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111. 发明申请

WO2014150090A1 ORAL NEURAL STIMULATOR 审中-公开
标题翻译：口腔神经刺激仪
公开(公告)号：WO2014150090A1
公开(公告)日：2014-09-25
申请号：PCT/US2014/022184
申请日：2014-03-08
申请人： ORALTONE LLC
发明人： TINGEY, Terrell F.
IPC分类号： A61N1/04 , A61N1/18 , A61N1/36 , A61N1/372
CPC分类号： A61N1/0548 , A61N1/36025
摘要： The present disclosure is directed to treatment of a migraine headache or other nervous system malady such as seizures and epilepsy by applying electrical stimulation to a subjects oral mucosa. Noninvasive electrodes may be placed against the subjects oral mucosa tissue by inserting a mouthpiece comprising the electrodes into the subjects mouth. One or more electrical pulses may be applied to the electrodes to stimulate the subjects cranial nerves and thereby treat the malady.
摘要翻译：本公开涉及通过对受试者口腔粘膜施加电刺激来治疗偏头痛或其它神经系统疾病，例如癫痫发作和癫痫。通过将包括电极的接口插入受试者口中，可以将非侵入性电极放置在受试者口腔粘膜组织上。可以向电极施加一个或多个电脉冲以刺激受试者颅神经，从而治疗疾病。

112. 发明申请

WO2014120584A2 ELECTROSTIMULATION IN TREATING CEREBROVASCULAR CONDITIONS 审中-公开
标题翻译：电凝治疗脑血管病变
公开(公告)号：WO2014120584A2
公开(公告)日：2014-08-07
申请号：PCT/US2014/013094
申请日：2014-01-27
申请人： SAMSON NEUROSCIENCES LTD. , KLEIN, David
发明人： LEVY, Ronnie , BEINART, Yiftach , SHALEV, Alon
IPC分类号： A61N1/36
CPC分类号： A61N1/05 , A61N1/0558 , A61N1/08 , A61N1/36025 , A61N1/36053 , A61N1/36057 , A61N1/375
摘要： An electrostimulation device (10) includes an electrode shaft (12) that includes a plurality of electrodes (24). In one embodiment, a controller (28) is in electrical communication with the electrodes (24), and the controller (28) controls operating parameters associated with energization of the electrodes (24). A fixation member (60) includes a member (66) for receiving therein a portion of the electrode shaft (12) and a locking member (86) is provided for releasably affixing the electrode shaft (12) to the fixation member (60).
摘要翻译：电刺激装置（10）包括具有多个电极（24）的电极轴（12）。在一个实施例中，控制器（28）与电极（24）电连通，并且控制器（28）控制与电极（24）的激励相关的操作参数。固定构件（60）包括用于在其中接收电极轴（12）的一部分的构件（66），并且设置有用于将电极轴（12）可释放地固定到固定构件（60）的锁定构件（86）。

113. 发明申请

WO2014107564A1 METHODS AND DEVICES FOR PREDICTING AND/OR DETECTING SEIZURES 审中-公开
标题翻译：用于预测和/或检测特征的方法和装置
公开(公告)号：WO2014107564A1
公开(公告)日：2014-07-10
申请号：PCT/US2014/010159
申请日：2014-01-03
申请人： WAKE FOREST UNIVERSITY HEALTH SCIENCES
发明人： WITCHER, Mark R. , HAMPSON, Robert E. , DEADWYLER, Sam , COUTURE, Daniel E. , POPLI, Gautam
IPC分类号： A61B5/0476
CPC分类号： A61B5/7275 , A61B5/0476 , A61B5/4094 , A61N1/0529 , A61N1/36025 , A61N1/36064 , G06F19/00
摘要： The present invention provides methods and devices for predicting, preventing, detecting and/or treating seizures. In some embodiments, the present invention provides methods/devices for predicting a seizure prior to its inception, wherein the seizure is predicted based upon neuronal activity in the CA3 region of a patient's hippocampus.
摘要翻译：本发明提供了用于预测，预防，检测和/或治疗癫痫发作的方法和装置。在一些实施方案中，本发明提供用于在其开始之前预测癫痫发作的方法/装置，其中基于患者海马CA3区域中的神经元活动预测癫痫发作。

