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1. 发明授权

US09242948B2 Diepoxy compound, process for producing same, and composition containing the diepoxy compound 有权
标题翻译：二环氧化合物，其制备方法和含有二环氧化合物的组合物
公开(公告)号：US09242948B2
公开(公告)日：2016-01-26
申请号：US13390705
申请日：2010-08-26
申请人： Taku Asaumi , Makoto Itagaki
发明人： Taku Asaumi , Makoto Itagaki
IPC分类号： C07C69/88 , C07D301/27 , C07D303/12 , C07D303/32 , C07D301/28 , C07C67/08 , C07C67/31 , C07D303/22 , C07D303/28 , C07D303/30 , C07D303/40 , C08G59/22 , C08L63/00
CPC分类号： C07D301/28 , C07C67/08 , C07C67/31 , C07C2601/14 , C07D303/22 , C07D303/28 , C07D303/30 , C07D303/40 , C08G59/22 , C08L63/00 , C07C69/92 , C07C69/84
摘要： A diepoxy compound represented by the formula (1) wherein R1, R2, R3 and R4 independently each represent a hydrogen atom or an alkyl group having 1 to 3 carbon atoms.
摘要翻译：由式（1）表示的二环氧化合物，其中R 1，R 2，R 3和R 4各自独立地表示氢原子或具有1至3个碳原子的烷基。

2. 发明授权

US09133150B2 O-nitro compounds and pharmaceutical compositions including same 有权
标题翻译： O-硝基化合物和包含它们的药物组合物
公开(公告)号：US09133150B2
公开(公告)日：2015-09-15
申请号：US13951720
申请日：2013-07-26
申请人： Orbital ATK, Inc.
发明人： Mark D. Bednarski , Susan Knox , Louis F. Cannizzo , Kirstin F. Warner , Robert B. Wardle , Stephen P. Velarde , Shoucheng Ning
IPC分类号： C07D307/02 , C07D305/00 , C07D407/00 , C07D493/00 , A01N43/02 , A61K31/335 , C07D303/22 , A61K31/21 , A61K31/336 , A61K31/38 , A61K31/395 , A61K45/06
CPC分类号： C07D303/22 , A61K31/21 , A61K31/336 , A61K31/38 , A61K31/395 , A61K45/06
摘要： The present invention provides O-nitro compounds, pharmaceutical compositions of O-nitro compounds and methods of using O-nitro compounds and/or pharmaceutical compositions thereof to treat or prevent diseases or disorders characterized by abnormal cell proliferation, such as cancer, inflammation, cardiovascular disease and autoimmune disease.
摘要翻译：本发明提供O-硝基化合物，O-硝基化合物的药物组合物和使用O-硝基化合物和/或其药物组合物的方法来治疗或预防以异常细胞增殖为特征的疾病或病症，例如癌症，炎症，心血管疾病和自身免疫性疾病。

3. 发明授权

US08889840B2 Vascular leakage inhibitor 有权
标题翻译：血管渗漏抑制剂
公开(公告)号：US08889840B2
公开(公告)日：2014-11-18
申请号：US13504368
申请日：2010-10-29
申请人： Young-Guen Kwon , Young-Ger Suh
发明人： Young-Guen Kwon , Young-Ger Suh
IPC分类号： C07J41/00 , C07J17/00 , A01N45/00 , A61K31/59 , A61K31/58 , A61K31/56 , C07D309/12 , C07D239/34 , C07D309/30 , C07D309/10 , C07D303/22
CPC分类号： C07D309/12 , C07D239/34 , C07D303/22 , C07D309/10 , C07D309/30 , C07J9/00 , C07J9/005 , C07J17/00 , C07J17/005 , C07J31/006 , C07J41/0055 , C07J43/003
摘要： The present disclosure relates to a novel vascular leakage inhibitor. The novel vascular leakage inhibitor of the present disclosure inhibits the apoptosis of vascular endothelial cells, inhibits the formation of actin stress fibers induced by VEGF, enhances the cortical actin ring structure, and improves the stability of the tight junctions (TJs) between vascular cells, thereby inhibiting vascular leakage. The vascular leakage inhibitor of the present disclosure has the activity of not only reducing vascular permeability but also recovering the integrity of damaged blood vessels. Accordingly, the vascular leakage inhibitor of the present disclosure can prevent or treat various diseases caused by vascular leakage. Since the vascular leakage inhibitor of the present disclosure is synthesized from commercially available or easily synthesizable cholesterols, it has remarkably superior feasibility of commercial synthesis.
摘要翻译：本公开涉及一种新型血管渗漏抑制剂。本公开的新型血管渗漏抑制剂抑制血管内皮细胞的凋亡，抑制由VEGF诱导的肌动蛋白应激纤维的形成，增强皮层肌动蛋白环结构，并改善血管细胞之间紧密连接（TJ）的稳定性，从而抑制血管渗漏。本公开的血管渗漏抑制剂具有不仅降低血管渗透性，而且恢复受损血管完整性的活性。因此，本公开的血管渗漏抑制剂可以预防或治疗由血管渗漏引起的各种疾病。由于本公开的血管渗漏抑制剂由市售或容易合成的胆固醇合成，因此具有商业合成的显着优异的可行性。

