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1. 发明授权

US4707295A Bicyclooctane derivatives 失效
标题翻译：双环辛烷衍生物
公开(公告)号：US4707295A
公开(公告)日：1987-11-17
申请号：US843407
申请日：1986-03-24
申请人： Ludwig Pohl , Bernhard Scheuble , Andreas Wachtler , Reinhard Hittich , Peter Fuss
发明人： Ludwig Pohl , Bernhard Scheuble , Andreas Wachtler , Reinhard Hittich , Peter Fuss
IPC分类号： C07C1/00 , C07C13/44 , C07C17/00 , C07C23/10 , C07C23/20 , C07C41/00 , C07C43/115 , C07C43/18 , C07C45/00 , C07C47/34 , C07C49/115 , C07C67/00 , C07C69/608 , C07C253/00 , C07C255/45 , C07C255/46 , C07C313/00 , C07C317/10 , C07C317/18 , C07C317/20 , C07C317/24 , C07C317/44 , C07C317/46 , C07C323/06 , C09K19/30 , C09K19/32 , C09K19/44 , C09K19/46 , C09K19/54 , G02F1/13 , C07C23/32 , C07C69/753 , C07C121/46
CPC分类号： C07C255/00 , C07C13/44 , C07C23/20 , C09K19/321
摘要： Bicyclooctane derivatives of the formula IR.sup.1 --A.sup.1 --A.sup.2 --R.sup.2 IwhereinR.sup.1 and R.sup.2 independently of one another are each an alkyl group which has 1-12 C atoms and in which it is also possible for one or two non-adjacent CH.sub.2 groups to be replaced by O atoms and/or CO groups and/or --O13 CO groups and/or --CO--O groups and/or --CH.dbd.CH-- groups, one of the radicals R.sup.1 and R.sup.2 being also --A.sup.3 --R.sup.3,A.sup.1 is a 1,4-cyclohexylene group which is unsubstituted or substituted in the 1-position and/or 2-position and/or 3-position and/or 4-position by alkyl which has in each case 1-5 C atoms and is unsubstituted or substituted or fluorinated, and in which it is also possible for one or two non-adjacent CH.sub.2 groups to be replaced by one or two different groupings from the group --O--, --CO--, --CH.dbd.CH--, --S--, --SO-- or --SO.sub.2 --, or is substituted by F, Cl, Br, CN and/or CHO,A.sup.2 is a 1,4-bicyclo[2.2.2] octylene group,--A.sup.3 --R.sup.3 is --Cy--R.sup.3, --Ph--R.sup.3, --Cy--Ph--R.sup.3 or --Ph--Cy--R.sup.3,Cy is 1,4-cyclohexylene or one of the other groups recited for A.sup.1,Ph is 1,4-phenylene which is unsubstituted or substituted by or one two F atoms and/or CH.sub.3 groups andR.sup.3 is an alkyl group which has 1-12 C atoms and in which it is also possible for one or two non-adjacent CH.sub.2 groups to be replaced by O atoms and/or CO groups and/or O--CO groups and/or --CO--O groups and/or --CH.dbd.CH-- groupsare suitable for use as components of liquid-crystal phases for field effect and/or bistability effect displys.
摘要翻译：式I R1-A1-A2-R2 I的双环辛烷衍生物，其中R 1和R 2彼此独立地是具有1-12个C原子的烷基，并且其中一个或两个不相邻的CH 2基团也是可能的被O原子和/或CO基团和/或-O13CO基团和/或-CO-O基团和/或-CH = CH-基团取代，基团R1和R2之一也是-A3-R3， A1是未取代的或在1位和/或2位和/或3位和/或4位上被烷基取代的1,4-亚环己基，其各自为1-5个C原子和是未取代或取代或氟化的，并且其中一个或两个不相邻的CH 2基团也可以被-O - ， - CO - ， - CH = CH - ， - S，-SO-或-SO 2 - ，或被F，Cl，Br，CN和/或CHO取代，A2是1,4-双环[2.2.2]亚辛基，-A3-R3是-Cy -R3，-Ph-R3，-Cy-Ph-R3或-Ph-Cy-R3，Cy为1,4-亚环己基或为A1所列举的其它基团之一， Ph是未被取代或被两个F原子和/或CH 3基团取代的1,4-亚苯基，R 3是具有1-12个C原子的烷基，并且其中也可以有一个或两个不相邻的被O原子和/或CO基团和/或O-CO基团和/或-CO-O基团和/或-CH = CH-基团取代的CH 2基团适用于现场的液晶相的组分效果和/或双稳性效应不好。

