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1. 发明申请

WO2007098234A2 GRAFT MATERIAL FOR PROSTHESES 审中-公开
标题翻译：遗传物质
公开(公告)号：WO2007098234A2
公开(公告)日：2007-08-30
申请号：PCT/US2007/004565
申请日：2007-02-20
申请人： MED INSTITUTE, INC. , PURDY, James, D. , GREWE, David, D. , NINAN, Lal , SUN, Jichao , DIERKING, William, K.
发明人： PURDY, James, D. , GREWE, David, D. , NINAN, Lal , SUN, Jichao , DIERKING, William, K.
IPC分类号： A61L27/34 , A61L31/12
CPC分类号： A61L27/34 , A61L27/3629 , A61L27/3633 , A61L27/48 , A61L27/56 , A61L31/005 , A61L31/10 , A61L31/128 , A61L31/146 , B32B1/08 , B32B5/02 , B32B5/18 , B32B27/065 , B32B27/12 , B32B27/18 , B32B27/205 , B32B27/28 , B32B27/283 , B32B27/40 , B32B2262/0276 , B32B2266/06 , B32B2535/00 , C08F255/00 , C08F283/006 , C08F283/12 , C08F289/00 , C08F291/00 , C08G18/3228 , C08G18/4854 , C08G18/61 , C08G2101/00 , Y10T428/31844
摘要： A graft material (200) for an endoluminal prosthesis comprises a porous polymeric sheet (210), extracellular matrix material (ECM) such as small intestine submucosa (211) disposed on at least a portion of the porous polymeric sheet and at least one polymer layer (212) disposed on at least a portion of the ECM. The ECM (211) may be in gel form. The polymer stent (210) and the polymer layer (212) may be of foam material and may comprise a polyurethane urea and a surface modifying agent such as a siloxane.
摘要翻译：用于腔内假体的移植材料（200）包括多孔聚合物片（210），细胞外基质材料（ECM），例如设置在多孔聚合物片材的至少一部分上的小肠粘膜下层（211）和至少一个聚合物层（212）设置在ECM的至少一部分上。 ECM（211）可以是凝胶形式。聚合物支架（210）和聚合物层（212）可以是泡沫材料，并且可以包含聚氨酯脲和表面改性剂如硅氧烷。

2. 发明申请

WO2009123715A1 SELF CLEANING DEVICES, SYSTEMS AND METHODS OF USE 审中-公开
标题翻译：自清洁装置，系统和使用方法
公开(公告)号：WO2009123715A1
公开(公告)日：2009-10-08
申请号：PCT/US2009/002020
申请日：2009-04-01
申请人： MED INSTITUTE, INC. , GREWE, David, D.
发明人： GREWE, David, D.
IPC分类号： A61F2/01 , A61F2/86
CPC分类号： A61F2/01 , A61F2/0077 , A61F2/856 , A61F2/86 , A61F2002/018 , A61F2220/0008 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2220/0075 , A61F2230/0006 , A61F2230/0008 , A61F2230/0067 , A61F2230/0069 , A61F2230/0071 , A61F2230/008 , A61F2250/0039
摘要： The application relates to medical devices and systems for preventing the embolic material flowing about a junction of at least one branch blood vessel and another blood vessel from entering the other blood vessel. The device includes a self cleaning flexible filter (100) and a frame (180). The external surface of the filter (152) is configured to temporarily trap at least some of the embolic material flowing about the junction as a result of the blood inflow though the filter. The filter is also configured to expel the trapped embolic material into the other blood vessel.
摘要翻译：本申请涉及用于防止栓塞材料在至少一个分支血管和另一个血管的交界处流动的医疗装置和系统进入另一个血管。该装置包括自清洁柔性过滤器（100）和框架（180）。过滤器（152）的外表面构造成临时捕获由于通过过滤器的血液流入而围绕该结点流动的至少一些栓塞材料。过滤器还构造成将捕获的栓塞物质排出到另一个血管中。