114. 发明申请

WO2014089366A2 MEDICAL DEVICE ANCHORING APPARATUS AND METHODS 审中-公开
标题翻译：医疗器械锚定装置和方法
公开(公告)号：WO2014089366A2
公开(公告)日：2014-06-12
申请号：PCT/US2013/073429
申请日：2013-12-05
申请人： MEDTRONIC, INC.
发明人： BEHYMER, Bruce A. , BONDE, Eric H.
IPC分类号： A61N1/05
CPC分类号： A61N1/0539 , A61B17/3468 , A61B17/3472 , A61B90/11 , A61B2017/347 , A61B2034/301 , A61B2034/302 , A61B2090/103 , A61M5/00 , A61M25/04 , A61M2025/024 , A61N1/36025
摘要： Methods and apparatus for anchoring an elongate medical device within a body portal, for example, a stimulation lead in a cranial burr hole, employ opposing engagement surfaces, spring biased toward one another. A retaining member may be inserted between the opposing surfaces, to hold the surfaces apart for initial positioning of the device therebetween. For example, a delivery catheter in which the device is moved through the body portal can serve as the retaining member, in one type of apparatus, the engagement surfaces are formed within an anchoring aperture of one plate member of a pair of plate members. In another type of apparatus, the engagement surfaces are formed by sides of a slot that extend through a ring member and into a plug member, wherein a portion of the plug member is preferably formed by an elastomer material, and, in some cases, an entirety of the apparatus.
摘要翻译：用于将细长医疗装置锚定在身体入口内的方法和装置，例如颅侧钻孔中的刺激导线，采用相对的接合表面，弹簧朝向彼此偏置。保持构件可以插入在相对的表面之间，以将表面保持分开以便将装置在其间初始定位。例如，其中装置通过身体入口移动的输送导管可以用作保持构件，在一种类型的装置中，接合表面形成在一对板构件中的一个板构件的锚定孔内。在另一种类型的设备中，接合表面由狭槽的侧面形成，所述狭槽延伸穿过环构件并且进入插塞构件，其中插塞构件的一部分优选地由弹性体材料形成，并且在一些情况下，整个设备。

115. 发明申请

WO2014084977A1 CATHETER WITH DEPTH ELECTRODE FOR DUAL-PURPOSE USE 审中-公开
标题翻译：带深度电极的导管用于双目的使用
公开(公告)号：WO2014084977A1
公开(公告)日：2014-06-05
申请号：PCT/US2013/065399
申请日：2013-10-17
申请人： AD-TECH MEDICAL INSTRUMENT CORPORATION
发明人： PUTZ, David, A.
IPC分类号： A61B5/0476
CPC分类号： A61M25/0052 , A61B5/0478 , A61B5/065 , A61B5/4836 , A61B5/6852 , A61B5/6868 , A61M25/007 , A61M2025/0063 , A61M2025/0166 , A61M2210/0693 , A61N1/0534 , A61N1/36025 , A61N1/36064
摘要： A catheter assembly (10) for intracranial treatment of a patient for facilitating concurrent electrical sensing and fluid flow is provided and includes an outer flexible tube (12) having a proximal end (22), a principal lumen (14) extending therealong to the proximal end, and at least one radial aperture (16) through the wall communicating with the lumen as well as a secondary lumen (18) adjacent to the tube outer-wall surface (20) and extending therealong. The catheter assembly including a depth electrode (24) within the secondary lumen, extending along the length thereof. The depth electrode having electrical contacts (26) exposed to brain tissue along the flexible tube.
摘要翻译：提供了一种用于颅内治疗患者用于促进并发的电传感和流体流动的导管组件（10），其包括具有近端（22）的外部柔性管（12），与所述近端端部以及穿过与内腔连通的壁的至少一个径向孔（16）以及与管外壁表面（20）相邻并沿其延伸的次级腔（18）。所述导管组件包括在所述次内腔内的深度电极（24），沿其长度延伸。所述深度电极具有沿柔性管暴露于脑组织的电触点（26）。

