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1. 发明申请

WO2009050667A1 TUMOR DEMARCATION USING TARGETED FLUORESCENT PROBE AND PHOTONIC NEEDLE 审中-公开
标题翻译：使用指定的荧光探针和光子针头进行肿瘤分解
公开(公告)号：WO2009050667A1
公开(公告)日：2009-04-23
申请号：PCT/IB2008/054253
申请日：2008-10-16
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , VAN DER MARK, Martinus, B. , HENDRIKS, Bernardus, H., W.
发明人： VAN DER MARK, Martinus, B. , HENDRIKS, Bernardus, H., W.
IPC分类号： A61B5/00
CPC分类号： A61B90/39 , A61B2090/306 , A61B2090/3908 , A61B2090/3941
摘要： The present invention refers to the field of image-guided percutaneous needle biopsies, in particular to a light guiding hook wire comprising a light-guiding optical fiber (LGM, LGHW) for transferring light from one end on which a beam of input light are incident to another end placed in a cancerous tissue region around the tip of the hookwire, thereby providing an output light assignable to the intensity of the input light; and a liquid guiding device for providing a liquid to the region of interest. The present invention further refers to a method for excising non-palpable pathological tissue regions in the interior of a patient's body, especially tissue regions indicative of breast or prostate cancer, by using such a hookwire. A targeted contrast agent fluorescent in the visible or near-infrared spectrum of light can be used to mark cancerous tissue anomalies, and a light-guiding optical fiber (LGM, LGHW) may provide the light needed for an excitation of this tissue.
摘要翻译：本发明涉及图像引导的经皮针活检领域，特别涉及一种导光钩线，其包括用于从输入光束入射的一端传输光的导光光纤（LGM，LGHW）到另一端放置在钩线尖端周围的癌组织区域中，从而提供可分配给输入光强度的输出光; 以及用于向感兴趣区域提供液体的液体引导装置。本发明还涉及通过使用这种钩线来切除患者身体内部，特别是指示乳腺癌或前列腺癌的组织区域中的不可触知的病理组织区域的方法。在可见光或近红外光谱中荧光的靶向对比剂可用于标记癌组织异常，并且导光光纤（LGM，LGHW）可提供激发该组织所需的光。

2. 发明申请

WO2010084445A1 OPTICAL EXAMINATION DEVICE ADAPTED TO BE AT LEAST PARTIALLY INSERTED INTO A TURBID MEDIUM 审中-公开
标题翻译：光学检查装置适用于至少部分插入涡轮介质
公开(公告)号：WO2010084445A1
公开(公告)日：2010-07-29
申请号：PCT/IB2010/050208
申请日：2010-01-18
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , DESJARDINS, Adrien, E. , VAN DER MARK, Martinus, B. , HENDRIKS, Bernardus, H., W. , 'T HOOFT, Gert
发明人： DESJARDINS, Adrien, E. , VAN DER MARK, Martinus, B. , HENDRIKS, Bernardus, H., W. , 'T HOOFT, Gert
IPC分类号： A61B5/00
CPC分类号： A61B5/0075 , A61B5/0062 , A61B5/0084 , A61B5/6848
摘要： An optical examination device (10) adapted to be at least partially inserted into a turbid medium is provided. The optical examination device comprises a shaft portion (21) adapted to be inserted into the turbid medium, the shaft portion (21) comprising a tip portion (22) adapted to be the foremost portion during insertion into the turbid medium. At least one light source device adapted to emit abeam (11) of broad-band light is provided in the region of the tip portion (21). The beam (11) of broad-band light comprises different wavelength bands (2a, 2b,..., 2n) which are differently modulated. At least one photodetector (27a, 27b, 27c) for detecting broad-band light is provided in a region adapted to be inserted into the turbid medium of the shaft portion (21).
摘要翻译：提供了适于至少部分地插入混浊介质中的光学检查装置（10）。光学检查装置包括适于插入混浊介质的轴部分（21），该轴部分（21）包括在插入混浊介质期间适于最前部分的末端部分（22）。在尖端部分（21）的区域中设置适于发射宽带光的光束（11）的至少一个光源装置。宽带光束（11）包括不同调制的不同波长带（2a，2b，...，2n）。用于检测宽带光的至少一个光电检测器（27a，27b，27c）设置在适于插入到轴部（21）的混浊介质中的区域中。

