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1. 发明授权

US06987263B2 High throughput systems and methods for parallel sample analysis 有权
标题翻译：高通量系统和并行样本分析方法
公开(公告)号：US06987263B2
公开(公告)日：2006-01-17
申请号：US10736154
申请日：2003-12-13
申请人： Steven E. Hobbs , Stephen D. O'Connor , Ronald C. Gamble
发明人： Steven E. Hobbs , Stephen D. O'Connor , Ronald C. Gamble
IPC分类号： B01D54/44 , H01J49/00
CPC分类号： G01N30/6043 , B01L3/5027 , G01N30/6095 , G01N30/72 , H01J49/009 , H01J49/04
摘要： Systems for analyzing multiple samples in parallel using mass spectrometric preferably coupled with fluid phase separation techniques are provided. A multi-analyzer mass spectrometer includes multiple inlets, multiple mass analyzers, and multiple transducers to conduct mass analyses of multiple samples in parallel. A modular mass analyzer may include a vacuum enclosure, a chassis, and multiple mass analysis modules disposed within the chassis. Modules are preferably disposed in a spatially compact two-dimensional array. A common multi-stage vacuum system may be utilized in conjunction with baffles or partitions disposed within and between modules to maintain differential vacuum conditions within the spectrometer utilizing a minimum number of pumps. Common control inputs may be provided to multiple modules or other components within a multi-analyzer spectrometer. Fluid phase separation devices for use with a multi-analyzer spectrometer may be microfluidic devices utilizing chromatographic, electrophoretic, or other separation methods.
摘要翻译：提供了使用优选与流体相分离技术耦合的质谱分析多个样品的系统。多分析仪质谱仪包括多个入口，多个质量分析仪和多个换能器，用于并行进行多个样品的质量分析。模块化质量分析器可以包括真空外壳，底盘以及设置在底盘内的多个质量分析模块。模块优选地设置在空间紧凑的二维阵列中。共同的多级真空系统可以与设置在模块内和模块之间的挡板或隔板一起使用，以利用最少数量的泵来保持光谱仪内的差分真空条件。通常的控制输入可以提供给多分析仪光谱仪中的多个模块或其他组件。用于多分析仪光谱仪的流体相分离装置可以是利用色谱，电泳或其它分离方法的微流体装置。

2. 发明申请

US20110178610A1 SYSTEMS AND METHODS FOR MANAGING UTILITY CONSUMPTION 审中-公开
标题翻译：用于管理实用消费的系统和方法
公开(公告)号：US20110178610A1
公开(公告)日：2011-07-21
申请号：US13120920
申请日：2009-10-15
申请人： Stephen D. O'Connor , Ronald C. Gamble , Richard A. Suchter
发明人： Stephen D. O'Connor , Ronald C. Gamble , Richard A. Suchter
IPC分类号： G05B13/04 , G06G7/48
CPC分类号： G06Q10/06
摘要： A system and method for monitoring and managing utility consumption includes use of (A) one or more sensors arranged to monitor an operating condition and/or utility consumption of at least one segment or appliance of a first facility; (B) a memory including at least one of (i) stored utility consumption information correlated or normalized to at least one designated parameter affecting utility consumption or (ii) hypothetical utility consumption; (C) a processor to compare the monitored information with the stored information, and (D) an output medium to store and/or display the comparison information. Stored consumption information may relate to the first facility or a second facility. Hypothetical utility consumption information may relate to a segment or appliance of the first facility operated according to optimized conditions, or an upgraded segment or appliance.
摘要翻译：一种用于监测和管理公用事业消耗的系统和方法包括使用（A）布置成监测第一设施的至少一个段或设备的运行状况和/或公用事业消耗的一个或多个传感器; （B）存储器，其包括以下至少一个：（i）存储的与至少一个影响公用事业消耗的指定参数相关或归一化的公用消费信息;（ii）假设的公用事业消费; （C）处理器，用于将所监视的信息与存储的信息进行比较，以及（D）存储和/或显示比较信息的输出介质。存储的消费信息可能与第一设施或第二设施有关。假设效用消耗信息可以涉及根据优化条件操作的第一设施的段或设备，或升级的段或设备。

