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1. 发明授权

US10537889B2 Addressable flow cell using patterned electrodes 有权
公开(公告)号：US10537889B2
公开(公告)日：2020-01-21
申请号：US15107882
申请日：2014-12-30
申请人： Illumina, Inc.
发明人： Chenlu Hou , Byoungsok Jung , Yir-Shyuan Wu , Tarun Khurana
IPC分类号： B01L3/00 , C40B60/00 , C12Q1/6874 , C12Q1/68
摘要： Disclosed are methods and systems concerning flow cells for sequencing a nucleic acid sample that may be characterized by the following components: (a) a substrate having an inner surface facing a library sequencing region, and an outer surface; (b) a plurality of a plurality of forward and reverse amplification primers immobilized over the inner surface and providing a nucleic acid library capture surface of the library sequencing region; (c) a plurality of electrodes disposed along the inner surface directly under at least some of the forward and reverse amplification primers, and configured to provide, when charged, an electric field through the library capture surface and into the library sequencing region; (d) electrical leads connected to the plurality of electrodes to permit the electrodes to be independently addressable; and (e) fluidic couplings configured to deliver a plurality of nucleic acid libraries to the flow cell during different time periods.

2. 发明授权

US10144945B2 Layered microfluidic living cell array 有权
公开(公告)号：US10144945B2
公开(公告)日：2018-12-04
申请号：US14257182
申请日：2014-04-21
申请人： Research Foundation of the City University of New York , Memorial Sloan Kettering Cancer Center
发明人： Sihong Wang , Zeynep Dereli-Korkut , Xuejun Jiang
IPC分类号： C12Q1/00 , C40B60/00 , C12M3/06 , C12N5/00 , C12N5/09 , C40B40/00
摘要： A layered, microfluidic living cell array is disclosed. The cell array comprises a first layer comprising at least one cell culture channel; a second layer comprising at least one microfluidic channel; and a third layer, disposed between the first layer and the second layer. The third layer comprises a filter membrane with a plurality of pores, each pore fluidly connecting the microfluidic channel to the cell culture channel.

3. 发明授权

US10106843B2 Devices and methods for thermally-mediated chemical reactions 有权
公开(公告)号：US10106843B2
公开(公告)日：2018-10-23
申请号：US14934946
申请日：2015-11-06
申请人： LIFE TECHNOLOGIES CORPORATION
发明人： Colin J. H. Brenan , Thomas B. Morrison , Tanya S. Kanigan
IPC分类号： B01L7/00 , C40B60/00 , C12Q1/686 , B01L3/00
摘要： One aspect of the invention provides container for thermal cycling a plurality of samples in a microfluidic array. The container includes a plurality of walls defining an interior volume and a conductive member for heating the interior volume. Another aspect of the invention provides container for thermal cycling a plurality of samples in a microfluidic array. The container includes a plurality of walls defining an interior volume and a plurality of conductive members for heating an interior volume. Another aspect of the invention provides a container for thermal cycling a plurality of samples in a microfluidic array. The container includes a plurality of walls defining an interior volume and a first conductive member located in the interior volume and adapted to contact a first end of the microfluidic array.

4. 发明授权

US08815536B2 Methods and systems for sampling, screening, and diagnosis 有权
标题翻译：采样，筛选和诊断的方法和系统
公开(公告)号：US08815536B2
公开(公告)日：2014-08-26
申请号：US10587927
申请日：2005-02-04
申请人： Rolf U. Halden
发明人： Rolf U. Halden
IPC分类号： C12Q1/04 , A62D3/02 , C40B30/10 , C40B60/00 , C40B60/04 , C40B60/06 , C40B40/02 , C40B60/08 , C40B60/10 , C40B60/12 , C40B60/14
CPC分类号： C12Q1/04 , B01L3/5025 , B01L2200/0668 , B01L2300/0829 , B01L2300/0838 , C12Q1/24 , C12Q1/26 , C12Q1/70 , G01N1/10 , G01N33/5008 , G01N33/6818 , G01N33/6848 , G01N2333/90241 , G01N2500/00 , G01N2500/10 , H01J49/04
摘要： Apparatus, systems, and methods for detecting, screening and sampling of cells are disclosed.
摘要翻译：公开了用于检测，筛选和取样细胞的装置，系统和方法。

