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1. 发明授权

US09187846B2 Microarray package device and method of manufacturing the same 有权
标题翻译：微阵列封装器件及其制造方法
公开(公告)号：US09187846B2
公开(公告)日：2015-11-17
申请号：US12938485
申请日：2010-11-03
申请人： Woochang Lee , Jeo-young Shim , Myo-yong Lee , Kak Namkoong , Won-seok Chung
发明人： Woochang Lee , Jeo-young Shim , Myo-yong Lee , Kak Namkoong , Won-seok Chung
IPC分类号： B01L3/00 , C40B60/12
CPC分类号： C40B60/12 , B01L3/508 , B01L2200/025 , B01L2300/0819
摘要： A microarray package device and a method of manufacturing the same. An effective microarray analyzing reaction is performed by using the microarray package device that provides structural stability and reliable experimental results.
摘要翻译：微阵列包装装置及其制造方法。通过使用提供结构稳定性和可靠的实验结果的微阵列包装装置进行有效的微阵列分析反应。

2. 发明授权

US08647591B2 Microarray reaction device and method of using the same 失效
标题翻译：微阵列反应装置及其使用方法
公开(公告)号：US08647591B2
公开(公告)日：2014-02-11
申请号：US13007750
申请日：2011-01-17
申请人： Won-seok Chung , Myo-yong Lee , Kak Namkoong , Woochang Lee
发明人： Won-seok Chung , Myo-yong Lee , Kak Namkoong , Woochang Lee
IPC分类号： B01L3/00 , B01L99/00 , F16K3/00 , C40B40/00 , C40B60/00 , F16K31/00
CPC分类号： C40B30/00 , C40B40/06 , C40B40/10 , C40B60/12
摘要： A microarray reaction device includes a fluid container, a reaction chamber, a first channel connected with the fluid container, a second channel connected with the reaction chamber, and a valve. The valve includes a first and second support unit, respectively including a first and second penetration opening unit, extended through a first and second surface thereof. The first and second penetration opening unit is connected to a second end of the first and second channel, respectively. The second support unit includes a third penetration opening unit extended through a second surface thereof. The first and second surfaces contact each other, such that the first support unit and the second support unit are slidably disposed with each other. The microarray reaction device further includes a storing chamber connected with the third penetration opening unit, and a pump connected to the storing chamber and providing pressure to the storing chamber.
摘要翻译：微阵列反应装置包括流体容器，反应室，与流体容器连接的第一通道，与反应室连接的第二通道和阀。阀包括第一和第二支撑单元，分别包括延伸穿过其第一和第二表面的第一和第二穿透开口单元。第一和第二穿透开口单元分别连接到第一和第二通道的第二端。第二支撑单元包括延伸穿过其第二表面的第三穿透开口单元。第一和第二表面彼此接触，使得第一支撑单元和第二支撑单元彼此可滑动地布置。微阵列反应装置还包括与第三穿透开口单元连接的储存室，以及连接到储存室并向储存室提供压力的泵。

3. 发明授权

US08663976B2 Polymerase chain reaction apparatus 有权
标题翻译：聚合酶链反应装置
公开(公告)号：US08663976B2
公开(公告)日：2014-03-04
申请号：US13039630
申请日：2011-03-03
申请人： Won-seok Chung , Kak Namkoong , Joon-ho Kim
发明人： Won-seok Chung , Kak Namkoong , Joon-ho Kim
IPC分类号： C12M1/34 , C12M3/00
CPC分类号： B01L9/527 , B01L3/502715 , B01L7/52 , B01L2200/025 , B01L2200/147 , B01L2300/1827
摘要： A polymerase chain reaction (“PCR”) apparatus includes a PCR chip holder which accommodates and supports a PCR chip, a housing which supports ends of the PCR chip holder, a temperature control element which moves perpendicularly with respect to the PCR chip holder in a space between the housing and the PCR chip holder in the housing, and an elastic unit which elastically biases the temperature control element toward the PCR chip holder, between the temperature control element and the housing. The temperature control element includes a top surface which is selectively contacted to a bottom surface of the PCR chip.
摘要翻译：聚合酶链式反应（“PCR”）装置包括：一个PCR芯片保持器，其容纳和支持PCR芯片;支撑PCR芯片保持器端部的壳体;一个相对于PCR芯片保持器垂直移动的温度控制元件壳体和壳体中的PCR芯片保持器之间的空间以及在温度控制元件和壳体之间弹性地将温度控制元件朝向PCR芯片保持器偏置的弹性单元。温度控制元件包括选择性地接触PCR芯片的底表面的顶表面。

