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1. 发明申请

WO2011132128A1 DETERMINATION OF A LIPID WATER RATIO 审中-公开
标题翻译：脂肪水比的测定
公开(公告)号：WO2011132128A1
公开(公告)日：2011-10-27
申请号：PCT/IB2011/051662
申请日：2011-04-18
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , HENDRIKS, Bernardus, Hendrikus, Wilhelmus , HORIKX, Jeroen, Jan, Lambertus , LUCASSEN, Gerhardus, Wilhelmus , NACHABE, Rami , VAN DER VOORT, Marjolein
发明人： HENDRIKS, Bernardus, Hendrikus, Wilhelmus , HORIKX, Jeroen, Jan, Lambertus , LUCASSEN, Gerhardus, Wilhelmus , NACHABE, Rami , VAN DER VOORT, Marjolein
IPC分类号： A61B5/00 , G01N21/35
CPC分类号： A61B5/0059 , A61B5/4869 , G01N21/359
摘要： The present invention relates to an apparatus, a method and a computer program for determining a lipid- water ratio and a scattering parameter of a sample. In particular, the invention relates to an apparatus comprising a light source and a detector arranged to measure an optical parameter at various wavelengths, where the wavelengths are selected so that at two of the wavelengths the absorption coefficients for both water and lipids are substantially identical. This enables determination of a scattering parameter. A further measurement at a third wavelength enables determination of a water- lipid ratio. According to a specific embodiment, the light source and the detector are arranged in relation to an interventional device, so as to be able to examine a tissue in terms of lipid- water ratio and scattering during an intervention.
摘要翻译：本发明涉及用于确定样品的脂质 - 水比和散射参数的装置，方法和计算机程序。具体地，本发明涉及一种包括光源和检测器的设备，其被布置成测量各种波长的光学参数，其中选择波长使得在两个波长处，水和脂质的吸收系数基本相同。这使得能够确定散射参数。在第三波长处的进一步测量使得能够测定水 - 油比。根据具体实施例，光源和检测器相对于介入装置布置，以便能够在干预期间根据脂质 - 水的比例和散射来检查组织。

2. 发明申请

WO2011092617A1 LYMPH NODE DETECTION SYSTEM 审中-公开
标题翻译： LYMPH节点检测系统
公开(公告)号：WO2011092617A1
公开(公告)日：2011-08-04
申请号：PCT/IB2011/050282
申请日：2011-01-21
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , HENDRIKS, Bernardus Hendrikus Wilhelmus , LUCASSEN, Gerhardus, Wilhelmus , RUERS, Theodoor Jacques Marie , NACHABE, Rami , DESJARDINS, Adrien , VAN DER VOORT, Marjolein
发明人： HENDRIKS, Bernardus Hendrikus Wilhelmus , LUCASSEN, Gerhardus, Wilhelmus , RUERS, Theodoor Jacques Marie , NACHABE, Rami , DESJARDINS, Adrien , VAN DER VOORT, Marjolein
IPC分类号： A61B5/00
CPC分类号： A61B5/415 , A61B1/043 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/418 , A61B5/6848
摘要： Finding the sentinel lymph node during tumor resection is important for proper cancer staging. Using a fluorescence imaging system significantly improves the procedure. However, for deeply localized nodes this camera system is not sensitive enough due to the limited penetration depth. We propose to combine the fluorescence imaging system with an elongated interventional device both capable of detecting the fluorescence. This imaging system is capable of imaging the global fluorescence distribution of a fluorescent agent distributed in a material while the elongated interventional device is capable of detecting the local distribution of the fluorescent agent.
摘要翻译：在肿瘤切除期间发现前哨淋巴结对于正确的癌症分期是重要的。使用荧光成像系统显着改善手术。然而，对于深度本地化的节点，由于穿透深度有限，该相机系统不够灵敏。我们建议将荧光成像系统与能够检测荧光的细长介入装置相结合。该成像系统能够对分布在材料中的荧光剂的全局荧光分布进行成像，而细长的介入装置能够检测荧光剂的局部分布。

