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1. 发明授权

US08642516B2 Chemically-defined arrays for screening cell-substrate interactions 有权
标题翻译：用于筛选细胞 - 底物相互作用的化学定义阵列
公开(公告)号：US08642516B2
公开(公告)日：2014-02-04
申请号：US13465120
申请日：2012-05-07
申请人： Justin T. Koepsel , William L. Murphy
发明人： Justin T. Koepsel , William L. Murphy
IPC分类号： C40B60/14 , C40B60/00 , C40B40/00
CPC分类号： G01N33/553 , G01N2610/00
摘要： Patterned SAM arrays and methods of preparing patterned SAM arrays are disclosed. Advantageously, the methods used to prepare the patterned SAM arrays allow for controlling SAM spot-to-spot conditions such as ligand identity and ligand density, which allows for preparing a wide range of SAM spots in a single array format. Additionally, the patterned SAM arrays of the present disclosure support the culture of a range of cell types. The patterned SAM arrays offer the ability to rapidly screen substrate components for influencing cell attachment, spreading, proliferation, migration, and differentiation.
摘要翻译：公开了图案化SAM阵列和制备图案化SAM阵列的方法。有利地，用于制备图案化SAM阵列的方法允许控制SAM点对点条件，例如配体同一性和配体密度，这允许以单一阵列格式制备宽范围的SAM斑点。另外，本公开的图案化SAM阵列支持一系列细胞类型的培养。图案化的SAM阵列提供快速筛选底物组分以影响细胞附着，扩散，增殖，迁移和分化的能力。

2. 发明申请

US20130296177A1 CHEMICALLY-DEFINED ARRAYS FOR SCREENING CELL-SUBSTRATE INTERACTIONS 有权
标题翻译：用于筛选细胞基底相互作用的化学定义的阵列
公开(公告)号：US20130296177A1
公开(公告)日：2013-11-07
申请号：US13465120
申请日：2012-05-07
申请人： Justin T. Koepsel , William L. Murphy
发明人： Justin T. Koepsel , William L. Murphy
IPC分类号： C40B30/04 , B05D1/36
CPC分类号： G01N33/553 , G01N2610/00
摘要： Patterned SAM arrays and methods of preparing patterned SAM arrays are disclosed. Advantageously, the methods used to prepare the patterned SAM arrays allow for controlling SAM spot-to-spot conditions such as ligand identity and ligand density, which allows for preparing a wide range of SAM spots in a single array format. Additionally, the patterned SAM arrays of the present disclosure support the culture of a range of cell types. The patterned SAM arrays offer the ability to rapidly screen substrate components for influencing cell attachment, spreading, proliferation, migration, and differentiation.
摘要翻译：公开了图案化SAM阵列和制备图案化SAM阵列的方法。有利地，用于制备图案化SAM阵列的方法允许控制SAM点对点条件，例如配体同一性和配体密度，这允许以单一阵列格式制备宽范围的SAM斑点。另外，本公开的图案化SAM阵列支持一系列细胞类型的培养。图案化的SAM阵列提供快速筛选底物组分以影响细胞附着，扩散，增殖，迁移和分化的能力。

3. 发明申请

US20110022085A1 BIOLOGICALLY ACTIVE SUTURES FOR REGENERATIVE MEDICINE 有权
标题翻译：生物医学的生物活性物质
公开(公告)号：US20110022085A1
公开(公告)日：2011-01-27
申请号：US12507635
申请日：2009-07-22
申请人： William L. Murphy , Jae Sung Lee , Mark D. Markel , Ben K. Graf , Geoffrey Baer , Yan Lu
发明人： William L. Murphy , Jae Sung Lee , Mark D. Markel , Ben K. Graf , Geoffrey Baer , Yan Lu
IPC分类号： A61B17/04
CPC分类号： A61B17/06166 , A61B2017/00889 , A61B2017/00893 , A61L17/005 , A61L17/06 , A61L17/145 , A61L27/32 , A61L27/54 , A61L27/58 , A61L29/106 , A61L29/148 , A61L29/16 , A61L31/086 , A61L31/148 , A61L31/16
摘要： The present disclosure generally relates to biodegradable and bioresorbable materials having a mineral layer on the surface of the material. More particularly, the disclosure relates to biodegradable and bioresorbable orthopedic devices having a degradable mineral layer on the surface thereof that can be used as a delivery vehicle for biological substances. Also provided are various methods of using the mineralized devices in tissue regeneration, including bone tissue engineering, and methods for producing the mineralized devices.
摘要翻译：本公开通常涉及在材料表面上具有矿物层的可生物降解和生物可再吸收的材料。更具体地说，本公开内容涉及在其表面上具有可降解矿物层的可生物降解和生物可吸收的矫形装置，其可用作生物物质的递送载体。还提供了在组织再生中使用矿化装置的各种方法，包括骨组织工程，以及用于生产矿化装置的方法。