4. 发明授权

US09000399B2 Fluorescence detecting optical system and multi-channel fluorescence detection apparatus including the same 有权
标题翻译：荧光检测光学系统和包括其的多通道荧光检测装置
公开(公告)号：US09000399B2
公开(公告)日：2015-04-07
申请号：US13271101
申请日：2011-10-11
申请人： Kyung-ho Kim , Joon-ho Kim , Kak Namkoong , Won-seok Chung
发明人： Kyung-ho Kim , Joon-ho Kim , Kak Namkoong , Won-seok Chung
IPC分类号： G01N21/64 , G01J3/44 , G01J3/02 , G01N21/05 , G01N21/03
CPC分类号： G01N21/645 , G01J3/0208 , G01J3/0229 , G01J3/0237 , G01J3/4406 , G01N21/05 , G01N2021/0346 , G01N2021/6419 , G01N2021/6421 , G01N2021/6478 , G01N2201/0635
摘要： A fluorescence detection optical system detects fluorescence beams with two or more different wavelengths and maintains a focal position through an automatic focusing function. A multi-channel fluorescence detection apparatus includes the fluorescence detection optical system. The fluorescence detection optical system includes an automatic focusing unit which receives light reflected off a microfluidic device and determines a focal point by using an astigmatic method or a knife edge method, and an actuator which adjusts a position of an objective lens according to control of the automatic focusing unit. In addition, the fluorescence detection optical system may include a plurality of dual band pass filters, dichroic devices, etc., which provide light beams emitted from at least two light sources and transfer fluorescence generated from the microfluidic device to a photodetector.
摘要翻译：荧光检测光学系统检测具有两个或更多个不同波长的荧光束并通过自动聚焦功能保持焦点位置。多通道荧光检测装置包括荧光检测光学系统。荧光检测光学系统包括自动聚焦单元，其接收从微流体装置反射的光并且通过使用散光方法或刀刃方法确定焦点，以及致动器，其根据控制的方式调整物镜的位置自动对焦单元此外，荧光检测光学系统可以包括多个双带通滤波器，二向色装置等，其提供从至少两个光源发射的光束并将从微流体装置产生的荧光转移到光电检测器。

5. 发明授权

US09044751B2 Gene analysis device 有权
标题翻译：基因分析装置
公开(公告)号：US09044751B2
公开(公告)日：2015-06-02
申请号：US13608533
申请日：2012-09-10
申请人： Won-jong Jung , Sun-ok Jung , Won-seok Chung , Chin-sung Park , Joon-ho Kim , Kak Namkoong
发明人： Won-jong Jung , Sun-ok Jung , Won-seok Chung , Chin-sung Park , Joon-ho Kim , Kak Namkoong
IPC分类号： C12M1/34 , C12M3/00 , B01L3/00 , G01N21/64 , G01N21/03 , G01N21/05
CPC分类号： B01L3/502715 , B01L2300/0654 , B01L2300/0816 , G01N21/6452 , G01N2021/0314 , G01N2021/0325 , G01N2021/058 , G01N2021/6463
摘要： A gene analysis device including an illumination optical system radiating exciting light onto a sample solution; a microfluidic device for forming a bio-reaction space of the sample solution and including at least one micro-chamber in which a reflection pattern is formed; and a detection optical system for detecting a fluorescence signal generated by a bio-reaction in the micro-chamber and comprising a photodetector.
摘要翻译：一种基因分析装置，包括将激发光照射到样品溶液上的照明光学系统; 微流体装置，用于形成样品溶液的生物反应空间，并且包括至少一个其中形成有反射图案的微室; 以及检测光学系统，用于检测由微室中的生物反应产生的荧光信号，并包括光电检测器。

