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1. 发明申请

US20180030012A1 METHOD FOR THE EPOXIDATION OF AN OLEFIN WITH HYDROGEN PEROXIDE 审中-公开
公开(公告)号：US20180030012A1
公开(公告)日：2018-02-01
申请号：US15550872
申请日：2016-02-03
申请人： Evonik Degussa GmbH
发明人： Jürgen Stock , Joao ANDRÉ , Sebastian IMM , Matthias PASCALY
IPC分类号： C07D301/12 , B01D61/02 , C07D303/02
CPC分类号： C07D301/12 , B01D61/027 , B01J23/34 , C07C11/04 , C07C11/06 , C07C21/067 , C07D303/02
摘要： In the method for the epoxidation of an olefin, the olefin is continuously reacted with hydrogen peroxide in a mixed reactor in the presence of a water soluble epoxidation catalyst, comprising a manganese complex, the reaction is carried out in a reaction mixture comprising an aqueous liquid phase and an organic liquid phase with mixing of the liquid phases, reaction mixture is continuously withdrawn from the mixed reactor and separated into a separated aqueous phase and a separated organic phase, and part of the separated aqueous phase is continuously recycled into the mixed reactor, with the combined hold-up time of aqueous phase in withdrawing, separating phases and recycling aqueous phase being kept at less than 15 minutes.

2. 发明授权

US08664412B2 Epoxidation process 有权
标题翻译：环氧化工艺
公开(公告)号：US08664412B2
公开(公告)日：2014-03-04
申请号：US13811283
申请日：2011-07-14
申请人： Jan-Karel Frederik Buijink
发明人： Jan-Karel Frederik Buijink
IPC分类号： C07D301/02
CPC分类号： C07D303/02 , B01J21/06 , B01J37/0201 , B01J37/0213 , B01J37/0238 , B01J37/10 , B01J2229/32 , B01J2229/36
摘要： The present invention relates to an epoxidation process for the preparation of alkylene oxide comprising contacting a hydroperoxide with an olefin in the presence of a catalyst, wherein the catalyst is a titanium containing catalyst obtainable by a method comprising the steps of (a) making a support by a method comprising reacting a silicate with water in the presence of a surfactant selected from block copolymers based on ethylene oxide (EO) and propylene oxide (PO), and calcining the obtained reaction product; and (b) impregnating the support of step (a) with a titanium containing agent.
摘要翻译：本发明涉及用于制备环氧烷的环氧化方法，包括在催化剂存在下使氢过氧化物与烯烃接触，其中催化剂是含钛催化剂，其可通过以下方法获得，所述方法包括以下步骤：（a）通过包括在选自基于环氧乙烷（EO）和环氧丙烷（PO）的嵌段共聚物的表面活性剂存在下使硅酸盐与水反应的方法，并煅烧所得反应产物; 和（b）用含钛剂浸渍步骤（a）的载体。