2. 发明授权

US4614813A Process for the preparation of N-hydroxy organo imidate compounds 失效
标题翻译：制备N-羟基有机亚氨酸酯化合物的方法
公开(公告)号：US4614813A
公开(公告)日：1986-09-30
申请号：US599433
申请日：1984-04-12
申请人： Chempolil T. Mathew , Harry E. Ulmer
发明人： Chempolil T. Mathew , Harry E. Ulmer
IPC分类号： C07C259/06 , B01J31/00 , B01J31/02 , C07C67/00 , C07C239/00 , C07C259/08 , C07C259/10 , C07C313/00 , C07C317/18 , C07C317/20 , C07C317/22 , C07C323/12 , C07C119/18
CPC分类号： C07C259/06
摘要： This invention relates to a process for preparing N-hydroxyl organo imidate compounds by reacting an oxime compound with a halogenating agent and reacting the resulting 1-halosubstituted oxime compound with the alkali metal or alkaline earth metal salt of an alcohol.
摘要翻译：本发明涉及一种通过使肟化合物与卤化剂反应制备N-羟基有机亚氨酸酯化合物的方法，并使所得1-卤代肟化合物与醇的碱金属或碱土金属盐反应。

3. 发明授权

US4350706A Urea and thiourea compounds and insecticidal compositions 失效
标题翻译：尿素和硫脲化合物和杀虫组合物
公开(公告)号：US4350706A
公开(公告)日：1982-09-21
申请号：US52371
申请日：1979-06-27
申请人： Marius S. Brouwer , Arnoldus C. Grosscurt
发明人： Marius S. Brouwer , Arnoldus C. Grosscurt
IPC分类号： A01N47/34 , A01N47/36 , C07C67/00 , C07C275/54 , C07C313/00 , C07C315/04 , C07C317/18 , C07C317/20 , C07C317/22 , C07C317/28 , C07C317/30 , C07C317/32 , C07C317/40 , C07C317/42 , C07C317/46 , C07C317/48 , C07C323/19 , C07C323/32 , C07C323/44 , C07C323/65 , C07C325/00 , C07C335/26 , C07D213/30 , C07D213/40 , C07D213/75 , C07D213/81 , C07D333/16 , C07D333/18 , C07C127/22 , A01N9/20
CPC分类号： C07D213/30 , A01N47/34 , C07C275/54 , C07C317/42 , C07D213/40 , C07D213/75 , C07D213/81 , C07D333/16 , C07D333/18
摘要： The invention relates to new urea and thiourea compounds as insecticides.The compounds, after having been processed to compositions, can successfully be used to control insects in a dosage from 10 to 5000 g of active substance per hectare.
摘要翻译：本发明涉及新的脲和硫脲化合物作为杀虫剂。这些化合物在被加工成组合物后，可以成功地用于以每公顷10-5000克活性物质的剂量控制昆虫。

