专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US12146199B2 Methods and compositions for influenza a virus subtyping 有权
公开(公告)号：US12146199B2
公开(公告)日：2024-11-19
申请号：US17555862
申请日：2021-12-20
申请人： The United States of America, as represented by the Secretary, Dept. of Health and Human Services
发明人： Genyan Yang , Charles Todd Davis
IPC分类号： C12Q1/70 , C12Q1/6806 , C12Q1/6816 , C12Q1/686
CPC分类号： C12Q1/701 , C12Q1/6806 , C12Q1/6816 , C12Q1/686 , C12Q1/70 , C12Q2600/112 , C12Q2600/156 , C12Q2600/16 , C12Q2600/166 , C12Q1/6816 , C12Q2525/155 , C12Q2531/113 , C12Q2537/143 , C12Q2563/143 , C12Q2565/1015
摘要： Disclosed herein are methods for detecting presence of a target nucleic acid (such as an influenza virus nucleic acid) in a sample. In some embodiments, the methods include contacting the sample with a first probe capable of hybridizing to the target nucleic acid and a second probe capable of hybridizing to the target nucleic acid, contacting the resulting complex with one or more gap filling reagents, thereby producing a gap-filled target nucleic acid, isolating and amplifying the gap-filled target nucleic acid. The amplified gap-filled target nucleic acid covalently linked to the substrate is then detected, for example with a detectably labeled probe. Also disclosed herein are probes capable of hybridizing to influenza virus nucleic acids. The disclosure also includes kits for detecting and/or discriminating influenza virus nucleic acids in a sample. In some examples, the kits include two or more of the disclosed probes.

2. 发明授权

US12144856B2 Compositions and methods for enhancing immune response to vaccination and improving vaccine production 有权
公开(公告)号：US12144856B2
公开(公告)日：2024-11-19
申请号：US16738692
申请日：2020-01-09
申请人： Versitech Limited
发明人： Kwok Yung Yuen , Kai Wang Kelvin To , Shuofeng Yuan , Fuk Woo Jasper Chan , Jinxia Zhang , Fan Ngai Hung , Johnson Yiu-Nam Lau
IPC分类号： A61K39/145 , A61K8/55 , A61K9/00 , A61K31/16 , A61K31/685 , A61K39/00 , A61K39/215 , A61K47/54 , C12N7/00 , C12Q1/70 , G01N33/94
CPC分类号： A61K39/145 , A61K8/553 , A61K9/0014 , A61K31/16 , A61K31/685 , A61K39/215 , A61K47/544 , C12N7/00 , C12Q1/70 , G01N33/948 , A61K2039/55511 , C12N2760/16034 , C12N2770/20034
摘要： Miltefosine is utilized to enhance immune response to vaccination, for example an influenza and/or coronavirus vaccination. The inventive subject matter also provides compositions and methods for enhancing viral yield in cultured cells, by application of a cannabinoid receptor agonist (such as methanandamide) to such cells. Such enhanced viral yield can be used to enhance virus production for purposes of vaccine formulation and/or to improve sensitivity of cell-based virus assays.

3. 发明授权

US12139706B2 Method of nonspecific target capture of nucleic acids 有权
公开(公告)号：US12139706B2
公开(公告)日：2024-11-12
申请号：US17126693
申请日：2020-12-18
申请人： Gen-Probe Incorporated
发明人： Michael M. Becker , Mehrdad R. Majlessi
IPC分类号： C12N15/11 , C07H21/02 , C07H21/04 , C12N15/10 , C12Q1/6806 , C12Q1/6834 , C12Q1/70
CPC分类号： C12N15/11 , C07H21/02 , C07H21/04 , C12N15/1006 , C12Q1/6806 , C12Q1/6834 , C12Q1/70 , C12N2310/18 , C12N2310/31 , C12N2310/321 , C12N2310/351 , C12N2330/30 , C12Q1/6806 , C12Q2565/519 , C12Q2565/518
摘要： Methods for capturing a target nucleic acid from a sample by using a capture probe that binds nonspecifically to the target nucleic acid and binds specifically to an immobilized probe via a specific binding pair that has one member on the capture probe and one member on the immobilized probe are disclosed. Compositions that include a capture probe that binds nonspecifically to a target nucleic acid and specifically to an immobilized probe via binding of members of a specific binding pair in a solution phase of a reaction mixture are disclosed.

