G11B7/00 , G11B7/135
CPC分类号： G11B7/1353 , G11B7/0903 , G11B2007/0006
摘要： A diffractive part for an optical scanning device is described. The device is for scanning a first information layer by means of a first radiation beam having a first wavelength and a first polarisation, a second information layer by means of a second radiation beam having a second wavelength and a second polarisation, and a third information layer by means of a third radiation beam having a third wavelength and a third polarisation. The first, second and third wavelengths differ from each other. The device includes a radiation source for supplying the first, second and third radiation beams, an objective lens system for converging the radiation beams on the respective information layer, and a diffractive part arranged in the optical path of the radiation beams. The diffractive part includes a first diffractive grating structure having a series of steps of predetermined height to introduce a phase change that is an integral multiple of 27E for both the second and third wavelengths but not the first wavelength, and a second diffractive grating structure having a series of steps of predetermined height to introduce a phase change that is an integral multiple of 2p for the first and third wavelengths but not the second wavelength.
摘要翻译：描述了用于光学扫描装置的衍射部分。该设备用于借助于具有第一波长和第一偏振的第一辐射束扫描第一信息层，借助于具有第二波长和第二偏振的第二辐射束扫描第二信息层，以及第三信息层借助于具有第三波长和第三偏振的第三辐射束。第一，第二和第三波长彼此不同。该装置包括用于提供第一，第二和第三辐射束的辐射源，用于将辐射束会聚在相应的信息层上的物镜系统，以及设置在辐射束的光路中的衍射部分。衍射部分包括第一衍射光栅结构和第二衍射光栅结构，第一衍射光栅结构具有预定高度的一系列台阶，以引入相对于第二和第三波长为27E的整数倍的相位变化，而不是第一波长，预定高度的一系列台阶引入对于第一和第三波长而言不是第二波长的2p的整数倍的相位变化。

20. 发明申请

WO2006046184A1 OPTICAL DEVICE FOR SCANNING AN INFORMATION CARRIER 审中-公开
标题翻译：用于扫描信息载体的光学装置
公开(公告)号：WO2006046184A1
公开(公告)日：2006-05-04
申请号：PCT/IB2005/053464
申请日：2005-10-24
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , HENDRIKS, Robert , STALLINGA, Sjoerd , HENDRIKS, Bernardus
发明人： HENDRIKS, Robert , STALLINGA, Sjoerd , HENDRIKS, Bernardus
IPC分类号： G11B7/135 , G11B7/12 , G11C13/04
CPC分类号： G11B7/1381 , G11B7/12 , G11B7/1374 , G11B7/13922 , G11B7/14
摘要： An optical scanning device for scanning an information carrier. The device includes an array optical element arranged to generate an array of radiation spots from an incident radiation beam, for the scanning of the information carrier. The device further includes an aberration optical element arranged to apply a predetermined optical aberration to the radiation for correction of optical aberration in the radiation spots.
摘要翻译：一种用于扫描信息载体的光学扫描装置。该装置包括阵列光学元件，其布置成从入射辐射束产生辐射点阵列，用于信息载体的扫描。该装置还包括一个像差光学元件，该像差光学元件被布置成对辐射施加预定的光学像差以校正辐射光斑中的光学像差。

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