3. 发明申请

WO2008062346A1 A SYSTEM, METHOD, COMPUTER-READABLE MEDIUM AND USE FOR IMAGING OF TISSUE IN AN ANATOMICAL STRUCTURE 审中-公开
标题翻译：系统，方法，计算机可读介质和用于在解剖结构中形成组织的用途
公开(公告)号：WO2008062346A1
公开(公告)日：2008-05-29
申请号：PCT/IB2007/054626
申请日：2007-11-14
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , VAN BEEK, Michael, C. , VAN DER MARK, Martinus, B. , BAKKER, Levinus, P. , VAN DEN HAM, René , HENDRIKS, Bernardus, H., W. , HOFFMANN, Ralf , VAN DER VAART, Nijs, C. , VAN DER VOORT, Marjolein
发明人： VAN BEEK, Michael, C. , VAN DER MARK, Martinus, B. , BAKKER, Levinus, P. , VAN DEN HAM, René , HENDRIKS, Bernardus, H., W. , HOFFMANN, Ralf , VAN DER VAART, Nijs, C. , VAN DER VOORT, Marjolein
IPC分类号： A61B5/00
CPC分类号： A61B5/4381 , A61B5/0073 , A61B5/0084 , A61B5/0086 , A61B8/12
摘要： A system for imaging of prostate cancer in a prostate in vivo is provided. The system utilizes Diffuse Optical Tomography (DOT) for creating a 3D image for the detection of suspicious prostate tissue. The DOT image may be used to guide the biopsy, thereby reducing the number of false negatives. A method, computer-readable medium and use are also provided.
摘要翻译：提供了一种用于前列腺体内前列腺癌成像的系统。该系统利用漫射光学层析成像（DOT）创建用于检测可疑前列腺组织的3D图像。 DOT图像可用于指导活组织检查，从而减少假阴性的数量。还提供了一种方法，计算机可读介质和使用。

4. 发明申请

WO2008062354A1 A SYSTEM, DEVICE, METHOD, COMPUTER-READABLE MEDIUM, AND USE FOR IN VIVO IMAGING OF TISSUE IN AN ANATOMICAL STRUCTURE 审中-公开
标题翻译：系统，装置，方法，计算机可读介质和用于在解剖结构中进行组织成像的用途
公开(公告)号：WO2008062354A1
公开(公告)日：2008-05-29
申请号：PCT/IB2007/054674
申请日：2007-11-16
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , BAKKER, Levinus, P. , VAN BEEK, Michael, C. , VAN DER MARK, Martinus, B. , VAN DEN HAM, Rene , HENDRIKS, Bernardus, H., W. , HOFFMANN, Ralf , VAN DER VAART, Nijs, C. , VAN DER VOORT, Marjolein
发明人： BAKKER, Levinus, P. , VAN BEEK, Michael, C. , VAN DER MARK, Martinus, B. , VAN DEN HAM, Rene , HENDRIKS, Bernardus, H., W. , HOFFMANN, Ralf , VAN DER VAART, Nijs, C. , VAN DER VOORT, Marjolein
IPC分类号： A61B5/00 , A61B8/12
CPC分类号： A61B5/0095 , A61B5/0035 , A61B5/0084 , A61B5/0086 , A61B8/12 , A61B8/4416
摘要： A system is provided that may be used for locating and diagnosing lesions in the human body in vivo. In some embodiments, once the exact position of a lesion is found, a biopsy may be taken from the lesion using e.g. ultra sound techniques for guidance of the biopsy needle. Use of the system drastically reduces the negative biopsy samples compared to currently used "blind sampling" techniques. This reduces patient discomfort and minimizes infections as the number of biopsy samples is reduced. A method and computer- readable medium is also provided.
摘要翻译：提供了可用于在体内定位和诊断人体损伤的系统。在一些实施例中，一旦发现病变的确切位置，可以使用例如病变从病变中取出活组织检查。超声技术用于指导活检针。与目前使用的“盲采”技术相比，使用该系统大大减少了活检样本的阴性。这减少了患者的不适，并使活检样本的数量减少了感染的最小程度。还提供了一种方法和计算机可读介质。