6. 发明授权

US09044755B2 Gene analysis apparatus and gene analysis method using the same 有权
标题翻译：基因分析仪和基因分析方法采用相同的方法
公开(公告)号：US09044755B2
公开(公告)日：2015-06-02
申请号：US13176777
申请日：2011-07-06
申请人： Chin-sung Park , Won-jong Jung , Joon-ho Kim , Kak Namkoong , Kyu-youn Hwang , Won-seok Chung , Hee-kyun Lim , Sung-hong Kwon , Sun-ok Jung
发明人： Chin-sung Park , Won-jong Jung , Joon-ho Kim , Kak Namkoong , Kyu-youn Hwang , Won-seok Chung , Hee-kyun Lim , Sung-hong Kwon , Sun-ok Jung
IPC分类号： C12Q1/68 , G01N21/75 , B01L7/00 , B01L3/00
CPC分类号： B01L7/52 , B01L3/502715 , B01L2200/027 , B01L2200/028 , B01L2200/04 , B01L2200/0605 , B01L2200/0621 , B01L2200/0684 , B01L2200/10 , B01L2200/16 , B01L2300/0627 , B01L2300/0816 , B01L2300/087 , B01L2300/0874 , B01L2300/0887 , B01L2300/18 , B01L2400/0487 , B01L2400/06 , B01L2400/0655 , C12Q1/68 , G01N21/75
摘要： A gene analysis apparatus includes a sample preparation chip in which a polymerase chain reaction (“PCR”) sample is prepared, a PCR chip in which a PCR is performed on the PCR sample, and a package layer on which the sample preparation chip and the PCR chip are mounted. The package layer includes a channel through which a material flows from the sample preparation chip to the PCR chip. The sample preparation chip and the PCR chip are on a same side or on opposing sides of the package layer.
摘要翻译：基因分析装置包括准备了聚合酶链式反应（“PCR”）样品的样品制备芯片，对PCR样品进行PCR的PCR芯片，以及将样品制备芯片和 PCR芯片安装。封装层包括材料从样品制备芯片流向PCR芯片的通道。样品制备芯片和PCR芯片在封装层的相同侧或相对侧上。

7. 发明授权

US08624201B2 Fluorescence detecting optical system and multi-channel fluorescence detection apparatus having the same 有权
标题翻译：荧光检测光学系统和具有该荧光检测光学系统的多通道荧光检测装置
公开(公告)号：US08624201B2
公开(公告)日：2014-01-07
申请号：US13421119
申请日：2012-03-15
申请人： Kyung-ho Kim , Joon-ho Kim , Kak Namkoong , Won-seok Chung
发明人： Kyung-ho Kim , Joon-ho Kim , Kak Namkoong , Won-seok Chung
IPC分类号： G01N21/64
CPC分类号： G01N21/645 , G01N21/6445
摘要： A fluorescence detecting optical system, and a multi-channel fluorescence detection apparatus comprising same, comprising a light source that emits excitation light, a polarizer that transmits light having a predetermined polarization component, a polarizing beam splitter that transmits light having a predetermined polarization component and reflects light having a different polarization component than the predetermined polarization component, and a quarter-wave plate converting linearly polarized to circularly polarized light or vice versa.
摘要翻译：一种荧光检测光学系统和包括其的多通道荧光检测装置，包括发射激发光的光源，透射具有预定偏振分量的光的偏振器，透射具有预定偏振分量的光的偏振分束器和反射具有与预定偏振分量不同的偏振分量的光，以及将线偏振成圆偏振光的四分之一波片反射。

8. 发明授权

US08235073B2 Microfluidic valve unit for controlling flow of fluid and method of fabricating the same 有权
标题翻译：用于控制流体流动的微流控阀单元及其制造方法
公开(公告)号：US08235073B2
公开(公告)日：2012-08-07
申请号：US12555173
申请日：2009-09-08
申请人： Kak Namkoong , Won-seok Chung , Joon-ho Kim , Kyu-youn Hwang , Hee-kyun Lim
发明人： Kak Namkoong , Won-seok Chung , Joon-ho Kim , Kyu-youn Hwang , Hee-kyun Lim
IPC分类号： F15C1/04
CPC分类号： F16K99/0001 , B01L3/502707 , B01L3/502738 , B01L2400/0406 , B01L2400/0677 , F16K99/0032 , F16K99/004 , F16K2099/008 , F16K2099/0084 , Y10T29/49405 , Y10T137/218 , Y10T137/2196 , Y10T137/2202
摘要： A microfluidic valve unit for controlling the flow of fluid flowing along a channel, and a method of fabricating the same are provided. The valve unit includes a channel formed in a platform; a valve filler which includes a phase transition material that is disposed in the channel in a solid state at room temperature to close the channel and is melted when energy is applied thereto; and at least one capillary channel which extends from a sidewall of the channel and into which the valve filler flows when the valve filler is melted, wherein the at least one capillary channel has a cross-sectional area which is less than a cross-sectional area of the channel.
摘要翻译：提供一种用于控制沿着通道流动的流体的流动的微流体阀单元及其制造方法。阀单元包括形成在平台中的通道; 阀填料，其包括相变过渡材料，所述相变材料在室温下以固态设置在通道中以封闭通道，并且当施加能量时熔化; 以及至少一个毛细通道，其从所述通道的侧壁延伸并且当所述阀填充物熔化时阀填充物流动到所述毛细通道中，其中所述至少一个毛细通道的横截面积小于横截面积的频道。

