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101. 发明申请

WO0220150A3 PHOTOCLEAVABLE PROTECTING GROUPS 审中-公开
标题翻译：光电保护组
公开(公告)号：WO0220150A3
公开(公告)日：2003-03-13
申请号：PCT/IB0101650
申请日：2001-09-11
申请人： AFFYMETRIX INC , MCGALL GLENN H , BARONE ANTHONY D
发明人： MCGALL GLENN H , BARONE ANTHONY D
IPC分类号： C07B61/00 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C07K1/04 , C07K1/06 , C40B40/06 , C40B40/10 , C40B40/12 , C40B60/14 , C07K17/06
CPC分类号： B82Y30/00 , B01J2219/00432 , B01J2219/00527 , B01J2219/00529 , B01J2219/00585 , B01J2219/0059 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , C07B2200/11 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C07K1/04 , C07K1/047 , C07K1/062 , C07K1/063 , C07K1/064 , C07K1/065 , C07K1/066 , C40B40/06 , C40B40/10 , C40B40/12 , C40B60/14 , Y02P20/55
摘要： Novel compounds are provided which are useful as linking groups in chemical synthesis, preferably in the solid phase synthesis of oligonucleotides and polypeptides. The compounds are generally photolabile and comprise protecting groups which can be removed by photolysis to unmask a reactive group. The protecting groups has the general formula (Y), wherein: (Y) is a chemical structure as shown the Figure. Also provided is a method of forming, from component molecules, a plurality of compounds on a support, each compound occupying a separate predefined region of the support, using the protected compounds described above.
摘要翻译：提供了新的化合物，其可用作化学合成中的连接基团，优选在寡核苷酸和多肽的固相合成中。化合物通常是光不稳定的，并且包含可以通过光解除去以揭示反应性基团的保护基团。保护基具有通式（Y），其中：（Y）是如图所示的化学结构。还提供了使用上述保护的化合物从成分分子在载体上形成多种化合物的方法，每种化合物占据支持体的单独的预定区域。

102. 发明申请

WO03018837A2 METHOD AND DIAGNOSTIC KIT FOR THE MOLECULAR DIAGNOSIS OF PHARMACOLOGICALLY RELEVANT GENES 审中-公开
标题翻译：法和分子诊断的诊断试剂盒用于PHARMACOLOGICALL相关基因
公开(公告)号：WO03018837A2
公开(公告)日：2003-03-06
申请号：PCT/EP0209386
申请日：2002-08-22
申请人： ADNAGEN AG , WASCHUETZA STEFANIE , SCHNAKENBERG ECKART , LUSTIG MICHAEL
发明人： WASCHUETZA STEFANIE , SCHNAKENBERG ECKART , LUSTIG MICHAEL
IPC分类号： C12Q1/68 , C40B40/06 , G01N33/50 , B01J19/00
CPC分类号： G01N33/5091 , B01J2219/00529 , B01J2219/00608 , B01J2219/00722 , C12Q1/6883 , C12Q2600/156 , C40B40/06
摘要： The invention relates to a diagnosis kit and a method for determining a person's tolerance to medicaments. Said diagnosis kit contains at least two pairs of oligonucleotides (reverse primer, forward primer). The two oligonucleotides of each pair are suitable as primers for amplification by means of a polymerase chain reaction of respectively one of the two additional strands of a sought DNA segment. Said sought DNA segment which is respectively associated with a pair of oligonucleotides is part of the gene of a human enzyme of phase I and/or phase II of the detoxification metabolism.
摘要翻译：本发明涉及诊断试剂盒和用于确定一个人的药物耐受性的方法。诊断试剂盒包括至少两对寡核苷酸（反向引物，正向引物），从而各对的两个寡核苷酸在每种情况下一个期望的DNS部分的两条互补链中的一个适合作为引物用于扩增通过聚合酶链反应。相关联的相应的一对寡核苷酸搜索DNA节段是阶段I和/或II期解毒代谢的人类的酶的基因的一部分。