5. 发明申请

WO2010136922A1 RE-CALIBRATION OF PRE-RECORDED IMAGES DURING INTERVENTIONS USING A NEEDLE DEVICE 审中-公开
标题翻译：使用针头装置进行干预时预先记录的图像重新校准
公开(公告)号：WO2010136922A1
公开(公告)日：2010-12-02
申请号：PCT/IB2010/052030
申请日：2010-05-07
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , BAKKER, Levinus, P. , HENDRIKS, Bernardus, H., W. , DESJARDINS, Adrien, E.
发明人： BAKKER, Levinus, P. , HENDRIKS, Bernardus, H., W. , DESJARDINS, Adrien, E.
IPC分类号： A61B5/00 , G06T7/00 , A61B19/00 , A61B6/12
CPC分类号： A61B8/0841 , A61B5/0062 , A61B5/0066 , A61B5/0068 , A61B5/0071 , A61B5/0073 , A61B5/0075 , A61B5/0084 , A61B5/6848 , A61B6/12 , A61B6/5247 , A61B8/00 , A61B8/5238 , A61B17/34 , A61B17/3403 , A61B17/3417 , A61B2090/3614 , A61B2090/374 , A61B2090/376 , A61B2090/378 , A61B2090/3784
摘要： Re-calibration of pre-recorded images during interventions is proposed, utilizing an interventional system comprising an imaging device providing images of an object, a needle device, and a processing device. The needle device comprises a sensor for providing data corresponding to tissue properties. The processing device is adapted to perform an overlay registration of pre-recorded images and live images provided by the imaging device, utilizing the data from the sensor. Thus, the accuracy of an overlay of images is increased.
摘要翻译：提出了在干预期间重新校准预先记录的图像，利用包括提供物体，针装置和处理装置的图像的成像装置的介入系统。针装置包括用于提供对应于组织性质的数据的传感器。处理装置适用于利用来自传感器的数据来执行由成像装置提供的预先记录的图像和实况图像的重叠注册。因此，图像的重叠的精度增加。

6. 发明申请

WO2010131181A1 AN OPTICAL PROBE WITH FEEDBACK CORRECTION 审中-公开
标题翻译：具有反馈校正的光学探头
公开(公告)号：WO2010131181A1
公开(公告)日：2010-11-18
申请号：PCT/IB2010/052044
申请日：2010-05-10
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , HEZEMANS, Cornelius, A. , HENDRIKS, Bernardus, H., W. , BIERHOFF, Waltherus, C., J. , BRAUN, Augustinus, L. , MIHAJLOVIC, Nenad
发明人： HEZEMANS, Cornelius, A. , HENDRIKS, Bernardus, H., W. , BIERHOFF, Waltherus, C., J. , BRAUN, Augustinus, L. , MIHAJLOVIC, Nenad
IPC分类号： A61B5/00 , G02B23/24 , G02B26/10 , G02B21/00
CPC分类号： A61B5/6848 , A61B5/0068 , A61B5/0084 , G02B21/0012 , G02B21/0036 , G02B23/2423 , G02B23/26 , G02B26/103
摘要： The present invention relates to an optical probe (1) suitable for miniature applications. An example application is a fibre-based confocal miniaturized microscope. The optical probe comprises a coil-based actuation system (9, 10) comprising drive coils (9) capable of displacing the distal end (3) of an optical guide (2) housed (4) by the optical probe. The probe makes use of a feedback loop which alternate between driving the displacement of the optical guide by driving a current through the drive coils and switching off the current through the drive coils, and while the drive current being switched off, measure the speed of the distal end of the optical guide. The measured speed is compared to the set -point speed, and if a difference is detected, the drive current is adjusted to eliminate, or at least bring down, this difference.
摘要翻译：本发明涉及适合于微型应用的光学探头（1）。一个示例应用是基于光纤的共聚焦微型显微镜。光探头包括基于线圈的致动系统（9,10），其包括驱动线圈（9），该驱动线圈能够移动由光学探头容纳（4）的光导（2）的远端（3）。探头利用反馈回路，通过驱动通过驱动线圈的电流驱动光导的位移，并切断通过驱动线圈的电流之间交替的反馈回路，并且当驱动电流被切断时，测量速度光导的远端。将测量的速度与设定点速度进行比较，并且如果检测到差异，则调节驱动电流以消除或至少降低该差异。