3. 发明申请

WO2010136922A1 RE-CALIBRATION OF PRE-RECORDED IMAGES DURING INTERVENTIONS USING A NEEDLE DEVICE 审中-公开
标题翻译：使用针头装置进行干预时预先记录的图像重新校准
公开(公告)号：WO2010136922A1
公开(公告)日：2010-12-02
申请号：PCT/IB2010/052030
申请日：2010-05-07
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , BAKKER, Levinus, P. , HENDRIKS, Bernardus, H., W. , DESJARDINS, Adrien, E.
发明人： BAKKER, Levinus, P. , HENDRIKS, Bernardus, H., W. , DESJARDINS, Adrien, E.
IPC分类号： A61B5/00 , G06T7/00 , A61B19/00 , A61B6/12
CPC分类号： A61B8/0841 , A61B5/0062 , A61B5/0066 , A61B5/0068 , A61B5/0071 , A61B5/0073 , A61B5/0075 , A61B5/0084 , A61B5/6848 , A61B6/12 , A61B6/5247 , A61B8/00 , A61B8/5238 , A61B17/34 , A61B17/3403 , A61B17/3417 , A61B2090/3614 , A61B2090/374 , A61B2090/376 , A61B2090/378 , A61B2090/3784
摘要： Re-calibration of pre-recorded images during interventions is proposed, utilizing an interventional system comprising an imaging device providing images of an object, a needle device, and a processing device. The needle device comprises a sensor for providing data corresponding to tissue properties. The processing device is adapted to perform an overlay registration of pre-recorded images and live images provided by the imaging device, utilizing the data from the sensor. Thus, the accuracy of an overlay of images is increased.
摘要翻译：提出了在干预期间重新校准预先记录的图像，利用包括提供物体，针装置和处理装置的图像的成像装置的介入系统。针装置包括用于提供对应于组织性质的数据的传感器。处理装置适用于利用来自传感器的数据来执行由成像装置提供的预先记录的图像和实况图像的重叠注册。因此，图像的重叠的精度增加。

4. 发明申请

WO2010131181A1 AN OPTICAL PROBE WITH FEEDBACK CORRECTION 审中-公开
标题翻译：具有反馈校正的光学探头
公开(公告)号：WO2010131181A1
公开(公告)日：2010-11-18
申请号：PCT/IB2010/052044
申请日：2010-05-10
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , HEZEMANS, Cornelius, A. , HENDRIKS, Bernardus, H., W. , BIERHOFF, Waltherus, C., J. , BRAUN, Augustinus, L. , MIHAJLOVIC, Nenad
发明人： HEZEMANS, Cornelius, A. , HENDRIKS, Bernardus, H., W. , BIERHOFF, Waltherus, C., J. , BRAUN, Augustinus, L. , MIHAJLOVIC, Nenad
IPC分类号： A61B5/00 , G02B23/24 , G02B26/10 , G02B21/00
CPC分类号： A61B5/6848 , A61B5/0068 , A61B5/0084 , G02B21/0012 , G02B21/0036 , G02B23/2423 , G02B23/26 , G02B26/103
摘要： The present invention relates to an optical probe (1) suitable for miniature applications. An example application is a fibre-based confocal miniaturized microscope. The optical probe comprises a coil-based actuation system (9, 10) comprising drive coils (9) capable of displacing the distal end (3) of an optical guide (2) housed (4) by the optical probe. The probe makes use of a feedback loop which alternate between driving the displacement of the optical guide by driving a current through the drive coils and switching off the current through the drive coils, and while the drive current being switched off, measure the speed of the distal end of the optical guide. The measured speed is compared to the set -point speed, and if a difference is detected, the drive current is adjusted to eliminate, or at least bring down, this difference.
摘要翻译：本发明涉及适合于微型应用的光学探头（1）。一个示例应用是基于光纤的共聚焦微型显微镜。光探头包括基于线圈的致动系统（9,10），其包括驱动线圈（9），该驱动线圈能够移动由光学探头容纳（4）的光导（2）的远端（3）。探头利用反馈回路，通过驱动通过驱动线圈的电流驱动光导的位移，并切断通过驱动线圈的电流之间交替的反馈回路，并且当驱动电流被切断时，测量速度光导的远端。将测量的速度与设定点速度进行比较，并且如果检测到差异，则调节驱动电流以消除或至少降低该差异。