116. 发明申请

WO2014055507A3 WEARABLE, UNSUPERVISED TRANSCRANIAL DIRECT CURRENT STIMULATION (tDCS) DEVICE FOR MOVEMENT DISORDER THERAPY, AND METHOD OF USING 审中-公开
标题翻译：用于运动障碍治疗的可穿戴的，不受监视的经颅直流电刺激（tDCS）装置，以及使用方法
公开(公告)号：WO2014055507A3
公开(公告)日：2014-05-30
申请号：PCT/US2013062854
申请日：2013-10-01
申请人： GREAT LAKES NEUROTECHNOLOGIES INC
发明人： HELDMAN DUSTIN A , GIUFFRIDA JOSEPH P
IPC分类号： A61N1/36
CPC分类号： A61N1/36014 , A61N1/0484 , A61N1/0492 , A61N1/0526 , A61N1/0529 , A61N1/20 , A61N1/36025
摘要： The present invention relates to a system and methods for noninvasively providing therapy for movement disorder symptoms. The present invention provides such a therapy system which provides trans-cranial direct current stimulation (tDCS) in order to treat those symptoms and the disorders. The present invention further provides such tDCS therapy while the subject sleeps in order to minimize the time required and impact of the therapy on the subject's waking life. The system, methods, and devices of the present invention are intended to provide a low-dose electrical current, trans-cranially, to a specific area of the subject's brain while he or she sleeps in order to decrease the occurrence, severity, and duration of the symptoms of movement disorders. The present invention aims to reduce the amount of medication necessary, counteract the effects of medication wearing off during sleep, and to overall improve the quality of life of subjects suffering from movement disorders.
摘要翻译：本发明涉及用于无创地提供运动障碍症状治疗的系统和方法。本发明提供了这样的治疗系统，其提供经颅直流电刺激（tDCS）以治疗那些症状和病症。本发明进一步提供这种tDCS疗法，同时受试者睡眠以最小化治疗对受试者醒来寿命所需的时间和影响。本发明的系统，方法和装置旨在经颅睡眠时向受试者大脑的特定区域提供经颅的低剂量电流，以减少发生，严重程度和持续时间运动障碍的症状。本发明旨在减少必要的药物量，抵消睡眠期间药物磨损的影响，并总体上改善患有运动障碍的受试者的生活质量。

117. 发明申请

WO2013163594A1 NON-INVASIVE AUTOMATED ELECTRICAL CONTROL SYSTEMS AND METHODS FOR MONITORING ANIMAL CONDITIONS 审中-公开
标题翻译：非自动电气控制系统和监测动物条件的方法
公开(公告)号：WO2013163594A1
公开(公告)日：2013-10-31
申请号：PCT/US2013/038483
申请日：2013-04-26
申请人： BOARD OF GOVERNORS FOR HIGHER EDUCATION, STATE OF RHODE ISLAND AND PROVIDENCE PLANTATIONS
发明人： BESIO, Walter, G.
IPC分类号： G01N33/53 , G01N33/48 , G01N27/00 , G01N33/15
CPC分类号： A61N1/36025 , A61K31/5513 , A61N1/0408 , A61N1/0472
摘要： The present invention employed a method to control electrical activity in a target area of an animal' s body by administering transcranial focal stimulation to the target area to adjust activity to normal levels. An advanced automated control system would first detect the abnormal electrical activity using tripolar concentric ring electrodes and then provides transcranial focal electrical stimulation to the target area using noninvasive tripolar concentric ring electrode system in a closed-loop continuous feedback. The automated control system wou ld be adaptable to include the use of therapeutic drugs, either non-continuously or continuously, as a more comprehensive treatment of the abnormal electric activity.
摘要翻译：本发明采用通过对目标区域进行经颅局部刺激以将活动调整至正常水平来控制动物体内目标区域的电活动的方法。先进的自动化控制系统将首先使用三极同心环电极检测异常电活动，然后使用非侵入性三极同心环电极系统在闭环连续反馈中向目标区域提供经颅聚焦电刺激。自动化控制系统可以适应于包括非连续或连续使用治疗药物，作为对异常电活动的更全面的处理。

118. 发明申请

WO2013162709A1 TRIAL STIMULATION SYSTEMS 审中-公开
标题翻译：试验刺激系统
公开(公告)号：WO2013162709A1
公开(公告)日：2013-10-31
申请号：PCT/US2013/029281
申请日：2013-03-06
申请人： MEDTRONIC, INC.
发明人： SHISHILLA, John , PEDERSON, Kathryn, A. , JAIN, Mukul , MAIRS, Nicholas, S.
IPC分类号： A61N1/36 , A61N1/08 , A61N1/05
CPC分类号： A61N1/375 , A61N1/0502 , A61N1/08 , A61N1/36017 , A61N1/36021 , A61N1/36025 , A61N1/37241
摘要： A trial stimulation system includes a disposable trial electrical stimulator that, in some examples, is sterilized for a single use in a stimulation trial of one patient. Additionally, systems for securing a disposable trial stimulator to the body of a patient are described, which may function to improve the durability of the system during the trial period and reduce the risk of damage or malfunction to the system due to lead/electrode dislocation and/or off-label uses like showering or bathing with the trial stimulator still secured to the body
摘要翻译：试验刺激系统包括一次性试用电刺激器，其在一些实例中在一名患者的刺激试验中被消毒以用于单次使用。另外，描述了用于将一次性试用刺激器固定到患者身体的系统，其可以用于在试用期间提高系统的耐久性并且降低由于铅/电极错位导致系统损坏或故障的风险， /或标签外的使用，如淋浴或洗澡与试验刺激器仍然固定在身上