4. 发明申请

US20090087472A1 CONTROLLED RELEASE OF BIOPHARMACEUTICAL GROWTH FACTORS FROM HYDROXYAPATITE COATING ON BIORESORBABLE INTERFERENCE SCREWS USED IN CRUCIATE LIGAMENT RECONSTRUCTION SURGERY 有权
标题翻译：从生物降解性干扰因子中分离生物生长因子的控制释放用于重组大肠重建手术
公开(公告)号：US20090087472A1
公开(公告)日：2009-04-02
申请号：US12145672
申请日：2008-06-25
申请人： William L. Murphy , Jae-Sam Lee , Mark D. Markel , Ben K. Graf
发明人： William L. Murphy , Jae-Sam Lee , Mark D. Markel , Ben K. Graf
IPC分类号： A61F2/00 , A61L27/32 , A61K38/16 , C07K7/08 , C07K14/00 , C07H21/00 , C12N5/00 , A61B17/68
CPC分类号： C07K14/51 , A61B17/80 , A61B17/866 , A61K38/1875 , A61L31/06 , A61L31/086 , A61L31/148 , A61L31/16 , A61L2300/252 , A61L2300/414 , C07K7/06 , C07K7/08 , C08L67/04
摘要： Controlled release of biopharmaceutical growth factors from a hydroxyapatite coating on a bioresorbable interference screw used in cruciate ligament reconstruction surgery on a human. Biologically active scaffolds, such as interference bone screws used for ligament fixation, made by growing calcium phosphate-based hydroxyapatite coatings on bioresorbable poly(α-hydroxy ester) scaffolds that provide controlled mineral dissolution and controlled release of bone morphogenetic protein-2. The biologically active scaffold provides improved bioavailability of BMP-2 growth factor that in turn provides enhanced graft-bone healing in the tibial bone tunnel. The coating method uses surface hydrolysis and modified simulated body fluid incubation which does not require solvent or heat and is conducted at room temperature.
摘要翻译：将生物药物生长因子从羟基磷灰石涂层控制释放到用于人类十字韧带重建手术的生物可再吸收的干涉螺钉上。生物活性支架，例如用于韧带固定的干涉骨螺钉，其通过在生物可再吸收的聚（α-羟基酯）支架上生长磷酸钙基羟基磷灰石涂层而提供，其提供受控的矿物溶解和骨形态发生蛋白-2的受控释放。生物活性支架提供改善的BMP-2生长因子的生物利用度，其进而在胫骨骨隧道中提供增强的移植骨愈合。涂覆方法使用表面水解和改性的模拟体液培养，其不需要溶剂或热量并在室温下进行。

5. 发明授权

US6066591A Reactive medium for purifying fluids 失效
标题翻译：用于净化流体的活性介质
公开(公告)号：US6066591A
公开(公告)日：2000-05-23
申请号：US184349
申请日：1998-11-02
申请人： William L. Murphy , Bruce A. Wilson
发明人： William L. Murphy , Bruce A. Wilson
IPC分类号： B01D46/12 , B01D46/10 , B01D46/54 , B01D53/34 , B01J20/20 , B01J20/32 , B01J20/02
CPC分类号： B01D46/0012 , B01D46/10 , B01D46/54 , B01D53/34 , B01J20/0229 , B01J20/06 , B01J20/20 , B01J20/3085 , B01J20/3204 , B01J20/3236 , B01J20/324 , B01J20/3289 , Y10S95/901 , Y10T29/49604 , Y10T29/49885 , Y10T29/49982
摘要： A method for forming a reactive medium for removing homogenous and heterogeneous impurities from a fluid is provided which includes forming a uniform oxide layer on all exposed surfaces of a porous metal substrate, depositing at least one layer of carbon on substantially all of the oxide layer formed on the porous metal substrate, depositing a precursor metal species on the carbon layer, and heating the porous metal substrate containing the carbon layer to form active sites on the carbon layer, wherein the active sites include at least partially deoxygenated metal species chemically bonded to the carbon layer. Also provided is a reactive medium for purifying a fluid, the reactive medium comprising a porous inorganic substrate, a layer including carbon and an oxide layer between the porous inorganic substrate and the layer including carbon. The reactive medium further comprises active sites including at least partially deoxygenated metal species, the active sites being bonded to the layer including carbon.
摘要翻译：提供了一种形成用于从流体中除去均质和不均匀杂质的反应介质的方法，其包括在多孔金属基底的所有暴露表面上形成均匀的氧化物层，在形成的氧化物层的基本上全部沉积至少一层碳在所述多孔金属基底上，在所述碳层上沉积前体金属物质，以及加热含有所述碳层的多孔金属基底以在所述碳层上形成活性位点，其中所述活性位点包括至少部分脱氧金属物质，碳层。还提供了用于净化流体的反应性介质，所述反应性介质包括多孔无机基材，在多孔无机基材和包含碳的层之间包含碳和氧化物层的层。反应性介质还包含活性位点，其包括至少部分脱氧金属物质，活性位点与包含碳的层结合。