3. 发明申请

WO2009091974A1 INTRAVASCULAR DEVICE ATTACHMENT SYSTEM HAVING BIOLOGICAL MATERIAL 审中-公开
标题翻译：具有生物材料的血管内装置附件系统
公开(公告)号：WO2009091974A1
公开(公告)日：2009-07-23
申请号：PCT/US2009/031245
申请日：2009-01-16
申请人： MED INSTITUTE, INC. , HASELBY, Kenneth , CHOULES, Brian, D. , ROEDER, Blayne, A. , SISKEN, Richard, B. , ORR, David, Eric , PURDY, James, D. , CHARLEBOIS, Steven, J. , GREWE, David, D. , FEARNOT, Neal, E. , LEEWOOD, Alan, R.
发明人： HASELBY, Kenneth , CHOULES, Brian, D. , ROEDER, Blayne, A. , SISKEN, Richard, B. , ORR, David, Eric , PURDY, James, D. , CHARLEBOIS, Steven, J. , GREWE, David, D. , FEARNOT, Neal, E. , LEEWOOD, Alan, R.
IPC分类号： A61F2/24 , A61F2/86 , A61M1/10
CPC分类号： A61M1/125 , A61B5/076 , A61B5/14535 , A61B5/14539 , A61B5/6862 , A61B5/6876 , A61B5/6882 , A61F2/0077 , A61F2/2418 , A61F2/2475 , A61F2/86 , A61F2002/068 , A61F2002/8486 , A61F2220/0016 , A61F2220/0058 , A61F2220/0075 , A61F2230/005 , A61F2230/0071 , A61F2230/008 , A61M1/1006 , A61M1/1008 , A61M1/101 , A61M1/1098 , A61M1/122 , A61M1/3653 , A61M1/3659
摘要： An attachment system for attaching an intravascular device to a vessel wall of a body vessel is disclosed. The attachment system includes an intravascular device and biological attachment material connected to the intravascular device. The biological attachment material is configured to attach the intravascular device to the vessel wall.
摘要翻译：公开了一种用于将血管内装置附接到身体血管的血管壁的附接系统。附件系统包括连接到血管内装置的血管内装置和生物附着材料。生物附着材料构造成将血管内装置附接到血管壁。

4. 发明申请

WO2009091965A1 INTRAVASCULAR DEVICE ATTACHMENT SYSTEM HAVING TUBULAR EXPANDABLE BODY 审中-公开
标题翻译：具有管状膨胀体的血管内装置附件系统
公开(公告)号：WO2009091965A1
公开(公告)日：2009-07-23
申请号：PCT/US2009/031232
申请日：2009-01-16
申请人： MED INSTITUTE, INC. , HASELBY, Kenneth , CHOULES, Brian, D. , ROEDER, Blayne, A. , SISKEN, Richard, B. , ORR, David, Eric , PURDY, James, D. , CHARLEBOIS, Steven, J. , GREWE, David, D. , FEARNOT, Neal, E. , LEEWOOD, Alan, R.
发明人： HASELBY, Kenneth , CHOULES, Brian, D. , ROEDER, Blayne, A. , SISKEN, Richard, B. , ORR, David, Eric , PURDY, James, D. , CHARLEBOIS, Steven, J. , GREWE, David, D. , FEARNOT, Neal, E. , LEEWOOD, Alan, R.
IPC分类号： A61F2/86 , A61F2/24
CPC分类号： A61M1/125 , A61B5/076 , A61B5/14535 , A61B5/14539 , A61B5/6862 , A61B5/6876 , A61B5/6882 , A61F2/0077 , A61F2/2418 , A61F2/2475 , A61F2/86 , A61F2002/068 , A61F2002/8486 , A61F2220/0016 , A61F2220/0058 , A61F2220/0075 , A61F2230/005 , A61F2230/0071 , A61F2230/008 , A61M1/1006 , A61M1/1008 , A61M1/101 , A61M1/1098 , A61M1/122 , A61M1/3653 , A61M1/3659
摘要： An attachment system for attaching an intravascular device to a vessel wall of a body vessel is disclosed. The attachment system includes a tubular expandable body defining a lumen therethrough. The tubular expandable body is configured to move between an expanded state to contact the body vessel and a collapsed state for delivery or retrieval. The tubular expandable body is configured to contact the vessel wall along the length of the tubular expandable body in the expanded state when deployed in the body vessel. An intravascular device is held to the exterior side of the tubular expandable body and is configured to contact the vessel wall when the tubular expandable body is in the expanded state and the system is deployed within a body vessel.
摘要翻译：公开了一种用于将血管内装置附接到身体血管的血管壁的附接系统。附接系统包括限定通过其中的腔的管状可扩张体。管状可膨胀体构造成在膨胀状态下与身体容器接触并且用于输送或取出的折叠状态。管状可膨胀体构造成当展开在身体容器中时，在展开状态下沿管状可膨胀体的长度接触血管壁。血管内装置被保持在管状可膨胀体的外侧，并且构造成当管状可膨胀体处于膨胀状态并且系统部署在体内容器内时与血管壁接触。