3. 发明授权

US08541555B2 Hydrazone-based and oxime-based fluorescent and chromophoric/pro-fluorescent and pro-chromophoric reagents and linkers 有权
标题翻译：腙基和肟基荧光和发色/前荧光和原色发色试剂和接头
公开(公告)号：US08541555B2
公开(公告)日：2013-09-24
申请号：US11787932
申请日：2007-04-18
申请人： David A. Schwartz , Leopoldo Mendoza
发明人： David A. Schwartz , Leopoldo Mendoza
IPC分类号： C07K16/00 , C07H21/04 , C07D235/02
CPC分类号： G01N33/582 , C07D303/02
摘要： Conjugationally extended hydrazine compositions of the formula (RR2)N(H)n(NH2)n, fluorescent hydrazone compositions of the formula (RR2)NN═C(R1R2), methods of the formation of hydrazones from the reaction of conjugationally extended hydrazines with conjugationally extended carbonyls and methods of their use in assays systems are described. Use of these conjugationally extended hydrazine and oxime compositions for direct calorimetric and fluorometric assays wherein a chromophore or the fluorophore is incorporated into the linker that is positioned between a reactive linking moiety and a biotin molecule. More specifically the linker comprises one molecule of a high affinity binding pair such as for example biotin of the biotin/avidin high affinity binding pair, connected to a spacer molecule such as for example a length of polyethyleneglycol followed by a pro-chromophoric, chromophoric, pro-fluorescent or fluorescent moiety connected to an amino-, thiol- or carbohydrate-reactive moiety such as for example succinimidyl, maleimido or aminoxy group respectively, that may covalently link to a biomolecule.
摘要翻译：式（RR2）N（H）n（NH2）n的共轭延伸的肼组合物，式（RR2）NN = C（R1R2）的荧光腙组合物，从共轭延伸的肼与描述了缀合扩展的羰基及其在测定系统中的用途。使用这些共轭延伸的肼和肟组合物用于直接量热和荧光测定，其中发色团或荧光团被引入位于反应性连接部分和生物素分子之间的连接体中。更具体地，接头包含一个高亲和力结合对分子，例如生物素/抗生物素蛋白高亲和力结合对的生物素，连接到间隔分子，例如长度的聚乙二醇，随后是发色团，发色团，分别连接到可以共价连接到生物分子的氨基，硫醇或碳水化合物反应性部分的前荧光或荧光部分，例如琥珀酰亚胺基，马来酰亚胺基或氨氧基。

4. 发明申请

US20090299104A1 CATALYST FOR PARTIAL OXIDATION OF OLEFIN, PREPARATION METHOD THEREOF, AND PROCESS FOR PREPARING ALKYLENE OXIDE 有权
标题翻译：用于部分氧化烯烃的催化剂，其制备方法和制备氧化亚烷基的方法
公开(公告)号：US20090299104A1
公开(公告)日：2009-12-03
申请号：US12298978
申请日：2007-05-01
申请人： Masahide Shima , Masafumi Sugio , Tatsuya Kawabata
发明人： Masahide Shima , Masafumi Sugio , Tatsuya Kawabata
IPC分类号： C07C29/04 , B01J21/12
CPC分类号： C07D301/10 , B01J21/04 , B01J21/12 , B01J23/66 , B01J35/0006 , B01J37/0201 , B01J37/08 , C07D301/02 , C07D303/02 , C07D303/04 , Y02P20/52
摘要： A catalyst for partial oxidation of olefin, which comprises silver or silver oxide and an alkali metal or a compound thereof supported on an α-alumina carrier containing silicon or a compound thereof, wherein the silicon or the compound thereof exists at a position substantially identical to that of a particle of the alkali metal or the compound thereof, a preparation method thereof, and a process for preparing olefin oxide which comprises subjecting olefin to vapor-phase oxidation with a molecular oxygen-containing gas in the presence of the catalyst.
摘要翻译：一种用于部分氧化烯烃的催化剂，其包含银或氧化银及其负载在含有硅或其化合物的α-氧化铝载体上的碱金属或其化合物，其中硅或其化合物存在于与碱金属或其化合物的颗粒，其制备方法和制备烯烃氧化物的方法，其包括在催化剂存在下用含分子氧的气体对烯烃进行气相氧化。

