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1. 发明申请

WO2018067917A1 DEVICES AND METHODS TO EVALUATE TISSUE COOLING 审中-公开
标题翻译：评估组织冷却的装置和方法
公开(公告)号：WO2018067917A1
公开(公告)日：2018-04-12
申请号：PCT/US2017/055520
申请日：2017-10-06
申请人： WAKE FOREST UNIVERSITY HEALTH SCIENCES
发明人： GAYZIK, F., Scott , PACKETT, Ryan, D.M. , BROWN, Philip, J. , POPLI, Gautam , FRITZ, Megan
IPC分类号： A61F7/00 , A61H39/06
摘要： The present invention provides devices, systems, and methods for using them to monitor therapeutic cooling of blood perfused tissues or organs such as the brain. In one embodiment, the invention comprises a device for evaluating tissue cooling comprising a container that contains a polymer-fluid matrix having a thermal cooling property that is substantially similar to a tissue or organ such as a human brain. In another embodiment, the invention comprises a system for evaluating tissue cooling comprising: (a) a device for evaluating tissue cooling as described above and (b) a warm loop. In another embodiment, the invention comprises a method for evaluating a technique for cooling a tissue or organ comprising (a) providing a device comprising a container that contains a polymer-fluid matrix having a thermal cooling property that is substantially similar to a tissue or organ such as human brain, and (b) perfusing the polymer-fluid matrix with a fluid.
摘要翻译：本发明提供了使用它们来监测灌注血液的组织或器官如脑的治疗性冷却的装置，系统和方法。在一个实施例中，本发明包括用于评估组织冷却的装置，该装置包括含有聚合物 - 流体基质的容器，所述聚合物 - 流体基质具有与组织或器官如人脑基本相似的热冷却性质。在另一个实施例中，本发明包括用于评估组织冷却的系统，其包括：（a）如上所述的用于评估组织冷却的装置和（b）温环。在另一个实施方案中，本发明包括用于评估冷却组织或器官的技术的方法，其包括（a）提供包含容器的装置，所述容器包含聚合物 - 流体基质，所述聚合物 - 流体基质具有基本上类似于组织或器官如人脑，和（b）用流体灌注聚合物 - 流体基质。

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