119. 发明申请

WO2013162698A1 ASSESSING COGNITIVE DISORDERS BASED ON NON-MOTOR EPILEPTIFORM BIOELECTRICAL BRAIN ACTIVITY 审中-公开
标题翻译：基于非电动机电生理大脑活动评估认知障碍
公开(公告)号：WO2013162698A1
公开(公告)日：2013-10-31
申请号：PCT/US2013/027978
申请日：2013-02-27
申请人： MEDTRONIC, INC.
发明人： NELSON, Dwight E. , GIFTAKIS, Jonathon E.
IPC分类号： A61N1/36
CPC分类号： A61N1/36139 , A61B5/4052 , A61B5/4088 , A61B5/4094 , A61B5/4842 , A61N1/36025 , A61N1/36064 , A61N1/36082
摘要： Various embodiments concern assessing a degenerative cognitive disorder of a patient based on a plurality of episodes of non-motor epileptiform bioelectrical activity. The non-motor epileptiform bioelectrical activity can be detected from one or more bioelectrical brain signals. A worsening cognitive disorder may be indicated by an increase in one or more of intensity, duration, and frequency of occurrence of the episodes of non-motor epileptiform bioelectrical activity. A therapy can be delivered to reduce one or more of intensity, duration, and frequency of occurrence of the episodes of non-motor epileptiform bioelectrical activity. The delivery of the therapy can be controlled based on the plurality of episodes of non-motor epileptiform bioelectrical activity.
摘要翻译：各种实施方案涉及基于多次发作的非运动性癫痫样生物电活性来评估患者的退行性认知障碍。可以从一个或多个生物电脑信号检测非运动性癫痫样生物电活动。恶化的认知障碍可以通过非运动性癫痫样生物电活动发作的强度，持续时间和发生频率中的一种或多种的增加来表示。可以递送治疗以减少非运动性癫痫样生物电活动发作的强度，持续时间和发生频率中的一种或多种。可以基于多次非运动性癫痫样生物电活动来控制治疗的递送。

120. 发明申请

WO2013130421A1 SYSTEM AND METHOD FOR NEUROMODULATION USING COMPOSITE PATTERNS OF STIMULATION OR WAVEFORMS 审中-公开
标题翻译：使用复合图案刺激或波形进行神经网络的系统和方法
公开(公告)号：WO2013130421A1
公开(公告)日：2013-09-06
申请号：PCT/US2013/027721
申请日：2013-02-26
申请人： THE CLEVELAND CLINIC FOUNDATION
发明人： MACHADO, Andre
IPC分类号： A61N1/36 , A61B5/0476 , A61B5/00
CPC分类号： A61N1/36025 , A61B5/04001 , A61B5/1118 , A61N1/0529 , A61N1/0534 , A61N1/36017 , A61N1/36067 , A61N1/36103 , A61N1/36189
摘要： A neurostimulation system can include a memory, a playback system, a stimulation electrode, and a controller. The memory can store data for first and second input waveforms. The playback system can provides first and second output waveforms, based on the first and second input waveforms in the memory, respectively, to form a composite pattern of stimulation or waveform. The first output waveform can be different than the second output waveform. The second output waveform can be periodically superimposed on the first output waveform. The controller can be in communication with the stimulation electrode. The controller can be configured to control application of the composite pattern of stimulation or waveform to a target site in a body of a subject suffering from a medical condition.
摘要翻译：神经刺激系统可以包括存储器，回放系统，刺激电极和控制器。存储器可以存储第一和第二输入波形的数据。播放系统可以分别基于存储器中的第一和第二输入波形来提供第一和第二输出波形，以形成刺激或波形的复合图案。第一个输出波形可以与第二个输出波形不同。第二输出波形可以周期地叠加在第一输出波形上。控制器可以与刺激电极连通。控制器可以被配置为控制刺激或波形的复合图案的应用到患有医疗状况的受试者的身体中的目标部位。

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