5. 发明授权

US06566541B2 Type 2 methionine aminopeptidase (MetAP2) inhibitors and uses thereof 失效
标题翻译： 2型甲硫氨酸氨基肽酶（MetAP2）抑制剂及其用途
公开(公告)号：US06566541B2
公开(公告)日：2003-05-20
申请号：US09813555
申请日：2001-03-21
申请人： Jun O. Liu , Eric C. Griffith , Zhuang Su
发明人： Jun O. Liu , Eric C. Griffith , Zhuang Su
IPC分类号： C07D30308
CPC分类号： C07D495/04 , C07D303/02 , C07D303/14
摘要： Novel compounds that are anti-angiogenic or immunosuppressive are described. Also described are methods for determining if an animal is at risk for a disease involving abnormal angiogenesis or an immune reaction resulting in pathology comprising evaluating an aspect of MetAP2 metabolism or structure; methods for identifying agents that are anti-angiogenic or immunosuppressive comprising evaluating the effect of the agent on an aspect of MetAP2 metabolism; methods for treating a cell having an abnormality in metabolism or structure of MetAP2; and methods for treating abnormal angiogenesis or an immune reaction which results in pathology in an animal. Pharmaceutical compositions are also provided.
摘要翻译：描述了抗血管生成或免疫抑制的新型化合物。还描述了用于确定动物是否处于涉及异常血管发生的疾病或导致病理学的免疫反应的风险的方法，包括评估MetAP2代谢或结构的一个方面; 用于鉴定抗血管生成或免疫抑制剂的试剂的方法，包括评估试剂在MetAP2代谢方面的作用; 用于治疗MetAP2的代谢异常或结构异常的细胞的方法; 以及用于治疗导致动物病理学的异常血管生成或免疫反应的方法。还提供药物组合物。

6. 发明申请

US20010034455A1 Type 2 methionine aminopeptidase (MetAP2) inhibitors and uses thereof 失效
标题翻译： 2型甲硫氨酸氨基肽酶（MetAP2）抑制剂及其用途
公开(公告)号：US20010034455A1
公开(公告)日：2001-10-25
申请号：US09813555
申请日：2001-03-21
发明人： Jun O. Liu , Eric C. Griffith , Zhuang Su
IPC分类号： C07D303/36
CPC分类号： C07D495/04 , C07D303/02 , C07D303/14
摘要： Novel compounds that are anti-angiogenic or immunosuppressive are described. Also described are methods for determining if an animal is at risk for a disease involving abnormal angiogenesis or an immune reaction resulting in pathology comprising evaluating an aspect of MetAP2 metabolism or structure; methods for identifying agents that are anti-angiogenic or immunosuppressive comprising evaluating the effect of the agent on an aspect of MetAP2 metabolism; methods for treating a cell having an abnormality in metabolism or structure of MetAP2; and methods for treating abnormal angiogenesis or an immune reaction which results in pathology in an animal. Pharmaceutical compositions are also provided.
摘要翻译：描述了抗血管生成或免疫抑制的新型化合物。还描述了用于确定动物是否处于涉及异常血管发生的疾病或导致病理学的免疫反应的风险的方法，包括评估MetAP2代谢或结构的一个方面; 用于鉴定抗血管生成或免疫抑制剂的试剂的方法，包括评估试剂在MetAP2代谢方面的作用; 用于治疗MetAP2的代谢异常或结构异常的细胞的方法; 以及用于治疗导致动物病理学的异常血管生成或免疫反应的方法。还提供药物组合物。

7. 发明授权

US4911746A 1-hydroxyethyl-azole compounds and agricultural compositions 失效
公开(公告)号：US4911746A
公开(公告)日：1990-03-27
申请号：US732191
申请日：1985-05-08
申请人： Graham Holmwood , Karl H. Buchel , Klaus Lurssen , Paul-Ernst Frohberger , Wilhelm Brandes
发明人： Graham Holmwood , Karl H. Buchel , Klaus Lurssen , Paul-Ernst Frohberger , Wilhelm Brandes
IPC分类号： A01N20060101 , A01N43/20 , A01N43/50 , A01N43/64 , A01N43/653 , C07D20060101 , C07D233/60 , C07D249/08 , C07D301/00 , C07D301/02 , C07D303/02 , C07D303/04 , C07D303/08 , C07D303/20 , C07D303/22 , C07D521/00
CPC分类号： A01N43/50 , A01N43/653 , C07D231/12 , C07D233/56 , C07D249/08 , C07D303/02 , C07D303/04 , C07D303/08 , C07D303/22
摘要： New 1-hydroxyethyl-azole derivatives of the general formula ##STR1## in which R represents an alkyl radical, an optionally substituted cycloalkyl radical or an optionally substituted phenyl radical,X represents a nitrogen atom or a CH group,Y represents a grouping --OCH.sub.2 --, --CH.sub.2 CH.sub.2 --or --CH.dbd.CH--,Z represents a halogen atom, an alkyl, cycloalkyl, alkoxy, alkylthio, halogenoalkyl, halogenoalkoxy or halogenoalkylthio radical, an optionally substituted phenyl radical, an optionally substituted phenoxy radical, an optionally substituted phenylalkyl radical or an optionally substituted phenylalkoxy radical andm is 0, 1, 2 or 3, a process for their preparation and their use as plant growth regulators and fungicides.