4. 发明申请

US20050234109A1 Beta-amyloid protein production. secretion inhibitor 失效
标题翻译： β-淀粉样蛋白生产。分泌抑制剂
公开(公告)号：US20050234109A1
公开(公告)日：2005-10-20
申请号：US10500156
申请日：2002-12-27
申请人： Takanori Yasukouchi , Masayuki Ito , Hideki Kubota , Satoru Miyauchi , Masanori Saito
发明人： Takanori Yasukouchi , Masayuki Ito , Hideki Kubota , Satoru Miyauchi , Masanori Saito
IPC分类号： C07C311/28 , C07C317/14 , C07C317/18 , C07C317/20 , C07C317/22 , C07C317/44 , C07C323/65 , C07D207/32 , C07D207/325 , C07D211/24 , C07D211/54 , C07D213/34 , C07D213/61 , C07D213/65 , C07D213/71 , C07D213/74 , C07D213/82 , C07D215/12 , C07D215/36 , C07D233/54 , C07D233/68 , C07D233/84 , C07D235/06 , C07D235/28 , C07D239/26 , C07D239/38 , C07D257/04 , C07D263/22 , C07D263/32 , C07D277/26 , C07D277/36 , C07D277/76 , C07D295/096 , C07D307/10 , C07D307/38 , C07D309/08 , C07D311/56 , C07D333/18 , C07D335/02 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/04 , C07D405/06 , A61K31/44 , A61K31/165 , A61K31/40 , C07C317/32 , C07C323/29
CPC分类号： C07D213/34 , C07D207/325 , C07D211/24 , C07D211/54 , C07D213/61 , C07D213/65 , C07D213/71 , C07D213/74 , C07D213/82 , C07D215/12 , C07D215/36 , C07D233/64 , C07D233/68 , C07D233/84 , C07D235/06 , C07D235/28 , C07D239/26 , C07D239/38 , C07D257/04 , C07D263/22 , C07D263/32 , C07D277/26 , C07D277/36 , C07D277/76 , C07D295/096 , C07D307/10 , C07D307/38 , C07D309/08 , C07D311/56 , C07D333/18 , C07D335/02 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/04 , C07D405/06
摘要： Provided are novel compounds having an inhibitory activity against production or secretion of β-amyloid protein. They embrace compounds represented by the following formula (1): and capable of being replaced with a variety of substituents; and salts thereof, and solvates of any one of them.
摘要翻译：提供了对β-淀粉样蛋白的产生或分泌具有抑制活性的新化合物。它们包括由下式（1）表示的化合物：并且能够被各种取代基取代; 及其盐，以及它们中任何一种的溶剂合物。

5. 发明授权

US5034052A Fungicidal and plant growth-regulating azolylmethyl-cyclopropyl derivatives 失效
标题翻译：杀真菌和植物生长调节性唑基甲基 - 环丙基衍生物
公开(公告)号：US5034052A
公开(公告)日：1991-07-23
申请号：US479129
申请日：1990-02-13
申请人： Klaus Stroech , Wilhelm Brandes , Stefan Dutzmann
发明人： Klaus Stroech , Wilhelm Brandes , Stefan Dutzmann
IPC分类号： C07C43/196 , A01N31/04 , A01N31/08 , A01N41/10 , A01N43/50 , A01N43/653 , C07C27/00 , C07C29/40 , C07C33/34 , C07C33/50 , C07C41/00 , C07C41/30 , C07C43/23 , C07C43/295 , C07C67/00 , C07C313/00 , C07C317/14 , C07C317/20 , C07C323/17 , C07C323/19 , C07C323/64 , C07C323/65 , C07D20060101 , C07D233/60 , C07D249/08 , C07D303/02 , C07D303/08 , C07D303/22 , C07D303/34 , C07D521/00
CPC分类号： C07D231/12 , A01N43/50 , A01N43/653 , C07C33/50 , C07D233/56 , C07D249/08 , C07D303/02
摘要： Fungicidal and plant growth-regulating azolylmethylcyclopropyl derivatives of the formula ##STR1## in which R repesents halogen, alkyl or optionally substituted phenyl, or represents the groupings --Y--R.sup.2,whereinY represents oxygen, sulphur, SO or SO.sub.2 andR.sup.2 represents optionally substituted phenyl,R.sup.1 represents hydrogen, alkyl or acyl,X represents nitrogen or a CH group,Z represents halogen, alkyl with 1 to 4 carbon atoms, alkoxy with 1 to 4 carbon atoms, alkylthio with 1 or 4 carbon atoms, halogenoalkyl with 1 or 2 carbon atoms and 1 to 5 halogen atoms, halogenoalkoxy with 1 or 2 carbon atoms and 1 to 5 halogen atoms, halogenoalkylthio with 1 or 2 carbon atoms and 1 to 5 halogen atoms or phenyl which is optionally substituted by alkyl with 1 or 2 carbon atoms and/or halogen, or represents phenoxy which is optionally substituted by alkyl with 1 or 2 carbon atoms and/or halogen andm represents the number 0, 1, 2 or 3,and addition products thereof with acids and metal salts. Intermediates therefor of the formulas ##STR2## are also new.