7. 发明申请

WO2010004493A1 AN OPTICAL IMAGE PROBE 审中-公开
标题翻译：光学图像探测器
公开(公告)号：WO2010004493A1
公开(公告)日：2010-01-14
申请号：PCT/IB2009/052900
申请日：2009-07-03
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , KUIPER, Stein , HENDRIKS, Bernardus, H., W. , MIHAJLOVIC, Nenad
发明人： KUIPER, Stein , HENDRIKS, Bernardus, H., W. , MIHAJLOVIC, Nenad
IPC分类号： G02B3/14 , G02B23/24
CPC分类号： G02B23/2438 , A61B1/0019 , G02B3/14
摘要： The invention relates to an optical image probe(20) for particularly suited for miniature application e.g. in-vivo. A fluid lens(5) is positioned a housing (19),the fluid lens having a changeable optical power. An image collector (40) is positioned within the housing, the collector being arranged on an optical path of the fluid lens, the collector being displaceable along the said optical path by an actuator (42, 70, 80, 90) in various ways. It is highly advantageous in obtaining a compact optical image probe and which simultaneously has a high zoom factor. Due the possible displacement of the image collector and the changeable optical power of the fluid lens, and cooperation between these two elements, it is possible to obtain a compact endoscope with a wide dynamic range of zoom factor with satisfactory focusing properties.
摘要翻译：本发明涉及一种特别适用于微型应用的光学图像探针（20）。被检体内。液体透镜（5）定位在壳体（19）上，流体透镜具有可变光学功率。图像收集器（40）定位在壳体内，集电器布置在流体透镜的光路上，集电器可以通过致动器（42,70,80,90）以各种方式沿着所述光路移动。在获得紧凑型光学图像探针并且同时具有高变焦系数方面是非常有利的。由于图像收集器的可能位移和流体透镜的可变光学功率以及这两个元件之间的协调，可以获得具有良好聚焦性能的宽动态范围的变焦系数的紧凑型内窥镜。

8. 发明申请

WO2009144635A2 A HIGHER ORDER DISPERSION COMPENSATION DEVICE 审中-公开
标题翻译：更高排序补偿装置
公开(公告)号：WO2009144635A2
公开(公告)日：2009-12-03
申请号：PCT/IB2009/052114
申请日：2009-05-20
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , HET HOOFT, Gert , HENDRIKS, Bernardus, H., W. , MEGENS, Mischa
发明人： HET HOOFT, Gert , HENDRIKS, Bernardus, H., W. , MEGENS, Mischa
CPC分类号： G02B5/00 , G02B5/04 , G02B27/095 , G02B2207/117 , H01S3/0057
摘要： The present invention relates to a higher-order dispersion compensation device (210), the device being adapted to cooperate with a pair of optical components (Pl, P2), e.g. a pair of prisms, being arranged to compensate first-order dispersion by separating different wavelengths spatially. The compensation device (210) has the form of a phase plate, wherein the phase change for each wavelength is adjusted by designing the height (h) at the corresponding position (x) of the plate so as to substantially compensate for higher-order dispersion. The invention is advantageous for obtaining a higher-order dispersion compensation device which is relatively simple to construct and use making it a quite cost- effective device. The invention also relates to a corresponding optical system and method for compensating dispersion where this is important, e.g. in a multiple-photon imaging system.
摘要翻译：本发明涉及一种高阶色散补偿装置（210），该装置适于与一对光学部件（P1，P2）配合，例如，一对棱镜被布置成通过在空间上分离不同波长来补偿一阶色散。补偿装置（210）具有相位板的形式，其中通过设计板的对应位置（x）处的高度（h）来调整每个波长的相位变化，以便基本上补偿高阶色散。本发明有利于获得构造和使用相对简单的高阶色散补偿装置，使其成为一种非常具有成本效益的装置。本发明还涉及一种相应的光学系统和方法，用于补偿这一点很重要的色散。在多光子成像系统中。