5. 发明申请

WO2010119392A1 NEEDLE WITH INTEGRATED FIBERS IN THE CUTTING FACETS OF THE BEVEL 审中-公开
标题翻译：带有整体纤维的针在水平切割面上
公开(公告)号：WO2010119392A1
公开(公告)日：2010-10-21
申请号：PCT/IB2010/051570
申请日：2010-04-12
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , HENDRIKS, Bernardus , BRAUN, Augustinus , HARBERS, Rik , VAN DER VOORT, Marjolein , DESJARDINS, Adrien , NACHABE, Rami
发明人： HENDRIKS, Bernardus , BRAUN, Augustinus , HARBERS, Rik , VAN DER VOORT, Marjolein , DESJARDINS, Adrien , NACHABE, Rami
IPC分类号： A61B5/00
CPC分类号： A61B5/0084 , A61B5/0075 , A61B5/6848
摘要： A needle comprises a tip part, a holder part, a shaft, and fibers capable of transmitting light, wherein the shaft comprises a distal end connected to the tip part, and a proximal end connected to the holder part, wherein the tip part comprises a bevel, cutting facets, and at least one channel for accomodating a fiber, and wherein an end section of the fiber is located in the channel and an end surface of the fiber is located at one of the cutting facets. By way of the facets an introduction of the needle into tissue may be facilitated. A further aspect of the invention is a method for producing such a needle.
摘要翻译：针包括尖端部分，保持器部分，轴和能够透射光的光纤，其中所述轴包括连接到所述尖端部分的远端以及连接到所述保持器部分的近端，其中所述尖端部分包括斜面，切割面和用于容纳纤维的至少一个通道，并且其中纤维的端部位于通道中，并且纤维的端面位于切割面之一处。通过这些方面，可以促进将针引入组织中。本发明的另一方面是制造这种针的方法。

6. 发明申请

WO2010004493A1 AN OPTICAL IMAGE PROBE 审中-公开
标题翻译：光学图像探测器
公开(公告)号：WO2010004493A1
公开(公告)日：2010-01-14
申请号：PCT/IB2009/052900
申请日：2009-07-03
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , KUIPER, Stein , HENDRIKS, Bernardus, H., W. , MIHAJLOVIC, Nenad
发明人： KUIPER, Stein , HENDRIKS, Bernardus, H., W. , MIHAJLOVIC, Nenad
IPC分类号： G02B3/14 , G02B23/24
CPC分类号： G02B23/2438 , A61B1/0019 , G02B3/14
摘要： The invention relates to an optical image probe(20) for particularly suited for miniature application e.g. in-vivo. A fluid lens(5) is positioned a housing (19),the fluid lens having a changeable optical power. An image collector (40) is positioned within the housing, the collector being arranged on an optical path of the fluid lens, the collector being displaceable along the said optical path by an actuator (42, 70, 80, 90) in various ways. It is highly advantageous in obtaining a compact optical image probe and which simultaneously has a high zoom factor. Due the possible displacement of the image collector and the changeable optical power of the fluid lens, and cooperation between these two elements, it is possible to obtain a compact endoscope with a wide dynamic range of zoom factor with satisfactory focusing properties.
摘要翻译：本发明涉及一种特别适用于微型应用的光学图像探针（20）。被检体内。液体透镜（5）定位在壳体（19）上，流体透镜具有可变光学功率。图像收集器（40）定位在壳体内，集电器布置在流体透镜的光路上，集电器可以通过致动器（42,70,80,90）以各种方式沿着所述光路移动。在获得紧凑型光学图像探针并且同时具有高变焦系数方面是非常有利的。由于图像收集器的可能位移和流体透镜的可变光学功率以及这两个元件之间的协调，可以获得具有良好聚焦性能的宽动态范围的变焦系数的紧凑型内窥镜。