4. 发明授权

US07714153B2 Curable diamantane compound 失效
标题翻译：可固化的金刚烷化合物
公开(公告)号：US07714153B2
公开(公告)日：2010-05-11
申请号：US11664290
申请日：2005-09-29
申请人： Takayuki Maehara
发明人： Takayuki Maehara
IPC分类号： C07D303/20 , C07D303/22 , C07D305/06
CPC分类号： C08G65/18 , C07D303/30 , C07D305/06 , C08G59/1405 , C08G59/226 , C08G59/24 , C08G59/3218 , C08G59/38
摘要： A 4,9-bis(glycidyloxy)diamantane and a 4,9-bis[(3-ethyloxetane-3-yl)methyloxy]diamantane are novel curable diamantane compounds, and cured bodies thereof are useful as encapsulants exhibiting excellent light resistance and heat resistance, and can be favorably used, for example, as encapsulants for near ultraviolet LEDs and white LEDs.
摘要翻译： 4,9-双（缩水甘油氧基）二金刚烷和4,9-双[（3-乙基氧杂环丁烷-3-基）甲氧基]二金刚烷是新型可固化的二金刚烷化合物，其固化体可用作表现出优异的耐光性和耐热性的密封剂并且可以有利地用作例如近紫外LED和白色LED的密封剂。

5. 发明申请

US20050256236A1 Pumpable composition comprising tricyclodecanedimethylol 审中-公开
标题翻译：包含三环癸烷二羟甲基的可泵送组合物
公开(公告)号：US20050256236A1
公开(公告)日：2005-11-17
申请号：US11126182
申请日：2005-05-11
申请人： Lars Wittkowski , Rainer Papp
发明人： Lars Wittkowski , Rainer Papp
IPC分类号： C08L33/00 , C07C43/178 , C07D303/22 , C07D303/24 , C08F220/00 , C08K5/053 , C08L63/00 , C08F20/06
CPC分类号： C07D303/22 , C07C43/1781 , C08F220/00
摘要： Composition comprising tricyclodecanedimethylol and at least one polymerizable compound, preferably selected from (meth)acrylic acid, esters thereof, O— and N-vinyl compounds, epichlorohydrin, C1— to C10-alkylene oxides, in a ratio of from 100:1 to 1:1.
摘要翻译：包含三环癸烷基二羟甲基和至少一种可聚合化合物的组合物，优选选自（甲基）丙烯酸，其酯，O-和N-乙烯基化合物，表氯醇，C 1至C 10，亚烷基氧化物的比例为100:1至1:1。

6. 发明申请

US20050244734A1 Azine-based charge transport materials having two reactive rings 失效
标题翻译：具有两个反应性环的基于Azine的电荷传输材料
公开(公告)号：US20050244734A1
公开(公告)日：2005-11-03
申请号：US10834656
申请日：2004-04-29
申请人： Zbigniew Tokarski , Nusrallah Jubran , Vytautas Getautis , Vygintas Jankauskas , Tadas Malinauskas , Edmundas Montrimas
发明人： Zbigniew Tokarski , Nusrallah Jubran , Vytautas Getautis , Vygintas Jankauskas , Tadas Malinauskas , Edmundas Montrimas
IPC分类号： G03G5/04 , C07D303/22 , C07D303/30 , G03G5/06 , G03G5/00 , C07C251/72 , C07D209/82
CPC分类号： C07D303/30 , C07D303/22 , G03G5/0601 , G03G5/0603 , G03G5/0605 , G03G5/0609 , G03G5/0614 , G03G5/0616 , G03G5/0618 , G03G5/062 , G03G5/0625
摘要： An improved organophotoreceptor comprises an electrically conductive substrate and a photoconductive element on the electrically conductive substrate, the photoconductive element comprising: (a) a charge transport material having the formula where X and X′ are, each independently, a linking group; Ar comprises an aromatic group; R1, R2, and R3 comprise, each independently, H, an alkyl group, an alkenyl group, an alkynyl group, an aromatic group, or a heterocyclic group; and E1 and E2 are, each independently, a reactive ring group; and (b) a charge generating compound. Corresponding electrophotographic apparatuses, imaging methods, and a polymeric charge transport material prepared from the charge transport material above are described.
摘要翻译：一种改进的有机光感受器包括在导电衬底上的导电衬底和光电导元件，光电导元件包括：（a）具有下式的电荷传输材料，其中X和X'各自独立地为连接基团; Ar包含芳族基团; R 1，R 2和R 3各自独立地包括H，烷基，烯基，炔基，芳族基团或杂环基团; 和E 1和E 2各自独立地为反应性环基团; 和（b）电荷产生化合物。描述了相应的电子照相设备，成像方法和由上述电荷输送材料制备的聚合物电荷传输材料。