3. 发明授权

US07132650B1 High throughput multi-dimensional sample analysis 有权
标题翻译：高通量多维样本分析
公开(公告)号：US07132650B1
公开(公告)日：2006-11-07
申请号：US10951255
申请日：2004-09-25
申请人： Ronald C. Gamble , Stephen D. O'Connor , Bruce Wilcox , Matthew M. Gregori
发明人： Ronald C. Gamble , Stephen D. O'Connor , Bruce Wilcox , Matthew M. Gregori
IPC分类号： H01J49/42
CPC分类号： G01N30/7233 , G01N30/466 , G01N30/80 , G01N2030/8447 , H01J49/0018 , H01J49/0431 , H01J49/107 , Y10T137/86863 , Y10T137/86871 , Y10T436/115831
摘要： High throughput analytical systems and methods employing multiple liquid phase separation process regions coupled to a common mass spectrometer are provided. Disclosed systems and methods permits parallel separation and parallel storage of discrete eluate fractions, followed by sequential discharge and ionization of previously stored eluate portions to yield a composite ion stream containing the sequential series of eluate portions, followed by mass analysis of the ion stream. A common manifold may receive ions and utilize pressurized gas or ion gating to direct ions within the manifold toward the mass spectrometer inlet.
摘要翻译：提供了使用耦合到共同的质谱仪的多个液相分离工艺区域的高通量分析系统和方法。公开的系统和方法允许离散洗脱液级分的并行分离和平行存储，随后顺序地排出和离子化先前储存的洗脱液部分，以产生含有顺序一系列洗脱液部分的复合离子流，随后对离子流进行质量分析。常见的歧管可以接收离子并利用加压气体或离子门控来将歧管内的离子引向质谱仪入口。

4. 发明授权

US5958342A Jet droplet device 失效
标题翻译：喷射液滴装置
公开(公告)号：US5958342A
公开(公告)日：1999-09-28
申请号：US649535
申请日：1996-05-17
申请人： Ronald C. Gamble , Thomas P. Theriault , John Baldeschwieler
发明人： Ronald C. Gamble , Thomas P. Theriault , John Baldeschwieler
IPC分类号： C12N15/09 , B01J19/00 , B01L3/02 , C40B50/14 , C40B60/14 , G01N1/28 , G01N35/10 , G01N3/02
CPC分类号： B01L3/0268 , B01J19/0046 , B82Y30/00 , B01J2219/00378 , B01J2219/00531 , B01J2219/00533 , B01J2219/00536 , B01J2219/00605 , B01J2219/00612 , B01J2219/00637 , B01J2219/00659 , B01J2219/00675 , B01J2219/00677 , B01J2219/00691 , B01L2200/04 , C40B50/14 , C40B60/14 , G01N2001/282 , G01N2035/1041
摘要： Devices and methods are provided for precise production of arrays of microspots. A pulse jetting device is employed having a capillary of micron dimensions, with a portion of the capillary proximal to the jetting orifice circumferentially surrounded by a piezoelectric transducer. By appropriate design of the capillary, orifice and piezoelectric transducer, droplets can be formed on a surface, separated by as little as 80 microns center-to-center, and having at least about a 15 micron spacing at the border. The subject substrate arrays can be used for providing miniaturized arrays of reagents, such as nucleic acids, for detecting the presence of homologous sequences in a sample.
摘要翻译：提供了用于精确生产微孢子体阵列的装置和方法。使用脉冲喷射装置具有微米尺寸的毛细管，毛细管的一部分靠近喷射孔，周向地被压电换能器包围。通过毛细管，孔口和压电换能器的适当设计，液滴可以形成在中心至中心微小至80微米的表面上，并且在边界处具有至少约15微米的间距。主题衬底阵列可用于提供用于检测样品中同源序列的存在的小型试剂阵列，例如核酸。

5. 发明授权

US5847105A Methods for performing multiple sequential reactions on a matrix 失效
标题翻译：在矩阵上执行多个连续反应的方法
公开(公告)号：US5847105A
公开(公告)日：1998-12-08
申请号：US910727
申请日：1997-08-13
申请人： John D. Baldeschwieler , Ronald C. Gamble , Thomas P. Theriault
发明人： John D. Baldeschwieler , Ronald C. Gamble , Thomas P. Theriault
IPC分类号： C12Q1/68 , B01J19/00 , C07H21/00 , C07K1/04 , C40B40/06 , C40B40/10 , C40B50/14 , C40B60/14 , G01N33/53 , G01N37/00
CPC分类号： B82Y30/00 , B01J19/0046 , C07H21/00 , C07K1/042 , C07K1/047 , B01J2219/00369 , B01J2219/00378 , B01J2219/00475 , B01J2219/00513 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00675 , B01J2219/0068 , B01J2219/00722 , B01J2219/00725 , C40B40/06 , C40B40/10 , C40B50/14 , C40B60/14
摘要： A method and apparatus are provided for preparing a substrate upon which is located microdrop-sized loci at which chemical compounds are synthesized or diagnostic tests are conducted. The loci are formed by applying microdrops from a dispenser from which a microdrop is pulse fed onto the surface of the substrate.
摘要翻译：提供了一种用于制备基底的方法和装置，其上定位有微小尺寸的位置，在该位置处合成化合物或进行诊断测试。通过将微滴从脉冲馈送到基底表面上的分配器施加微滴而形成位点。