7. 发明申请

WO2009144635A2 A HIGHER ORDER DISPERSION COMPENSATION DEVICE 审中-公开
标题翻译：更高排序补偿装置
公开(公告)号：WO2009144635A2
公开(公告)日：2009-12-03
申请号：PCT/IB2009/052114
申请日：2009-05-20
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , HET HOOFT, Gert , HENDRIKS, Bernardus, H., W. , MEGENS, Mischa
发明人： HET HOOFT, Gert , HENDRIKS, Bernardus, H., W. , MEGENS, Mischa
CPC分类号： G02B5/00 , G02B5/04 , G02B27/095 , G02B2207/117 , H01S3/0057
摘要： The present invention relates to a higher-order dispersion compensation device (210), the device being adapted to cooperate with a pair of optical components (Pl, P2), e.g. a pair of prisms, being arranged to compensate first-order dispersion by separating different wavelengths spatially. The compensation device (210) has the form of a phase plate, wherein the phase change for each wavelength is adjusted by designing the height (h) at the corresponding position (x) of the plate so as to substantially compensate for higher-order dispersion. The invention is advantageous for obtaining a higher-order dispersion compensation device which is relatively simple to construct and use making it a quite cost- effective device. The invention also relates to a corresponding optical system and method for compensating dispersion where this is important, e.g. in a multiple-photon imaging system.
摘要翻译：本发明涉及一种高阶色散补偿装置（210），该装置适于与一对光学部件（P1，P2）配合，例如，一对棱镜被布置成通过在空间上分离不同波长来补偿一阶色散。补偿装置（210）具有相位板的形式，其中通过设计板的对应位置（x）处的高度（h）来调整每个波长的相位变化，以便基本上补偿高阶色散。本发明有利于获得构造和使用相对简单的高阶色散补偿装置，使其成为一种非常具有成本效益的装置。本发明还涉及一种相应的光学系统和方法，用于补偿这一点很重要的色散。在多光子成像系统中。

8. 发明申请

WO2009115952A1 BIOPSY DEVICE 审中-公开
标题翻译：生物装置
公开(公告)号：WO2009115952A1
公开(公告)日：2009-09-24
申请号：PCT/IB2009/051026
申请日：2009-03-12
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , BRAUN, Augustinus, L. , HENDRIKS, Bernardus, H., W. , VAN DER VLEUTEN, Cornelius, A., N., M.
发明人： BRAUN, Augustinus, L. , HENDRIKS, Bernardus, H., W. , VAN DER VLEUTEN, Cornelius, A., N., M.
IPC分类号： A61B1/04 , A61B5/00 , A61B10/02
CPC分类号： A61B10/0233 , A61B5/0084 , A61B2017/00057 , A61B2090/306
摘要： Biopsy needles equipped with fibres (20) allow tissue inspection to diagnoses. In order to allow detailed inspection side looking fibres should also be integrated around the needle. These fibres might be embedded in a transparent medium (18) to avoid direct contact of the sharp edges of the fibre to the tissue. A biopsy needle having such embedded fibres as well as a method for manufacturing said biopsy needle, based on curable transparent liquid, is provided by the invention.
摘要翻译：装有纤维（20）的活检针允许组织检查诊断。为了允许详细检查，侧面的纤维也应该围绕针整合。这些纤维可能嵌入在透明介质（18）中，以避免纤维的锋利边缘与组织的直接接触。本发明提供一种具有这种嵌入纤维的活检针以及基于可固化透明液体制造所述活检针的方法。