5. 发明授权

US08647591B2 Microarray reaction device and method of using the same 失效
标题翻译：微阵列反应装置及其使用方法
公开(公告)号：US08647591B2
公开(公告)日：2014-02-11
申请号：US13007750
申请日：2011-01-17
申请人： Won-seok Chung , Myo-yong Lee , Kak Namkoong , Woochang Lee
发明人： Won-seok Chung , Myo-yong Lee , Kak Namkoong , Woochang Lee
IPC分类号： B01L3/00 , B01L99/00 , F16K3/00 , C40B40/00 , C40B60/00 , F16K31/00
CPC分类号： C40B30/00 , C40B40/06 , C40B40/10 , C40B60/12
摘要： A microarray reaction device includes a fluid container, a reaction chamber, a first channel connected with the fluid container, a second channel connected with the reaction chamber, and a valve. The valve includes a first and second support unit, respectively including a first and second penetration opening unit, extended through a first and second surface thereof. The first and second penetration opening unit is connected to a second end of the first and second channel, respectively. The second support unit includes a third penetration opening unit extended through a second surface thereof. The first and second surfaces contact each other, such that the first support unit and the second support unit are slidably disposed with each other. The microarray reaction device further includes a storing chamber connected with the third penetration opening unit, and a pump connected to the storing chamber and providing pressure to the storing chamber.
摘要翻译：微阵列反应装置包括流体容器，反应室，与流体容器连接的第一通道，与反应室连接的第二通道和阀。阀包括第一和第二支撑单元，分别包括延伸穿过其第一和第二表面的第一和第二穿透开口单元。第一和第二穿透开口单元分别连接到第一和第二通道的第二端。第二支撑单元包括延伸穿过其第二表面的第三穿透开口单元。第一和第二表面彼此接触，使得第一支撑单元和第二支撑单元彼此可滑动地布置。微阵列反应装置还包括与第三穿透开口单元连接的储存室，以及连接到储存室并向储存室提供压力的泵。

6. 发明授权

US08642516B2 Chemically-defined arrays for screening cell-substrate interactions 有权
标题翻译：用于筛选细胞 - 底物相互作用的化学定义阵列
公开(公告)号：US08642516B2
公开(公告)日：2014-02-04
申请号：US13465120
申请日：2012-05-07
申请人： Justin T. Koepsel , William L. Murphy
发明人： Justin T. Koepsel , William L. Murphy
IPC分类号： C40B60/14 , C40B60/00 , C40B40/00
CPC分类号： G01N33/553 , G01N2610/00
摘要： Patterned SAM arrays and methods of preparing patterned SAM arrays are disclosed. Advantageously, the methods used to prepare the patterned SAM arrays allow for controlling SAM spot-to-spot conditions such as ligand identity and ligand density, which allows for preparing a wide range of SAM spots in a single array format. Additionally, the patterned SAM arrays of the present disclosure support the culture of a range of cell types. The patterned SAM arrays offer the ability to rapidly screen substrate components for influencing cell attachment, spreading, proliferation, migration, and differentiation.
摘要翻译：公开了图案化SAM阵列和制备图案化SAM阵列的方法。有利地，用于制备图案化SAM阵列的方法允许控制SAM点对点条件，例如配体同一性和配体密度，这允许以单一阵列格式制备宽范围的SAM斑点。另外，本公开的图案化SAM阵列支持一系列细胞类型的培养。图案化的SAM阵列提供快速筛选底物组分以影响细胞附着，扩散，增殖，迁移和分化的能力。