103. 发明申请

WO02073158A3 CONJUGATE PROBES AND OPTICAL DETECTION OF ANALYTES 审中-公开
标题翻译：联合检测和光学检测分析
公开(公告)号：WO02073158A3
公开(公告)日：2003-02-20
申请号：PCT/US0207402
申请日：2002-03-11
申请人： APOLLO BIOTECHNOLOGY INC , LIU ZHIPING , LI ZHENG
发明人： LIU ZHIPING , LI ZHENG
IPC分类号： G01N21/64 , C12M1/00 , C12M1/34 , C12N15/09 , C12Q1/68 , C40B40/06 , C40B40/10 , G01N33/483 , G01N33/53 , G01N33/543 , G01N33/548 , G01N33/566 , G01N37/00 , C07H19/00 , C07H21/02 , C07H21/04 , C12P19/34
CPC分类号： G01N33/54373 , B01J2219/00605 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00641 , B01J2219/00646 , B01J2219/00659 , B01J2219/00704 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , C40B40/06 , C40B40/10 , G01N33/54353 , G01N33/548
摘要： This invention relates to conjugate probes and optical detection of analytes. More specifically, this invention relates to conjugate probes which are used to form an array for a biosensor employing optical detection of analytes.
摘要翻译：本发明涉及共轭探针和分析物的光学检测。更具体地，本发明涉及用于通过光学检测分析物形成用于生物传感器的阵列的共轭探针。

104. 发明申请

WO2003008622A2 EXPONENTIAL NUCLEIC ACID AMPLIFICATION USING NICKING ENDONUCLEASES 审中-公开
标题翻译：指数核酸扩增使用内源性核酸内切酶
公开(公告)号：WO2003008622A2
公开(公告)日：2003-01-30
申请号：PCT/US2002/022657
申请日：2002-07-15
申请人： KECK GRADUATE INSTITUTE , VAN NESS, Jeffrey , GALAS, David, J. , VAN NESS, Lori, K.
发明人： VAN NESS, Jeffrey , GALAS, David, J. , VAN NESS, Lori, K.
IPC分类号： C12Q
CPC分类号： C12Q1/6809 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00659 , B01J2219/00722 , C12Q1/6844 , C12Q2600/156 , C12Q2600/158 , C40B40/06 , C12Q2525/131 , C12Q2521/313 , C12Q2565/501 , C12Q2527/107 , C12Q2525/155 , C12Q2521/301 , C12Q2531/119 , C12Q2521/513
摘要： The present invention provides methods and composition for exponential nucleic acid amplification using nicking agents. The invention is useful in many areas such as disease diagnosis, genetic variation detection and pre-mRNA alternative splicing analysis.
摘要翻译：本发明提供了使用切口剂进行指数型核酸扩增的方法和组合物。本发明在许多领域是有用的，例如疾病诊断，遗传变异检测和前体mRNA选择性剪接分析。

105. 发明申请

WO0228524A3 MULTI-WELL ROTARY SYNTHESIZER WITH SEALING WASTE TUBE SYSTEM 审中-公开
标题翻译：密封废物管系统的多井旋转合成器
公开(公告)号：WO0228524A3
公开(公告)日：2003-01-30
申请号：PCT/US0130612
申请日：2001-09-27
申请人： MCLUEN GARY R
发明人： MCLUEN GARY R
IPC分类号： B01J19/00 , C40B40/06 , C40B40/14 , C40B60/14 , F16K1/14 , F16L37/40
CPC分类号： B01J19/0046 , B01J2219/00286 , B01J2219/00308 , B01J2219/0034 , B01J2219/00389 , B01J2219/00416 , B01J2219/00423 , B01J2219/005 , B01J2219/00585 , B01J2219/00596 , B01J2219/00689 , B01J2219/00722 , C40B40/06 , C40B40/14 , C40B60/14
摘要： An apparatus (100) for synthesizing polymer chains includes a controller (480), a plurality of precision fit vials (181) circularly arranged in multiple banks (115, 125) on a cartridge (170, 300), a drain (740) corresponding to each bank of vials (115, 125), a chamberbowl (400), a plurality of valves for delivering reagents to selective vials (181), and a waste tube system (430) for purging material from the vials (181). A purging operation can be selectively performed on one or more of the banks of vials (115, 125). The multiple banks of valves (110, 120, 130, 470) provide an additional number of reagent choices while operating in a serial mode and faster reagent distribution while operating in a parallel mode. The plurality of vials (181) are stored in the cartridge (170, 300) and are divided among individual banks (115, 125) wherein each bank of vials (115, 125) has a corresponding drain. There is at least one waste tube system (430) for expelling the reagent solution from vials (181) within a particular bank of vials (115, 125) when the waste tube system (430) is coupled to the corresponding drain. The cartridge (170, 300) holding the plurality of vials (181) rotates relative to the stationary banks of valves (110, 120, 130, 470) and the waste tube system (430).
摘要翻译：一种用于合成聚合物链的设备（100）包括控制器（480），在筒（170,300）上的多个库（115,125）中循环布置的多个精密配合管（181），相应的排放管（740）到腔室（115,125），腔室（400），用于将试剂输送到选择性小瓶（181）的多个阀以及用于从小瓶（181）中清除材料的废物管系统（430）。可以在一个或多个小瓶组（115,125）上选择性地执行清洗操作。多个阀组（110,120,130,470）在以串行模式操作时提供额外数量的试剂选择，并且在并行模式下操作时更快地分配试剂。多个小瓶（181）被存储在盒（170,300）中并被分成单独的库（115,125），其中每个小瓶（115,125）具有对应的排出口。当废物管系统（430）连接到相应的排水管时，至少有一个废物管系统（430）用于从特定的小瓶（115,125）内的小瓶（181）排出试剂溶液。保持多个小瓶（181）的筒（170,300）相对于静止的阀组（110,120,130,470）和废物管系统（430）旋转。