7. 发明授权

US06960418B2 Organophotoreceptor with charge transport material with two N,N,N-trisubstituted-amino groups 失效
标题翻译：具有两个N，N，N-三取代 - 氨基的电荷转运材料的有机光感受器
公开(公告)号：US06960418B2
公开(公告)日：2005-11-01
申请号：US10692389
申请日：2003-10-23
申请人： Nusrallah Jubran , Zbigniew Tokarski , Vytautas Getautis , Osvaldas Paliulis , Valentas Gaidelis , Edmundas Montrimas
发明人： Nusrallah Jubran , Zbigniew Tokarski , Vytautas Getautis , Osvaldas Paliulis , Valentas Gaidelis , Edmundas Montrimas
IPC分类号： C07D303/22 , C07D303/23 , G03G5/05 , G03G5/06 , G03G9/12 , C07D303/12 , C07D303/36 , G03G15/10
CPC分类号： G03G5/0609 , C07D303/22 , G03G5/0614 , G03G5/0625
摘要： Improved organophotoreceptor comprises an electrically conductive substrate and a photoconductive element on the electrically conductive substrate, the photoconductive element comprising: (a) a charge transport material having the formula where R1, R2, R3, and R4 are, independently, an alkyl group, an alkaryl group, or an acyl group; Y is an alkyl group, alkaryl group, or aryl group; X is a linking group having the formula —(CH2)m—, branched or linear, where in is an integer between 1 and 20, inclusive, and one or more of the methylene groups is optionally replaced by O, S, C═O, O═S═O, a heterocyclic group, an aromatic group, urethane, urea, an ester group, a NR3 group, a CHR4 group, or a CR5R6 group where R3, R4, R,5 and R6 are, independently, H, hydroxyl group, thiol group, an alkyl group, an alkaryl group, a heterocyclic group, or an aryl group; and E is an epoxy group; and (b) a charge generating compound.
摘要翻译：改进的有机光感受器包括在导电衬底上的导电衬底和光电导元件，光电导元件包括：（a）具有下式的电荷传输材料：其中R 1，R 2， R 3，R 3和R 4独立地是烷基，烷芳基或酰基; Y是烷基，烷芳基或芳基; X是具有下式的连接基团：其中in为1〜20的整数，包括1和20的整数，和一个或多个的亚甲基任选被O，S，CO，OSO，杂环基，芳基，氨基甲酸酯，脲，酯基，NR 3基，CHR 4 其中R 3，R 4，R 3，R 3，R 3，R 3， R 5和R 6独立地为H，羟基，硫醇基，烷基，烷芳基，杂环基或芳基; E为环氧基; 和（b）电荷产生化合物。

8. 发明申请

US20050228062A1 Incorporable photoinitiator 有权
标题翻译：可并入的光引发剂
公开(公告)号：US20050228062A1
公开(公告)日：2005-10-13
申请号：US10512300
申请日：2003-04-17
申请人： Jean-Pierre Wolf , Rinaldo Husler , Wolfgang Peter , Reinhard Sommerlade , Souad Boulmaaz
发明人： Jean-Pierre Wolf , Rinaldo Husler , Wolfgang Peter , Reinhard Sommerlade , Souad Boulmaaz
IPC分类号： C07D303/22 , C07C69/716 , C07C271/20 , C07C275/62 , C08F2/50 , C08G2/00
CPC分类号： C08F2/50 , B33Y70/00
摘要： Compounds of formula (I), wherein Y is, for example, C3-C,12alkylene, butenylene, butynylene, or C4-C,12alkylene interrupted one or more times by non-consecutive —O— or —NR2—; R1 is a reactive group selected from OH, SH, NR3R4, —(CO)—OH, —(CO)—NH2, SO3H, —C(R5)═CR6R7, oxiranyl, —O—(CO)—NH—R8—NCO and —O—(CO)—R9—(CO)—X; R2 is hydrogen, C1-C4alkyl or C2-C4 hydroxyalkyl; R3 and R4 are each independently of the other hydrogen, C1-C4alkyl or C2-C4hydroxyalkyl; R5, R6 and R7 are each independently of the others hydrogen or methyl; R8 is, for example, linear or branched C4-C12alkylene, or phenylene; R9 is, for example, linear branched C1-C16alkylene, —CH═CH—, —CH═CH—CH2—, C6-cycloalkylene, phenylene or naphthylene; and X, X1 and X2 are each independently of the others OH, Cl, OCH3 or OC2H5; are suitable as photoinitiators that can be incorporated in a formulation to be cured.
摘要翻译：式（I）的化合物，其中Y为例如C 3 -C 12亚烷基，亚丁烯基，亚丁炔基或C 4-14亚烷基， C 1 -C 12亚烷基被非连续的-O-或-NR 2 - 2间隔一次或多次; R 1是选自OH，SH，NR 3 R 4， - （CO）-OH， - （CO） - NH 2，SO 3 H，-C（R 5） - CR 6 R 7， /（CO）-NH-R 8 -NCO和-O-（CO）-R 9 - （CO）-X; R 2是氢，C 1 -C 4烷基或C 2 -C 4烷基或C 2 -C 4 - 羟基烷基; R 3和R 4分别独立地为氢，C 1 -C 4烷基或C 1 -C 4烷基， S 2 -C 4羟烷基; R 5，R 6和R 7各自独立地为氢或甲基; R 8是例如直链或支链C 4 -C 12亚烷基或亚苯基; R 9是例如直链支链C 1 -C 16亚烷基，-CH-CH-，-CH-CH-CH 3，亚磺酰基，亚苯基或亚萘基; 和X，X 1和X 2各自独立地为OH，Cl，OCH 3或OC 2