5. 发明申请

WO2009011866A1 PROSTHESIS DELIVERY AND DEPLOYMENT DEVICE 审中-公开
标题翻译： PROSTHESIS交付和部署设备
公开(公告)号：WO2009011866A1
公开(公告)日：2009-01-22
申请号：PCT/US2008/008677
申请日：2008-07-16
申请人： COOK INCORPORATED , MED INSTITUTE, INC. , CHUTER, Timothy, A. , GREWE, David, D. , ROEDER, Blayne, A. , LEEWOOD, Alan, R.
发明人： CHUTER, Timothy, A. , GREWE, David, D. , ROEDER, Blayne, A. , LEEWOOD, Alan, R.
IPC分类号： A61F2/84
CPC分类号： A61F2/966 , A61F2/95 , A61F2002/9517
摘要： A device for delivering and deploying a prosthesis comprises an elongate sheath having a sheath lumen and a delivery catheter slidably disposed within the sheath lumen, the device having a deployment assist mechanism coupled to the delivery catheter and the sheath and configured to apply a retraction force to the delivery catheter and the sheath. The retraction force may vary during deployment; in particular it is less than or equal to the resistance to retraction during at least part of the deployment.
摘要翻译：用于递送和展开假体的装置包括细长护套，其具有鞘腔和可滑动地设置在护套管腔内的输送导管，该装置具有联接到输送导管和护套的展开辅助机构，并且构造成将收缩力施加到输送导管和护套。缩回力在部署期间可能不同; 特别是在至少部分部署期间，其小于或等于回缩阻力。

6. 发明申请

WO2008091925A2 TREATMENT OF AORTIC DISSECTION OR ANEURYSM 审中-公开
标题翻译：治疗动态断层或神经损伤
公开(公告)号：WO2008091925A2
公开(公告)日：2008-07-31
申请号：PCT/US2008/051762
申请日：2008-01-23
申请人： COOK INCORPORATED , MED INSTITUTE, INC. , GREWE, David, D. , BIGGS, David, Paul , RAGHEB, Anthony, O. , RUANE, Patrick, H.
发明人： GREWE, David, D. , BIGGS, David, Paul , RAGHEB, Anthony, O. , RUANE, Patrick, H.
IPC分类号： A61L27/00 , A61L31/16 , A61K31/415 , A61K38/16
CPC分类号： A61K38/556 , A61F2/07 , A61F2/915 , A61F2002/91541 , A61F2220/0016 , A61F2220/005 , A61F2220/0075 , A61F2230/005 , A61F2230/0054 , A61F2230/0067 , A61F2250/0067 , A61F2250/0068 , A61K9/0024 , A61K31/415 , A61L31/10 , A61L31/16 , A61L2300/434
摘要： This application relates to methods for treating an aneurysm or an aortic dissection (230; 530). The methods include delivering a medical device (10; 100; 150; 200; 400) and a c-Jun N-terminal kinase (JNK) inhibitor compound to a body lumen at a point of treatment within a subject having the aneurysm or aortic dissection (230; 530), the medical device (10; 100; 150; 200; 400) being adapted to release the JNK inhibitor within the body lumen of the subject. This application also relates to medical devices (10; 100; 150; 200; 400) and JNK inhibitor compounds, where the medical device (10; 100; 150; 200; 400) is adapted to release the JNK inhibitor compound within a patient. Medical devices may include coated stents, grafts, stent grafts, balloons and catheters.
摘要翻译：本申请涉及治疗动脉瘤或主动脉夹层的方法（230; 530）。所述方法包括在具有动脉瘤或主动脉夹层的受试者内的治疗点将医疗装置（10; 100; 150; 200; 400）和c-Jun N-末端激酶（JNK）抑制剂化合物递送至体腔（230; 530），所述医疗装置（10; 100; 150; 200; 400）适于将所述JNK抑制剂释放到所述受试者的体腔内。本申请还涉及医疗装置（10; 100; 150; 200; 400）和JNK抑制剂化合物，其中医疗装置（10; 100; 150; 200; 400）适于释放患者体内的JNK抑制剂化合物。医疗装置可以包括涂覆支架，移植物，支架移植物，气囊和导管。