8. 发明授权

US4904298A 1-Hydroxyethyl-azole compounds and agricultural compositions 失效
标题翻译： 1-羟基乙基 - 唑类化合物和农业组合物
公开(公告)号：US4904298A
公开(公告)日：1990-02-27
申请号：US58479
申请日：1987-06-05
申请人： Graham Holmwood , Karl H. Buchel , Klaus Lurssen , Paul-Ernst Frohberger , Wilhelm Brandes
发明人： Graham Holmwood , Karl H. Buchel , Klaus Lurssen , Paul-Ernst Frohberger , Wilhelm Brandes
IPC分类号： A01N20060101 , A01N43/20 , A01N43/50 , A01N43/64 , A01N43/653 , C07D20060101 , C07D233/60 , C07D249/08 , C07D301/00 , C07D301/02 , C07D303/02 , C07D303/04 , C07D303/08 , C07D303/20 , C07D303/22 , C07D521/00
CPC分类号： A01N43/50 , A01N43/653 , C07D231/12 , C07D233/56 , C07D249/08 , C07D303/02 , C07D303/04 , C07D303/08 , C07D303/22
摘要： New 1-hydroxyethyl-azole derivatives of the general formula ##STR1## in which R represents an alkyl radical, an optionally substituted cycloalkyl radical or an optionally substituted phenyl radical,X represents a nitrogen atom or a CH group,Y represents a grouping --OCH.sub.2 --, --CH.sub.2 CH.sub.2 -- or --CH.dbd.CH--,Z represents a halogen atom, an alkyl, cycloalkyl, alkoxy, alkylthio, halogenoalkyl, halogenoalkoxy or halogenoalkylthio radical, an optionally substituted phenyl radical, an optionally substituted phenoxy radical, an optionally substituted phenylalkyl radical or an optionally substituted phenylalkoxy radical andm is 0, 1, 2 or 3,a process for their preparation and their use as plant growth regulators and fungicides.
摘要翻译：式（II）的环氧乙烷化合物，其中R代表叔丁基，异丙基，环丙基，取代的环丙基，环戊基或取代的环戊基，环己基或取代的环己基，在各种情况下，取代基选自甲基或苯基，其任选被选自氟，氯，甲基和三氟甲基的相同或不同的取代基单取代或二取代，Y表示分组-OCH 2 - ，各Z独立地选自氟，氯或溴原子，甲基，叔丁基，环己基，甲氧基，甲硫基，三氟甲基，三氟甲氧基，三氟甲硫基，苯基，苯氧基，苄基和苄氧基，所述苯基，苯氧基，苄基和苄氧基任选被相同或不同的选自氟，氯和甲基，m为0,1,2或3; 这些化合物特别可用作农业组合物中用作植物生长调节剂的化合物的中间体。

