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1. 发明授权

US07397029B2 Method and apparatus for ion fragmentation in mass spectrometry 失效
标题翻译：离子质谱分离方法和装置
公开(公告)号：US07397029B2
公开(公告)日：2008-07-08
申请号：US11620504
申请日：2007-01-05
申请人： Vadym D. Berkout , Vladimir M. Doroshenko
发明人： Vadym D. Berkout , Vladimir M. Doroshenko
IPC分类号： B01D59/44
CPC分类号： H01J49/0045
摘要： An apparatus for mass analyzing molecules includes a mass spectrometer configured to select precursor ions having a mass to charge ratio range, a metastable species generator configured to generate a metastable species for introduction into the mass spectrometer, and a mass detector configured to detect a mass of the product ions. The apparatus also includes interaction region in the mass spectrometer where the precursor ions are converted into product ions via interaction of the precursor ions with the metastable species. The mass spectrometer includes at least one of a three-dimensional ion trap, a linear ion trap, or an ion guide. The interaction region is located inside the three-dimensional ion trap, the linear trap, or the ion guide; and at least one of the precursor ions or at least one of the product ions are excited by an alternating electric field or collisionally activated to produce additional product ions.
摘要翻译：用于质量分析分子的装置包括：质谱仪，其被配置为选择具有质荷比范围的前体离子;构造成产生用于引入质谱仪的亚稳态物质的亚稳态物质发生器;以及质量检测器，产品离子。该装置还包括质谱仪中的相互作用区域，其中前体离子通过前体离子与亚稳态物质的相互作用转化成产物离子。质谱仪包括三维离子阱，线性离子阱或离子导体中的至少一种。相互作用区域位于三维离子阱，线性阱或离子导向器内; 并且至少一种前体离子或至少一种产物离子被交变电场激发或者被碰撞激活以产生另外的产物离子。

2. 发明授权

US06791080B2 Method and apparatus for efficient transfer of ions into a mass spectrometer 有权
标题翻译：将离子有效转移到质谱仪中的方法和装置
公开(公告)号：US06791080B2
公开(公告)日：2004-09-14
申请号：US10367917
申请日：2003-02-19
申请人： Vladimir M. Doroshenko , Victor V. Laiko , Phillip V. Tan
发明人： Vladimir M. Doroshenko , Victor V. Laiko , Phillip V. Tan
IPC分类号： H01J4904
CPC分类号： H01J49/403
摘要： An apparatus and a method which produce a pulse of ions, generate a transient electric field correlated in time with a duration of the pulse of ions, receive the pulse of ions into the transient electric field, and collect the ions from an ion drift region of the transient electric field into a gas dynamic flow region of the mass analyzer. As such, an apparatus for transferring ions into a mass analyzer includes an ion source configured to generate the pulse of ions, a transient electric field device configured to receive the pulse of ions and generate the transient electric field, and an ion collector configured to collect the ions from the ion drift region and transfer the ions into the mass analyzer.
摘要翻译：产生离子脉冲的装置和方法产生时间上与离子脉冲持续时间相关的瞬时电场，将离子脉冲接收到瞬态电场中，并从离子漂移区域瞬态电场进入质量分析仪的气体动态流动区域。因此，用于将离子转移到质量分析器中的装置包括被配置为产生离子脉冲的离子源，被配置为接收离子脉冲并产生瞬态电场的瞬态电场装置，以及被配置为收集离子的离子收集器来自离子漂移区域的离子并将离子转移到质谱仪中。

3. 发明授权

US08440964B2 Multiple ion guide operating at elevated pressures 有权
标题翻译：多极离子导向器在高压下运行
公开(公告)号：US08440964B2
公开(公告)日：2013-05-14
申请号：US13213787
申请日：2011-08-19
申请人： Vadym D Berkout , Vladimir M. Doroshenko
发明人： Vadym D Berkout , Vladimir M. Doroshenko
IPC分类号： G21K1/08 , H01J49/42 , H01J49/00
CPC分类号： H01J49/063 , H01J49/24
摘要： A device and method for transporting ions along a longitudinal direction in an elevated gas pressure region. The device includes a multipole ion guide having a set of rods positioned along the longitudinal direction on an inscribed diameter equal to or less than 3.5 mm, a voltage source which provides alternating voltages to at least a subset of the rods to create a trapping field in a transverse direction, and a conductance limit having an opening d and placed at the exit of the multipole ion guide. At the end of this configuration near the opening of the conductance limit, a converging continuum gas flow through the conductance limit is provided that transfers the ions collimating near a center of the ion guide into a low gas pressure region. The method injects ions into the elevated gas pressure region of the ion guide, and transports the ions in the converging continuum gas flow into the low gas pressure region.
摘要翻译：一种用于在升高的气体压力区域沿着纵向输送离子的装置和方法。该装置包括多极离子导向器，其具有沿着纵向方向定位在一个等于或小于3.5mm的内接直径上的一组杆，电压源，其向至少一个棒的子集提供交流电压，以产生捕获场横向和具有开口d并放置在多极离子导向器的出口处的电导极限。在接近开路导通极限的结束时，提供通过电导限制的会聚连续气体流，其将在离子导向器的中心附近准直的离子转移到低气压区域。该方法将离子注入离子导向器的升高的气体压力区域，并将会聚的连续气流中的离子输送到低气体压力区域。