7. 发明授权

US08361781B2 Cell aggregation and encapsulation device and method 有权
标题翻译：细胞聚集和封装装置及方法
公开(公告)号：US08361781B2
公开(公告)日：2013-01-29
申请号：US12087937
申请日：2007-01-24
申请人： Jeffrey Morgan , Anthony Napolitano
发明人： Jeffrey Morgan , Anthony Napolitano
IPC分类号： C40B50/06 , C40B60/00 , C12M1/00 , C12N5/00 , B29C33/40
CPC分类号： C12M25/00 , B33Y80/00 , C12M21/08 , C12M23/12 , C12M25/14 , C12N5/0012 , C12N5/0062 , C12N2533/40 , C12N2533/74
摘要： The invention is a cell aggregation device comprising a hydrogel substrate having at least one, preferably a plurality, of cell-repellant compartments recessed into the uppermost surface. Each compartment is composed of an upper cell suspension seeding chamber having an open uppermost portion and a bottom portion, and one, or more than one, lower cell aggregation recess connected to the bottom portion of the upper cell suspension seeding chamber by a port. The diameter of the port may be fully contiguous with the walls of the chambers and walls of the recesses, or the diameter of the port may be more narrow than the walls of the chamber but fully contiguous with the walls of the recesses or more narrow than both the walls of the chamber and the walls of the recesses. The upper cell suspension seeding chambers are formed and positioned to funnel the cells into the lower cell aggregation recesses through gravitational force. The aggregation recesses are formed and positioned to promote cellular aggregation by coalescing cells into a finite region of minimum gravitational energy, increasing intercellular contact and minimizing or preventing cell adherence to the substrate. A device for encapsulating aggregates of live cells is provided. The device comprises (i) a biocompatible, bio-sustainable substrate having a cell-encapsulating face composed of one or more biocompatible, bio-sustainable, spaced-apart, cell-encapsulating compartments extending therefrom and (ii) a coating layer composed of a biocompatible, bio-sustainable polymer that completely surrounds the substrate and the cell-encapsulating compartments. A method for making the device is also provided.
摘要翻译：本发明是一种细胞聚集装置，其包括具有至少一个，优选多个凹陷到最上表面的细胞排斥隔室的水凝胶基底。每个隔室由具有开口最上部分和底部的上部细胞悬浮播种室组成，以及通过端口连接到上部细胞悬浮播种室的底部的一个或多于一个下部细胞聚集凹部。端口的直径可以与腔室的壁和凹部的壁完全邻接，或者端口的直径可以比室的壁更窄，但是与凹部的壁完全邻接或更窄房间的墙壁和凹槽的墙壁。形成并定位上细胞悬浮播种室，以通过重力将细胞漏入下细胞聚集凹槽。形成和定位聚集凹槽以通过将细胞聚结成最小引力能的有限区域，增加细胞间接触并最小化或防止细胞粘附于基底来促进细胞聚集。提供了用于封装活细胞聚集体的装置。所述装置包括（i）生物相容的生物可持续的底物，其具有由一个或多个生物相容性，生物可持续的间隔开的细胞包封的隔室组成的细胞封装面，所述细胞封装的区域从其延伸，和（ii）由生物相容的，生物可持续的聚合物，其完全包围底物和细胞封装隔室。还提供了制造该装置的方法。