6. 发明授权

US4877220A Hexasubstituted cyclohexane compounds 失效
标题翻译：六取代环己烷化合物
公开(公告)号：US4877220A
公开(公告)日：1989-10-31
申请号：US114365
申请日：1987-09-11
申请人： Klaus Praefcke , Bernd Kohne , Werner Stephan
发明人： Klaus Praefcke , Bernd Kohne , Werner Stephan
IPC分类号： C07C43/18 , C07C41/00 , C07C43/20 , C07C45/00 , C07C49/76 , C07C65/21 , C07C67/00 , C07C69/013 , C07C213/00 , C07C253/00 , C07C313/00 , C07C317/20 , C07C317/22 , C07C317/44 , C07C317/46 , C07C323/17 , C07C323/20 , C07C323/56 , C07C323/62 , C07C323/65 , C07C325/00 , C07C327/24 , C07C327/26 , C07C327/28 , C07C391/00 , C07D239/26 , C07D239/34 , C07D319/06 , C07D339/08 , C09K19/30 , C09K19/34 , G02F1/137 , G02F1/139
CPC分类号： C07C317/20 , C07C323/56 , C07C327/28 , C07C391/00 , C09K19/3001
摘要： Hexasubstituted cyclohexane compounds of the formula I ##STR1## in which Z.sup.1, Z.sup.2, Z.sup.3, X.sup.1, X.sup.2, A.sup.1, A.sup.2 and A.sup.3, p, R.sup.1 and R.sup.2, m and (n+m) have the meanings given in claim 1, are suitable as components of discotic liquid-crystalline phases.
摘要翻译： PCT No.PCT / EP86 / 00780 Sec。 371日期1987年9月11日 102（e）1987年9月11日PCT PCT日期：1986年12月24日PCT公布。公开号WO87 / 04155 日本1987年7月16日。其中Z1，Z2，Z3，X1，X2，A1，A2和A3，p，R1和R2，m和（n + m）具有式I的未取代的环己烷化合物权利要求1中给出的含义适合作为盘状液晶相的组分。