6. 发明授权

US4497791A Method for labeling phagocytic cells 失效
标题翻译：标记吞噬细胞的方法
公开(公告)号：US4497791A
公开(公告)日：1985-02-05
申请号：US465502
申请日：1983-02-10
申请人： Ronald C. Gamble , George W. Tin , Lawrence E. Williams
发明人： Ronald C. Gamble , George W. Tin , Lawrence E. Williams
IPC分类号： G01N33/60 , A61K9/127 , A61K51/00 , A61K51/12 , C12N5/06 , C12Q1/00 , A61K43/00 , A61K49/00
CPC分类号： A61K9/1272 , A61K51/1203 , A61K51/1227 , A61K51/1234 , A61K2123/00
摘要： Described herein is a process for labeling leukocytes and other phagocytic cells with labeled micellular particles involving incubating the cells with the micellular particles. Also described is a process for detecting the locus of an infection by administering to a subject leukocytes radiolabeled by incubation with labeled micellular particles followed by scanning the subject to detect the locus of radiation emitted by the particles.
摘要翻译：本文描述的是用标记的微胶囊颗粒标记白细胞和其它吞噬细胞的方法，包括将细胞与微胶粒颗粒一起孵育。还描述了通过向受试者进行放射性标记的白细胞来检测感染的轨迹的方法，所述白细胞通过与标记的微粒颗粒孵育，随后扫描受试者以检测由颗粒发射的辐射的轨迹。

7. 发明授权

US4310506A Means of preparation and applications of liposomes containing high concentrations of entrapped ionic species 失效
标题翻译：含有高浓度包埋离子物质的脂质体的制备和应用方法
公开(公告)号：US4310506A
公开(公告)日：1982-01-12
申请号：US123162
申请日：1980-02-20
申请人： John D. Baldeschwieler , Ronald C. Gamble , Marcia R. Mauk
发明人： John D. Baldeschwieler , Ronald C. Gamble , Marcia R. Mauk
IPC分类号： A61K9/127 , A61K51/12 , A61K49/00 , A61K43/00 , B01J13/00
CPC分类号： A61K51/1234 , A61K9/1278 , A61K2123/00 , Y10T428/2984
摘要： Unilamellar vesicles comprising a lipid bilayer, an ionophore being incorporated in said lipid bilayer, a chelating agent entrapped within the vesicles, and an effective amount of physiologically compatible cation bound to said chelating agent within the vesicles. Unilamellar vesicles are loaded by incubating the vesicles with the cation, terminating the incubation and recovering the loaded vesicles by chromatography. In some applications of the invention, the cation may be a radioactive tracer, in which case the vesicles can be administered to the human host and observed by scintillation techniques to produce a radioimage which is useful for diagnostic purposes.
摘要翻译：包含脂质双层的单层囊泡，掺入所述脂质双层中的离子载体，包封在囊泡内的螯合剂，以及与囊泡内的所述螯合剂结合的有效量的生理上相容的阳离子。通过将囊泡与阳离子孵育来加载单层囊泡，终止孵育并通过色谱法回收加载的囊泡。在本发明的一些应用中，阳离子可以是放射性示踪剂，在这种情况下，囊泡可以施用于人宿主并通过闪烁技术观察以产生可用于诊断目的的放射性图像。

8. 发明申请

US20130245437A1 SYSTEM AND METHOD FOR FACILITATING REFLECTOMETRIC DETECTION OF PHYSIOLOGIC ACTIVITY 有权
标题翻译：用于促进生物活性反射检测的系统和方法
公开(公告)号：US20130245437A1
公开(公告)日：2013-09-19
申请号：US13827555
申请日：2013-03-14
申请人： Ronald C. Gamble , Lawrence Randolph Weill , Steve Perry Monacos
发明人： Ronald C. Gamble , Lawrence Randolph Weill , Steve Perry Monacos
IPC分类号： A61B5/05 , A61B5/024 , A61B5/00
CPC分类号： A61B5/725 , A61B5/0006 , A61B5/0205 , A61B5/024 , A61B5/02405 , A61B5/0507 , A61B5/7257 , A61B5/7275 , A61B5/742 , A61B5/746
摘要： A method for remotely sensing cardiac-related data of an animal subject includes transmitting a RF signal to impinge on tissue of the subject, receiving a reflected portion of the RF signal, generating baseband data, filtering baseband data (e.g., including high pass filtering), performing waveform phase position determination, performing at least one auto-correlation of the waveform phase position determined data, determining periodicity of the auto-correlated data, and (i) computing heart rate using a maximum periodicity of the periodicity, or (ii) identifying abnormalities in cardiac function, such as may be indicated by temporal variations in heart rate and/or signal amplitude corresponding to cardiac activity. Multiple bandpass filtering schemes may be employed.
摘要翻译：用于远程感测动物对象的心脏相关数据的方法包括：发送RF信号以撞击对象的组织，接收RF信号的反射部分，产生基带数据，滤波基带数据（例如，包括高通滤波）执行波形相位位置确定，执行波形相位位置确定数据的至少一个自相关，确定自动相关数据的周期性，以及（i）使用周期的最大周期来计算心率，或者（ii）识别心脏功能异常，例如可以通过对应于心脏活动的心率和/或信号幅度的时间变化来指示。可以采用多个带通滤波方案。