106. 发明申请

WO0247075B1 INTEGRATED DEVICE WITH SURFACE-ATTACHED MOLECULAR MOIETIES AND RELATED MACHINE-READABLE INFORMATION 审中-公开
标题翻译：具有表面附着分子动力学的集成装置及相关机器可读信息
公开(公告)号：WO0247075B1
公开(公告)日：2003-01-09
申请号：PCT/US0143810
申请日：2001-11-13
申请人： PICOLITER INC , ELLSON RICHARD N , FOOTE JAMES K , MUTZ MITCHELL W
发明人： ELLSON RICHARD N , FOOTE JAMES K , MUTZ MITCHELL W
IPC分类号： B01J19/00 , B41J2/14 , C40B40/06 , C40B40/10 , C40B60/14 , C40B70/00 , G01N35/00 , G07D7/14 , G11B3/00 , G11B5/00 , G11B5/008 , G11B7/0037 , G11B7/24 , G11B9/00 , C12Q1/00 , C12Q1/68 , G01N33/00 , G01N33/543 , G11B7/00
CPC分类号： G01N35/00732 , B01J19/0046 , B01J2219/00317 , B01J2219/00378 , B01J2219/00518 , B01J2219/00527 , B01J2219/00536 , B01J2219/0054 , B01J2219/00547 , B01J2219/00563 , B01J2219/00565 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00707 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B41J2/14008 , B82Y10/00 , C40B40/06 , C40B40/10 , C40B60/14 , C40B70/00 , G01N35/00069 , G01N2035/00782 , G06Q20/102 , G11B3/00 , G11B5/00 , G11B5/00813 , G11B7/0037 , G11B7/24 , G11B9/14 , G11B9/1463 , G11B9/149 , G11B2005/0002 , G11B2005/0005
摘要： The invention provides a device comprising a substrate having a surface capable of attaching a plurality of moieties, or a surface having a plurality of moieties attached thereto. The substrate also contains machine-readable information realting to themoieties. The information may be contained in a discrete regions of the substrate that is non-coplanar with respect to the substrate surface having the plurality of moieties attached thereto. The information may, for example, relate to the identity of the attached moieties or to instructions for attaching the moieties. Also provided are methods and machines for forming and using the devices.
摘要翻译：本发明提供了一种装置，其包括具有能够附着多个部分的表面的基底，或具有连接到其上的多个部分的表面。基板还包含实现各种各样的机读信息。信息可以包含在相对于具有连接到其上的多个部分的基底表面的非共面的基底的离散区域中。该信息可以例如涉及附着部分的身份或附着部分的说明书。还提供了用于形成和使用装置的方法和机器。