7. 发明授权

US4783213A Certain 2-(2-substituted benzoyl)-4-(substituted oxy or substituted thio)-1,3-cyclohexanediones 失效
标题翻译：某些2-（2-取代苯甲酰基）-4-（取代的氧基或取代的硫代）-1,3-环己烷二酮
公开(公告)号：US4783213A
公开(公告)日：1988-11-08
申请号：US86268
申请日：1987-08-20
申请人： David L. Lee
发明人： David L. Lee
IPC分类号： C07C205/45 , A01N31/06 , A01N35/06 , A01N37/08 , A01N37/22 , A01N37/24 , A01N37/34 , A01N37/42 , A01N41/06 , A01N41/10 , A01N47/02 , C07C45/00 , C07C45/54 , C07C49/76 , C07C67/00 , C07C69/76 , C07C69/92 , C07C201/00 , C07C205/57 , C07C213/00 , C07C225/22 , C07C229/54 , C07C233/15 , C07C233/33 , C07C233/41 , C07C233/43 , C07C233/54 , C07C253/00 , C07C255/56 , C07C311/15 , C07C311/19 , C07C313/00 , C07C317/00 , C07C317/14 , C07C317/20 , C07C317/24 , C07C317/30 , C07C317/36 , C07C317/38 , C07C317/44 , C07C317/46 , C07C317/48 , C07C317/50 , C07C323/03 , C07C323/17 , C07C323/22 , C07C323/62 , C07C323/65 , A01N31/00
CPC分类号： C07C321/00 , A01N35/06 , A01N41/10 , C07C205/45 , C07C317/00 , C07C323/00 , C07C45/54 , C07C2101/14
摘要： Compounds of the formula ##STR1## wherein X is oxy, thio, sulfinyl or sulfonyl;R is halogen; C.sub.1 -C.sub.2 alkyl; C.sub.1 -C.sub.2 alkoxy; trifluoromethoxy; difluoromethoxy; nitro; cyano; C.sub.1 -C.sub.2 haloalkyl; R.sup.a SO.sub.n -- wherein n is 0 or 2 and R.sup.a is C.sub.1 -C.sub.2 alkyl, trifluoromethyl or difluoromethyl;R.sup.1 is hydrogen, C.sub.1 -C.sub.4 alkyl, phenyl or substituted phenyl;R.sup.2 is hydrogen or C.sub.1 -C.sub.4 alkyl; orR.sup.1 and R.sup.2 together are C.sub.2 -C.sub.5 alkylene;R.sup.3 is hydrogen, C.sub.1 -C.sub.4 alkyl, phenyl or substituted phenyl with the proviso that R.sup.1 and R.sup.3 are not both phenyl or substituted phenyl;R.sup.4 is hydrogen or C.sub.1 -C.sub.4 alkyl;R.sup.5 is hydrogen or C.sub.1 -C.sub.4 alkyl;R.sup.6 is hydrogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, or phenyl;R.sup.7 and R.sup.8 independently are (1) hydrogen; (2) halogen; (3) C.sub.1 -C.sub.4 alkyl; (4) C.sub.1 -C.sub.4 alkoxy; (5) trifluoromethoxy; (6) cyano; (7) nitro; (8) C.sub.1 -C.sub.4 haloalkyl; (9) R.sup.b SO.sub.n -- wherein n is the integer 0, 1 or 2; and R.sup.b is (a) C.sub.1 -C.sub.4 alkyl; (b) C.sub.1 -C.sub.4 alkyl substituted with halogen or cyano; (c) phenyl; or (d) benzyl; (10) --NR.sup.c R.sup.d wherein R.sup.c and R.sup.d independently are hydrogen or C.sub.1 -C.sub.4 alkyl; (11) R.sup.e C(O)-- wherein R.sup.e is C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.4 alkoxy; or (12) --SO.sub.2 NR.sup.c R.sup.d wherein R.sup.c and R.sup.d are as defined; and (13) --N(R.sup.c)C(O)R.sup.d wherein R.sup.c and R.sup.d are as defined; and their salts.
摘要翻译：其中X是氧基，硫基，亚磺酰基或磺酰基的式“IMAGE”的化合物; R是卤素; C1-C2烷基; C1-C2烷氧基; 三氟甲氧基二氟甲氧基硝基氰基; C1-C2卤代烷基; RaSO n-，其中n为0或2，Ra为C 1 -C 2烷基，三氟甲基或二氟甲基; R1是氢，C1-C4烷基，苯基或取代的苯基; R2是氢或C1-C4烷基; 或者R 1和R 2一起是C 2 -C 5亚烷基; R 3是氢，C 1 -C 4烷基，苯基或取代的苯基，条件是R 1和R 3不是苯基或取代的苯基; R4是氢或C1-C4烷基; R5是氢或C1-C4烷基; R6是氢，C1-C4烷基，C1-C4卤代烷基或苯基; R7和R8独立地是（1）氢; （2）卤素; （3）C 1 -C 4烷基; （4）C1-C4烷氧基; （5）三氟甲氧基; （6）氰基; （7）硝基; （8）C 1 -C 4卤代烷基; （9）RbSO n-，其中n是整数0,1或2; 并且R b是（a）C 1 -C 4烷基; （b）被卤素或氰基取代的C 1 -C 4烷基; （c）苯基; 或（d）苄基; （10）-NRcRd其中Rc和Rd独立地是氢或C1-C4烷基; （11）ReC（O） - 其中Re为C1-C4烷基或C1-C4烷氧基; 或（12）-SO 2 NR c R d其中R c和R d如所定义; 和（13）-N（R c）C（O）R d，其中R c和R d如所定义; 和它们的盐。

8. 发明授权

US2943097A Bis-sulfones by reaction of quinones with bis-sulfinic acids 失效
标题翻译：醌与双亚磺酸反应得到双砜
公开(公告)号：US2943097A
公开(公告)日：1960-06-28
申请号：US71684958
申请日：1958-02-24
申请人： AMERICAN CYANAMID CO
发明人： BEACHEM MICHAEL T
IPC分类号： C07C313/04 , C07C317/20 , C07C317/24
CPC分类号： C07C313/04 , C07C317/20 , C07C317/24 , C07C2601/14 , C07C2601/16