9. 发明授权

US4532341A Oxirane compounds 失效
标题翻译：环氧乙烷化合物
公开(公告)号：US4532341A
公开(公告)日：1985-07-30
申请号：US499679
申请日：1983-06-06
申请人： Graham Holmwood , Karl H. Buchel , Klaus Lurssen , Paul-Ernst Frohberger , Wilhelm Brandes
发明人： Graham Holmwood , Karl H. Buchel , Klaus Lurssen , Paul-Ernst Frohberger , Wilhelm Brandes
IPC分类号： A01N20060101 , A01N43/20 , A01N43/50 , A01N43/64 , A01N43/653 , C07D20060101 , C07D233/60 , C07D249/08 , C07D301/00 , C07D301/02 , C07D303/02 , C07D303/04 , C07D303/08 , C07D303/20 , C07D303/22 , C07D521/00
CPC分类号： A01N43/50 , A01N43/653 , C07D231/12 , C07D233/56 , C07D249/08 , C07D303/02 , C07D303/04 , C07D303/08 , C07D303/22
摘要： Oxirane compounds of the formula ##STR1## in which R represents tert-butyl, iso-propyl radical, cyclopropyl, substituted cyclopropyl, cyclopentyl or substituted cyclopentyl, cyclohexyl or substituted cyclohexyl, in each case the substituent being selected from methyl, or phenyl which is optionally mono or di-substituted by identical or different substituents selected from fluorine, chlorine, methyl and trifluoromethyl,Y represents a grouping --OCH.sub.2 --, each Z is individually selected from the group consisting of a fluorine, chlorine or bromine atom, methyl, tert-butyl, cyclohexyl, methoxy, methylthio, trifluoromethyl, trifluoromethoxy, trifluoromethylthio, phenyl, phenoxy, benzyl and benzyloxy, said phenyl, phenoxy, benzyl and benzyloxy being optionally mono or di-substituted by identical or different substituents selected from fluorine, chlorine and methyl,m is 0, 1, 2 or 3; these compounds are particularly useful as intermediates for compounds used in agricultural compositions as plant growth regulants.
摘要翻译：式（II）的环氧乙烷化合物，其中R代表叔丁基，异丙基，环丙基，取代的环丙基，环戊基或取代的环戊基，环己基或取代的环己基，在各种情况下，取代基选自甲基或苯基，其任选被选自氟，氯，甲基和三氟甲基的相同或不同的取代基单取代或二取代，Y表示分组-OCH 2 - ，各Z独立地选自氟，氯或溴原子，甲基，叔丁基，环己基，甲氧基，甲硫基，三氟甲基，三氟甲氧基，三氟甲硫基，苯基，苯氧基，苄基和苄氧基，所述苯基，苯氧基，苄基和苄氧基任选被相同或不同的选自氟，氯和甲基，m为0,1,2或3; 这些化合物特别可用作农业组合物中用作植物生长调节剂的化合物的中间体。

10. 发明授权

US10875986B2 Graphene fiber for aerospace composites 有权
公开(公告)号：US10875986B2
公开(公告)日：2020-12-29
申请号：US14589036
申请日：2015-01-05
申请人： The Boeing Company
发明人： Keith Daniel Humfeld , Kenneth H. Griess
IPC分类号： C08K9/04 , C08J5/24 , C08J5/06 , C08J5/00 , C01B32/194 , C08K7/06 , C07D303/02 , D01H1/14 , D02G3/02 , D02G3/06
CPC分类号： C08K9/04 , C01B32/194 , C07D303/02 , C08J5/005 , C08J5/06 , C08J5/24 , C08K7/06 , D01H1/14 , D02G3/02 , D02G3/06 , C08J2300/00 , C08J2300/24
摘要： Graphene fibers made from a graphene film formed into an elongated fiber-like shape and composite materials made from the graphene fibers. The graphene film has amine groups formed on at least an outer surface of the graphene film and epoxide groups formed on at least one edge of the graphene film. The amine groups are formed in a functionalized area on the outer surface of the graphene film that is within about 10 microns from the at least one edge of the graphene film, or the functionalized area may extend the entire width of the graphene film. The graphene film may also have holes formed through the graphene film. The elongated fiber-like shapes may be the graphene film in a rolled spiral orientation or the graphene film in a twisted formation.

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