107. 发明申请

WO2003000404A1 MATRIX SCREENING METHOD 审中-公开
标题翻译：矩阵筛选方法
公开(公告)号：WO2003000404A1
公开(公告)日：2003-01-03
申请号：PCT/GB2001/005330
申请日：2001-12-03
申请人： DOMANTIS LIMITED , HOLT, Lucy, Jessica , TOMLINSON, Ian
发明人： HOLT, Lucy, Jessica , TOMLINSON, Ian
IPC分类号： B01J19/00
CPC分类号： C40B30/04 , B01J19/0046 , B01J2219/0036 , B01J2219/00364 , B01J2219/00378 , B01J2219/0038 , B01J2219/00522 , B01J2219/00531 , B01J2219/00533 , B01J2219/00659 , B01J2219/00668 , B01J2219/00677 , B01J2219/00691 , B01J2219/0072 , B01J2219/00722 , B01J2219/0074 , B82Y30/00 , C40B40/06 , C40B60/14 , G01N33/5005 , G01N33/5008 , G01N33/54366 , G01N33/6845 , G01N2333/005 , G01N2500/02 , G01N2500/04 , G01N2500/10 , G01N2500/20
摘要： The invention concerns a method which can be used to screen two or more repertoires of molecules against one another and/or to create combinatorial repertoires by combining two or more repertoires. In particular, the invention relates to a method whereby two repertoires of molecules can be screened such that all members of the first repertoire are tested against all members of the second repertoire for functional interactions. Furthermore, the invention relates to the creation and screening of antibody repertoires by combining a repertoire of heavy chains with a repertoire of light chains such that antibodies formed by the all combinations of heavy and light chains can be screened against one or more target ligands.
摘要翻译：本发明涉及一种方法，其可用于通过组合两个或更多个谱组来筛选分子的两个或多个谱系和/或组合组合谱。特别地，本发明涉及一种可以筛选分子的两个谱系的方法，使得针对功能相互作用的第二个谱系的所有成员测试第一个谱系的所有成员。此外，本发明涉及通过将重链的谱系与轻链的所有组成相结合来产生和筛选抗体库，使得可以通过重链和轻链的全部组合形成的抗体相对于一种或多种靶配体进行筛选。

108. 发明申请

WO0210758A3 SURFACE-ATTACHED POLYFUNCTIONAL POLYMER NETWORKS FOR SENSOR CHIPS 审中-公开
标题翻译：表面附着的多功能聚合物网络传感器
公开(公告)号：WO0210758A3
公开(公告)日：2002-12-05
申请号：PCT/EP0108546
申请日：2001-07-24
申请人： BIOCHIP TECHNOLOGIES GMBH , RUEHE JUERGEN
发明人： RUEHE JUERGEN
IPC分类号： G01N33/53 , B01J20/26 , B01J20/291 , B01J20/32 , C07B61/00 , C07H21/00 , C08G85/00 , C12M1/00 , C12N15/09 , C12Q1/68 , C40B40/02 , C40B40/06 , C40B40/10 , C40B40/12 , C40B50/06 , G01N33/543 , G01N37/00
CPC分类号： B01J20/291 , B01J20/26 , B01J20/3204 , B01J20/3208 , B01J20/3219 , B01J20/327 , B01J20/3272 , B01J20/3278 , B01J20/3282 , B01J2219/00497 , B01J2219/00659 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , B01J2219/00731 , B01J2220/54 , C07B2200/11 , C07H21/00 , C12Q1/6837 , C40B40/06 , C40B40/10 , C40B40/12 , G01N30/482 , G01N33/5436 , G01N33/54393 , Y10T428/2991 , Y10T428/2996 , Y10T428/2998
摘要： The invention relates to polyfunctional polymer networks comprising an assembly of cross-linked poylmer subchains attached to a surface, with each polymer subchain comprising a multitude of identical or different repeating units carrying one or more functional groups which allows an interaction with a sample or probe molecule.
摘要翻译：本发明涉及多官能聚合物网络，其包括连接到表面上的交联聚合物链子的组合，每个聚合物子链包含多个相同或不同的携带一个或多个官能团的重复单元，其允许与样品或探针分子相互作用。