9. 发明申请

US20220251036A1 DIFLUOROHALOALLYLAMINE SULFONE DERIVATIVE INHIBITORS OF LYSYL OXIDASES, METHODS OF PREPARATION, AND USES THEREOF 有权
公开(公告)号：US20220251036A1
公开(公告)日：2022-08-11
申请号：US17629543
申请日：2020-07-24
申请人： PHARMAXIS LTD.
发明人： Dieter Wolfgang HAMPRECHT , Alison Dorothy FINDLAY , Craig Ivan TURNER , Mandar DEODHAR , Angelique Elsa GRECO , Wolfgang JAROLIMEK , Wenbin ZHOU
IPC分类号： C07C317/32 , C07C317/28 , C07C317/20 , C07D279/12 , C07D215/36 , C07C317/36 , C07B59/00 , C07B45/04 , C07D209/48 , C07D295/116 , C07D307/64 , C07D333/34
摘要： The present invention relates to methods for preparing a variety of difluorohaloallylamine derivatives. The present invention also relates to novel difluorohaloallylamine derivatives that are capable of inhibiting certain amine oxidase enzymes. These compounds are useful for the treatment of a variety of indications, e.g., fibrosis, cancer and/or scarring in human subjects as well as in pets and livestock. In addition, the present invention relates to pharmaceutical compositions containing these compounds, as well as uses thereof.

10. 发明授权

US09771320B2 Carbocyclic sulfone RORγ modulators 有权
公开(公告)号：US09771320B2
公开(公告)日：2017-09-26
申请号：US15109741
申请日：2015-01-05
申请人： BRISTOL-MYERS SQUIBB COMPANY
发明人： Jingwu Duan , T. G. Murali Dhar , Bin Jiang , Zhonghui Lu , Ananta Karmakar , Arun Kumar Gupta , Carolyn A. Weigelt
IPC分类号： C07C317/14 , C07D213/81 , C07D401/04 , C07D237/08 , C07C317/20 , C07C317/30 , C07C317/46 , C07D471/04 , C07D213/30 , C07D213/56 , C07D309/04 , C07D309/14 , C07D317/44 , C07D231/12 , C07D239/38 , C07D241/12 , C07D471/10 , C07D257/04 , C07D261/08 , C07D263/32 , C07D271/06 , C07D211/36 , C07D295/16 , C07D295/20 , C07D303/06 , C07D305/14 , C07D205/04 , C07D211/62 , C07D213/40 , C07D213/75 , C07D295/155 , C07D295/108 , C07D319/20 , C07D285/06 , C07D295/18 , C07D295/22 , C07D303/34 , C07C317/22 , C07C317/44 , C07C317/32 , C07C317/50 , C07D213/85 , C07D295/185
CPC分类号： C07C317/14 , C07C317/20 , C07C317/22 , C07C317/30 , C07C317/32 , C07C317/44 , C07C317/46 , C07C317/50 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C07C2602/08 , C07D205/04 , C07D211/36 , C07D211/62 , C07D213/30 , C07D213/40 , C07D213/56 , C07D213/75 , C07D213/81 , C07D213/85 , C07D231/12 , C07D237/08 , C07D239/38 , C07D241/12 , C07D257/04 , C07D261/08 , C07D263/32 , C07D271/06 , C07D285/06 , C07D295/108 , C07D295/155 , C07D295/18 , C07D295/185 , C07D295/20 , C07D295/22 , C07D303/06 , C07D303/34 , C07D305/14 , C07D309/04 , C07D309/14 , C07D317/44 , C07D319/20 , C07D401/04 , C07D471/04 , C07D471/10
摘要： Described are RORγ modulators of the formula (I), or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein all substituents are defined herein. Also provided are pharmaceutical compositions comprising the same. Such compounds and compositions are useful in methods for modulating RORγ activity in a cell and methods for treating a subject suffering from a disease or disorder in which the subject would therapeutically benefit from modulation of RORγ activity, for example, autoimmune and/or inflammatory disorders.

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