7. 发明申请

WO2008030488A3 STENTS WITH CONNECTORS AND STABILIZING BIODEGRADABLE ELEMENTS 审中-公开
公开(公告)号：WO2008030488A3
公开(公告)日：2008-03-13
申请号：PCT/US2007/019389
申请日：2007-09-06
申请人： MED INSTITUTE, INC. , COOK INCORPORATED , LEEWOOD, Alan, R. , GREWE, David, D. , HIATT, Mark , RAGHEB, Anthony, O. , VOORHEES, III, William, D. , ROEDER, Blayne, A. , PURDY, James, D.
发明人： LEEWOOD, Alan, R. , GREWE, David, D. , HIATT, Mark , RAGHEB, Anthony, O. , VOORHEES, III, William, D. , ROEDER, Blayne, A. , PURDY, James, D.
IPC分类号： A61F2/86 , A61F2/84
摘要： Various stent structures are provided with improved axial and torsional flexibility. One type of stent structure includes multiple segmented stent structures connected to each other by biodegradable interconnectors. A delivery system adapted to delivery the multiple segmented stents is also described. Another type of stent structure includes biodegradable connectors that are incorporated into a framework of non-biodegradable interconnecting members that form the support structure of the stent. The biodegradable connectors in both stent structures degrade or are absorbed after the stent is deployed. Stabilizing elements may be provided to the stent structures to supplement the stiffness of the stent with stability during loading and deployment.

8. 发明申请

WO2007062241A1 EXPANDABLE STENT 审中-公开
标题翻译：可扩展性
公开(公告)号：WO2007062241A1
公开(公告)日：2007-05-31
申请号：PCT/US2006/045503
申请日：2006-11-28
申请人： MED INSTITUTE, INC. , ROEDER, Blayne, A. , GREWE, David, D. , SWIFT, Richard, A.
发明人： ROEDER, Blayne, A. , GREWE, David, D. , SWIFT, Richard, A.
IPC分类号： A61F2/88
CPC分类号： A61F2/885
摘要： An expandable stent for medical implantation is described which has a generally cylindrical structure with a central longitudinal axis. At least a portion of the generally cylindrical structure is formed from an arrangement of circumferentially curved structural members. The portion expands from a compressed state to an expanded state by a spiraling motion of each of the structural members about the central longitudinal axis. In the compressed state, each of the structural members may nest within an open region formed by segments composing the structural member, such that the portion of the generally cylindrical structure has no overlapping regions. A ratio of a circumferential length of each structural member to a spacing between adjacent structural members may be in the range of about 1.8 to about 2.3.
摘要翻译：描述了用于医学植入的可扩张支架，其具有具有中心纵向轴线的大致圆柱形结构。大致圆柱形结构的至少一部分由周向弯曲的结构构件的布置形成。通过每个结构构件围绕中心纵向轴线的螺旋运动，该部分从压缩状态膨胀到膨胀状态。在压缩状态下，每个结构构件可以嵌套在由构成结构构件的段形成的开放区域内，使得大致圆柱形结构的部分没有重叠区域。每个结构构件的圆周长度与相邻结构构件之间的间隔的比率可以在约1.8至约2.3的范围内。