4. 发明申请

US20090152458A1 METHOD AND APPARATUS FOR ION FRAGMENTATION IN MASS SPECTROMETRY 有权
标题翻译：用于离子质谱分析的方法和装置
公开(公告)号：US20090152458A1
公开(公告)日：2009-06-18
申请号：US11959006
申请日：2007-12-18
申请人： Andrey Vilkov , Vladimir M. Doroshenko
发明人： Andrey Vilkov , Vladimir M. Doroshenko
IPC分类号： B01D59/44
CPC分类号： H01J49/0045
摘要： A method for fragmentation of analyte ions for mass spectroscopy and a system for mass spectroscopy. The method produces gas-phase analyte ions, produces gas-phase radical species separately from the analyte ions, and mixes the gas-phase analyte ions and the radical species at substantially atmospheric pressure conditions to produce fragment ions prior to introduction into a mass spectrometer. The system includes a gas-phase analyte ion source, a gas-phase radical species source separate from the gas-phase analyte ion source, a mixing region where the gas-phase analyte ions and the radical species are mixed at substantially atmospheric pressure to produce fragment ions of the analyte ions, a mass spectrometer having an entrance where at least a portion of the fragment ions are introduced into a vacuum of the mass spectrometer, and a detector in the mass spectrometer which determines a mass to charge ratio analysis of the fragment ions.
摘要翻译：用于质谱分析的分析物离子的碎裂方法和用于质谱的系统。该方法产生气相分析物离子，与分析物离子分开产生气相自由基物质，并在基本上大气压条件下将气相分析物离子和自由基物质混合，以便在引入质谱仪之前产生碎片离子。该系统包括气相分析物离子源，与气相分析物离子源分离的气相自由基物质源，气相分析物离子和自由基物质在大气压下混合以产生分析物离子的碎片离子，具有入口的质谱仪，其中至少一部分碎片离子被引入质谱仪的真空中;以及质谱仪中的检测器，其确定片段的质荷比分析离子。

5. 发明申请

US20090001263A1 ON-PROBE SAMPLE CLEANUP SYSTEM AND METHOD FOR MALDI ANALYSIS 失效
标题翻译：检测样品清洗系统和MALDI分析方法
公开(公告)号：US20090001263A1
公开(公告)日：2009-01-01
申请号：US11441175
申请日：2006-05-26
申请人： Appavu K. Sundaram , Nelli I. Taranenko , Vladimir M. Doroshenko
发明人： Appavu K. Sundaram , Nelli I. Taranenko , Vladimir M. Doroshenko
IPC分类号： B01D59/44
CPC分类号： G01N1/34 , G01N1/2813 , G01N1/4022 , G01N1/405 , H01J49/0418 , Y10S977/881 , Y10S977/891 , Y10S977/892 , Y10T436/25125 , Y10T436/255
摘要： A system and method for cleanup of biological samples from contaminants prior to spectroscopy analysis. The system includes a support configured to hold a sample including a liquid having at least one group of biological molecules with a surface of the support binding the molecules at a surface tension angle to the liquid of less than 180 degrees. The system includes an evaporator configured to evaporate liquid from the support, a solvent applicator configured to apply a solvent for dissolution of the contaminants in the sample, and a solvent removal device configured to remove applied solvent from the sample and thereby at least partially remove the contaminants.
摘要翻译：在光谱分析前从污染物中清除生物样品的系统和方法。该系统包括支撑件，其构造成将包含具有至少一组生物分子的液体的样品保持在支架的表面，该表面以小于180度的液体的表面张力角度将分子结合。该系统包括构造成从支撑体蒸发液体的蒸发器，配置成施加溶剂以溶解污染物到样品中的溶剂施加器，以及溶剂去除装置，其被配置为从样品中除去施加的溶剂，从而至少部分地除去污染物