9. 发明授权

US08038943B2 Method of detecting bio-molecules using field effect transistor without fixing probe bio-molecules on the gate sensing surface 有权
标题翻译：使用场效应晶体管检测生物分子的方法，而不将探针生物分子固定在栅极感测表面上
公开(公告)号：US08038943B2
公开(公告)日：2011-10-18
申请号：US11695905
申请日：2007-04-03
申请人： Kyu-tae Yoo , Kyu-sang Lee , Won-seok Chung , Jeo-young Shim , Yeon-ja Cho
发明人： Kyu-tae Yoo , Kyu-sang Lee , Won-seok Chung , Jeo-young Shim , Yeon-ja Cho
IPC分类号： G01N27/00
CPC分类号： G01N33/54373
摘要： A method of detecting a presence of bio-molecules, or a concentration of the target bio-molecules using a field effect transistor, includes allowing a first sample including a first target bio-molecule to contact a sensing surface of the field effect transistor and measuring a change in an electric signal of the field effect transistor, the field effect transistor including a substrate, a source region and a drain region, the source region and the drain region formed apart from each other on the substrate, the source region and the drain region each doped to having an opposite polarity than a polarity of the substrate, a channel region disposed between the source region and the drain region and an insulating layer including the sensing surface, the insulating layer disposed on the channel region.
摘要翻译：使用场效应晶体管检测生物分子的存在或靶生物分子的浓度的方法包括允许包含第一靶生物分子的第一样品接触场效应晶体管的感测表面并测量场效应晶体管的电信号的变化，所述场效应晶体管包括基板，源极区和漏极区，在所述基板上彼此分离形成的所述源极区和漏极区，所述源极区和漏极每个被掺杂为具有与衬底的极性相反的极性，设置在源区和漏区之间的沟道区和包括感测表面的绝缘层，绝缘层设置在沟道区上。

10. 发明授权

US07839134B2 Method and apparatus for simultaneously detecting size and concentration of ionic material 有权
标题翻译：用于同时检测离子材料的尺寸和浓度的方法和装置
公开(公告)号：US07839134B2
公开(公告)日：2010-11-23
申请号：US11619650
申请日：2007-01-04
申请人： Kyu-sang Lee , Kyu-tae Yoo , Jeo-young Shim , Won-seok Chung , Yeon-ja Cho
发明人： Kyu-sang Lee , Kyu-tae Yoo , Jeo-young Shim , Won-seok Chung , Yeon-ja Cho
IPC分类号： G01N27/00
CPC分类号： G01N27/4145 , G01N27/27
摘要： A method for simultaneously detecting a size and concentration of ionic materials includes measuring voltage drop values of at least three ionic materials of which sizes and concentrations are known using each of at least two FET-based sensors having different electrical characteristics, determining at least three points in a three-dimensional plot from the known sizes, concentrations and the measured voltage drop values, approximating the at least three points into a single plane, measuring a voltage drop value of an ionic material of which size and concentration are unknown using the at least two FET-based sensors, determining equipotential lines existing on the plane using the voltage drop value of the unknown ionic material and determining a cross point between each of the equipotential lines.
摘要翻译：用于同时检测离子材料的尺寸和浓度的方法包括测量至少三种离子材料的电压降值，其中尺寸和浓度已知使用具有不同电特性的至少两个基于FET的传感器中的每一个，确定至少三个点在已知尺寸，浓度和测量的电压降值的三维图中，将至少三个点近似为单个平面，测量其尺寸和浓度未知的离子材料的电压降值，至少使用至少两个基于FET的传感器，使用未知离子材料的电压降值确定在平面上存在的等电位线，并确定每个等电位线之间的交叉点。

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