9. 发明申请

WO2009091968A1 INTRAVASCULAR DEVICE ATTACHMENT SYSTEM HAVING STRUTS 审中-公开
标题翻译：具有结构的血管内装置附件系统
公开(公告)号：WO2009091968A1
公开(公告)日：2009-07-23
申请号：PCT/US2009/031236
申请日：2009-01-16
申请人： MED INSTITUTE, INC. , HASELBY, Kenneth , CHOULES, Brian, D. , ROEDER, Blayne, A. , SISKEN, Richard, B. , ORR, David, Eric , PURDY, James, D. , CHARLEBOIS, Steven, J. , GREWE, David, D. , FEARNOT, Neal, E. , LEEWOOD, Alan, R.
发明人： HASELBY, Kenneth , CHOULES, Brian, D. , ROEDER, Blayne, A. , SISKEN, Richard, B. , ORR, David, Eric , PURDY, James, D. , CHARLEBOIS, Steven, J. , GREWE, David, D. , FEARNOT, Neal, E. , LEEWOOD, Alan, R.
IPC分类号： A61F2/24 , A61F2/86
CPC分类号： A61M1/125 , A61B5/076 , A61B5/14535 , A61B5/14539 , A61B5/6862 , A61B5/6876 , A61B5/6882 , A61F2/0077 , A61F2/2418 , A61F2/2475 , A61F2/86 , A61F2002/068 , A61F2002/8486 , A61F2220/0016 , A61F2220/0058 , A61F2220/0075 , A61F2230/005 , A61F2230/0071 , A61F2230/008 , A61M1/1006 , A61M1/1008 , A61M1/101 , A61M1/1098 , A61M1/122 , A61M1/3653 , A61M1/3659
摘要： An attachment system for attaching an intravascular device to a vessel wall of a body vessel is disclosed. The attachment system has an intravascular device having a first end and a second end. The intravascular device defines a longitudinal axis along a length thereof. Several struts are connected to one or more ends of the intravascular device. Each strut is configured to move along a strut path relative to the longitudinal axis between an expanded state for engaging the vessel wall and a collapsed state for delivery or retrieval. Each strut has a free end configured to engage the vessel wall in the expanded state.
摘要翻译：公开了一种用于将血管内装置附接到身体血管的血管壁的附接系统。附接系统具有具有第一端和第二端的血管内装置。血管内装置沿其长度限定纵向轴线。几个支柱连接到血管内装置的一个或多个端部。每个支柱被构造成在用于接合血管壁的膨胀状态和用于输送或取回的折叠状态之间相对于纵向轴线沿着支柱路径移动。每个支柱具有构造成在膨胀状态下接合血管壁的自由端。

10. 发明申请

WO2009085281A1 IMPLANTABLE DEVICE 审中-公开
标题翻译：可植入设备
公开(公告)号：WO2009085281A1
公开(公告)日：2009-07-09
申请号：PCT/US2008/014035
申请日：2008-12-24
申请人： COOK INCORPORATED , MED INSTITUTE, INC. , KUPPURATHANAM, Shyam , CHARLEBOIS, Steven, J. , DIERKING, William, K. , GREWE, David, D.
发明人： KUPPURATHANAM, Shyam , CHARLEBOIS, Steven, J. , DIERKING, William, K. , GREWE, David, D.
IPC分类号： A61F2/06
CPC分类号： A61F2/07 , A61F2/89 , A61F2002/065 , A61F2002/075 , A61F2250/0017
摘要： An implantable device (10) having a composite weave graft is disclosed. The device (10) comprises a graft body (12) forming a lumen (20) defining a longitudinal axis and comprising a proximal end (21) and a distal end (22). The graft body (12) comprises a composite of low dernier yarns and polymeric yarns configured for low profile delivery and radial elongation relative to the longitudinal axis during use. The graft body (12) has a first portion (40) and a second portion (42) extending from the first portion. The first portion (40) comprises at least one expandable stent (43) radially attached thereto for support and the second portion (42) has corrugations (46) for enhanced kink resistance.
摘要翻译：公开了一种具有复合编织移植物的可植入装置（10）。装置（10）包括形成限定纵向轴线并包括近端（21）和远端（22）的内腔（20）的移植物体（12）。移植体（12）包括低倍数纱线和聚合纱线的复合材料，其在使用期间相对于纵向轴线配置为低轮廓输送和径向伸长。移植体（12）具有从第一部分延伸的第一部分（40）和第二部分（42）。第一部分（40）包括至少一个径向附接到其上的用于支撑的可扩张支架（43），并且第二部分（42）具有用于提高扭结阻力的波纹（46）。

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