4. 发明公开

US20240360435A1 BLOOD CELL LYSIS REAGENT 审中-公开
公开(公告)号：US20240360435A1
公开(公告)日：2024-10-31
申请号：US18771684
申请日：2024-07-12
申请人： Gen-Probe Incorporated
发明人： Kui GAO , Jijumon CHELLISERRY , Jeffrey LINNEN
IPC分类号： C12N15/10 , C12Q1/6806 , C12Q1/70
CPC分类号： C12N15/1003 , C12Q1/6806 , C12Q1/70 , Y02A50/30
摘要： Disclosed herein are lysis reagents for lysing red blood cells, thereby releasing an analyte, such as RNA from a host or pathogen, in a form suitable for analysis. The reagent includes at least a buffer, a detergent and one or both of a chloride containing salt and an anti-coagulant. The reagent serves to lyse blood cells, protect the released analyte from degradation in the lysate, and is compatible with subsequent steps for analysis of the analyte such as target capture, amplification, detection, or sequencing.

5. 发明授权

US12129511B2 Methods for isolating target analytes from biological samples using ATPS and solid phase media 有权
公开(公告)号：US12129511B2
公开(公告)日：2024-10-29
申请号：US18463313
申请日：2023-09-08
申请人： Phase Scientific International, Ltd.
发明人： Cheuk Yiu Tenny Chung , Vasu Saini , Daniel William Bradbury , Harsha Madan Kittur , Masae Kobayashi Wen , Cheuk Yin Lam , Kar Kee Tse , Kit Cheung , Wing Yee Ng , Yin To Chiu , Garrett Lee Mosley
IPC分类号： C12Q1/6806 , C12Q1/70
CPC分类号： C12Q1/6806 , C12Q1/70
摘要： The present disclosure relates to methods, compositions, and kits for concentrating and purifying at least one target analyte from a clinical biological sample. In some embodiments, the methods involve one or more aqueous two-phase system (ATPS) compositions and at least one solid phase medium. Some embodiments provide a kit comprising one or more ATPS compositions, a binding buffer; and a solid phase medium. Other embodiments provide methods of treating cancers or infectious diseases in a patient in need thereof.

6. 发明公开

US20240352542A1 MEANS AND METHODS FOR DIAGNOSING A VIRAL INFECTION OR A DISEASE ASSOCIATED THEREWITH 审中-公开
公开(公告)号：US20240352542A1
公开(公告)日：2024-10-24
申请号：US18628273
申请日：2024-04-05
申请人： Bruker Biospin GmbH & Co. KG , Murdoch University
发明人： Julien Wist , Samuele Sala , Philipp Nitschke , Jeremy K. Nicholson , Elaine Holmes , Christoph Trautwein , Claire Cannet
IPC分类号： C12Q1/70 , C12Q1/6872 , C12Q1/6876
CPC分类号： C12Q1/70 , C12Q1/6872 , C12Q1/6876
摘要： The invention relates to the field of viral diagnosis. In particular, it is directed to a method for diagnosing a viral infection or a disease associated therewith in a subject comprising the steps of: (a) determining in a sample of said subject the amount of at least one biomarker selected from the group of 3′(,5′-di)deoxy-3′,4′-didehydro furanose derivatives of formula (I) with the exception of 3′-deoxy-3′,4′-didehydro-cytidine (ddhC); and (b) comparing the amount(s) of the at least one biomarkers determined in (a) with a reference, thereby diagnosing a viral infection.
Further, the invention is directed to a method for diagnosing a viral infection or a disease associated therewith in a subject comprising the steps of: (A) determining in a sample of said subject the amount of 3′-deoxy-3′,4′-didehydro-cytidine (ddhC); and (B) comparing the amount of the ddhC determined in (A) with a reference, thereby diagnosing a viral infection; wherein the determination in (a) is done by NMR spectroscopy and the sample of the subject is a urine sample of said subject.
The invention is also related to a diagnostic means for use in diagnosing a viral infection or a disease associated therewith, said diagnostic means comprising at least one biomarker selected from the group of 3′(,5′-di)deoxy-3′,4′-didehydro furanose derivatives of formula (I) with the exception of 3′-deoxy-3′,4′-didehydro-cytidine (ddhC), but also to a diagnostic means comprising 3′-deoxy-3′,4′-didehydro-cytidine (ddhC) for use in diagnosing a viral infection or a disease associated therewith, wherein the amount of the biomarker is determined done by NMR spectroscopy in a urine sample of a subject.
Furthermore, the invention is directed to a device for diagnosing a viral infection or a disease associated therewith in a sample of a subject and to a kit for identifying a subject suffering from a viral infection or a disease associated therewith.