9. 发明授权

US07178386B1 Parallel fluid processing systems and methods 有权
标题翻译：平行流体处理系统和方法
公开(公告)号：US07178386B1
公开(公告)日：2007-02-20
申请号：US10821567
申请日：2004-04-09
申请人： Ronald C. Gamble , Sergey I. Osechinskiy
发明人： Ronald C. Gamble , Sergey I. Osechinskiy
IPC分类号： G01N30/02 , B01D15/08
CPC分类号： G01N30/466 , G01N30/6095 , G01N30/8665 , G01N30/8668
摘要： A parallel fluid processing system including multiple fluid process regions containing solid material in fluid communication with a common first fluid source may be used to conduct analyses and/or synthesis in parallel. A parallel fluid processing data correction method includes supplying and processing a calibrant in each fluid process region, measuring a first physical parameter and deriving at least one correction factor based on the parameter, supplying and processing at least one second fluid in each fluid process region, and then applying the correction factor to yield corrected process data. Retention time correction, peak area correction, and other useful data corrections may be performed. Parallel fluid processing may be performed with microfluidic devices and systems. A system for correcting retention times in parallel liquid chromatography is further provided.
摘要翻译：可以使用包括含有与公共第一流体源流体连通的固体材料的多个流体处理区域的平行流体处理系统来并行地进行分析和/或合成。并行流体处理数据校正方法包括在每个流体处理区域中提供和处理校准物，测量第一物理参数并基于该参数导出至少一个校正因子，在每个流体处理区域中提供和处理至少一个第二流体，然后应用校正因子来产生校正过程数据。可以执行保留时间校正，峰值区域校正和其他有用的数据校正。可以用微流体装置和系统进行并行流体处理。还提供了用于校正并联液相色谱中保留时间的系统。

10. 发明授权

US5874104A Treatment of systemic fungal infections with phospholipid particles encapsulating polyene antibiotics 失效
标题翻译：用包封多烯抗生素的磷脂颗粒治疗全身真菌感染
公开(公告)号：US5874104A
公开(公告)日：1999-02-23
申请号：US467864
申请日：1995-06-06
申请人： Jill Adler-Moore , Ronald C. Gamble , Richard T. Proffitt
发明人： Jill Adler-Moore , Ronald C. Gamble , Richard T. Proffitt
IPC分类号： A61K9/10 , A61K9/127 , A61K9/133 , A61K31/70
CPC分类号： A61K9/1271 , A61K31/7048 , B82Y5/00
摘要： Formulations consisting of phospholipid small unilamellar particles encapsulating polyene antifungal antibiotics and methods for using such compositions to treat systemic fungal infections are described. In a preferred embodiment, the particles are in the form of vesicles which comprise a polyene antifungal antibiotic, preferably amphotericin B and/or nystatin, egg phosphatidylcholine and cholesterol, preferably in the molar ratio of about 0.2 (AMB):2(PL):1(CHOL). These vesicles may also have an amine modified surface. The vesicles are suspended in a low isonic strength saccharide/tris solution at a pH of from about 6.0 to about 8.0 and may be administered to deliver the antifungal antibiotic to treat systemic fungal infections.
摘要翻译：描述由包含多烯抗真菌抗生素的磷脂小单层颗粒组成的制剂以及使用这些组合物治疗全身性真菌感染的方法。在优选的实施方案中，颗粒是囊泡形式，其包含多烯抗真菌抗生素，优选两性霉素B和/或制霉菌素，卵磷脂酰胆碱和胆固醇，优选摩尔比为约0.2（AMB）：2（PL）： 1（CHOL）。这些囊泡也可以具有胺改性的表面。将囊泡悬浮在pH为约6.0至约8.0的低等强度糖/ tris溶液中，并且可以施用以输送抗真菌抗生素以治疗全身性真菌感染。

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