6. 发明授权

US5829139A Method for forming a reactive medium 失效
标题翻译：形成反应介质的方法
公开(公告)号：US5829139A
公开(公告)日：1998-11-03
申请号：US976118
申请日：1997-11-21
申请人： William L. Murphy , Bruce A. Wilson
发明人： William L. Murphy , Bruce A. Wilson
IPC分类号： B01D46/12 , B01D46/10 , B01D46/54 , B01D53/34 , B01J20/20 , B01J20/32 , B23P25/00
CPC分类号： B01D46/0012 , B01D46/10 , B01D46/54 , B01D53/34 , B01J20/0229 , B01J20/06 , B01J20/20 , B01J20/3085 , B01J20/3204 , B01J20/3236 , B01J20/324 , B01J20/3289 , Y10S95/901 , Y10T29/49604 , Y10T29/49885 , Y10T29/49982
摘要： A method for forming a reactive medium for removing homogeneous and heterogeneous impurities from a fluid is provided. The method includes forming a uniform oxide layer, depositing at least one layer of carbon, depositing a precursor metal species, and heating a substrate having the layer including carbon.
摘要翻译：提供了一种用于形成用于从流体中除去均质和异质杂质的反应介质的方法。该方法包括形成均匀的氧化物层，沉积至少一层碳，沉积前体金属物质，以及加热含有碳层的基材。

7. 发明授权

US4372982A Refrigerated shelf stable dough 失效
标题翻译：冷藏架稳定面团
公开(公告)号：US4372982A
公开(公告)日：1983-02-08
申请号：US275008
申请日：1981-06-18
申请人： Michael J. Haasl , Kenneth D. Snider , William L. Murphy
发明人： Michael J. Haasl , Kenneth D. Snider , William L. Murphy
IPC分类号： A21D6/00 , A21D8/02 , A21D10/02
CPC分类号： A21D8/02 , A21D6/001
摘要： A dough composition for making quality, thinly sheeted farinaceous food products such as pie crust or the like and which is shelf stable. The dough composition contains a high-starch, low-enzyme flour, shortening, water, gluten and preservatives. The composition is particularly adapted for making a pie dough which, during manufacture, is pre-sheeted and folded twice for packaging, and then is unfolded by the consumer for use.
摘要翻译：用于制造质量好的薄片状食品的面团组合物，例如馅饼皮等，并且是稳定的。面团组合物含有高淀粉，低酶粉，起酥油，水，面筋和防腐剂。组合物特别适用于制造馅饼面团，其在制造期间被预先包装并折叠两次以进行包装，然后被消费者展开以供使用。

8. 发明授权

US09295755B2 Multilayer tissue regeneration system 有权
标题翻译：多层组织再生系统
公开(公告)号：US09295755B2
公开(公告)日：2016-03-29
申请号：US11583231
申请日：2006-10-18
申请人： William L. Murphy
发明人： William L. Murphy
IPC分类号： A61K38/18 , A61L27/30 , A61L27/32 , A61K45/06
CPC分类号： A61L27/32 , A61K38/1825 , A61K38/1866 , A61K38/1875 , A61K45/06 , A61L27/30 , A61L27/306
摘要： A system for growing tissue based upon layers of an inorganic matrix, wherein each layer of the inorganic matrix is designed to dissolve at a separate rate and result in sequential growth factor delivery upon its dissolution.
摘要翻译：用于基于无机基质层生长组织的系统，其中无机基质的每层被设计成以分开的速率溶解并且在其溶解时导致连续的生长因子递送。