9. 发明申请

US20050169881A1 Tnp-470 polymer conjugates and use thereof 有权
标题翻译： Tnp-470聚合物共轭物及其用途
公开(公告)号：US20050169881A1
公开(公告)日：2005-08-04
申请号：US10511009
申请日：2003-04-10
申请人： Ronit Satchi-Fainaro , Judah Folkman
发明人： Ronit Satchi-Fainaro , Judah Folkman
IPC分类号： A61K31/785 , A61K39/395 , A61K45/00 , A61K47/48 , A61P9/00 , A61P35/00 , C07D303/22
CPC分类号： C08L53/00 , A61K47/58 , C07D303/22 , C08F220/56 , C08F220/58 , C08L2666/02
摘要： The present invention relates to conjugates of water-soluble polymers and o(chloracetyl-carbamoyl) fumagillol (TNP-470) and use of those conjugates as specific intracellular carriers of the TNP-470 into tumor vessels. The present invention further relates to use of those conjugates to lower the neurotoxicity of TNP-470. Preferably, the polymer has a molecular weight in the range of 100 Da to 800 kDa. More preferably, the polymer has a molecular weight no greater than 60 kDa. Most preferably, the polymer has a molecular weight in the range of 15 kDa to 40 kDa.
摘要翻译：本发明涉及水溶性聚合物和o（氯乙酰基 - 氨基甲酰基）烟曲霉醇（TNP-470）的缀合物，并将这些缀合物作为TNP-470的特异性细胞内载体用于肿瘤血管。本发明还涉及这些缀合物降低TNP-470的神经毒性的用途。优选地，聚合物的分子量在100Da至800kDa的范围内。更优选地，聚合物的分子量不大于60kDa。最优选地，聚合物的分子量在15kDa至40kDa的范围内。

10. 发明申请

US20050104042A1 Process for the synthesis of amine ethers from secondary amino oxides 审中-公开
标题翻译：从仲氨基氧化物合成胺醚的方法
公开(公告)号：US20050104042A1
公开(公告)日：2005-05-19
申请号：US10496773
申请日：2002-11-19
申请人： Markus Frey , Valerie Rast
发明人： Markus Frey , Valerie Rast
IPC分类号： C07D491/20 , C07B61/00 , C07C239/20 , C07D211/94 , C07D295/24 , C07D303/22 , C07D401/12 , C07D401/14 , C07D405/12 , C07D491/10 , C07D493/10 , C07D498/04 , C08F2/38 , C08F4/00 , C08K5/34 , C08K5/3435 , C08K5/3492 , C09K15/20 , C09K15/30 , C09K15/04 , C07C215/00
CPC分类号： C07D295/24 , C07D211/94 , C07D303/22 , C07D401/14 , C07D491/10 , C08F4/00 , C08K5/34 , C09K15/20 , C09K15/30
摘要： Amine ethers of sterically hindered amines are obtained in good yield from the corresponding N-oxyl hindered amine precursor by reaction with a hydrocarbon in the presence of an organic hydroperoxide and an iodide. The products of present process find utility as polymerization regulators and/or light stabilizers for organic material.
摘要翻译：通过与有机氢过氧化物和碘化物存在下的烃反应，从相应的N-氧基受阻胺前体以良好的收率获得空间位阻胺的胺醚。本发明的产品可用作有机材料的聚合调节剂和/或光稳定剂。

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