9. 发明申请

WO2009109873A1 BIOPSY GUIDANCE BY IMAGE-BASED X-RAY GUIDANCE SYSTEM AND PHOTONIC NEEDLE 审中-公开
标题翻译：基于图像的X射线指导系统和光子针的生物指导
公开(公告)号：WO2009109873A1
公开(公告)日：2009-09-11
申请号：PCT/IB2009/050752
申请日：2009-02-25
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , HENDRIKS, Bernardus, H., W. , BABIC, Drazenko
发明人： HENDRIKS, Bernardus, H., W. , BABIC, Drazenko
IPC分类号： A61B5/00 , A61B5/055 , A61B6/12 , A61B8/08
CPC分类号： A61B5/6852 , A61B5/0066 , A61B5/6848 , A61B6/12 , A61B6/5247 , A61B8/0833 , A61B8/0841 , A61B8/5238 , A61B10/0275 , A61B17/3417 , A61B2090/3614
摘要： A system for providing integrated guidance for positioning a needle in a body has two levels of guidance: a coarse guidance and a fine guidance. The system comprises a non- invasive imaging system for obtaining an image of the biopsy device in the body, for providing the coarse guidance. Furthermore, the system comprises an optical element mounted on the needle for obtaining optical information discriminating tissue in the body, for providing the fine guidance.
摘要翻译：用于提供用于将针定位在身体中的集成指导的系统具有两个指导级别：粗略的引导和精细的引导。该系统包括用于获得身体中活检装置的图像的非侵入性成像系统，用于提供粗略的引导。此外，该系统包括安装在针上的光学元件，用于获得鉴别身体中的组织的光学信息，以提供精细引导。

10. 发明申请

WO2009087522A1 AN OPTICAL PROBE 审中-公开
标题翻译：光学探头
公开(公告)号：WO2009087522A1
公开(公告)日：2009-07-16
申请号：PCT/IB2008/055460
申请日：2008-12-19
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , HENDRIKS, Bernardus, H., W. , 'T HOOFT, Gert
发明人： HENDRIKS, Bernardus, H., W. , 'T HOOFT, Gert
IPC分类号： A61B1/04 , A61B1/07 , A61B5/00 , G02B6/00
CPC分类号： A61B5/0062 , A61B1/00096 , A61B1/00165 , A61B1/00183 , A61B5/0068 , A61B5/0075 , A61B5/0084
摘要： The invention relates an optical probe (1) suitable for non- linear optics such as two-photon imaging for medical purposes. The probe has an optical guide (2) and a lens system (6) positioned rigidly at an end portion (2a) of the optical guide. Additionally, a housing (3) with a cavity for the optical guide (2) and the lens system (6), the housing having at its distal end a transparent window (4), is comprised in the probe. The optical guide (2) with the lens system (6) is displaceably mounted within the housing, preferably in a transverse direction. Also, the housing (3) has an auxiliary, peripheral optical guide (5) optically connected to the transparent window (4). The invention is advantageous for obtaining an optical probe with a significantly larger collection efficiency. The optical probe may advantageous be applied in connection with two-photon spectroscopy where both ballisitic photons and diffusing fluorescence photons can be used in the detection of an event.
摘要翻译：本发明涉及适用于非线性光学的光学探针（1），例如用于医疗目的的双光子成像。探针具有光导件（2）和刚性地定位在光导的端部（2a）处的透镜系统（6）。此外，具有用于光导（2）和透镜系统（6）的空腔的壳体（3），其外壳在其远端处具有透明窗口（4），其包括在探针中。具有透镜系统（6）的光导（2）优选地在横向方向上可移动地安装在壳体内。另外，壳体（3）具有与透明窗（4）光学连接的辅助外周光导（5）。本发明有利于获得具有显着更大收集效率的光学探针。结合双光子光谱可以有利地应用光探针，其中可以使用Ballisitic光子和扩散荧光光子来检测事件。

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