9. 发明授权

US09072813B2 Mineralization and biological modification of biomaterial surfaces 有权
标题翻译：生物材料表面的矿化和生物修饰
公开(公告)号：US09072813B2
公开(公告)日：2015-07-07
申请号：US12433518
申请日：2009-04-30
申请人： William L. Murphy , Martin C. Peters , David J. Mooney , David H. Kohn
发明人： William L. Murphy , Martin C. Peters , David J. Mooney , David H. Kohn
IPC分类号： A61L27/00 , A61L27/50 , A61L27/18 , A61L27/44
CPC分类号： A61L27/58 , A61L27/00 , A61L27/18 , A61L27/306 , A61L27/44 , A61L27/50 , A61L27/56 , A61L2400/18 , A61L2430/02 , C08L67/04
摘要： Disclosed are advantageous methods for patterning and/or mineralizing biomaterial surfaces. The techniques described are particularly useful for generating three-dimensional or contoured bioimplant materials with patterned surfaces or patterned, mineralized surfaces. Also provided are various methods of using the mineralized and/or patterned biomaterials in tissue engineering, such as bone tissue engineering, providing more control over ongoing biological processes, such as mineralization, growth factor release, cellular attachment and tissue growth.
摘要翻译：公开了用于图案化和/或矿化生物材料表面的有利方法。所描述的技术对于生成具有图案化表面或图案化的矿化表面的三维或轮廓生物植入物材料特别有用。还提供了在组织工程中使用矿化和/或图案化生物材料的各种方法，例如骨组织工程，提供对正在进行的生物过程例如矿化，生长因子释放，细胞附着和组织生长的更多控制。

10. 发明申请

US20110282392A1 DEGRADABLE CAGE FOR BONE FUSION 审中-公开
标题翻译：骨质融化器可降解笼
公开(公告)号：US20110282392A1
公开(公告)日：2011-11-17
申请号：US13036470
申请日：2011-02-28
申请人： William L. Murphy , Chia-Ying Lin , Frank LaMarca , Scott J. Hollister
发明人： William L. Murphy , Chia-Ying Lin , Frank LaMarca , Scott J. Hollister
IPC分类号： A61B17/88 , A61F2/44 , A61B17/70
CPC分类号： A61F2/4455 , A61B17/7059 , A61F2002/2817 , A61F2002/30011 , A61F2002/30013 , A61F2002/30032 , A61F2002/30056 , A61F2002/30062 , A61F2002/30064 , A61F2002/3008 , A61F2002/30303 , A61F2002/30578 , A61F2002/30785 , A61F2002/30789 , A61F2002/30838 , A61F2002/30878 , A61F2002/30884 , A61F2002/30892 , A61F2002/30899 , A61F2002/3092 , A61F2002/4485 , A61F2210/0004 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00089 , A61F2310/00113 , A61F2310/00131 , A61F2310/00149 , A61F2310/00155 , A61F2310/00293 , A61F2310/00796 , A61F2310/0097 , A61F2310/00976 , A61K38/1825 , A61K38/1841 , A61K38/1858 , A61K38/1875 , A61K38/30
摘要： A cage for facilitating fusion of bones, such as vertebrae, or fusion of adjacent bone surfaces is disclosed. In one form, the cage includes a plurality of spaced apart walls comprising a biodegradable polymeric material (e.g., polycaprolactone); an osteoconductive mineral coating (e.g., a calcium compound) on at least a portion of the walls; and a bioactive agent (e.g., a bone morphogenetic protein) associated with the polymeric material and/or the coating. The bioactive agent is present in amount that induces ossification between the bones or adjacent bone surfaces. The cage may also include a fixation plate connected to at least one of the walls.
摘要翻译：公开了一种用于促进诸如椎骨之类的骨骼融合或相邻骨表面融合的笼子。在一种形式中，笼包括多个间隔开的壁，包括可生物降解的聚合材料（例如聚己内酯）; 在壁的至少一部分上的骨传导性矿物涂层（例如钙化合物）; 和与聚合物材料和/或涂层相关联的生物活性剂（例如骨形态发生蛋白）。生物活性剂的存在量是引起骨骼或相邻骨表面之间的骨化。保持架还可以包括连接到至少一个壁的固定板。

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