109. 发明申请

WO02078835A3 SUBSTRATES, PREPARATION AND USE 审中-公开
标题翻译：基材，制备和使用
公开(公告)号：WO02078835A3
公开(公告)日：2002-11-28
申请号：PCT/EP0203102
申请日：2002-03-20
申请人： UCB SA , LINDEKENS LUC , TIELEMANS MICHEL , CAPPELLE STEVEN , REMACLE JOSE , DE BECKER BENOIT
发明人： LINDEKENS LUC , TIELEMANS MICHEL , CAPPELLE STEVEN , REMACLE JOSE , DE BECKER BENOIT
IPC分类号： C12N15/09 , B01J19/00 , C08F291/00 , C08G85/00 , C40B40/06 , G01N33/543 , B01L3/00 , C08F20/02 , C12Q1/68
CPC分类号： G01N33/54366 , B01J19/0046 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00707 , B01J2219/0072 , B01J2219/00722 , C40B40/06 , G01N33/54386 , G01N33/54393 , Y10T428/31504
摘要： There is disclosed process for preparing a substrate 1. Process for preparing a substrate having thereon sites reactive with the reactive groups of a molecular probe, the process comprising the steps of applying to the substrate surface a material comprising one or more reactive sites having an activated ethylenically unsaturated double bond of the formula I: Wherein, if n= 0, m= 1, X is carbon and X is nitrogen, the bond between them being triple, and X does not exist; if n= 1, m= 1, X is carbon and X is oxygen or sulphur, the bond between them being double, and X is oxygen or sulphur or nitrogen substituted by an organo substituent; if n= 1, m= 1 or 2, X is sulphur and X is oxygen, the bond between them being double, and X is nitrogen substituted by an organo substituent; R1, R2, each independently represent hydrogen, hydroxyl or organo group, R3 and R4 each independently represent hydrogen or organo group, eventually containing a silicon atom R1 and R2 being not linked to R4. and, in a further step, of covalently binding the reactive group of the molecular probe to the activated ethylenically unsaturated double bond of the reactive sites having formula I. Preferred activated unsaturated moiet(ies) comprises unsaturated ester moiet(ies) such as (meth)acrylate moiet(ies). Preferred probes comprise amino groups thereon. Preferred strong links are covalent bonds. Preferred linking reactions are Michael addition reactions. The substrate having probes deposed thereon may be used to interact with a target. Other aspects of the invention relate to substrates and multi-reactive systems (such as microarrays) so prepared; uses thereof; and products and information obtained therefrom.
摘要翻译：公开了制备基底的方法1.制备其上具有与分子探针的反应性基团反应的位点的基底的方法，该方法包括以下步骤：向基底表面施加包含一个或多个具有活化的式I的烯属不饱和双键：其中，如果n = 0，m = 1，X 3为碳，X 1为氮，它们之间的键为三价，X 4不存在; 如果n = 1，m = 1，X 3为碳，X 1为氧或硫，它们之间的键为双键，X 2为氧或被有机取代基取代的硫或氮; 如果n = 1，m = 1或2，X 3为硫，X 1为氧，它们之间的键为双，X 2为被有机取代基取代的氮; R 1，R 2各自独立地表示氢，羟基或有机基团，R 3和R 4各自独立地表示氢或有机基团，最终含有硅原子，R 1和R 2不与R 4连接。并且在另一步骤中，将分子探针的反应性基团共价结合到具有式I的反应性位点的活化的烯属不饱和双键上。优选的活化的不饱和疏水物包括不饱和酯类，例如（甲基）丙烯酸酯。优选的探针包括其上的氨基。优先的联系是共价债券。优选的连接反应是迈克尔加成反应。可以使用其上放置的探针的基底与靶相互作用。本发明的其它方面涉及如此制备的底物和多反应体系（如微阵列）; 用途; 以及从中获得的产品和信息。

110. 发明申请

WO2002090963A1 OVERLYING ELECTRODE FOR ELECTROCHEMICAL MICROARRAYS 审中-公开
标题翻译：电化学微电极的电极
公开(公告)号：WO2002090963A1
公开(公告)日：2002-11-14
申请号：PCT/US2002/010669
申请日：2002-04-03
申请人： COMBIMATRIX CORPORATION
发明人： FUJI, H., Sho , NORTON, Barton, F. , PIERCE, Al , O'CONNOR, David, G.
IPC分类号： G01N27/26
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00495 , B01J2219/00529 , B01J2219/00585 , B01J2219/00596 , B01J2219/00608 , B01J2219/00612 , B01J2219/00637 , B01J2219/00639 , B01J2219/00653 , B01J2219/00675 , B01J2219/00704 , B01J2219/00722 , C40B40/06 , C40B50/14
摘要： There is disclosed an improved electrochemical-based microarray biochip that is able to increase chip density by moving a counter-electrode out of a grid pattern of microarrays and into an overlaying position using thin film electrodes.
摘要翻译：公开了一种改进的基于电化学的微阵列生物芯片，其能够通过使用薄膜电极将对电极移出微阵列的网格图案并进入覆盖位置来增加芯片密度。

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