7. 发明公开

US20240309435A1 METHODS FOR MEASURING AND VISUALIZING ALU RNA 审中-公开
公开(公告)号：US20240309435A1
公开(公告)日：2024-09-19
申请号：US18595259
申请日：2024-03-04
申请人： UNIVERSITY OF SOUTH FLORIDA
发明人： Hana Totary-Jain
IPC分类号： C12Q1/6841 , C12Q1/6809 , C12Q1/6876 , C12Q1/70
CPC分类号： C12Q1/6841 , C12Q1/6809 , C12Q1/6876 , C12Q1/70
摘要： The present disclosure describes methods of detecting the presence and/or the level of Alu RNA in a subject sample, using a novel competitive reverse-transcription PCR and in situ hybridization methods and reagents.

8. 发明公开

US20240309422A1 METHOD FOR DETECTING A PHAGE OR ANTIBIOTIC SENSITIVITY WITH RESPECT TO A BACTERIAL STRAIN 审中-公开
公开(公告)号：US20240309422A1
公开(公告)日：2024-09-19
申请号：US18604656
申请日：2024-03-14
申请人： COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES , UNIVERSITE GRENOBLE ALPES , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , INSTITUT POLYTECHNIQUE DE GRENOBLE
发明人： Pierre MARCOUX , Yoann ROUPIOZ , Marc ZELSMANN , Emmanuel PICARD , Larry O’CONNELL
IPC分类号： C12Q1/18 , C12M1/00 , C12M1/32 , C12Q1/70
CPC分类号： C12Q1/18 , C12M23/12 , C12M23/22 , C12M23/34 , C12M41/06 , C12Q1/70
摘要： A method for detecting a lytic activity of one or more types of phages or of the activity of one or more antibiotics with respect to a bacterial strain, the method including using a first multiwell plate, each well receiving a sample containing phages or antibiotics, making at least one deposit on a transparent area of a support, the deposit containing bacteria of the bacterial strain, applying the first plate against the support so that each sample in each well comes into contact with the deposit, for each well, determining, using the detection means, the activity or absence of activity of the phage or antibiotic with respect to the bacterial strain, taking into account the intensity of light signals transmitted through each well and/or the variation thereof over time.

9. 发明公开

US20240301517A1 A MICROFLUIDIC PIPELINE FOR ISOLATION AND ANALYSIS OF SINGLE VIRUSES 审中-公开
公开(公告)号：US20240301517A1
公开(公告)日：2024-09-12
申请号：US18590291
申请日：2024-02-28
申请人： Versitech Limited , Advanced Biomedical Instrumentation Centre Limited , Centre for Immunology & Infection Limited
发明人： Ho Cheung SHUM , Lit Man POON , Lang NAN , Man Yuk Alison LAI
IPC分类号： C12Q1/70 , B01L3/00 , C12N15/10 , C12Q1/6874 , G01N21/64
CPC分类号： C12Q1/70 , B01L3/502784 , C12N15/1096 , C12Q1/6874 , G01N21/6486 , B01L2200/0636 , B01L2300/0663 , B01L2300/0809 , B01L2400/0487
摘要： The subject invention pertains to a microfluidic pipeline which enables isolation and analysis of single viruses. Single viruses are encapsulated and manipulated within microfluidic droplets. The subject invention further pertains to the amplification of single viral genomes are amplified and confined within the droplets, followed by extraction and isolation of the single-droplet contents for sequencing analysis.

10. 发明公开

US20240301480A1 METHODS AND COMPOSITIONS FOR ANALYZING NUCLEIC ACIDS AND NUCLEASES IN A BODY FLUID AS INDICATORS OF DISEASE 审中-公开
公开(公告)号：US20240301480A1
公开(公告)日：2024-09-12
申请号：US18661301
申请日：2024-05-10
申请人： ARNA Genomics US Incorporated
发明人： Anatoliy Melnikov , George NIKITIN , Egor MELNIKOV , Charles R. CANTOR , Takeshi SANO
IPC分类号： C12Q1/6851 , C12Q1/37 , C12Q1/44 , C12Q1/6806 , C12Q1/6886 , C12Q1/70
CPC分类号： C12Q1/6851 , C12Q1/37 , C12Q1/44 , C12Q1/6806 , C12Q1/6886 , C12Q1/70
摘要： Provided herein are methods and compositions for analyzing extracellular (cell-free) nucleic acids and/or nucleases in a body fluid, to identify subjects having a disease or condition associated with a change in the amount of cell-free nucleic acids and/or nuclease activity compared to the amount of cell-free nucleic acids and/or nuclease activity in a healthy subject. The methods and compositions provided herein can be used to identify subjects having a disease such as cancer, or a disease caused by a pathogen, for example, a virus, such as SARS-CoV-2.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式