6. 发明申请

US20080067349A1 Multi-channel time-of-flight mass spectrometer 审中-公开
标题翻译：多通道飞行时间质谱仪
公开(公告)号：US20080067349A1
公开(公告)日：2008-03-20
申请号：US11441177
申请日：2006-05-26
申请人： Eugene Moskovets , Vladimir M. Doroshenko
发明人： Eugene Moskovets , Vladimir M. Doroshenko
IPC分类号： H01J49/40
CPC分类号： H01J49/401 , H01J49/009
摘要： A system and method for mass analysis of ions. The system includes an orthogonal acceleration time-of-flight mass analyzer having at least two channels configured to receive respective groups of ions from respective ion sources and having a field-free section configured to mass-separate ions during flight time. The groups of ions are directed to different ones of the channels of the mass analyzer for mass analysis of the respective groups of ions, and at least a part of the field-free section is shared between the channels. The method introduces the ions into an orthogonal acceleration time-of-flight mass analyzer, directs groups of ions from respective ones of the two sources into different channels of the mass analyzer, and simultaneously mass-analyzes the groups of ions from the different channels.
摘要翻译：用于离子质量分析的系统和方法。该系统包括正交加速飞行时间质量分析器，其具有至少两个通道，其被配置为从相应离子源接收相应的离子组，并且具有配置成在飞行时间内质量分离离子的无场区段。离子组被引导到质量分析器的不同通道，用于各组离子的质量分析，并且至少一部分无场区段在通道之间共享。该方法将离子引入正交加速度飞行时间质量分析仪，将来自两个源中的各个离子的群组引导到质量分析器的不同通道，同时对来自不同通道的离子群进行质量分析。

7. 发明授权

US06858840B2 Method of ion fragmentation in a multipole ion guide of a tandem mass spectrometer 失效
标题翻译：串联质谱仪多极离子导向离子破碎的方法
公开(公告)号：US06858840B2
公开(公告)日：2005-02-22
申请号：US10441004
申请日：2003-05-20
申请人： Vadym D. Berkout , Vladimir M. Doroshenko
发明人： Vadym D. Berkout , Vladimir M. Doroshenko
IPC分类号： B01D59/44 , H01J49/00 , H01J49/26 , H01J49/40 , H01J49/42
CPC分类号： H01J49/063 , H01J49/0054
摘要： A system and method for mass analysis of an ion beam. The system includes a mass selector, at least one multipole ion guide, and a mass analyzer. In the system and method, precursor ions are selected with a desired mass to charge ratio. Electrons are injected into the multipole ion guide. The precursor ions are fragmented into product ions via electron capture dissociation from the injected electrons. The product ions are passed to a mass analyzer for a mass analysis.
摘要翻译：一种用于离子束质量分析的系统和方法。该系统包括质量选择器，至少一个多极离子导向器和质量分析器。在该系统和方法中，以期望的质荷比选择前体离子。电子注入到多极离子导向器中。通过从注入的电子的电子俘获解离，前体离子被分裂成产物离子。将产物离子通过质谱仪进行质量分析。

8. 发明授权

US06777671B2 Time-of-flight/ion trap mass spectrometer, a method, and a computer program product to use the same 失效
标题翻译：飞行时间/离子阱质谱仪，一种方法和使用它们的计算机程序产品
公开(公告)号：US06777671B2
公开(公告)日：2004-08-17
申请号：US09828828
申请日：2001-04-10
申请人： Vladimir M. Doroshenko
发明人： Vladimir M. Doroshenko
IPC分类号： H01J4906
CPC分类号： H01J49/004 , H01J49/40 , H01J49/424
摘要： A mass spectrometer includes an ion source, an extraction device, a TOF mass analyzer, an ion trap mass analyzer, and an ion guiding optical element which guides at least one of extracted ions from the ion source and extracted ion fragments into the TOF mass analyzer in a normal mode of operation and into the IT mass analyzer in a tandem mode of operation. The apparatus operates by producing ions from a sample, extracting the ions from the ion source, selecting between the TOF mass analyzer and the IT mass analyzer, directing extracted ions to the selected mass analyzer, mass-separating the directed ions and fragments of the directed ions according to a mass-to-charge ratio, detecting mass-separated ions with the selected mass analyzer, and producing at least one of a normal mass spectrum and a tandem mass spectrum.
摘要翻译：质谱仪包括离子源，提取装置，TOF质量分析器，离子阱质谱仪和离子引导光学元件，其将离子源中提取的离子中的至少一种和提取的离子碎片引导到TOF质量分析器处于正常工作模式，并以串联操作模式进入IT质量分析器。该装置通过从样品中产生离子，从离子源中提取离子，在TOF质量分析器和IT质量分析器之间进行选择，将提取的离子引导到所选择的质量分析器，将定向离子和定向的分离物质量分离离子，根据质荷比，用所选质量分析器检测质量分离的离子，并产生正常质谱和串联质谱中的至少一种。