8. 发明授权

US08361392B2 Biochip having image sensor with back side illumination photodiode 有权
标题翻译：具有背面照明光电二极管的图像传感器的生物芯片
公开(公告)号：US08361392B2
公开(公告)日：2013-01-29
申请号：US12985083
申请日：2011-01-05
申请人： Byoung Su Lee , Do Young Lee
发明人： Byoung Su Lee , Do Young Lee
IPC分类号： G01N21/00 , C40B60/00 , H01L31/0232 , H01L31/00 , G01N21/64 , G01J1/58
CPC分类号： H01L27/14603 , G01N21/6454 , H01L27/14621 , H01L27/14627 , H01L27/1464
摘要： A biochip having an image sensor with a back side illumination photodiode structure includes: a biochip layer; and an image sensor layer attached to one surface of the biochip layer and configured to sense light with biochemical reaction information, which is emitted from the biochip layer, wherein the image sensor layer includes a plurality of light sensing parts which receive the light directed toward a back side of a wafer.
摘要翻译：具有背面照明光电二极管结构的图像传感器的生物芯片包括：生物芯片层; 以及图像传感器层，其附接到所述生物芯片层的一个表面并且被配置为用从所述生物芯片层发射的生化反应信息感测光，其中所述图像传感器层包括多个光敏部分，所述多个光感测部件接收朝向晶片背面。

9. 发明申请

US20120046202A1 STIRRING APPARATUS FOR COMBINATORIAL PROCESSING 失效
标题翻译：用于组合加工的搅拌装置
公开(公告)号：US20120046202A1
公开(公告)日：2012-02-23
申请号：US13283444
申请日：2011-10-27
申请人： Rajesh Kelekar
发明人： Rajesh Kelekar
IPC分类号： C40B50/14 , C40B99/00 , C40B60/00
CPC分类号： C25D21/10 , C23C18/1628 , C23C18/1669 , C25D5/08 , C25D17/001 , C25D17/008 , H01L21/67023
摘要： An apparatus and system for stirring liquid inside a flow cell. In one implementation, the apparatus includes a rotatable disc configured to receive liquid at a top side of the disc and distribute the liquid substantially evenly around a periphery of the flow cell. The disc has a triangular cross sectional area. The apparatus may further include a set of fins attached to a bottom side of the disc, wherein the set of fins is configured to draw the liquid from the periphery of the flow cell into the center of the flow cell.
摘要翻译：用于在流动池内搅拌液体的装置和系统。在一个实施方案中，该装置包括可旋转盘，其构造成在盘的顶侧处接收液体，并将液体基本均匀地分布在流动池的周边周围。盘具有三角形横截面积。该装置还可以包括附接到盘的底侧的一组翅片，其中所述翅片组被配置为将液体从流动池的周边抽吸到流动池的中心。

10. 发明申请

US20110098199A1 Microreactor Array 审中-公开
标题翻译：微反应器阵列
公开(公告)号：US20110098199A1
公开(公告)日：2011-04-28
申请号：US12884525
申请日：2010-09-17
申请人： Richard D. Oleschuk , Michelle Douma
发明人： Richard D. Oleschuk , Michelle Douma
IPC分类号： C40B40/00 , C40B40/10 , C40B50/00 , C40B60/00
CPC分类号： C40B60/14 , B01J19/0046 , B01J2219/00286 , B01J2219/00306 , B01J2219/00509 , B01J2219/00511 , B01J2219/00522 , B01J2219/00524 , B01J2219/00585 , B01J2219/00596 , B01J2219/00702 , B01J2219/00725 , B01L3/0268 , B01L3/5027 , B01L3/502707 , B01L2300/0636 , B01L2300/0816 , B01L2300/0838 , C40B50/14 , H01J49/0431
摘要： Provided is a microreactor array, comprising a single fibre comprising a matrix material; a plurality of capillaries formed within the matrix material, the capillaries substantially aligned along a longitudinal axis of the fibre; and one or more reagent associated with an inner surface of the capillaries; wherein each capillary corresponds to a microreactor of the array. Also provided are microreactor array methods and systems, including a manifold microreactor system and a microreactor array system microchip.
摘要翻译：提供了一种微反应器阵列，其包括包含基质材料的单纤维; 形成在基体材料内的多个毛细管，毛细管基本上沿着纤维的纵向轴线对齐; 以及与毛细管的内表面相关联的一种或多种试剂; 其中每个毛细管对应于阵列的微反应器。还提供了微反应器阵列方法和系统，包括歧管微反应器系统和微反应器阵列系统微芯片。

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