9. 发明申请

WO2009115952A1 BIOPSY DEVICE 审中-公开
标题翻译：生物装置
公开(公告)号：WO2009115952A1
公开(公告)日：2009-09-24
申请号：PCT/IB2009/051026
申请日：2009-03-12
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , BRAUN, Augustinus, L. , HENDRIKS, Bernardus, H., W. , VAN DER VLEUTEN, Cornelius, A., N., M.
发明人： BRAUN, Augustinus, L. , HENDRIKS, Bernardus, H., W. , VAN DER VLEUTEN, Cornelius, A., N., M.
IPC分类号： A61B1/04 , A61B5/00 , A61B10/02
CPC分类号： A61B10/0233 , A61B5/0084 , A61B2017/00057 , A61B2090/306
摘要： Biopsy needles equipped with fibres (20) allow tissue inspection to diagnoses. In order to allow detailed inspection side looking fibres should also be integrated around the needle. These fibres might be embedded in a transparent medium (18) to avoid direct contact of the sharp edges of the fibre to the tissue. A biopsy needle having such embedded fibres as well as a method for manufacturing said biopsy needle, based on curable transparent liquid, is provided by the invention.
摘要翻译：装有纤维（20）的活检针允许组织检查诊断。为了允许详细检查，侧面的纤维也应该围绕针整合。这些纤维可能嵌入在透明介质（18）中，以避免纤维的锋利边缘与组织的直接接触。本发明提供一种具有这种嵌入纤维的活检针以及基于可固化透明液体制造所述活检针的方法。

10. 发明申请

WO2009109873A1 BIOPSY GUIDANCE BY IMAGE-BASED X-RAY GUIDANCE SYSTEM AND PHOTONIC NEEDLE 审中-公开
标题翻译：基于图像的X射线指导系统和光子针的生物指导
公开(公告)号：WO2009109873A1
公开(公告)日：2009-09-11
申请号：PCT/IB2009/050752
申请日：2009-02-25
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , HENDRIKS, Bernardus, H., W. , BABIC, Drazenko
发明人： HENDRIKS, Bernardus, H., W. , BABIC, Drazenko
IPC分类号： A61B5/00 , A61B5/055 , A61B6/12 , A61B8/08
CPC分类号： A61B5/6852 , A61B5/0066 , A61B5/6848 , A61B6/12 , A61B6/5247 , A61B8/0833 , A61B8/0841 , A61B8/5238 , A61B10/0275 , A61B17/3417 , A61B2090/3614
摘要： A system for providing integrated guidance for positioning a needle in a body has two levels of guidance: a coarse guidance and a fine guidance. The system comprises a non- invasive imaging system for obtaining an image of the biopsy device in the body, for providing the coarse guidance. Furthermore, the system comprises an optical element mounted on the needle for obtaining optical information discriminating tissue in the body, for providing the fine guidance.
摘要翻译：用于提供用于将针定位在身体中的集成指导的系统具有两个指导级别：粗略的引导和精细的引导。该系统包括用于获得身体中活检装置的图像的非侵入性成像系统，用于提供粗略的引导。此外，该系统包括安装在针上的光学元件，用于获得鉴别身体中的组织的光学信息，以提供精细引导。

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