9. 发明授权

US06683300B2 Method and apparatus for mass spectrometry analysis of common analyte solutions 失效
标题翻译：普通分析物溶液质谱分析方法和装置
公开(公告)号：US06683300B2
公开(公告)日：2004-01-27
申请号：US09953403
申请日：2001-09-17
申请人： Vladimir M. Doroshenko , Victor V. Laiko , Mikhail Yakshin , Coorg R. Prasad , Hyo Sang Lee
发明人： Vladimir M. Doroshenko , Victor V. Laiko , Mikhail Yakshin , Coorg R. Prasad , Hyo Sang Lee
IPC分类号： H01J4916
CPC分类号： H01J49/04
摘要： A method, system, and apparatus for mass spectroscopic analysis of an analyte solution in which a liquid volume of the analyte solution is irradiated with a light source resulting in desorption of solution-specific ions into a surrounding gas to produce gas-phase ions, the gas-phase ions are transferred to an inlet port of a mass analyzer, and the gas-phase ions are mass analyzed. More specifically, the apparatus may include a laser configured to pulse irradiate a surface of the analyte solution, a mass spectrometer configured to mass-analyze the gas-phase ions according to the mass-to-charge ratio, and a transfer mechanism configured to transfer the gas-phase ions to an inlet port of the mass spectrometer.
摘要翻译：分析物溶液的质谱分析的方法，系统和装置，其中用光源照射分析物溶液的液体体积，导致溶液特异性离子解吸到周围气体中以产生气相离子，将气相离子转移到质量分析器的入口，并对气相离子进行质量分析。更具体地，该装置可以包括被配置为脉冲照射分析物溶液的表面的激光器，配置成根据质荷比对气相离子进行质量分析的质谱仪，以及被配置为转移气相离子到质谱仪的入口。

10. 发明授权

US5399857A Method and apparatus for trapping ions by increasing trapping voltage during ion introduction 失效
标题翻译：在离子引入期间通过增加捕获电压来捕获离子的方法和装置
公开(公告)号：US5399857A
公开(公告)日：1995-03-21
申请号：US68697
申请日：1993-05-28
申请人： Vladimir M. Doroshenko , Robert J. Cotter
发明人： Vladimir M. Doroshenko , Robert J. Cotter
IPC分类号： H01J49/42
CPC分类号： H01J49/4295 , H01J49/164 , H01J49/424
摘要： A method and apparatus for trapping ions in an ion trap having a ring electrode and a plurality of end-cap electrodes. Ions are introduced into a ion trap cavity of the ion trap from an external source or by desorption of a substance in the ion trap cavity. In a first embodiment, as the ions are introduced in the ion trap cavity, the amplitude of an RF voltage being applied to the ring electrode is gradually increased to trap the ions in the ion trap cavity. In a second embodiment, as the ions are introduced in the ion trap cavity, a retarding voltage is applied to the end-caps to reduce the initial kinetic energy of the ions. In a third embodiment, as the ions are introduced in the ion trap cavity from a probe tip inserted in the cavity, a retarding voltage is applied to the probe tip.
摘要翻译：一种用于在具有环形电极和多个端帽电极的离子阱中捕获离子的方法和装置。离子从外部源引入离子阱的离子阱空穴中或者通过物质在离子阱腔中的解吸引入。在第一实施例中，当离子被引入离子阱腔中时，施加到环形电极的RF电压的幅度逐渐增加以捕获离子陷阱腔中的离子。在第二实施例中，当离子被引入离子阱腔中时，延迟电压被施加到端帽以减小离子的初始动能。在第三实施例中，当离子从插入空腔中的探针尖端引入到离子阱腔中时，延迟电压被施加到探针尖端。

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