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1. 发明授权

US2020252A Device for improving the use of vacuum in the bleeding of animals 失效
标题翻译：用于改善动物出血中真空使用的装置
公开(公告)号：US2020252A
公开(公告)日：1935-11-05
申请号：US73319034
申请日：1934-06-30
申请人： ALLIED LAB
发明人： UTTERBACK WILLIAM B , NASH JAMES R , MUNCE THOMAS W
IPC分类号： A61M1/00 , A61M1/02
CPC分类号： A61M1/0023 , A61M1/0204 , A61M2202/0413 , A61M2250/00 , Y10S604/903

2. 发明授权

US06966894B1 Syringes and injectors incorporating mechanical fluid agitation devices 失效
标题翻译：注射器和注射器结合机械流体搅拌装置
公开(公告)号：US06966894B1
公开(公告)日：2005-11-22
申请号：US09763646
申请日：1999-08-26
申请人： Klaus Urich
发明人： Klaus Urich
IPC分类号： A61M5/142 , A61M1/02 , A61M5/145 , B01F11/00 , B01F13/00 , A61M37/00 , A61M5/00 , A61M5/315 , A61M31/00
CPC分类号： B01F13/005 , A61M1/0204 , A61M5/14546 , B01F11/0002 , B01F11/0017 , B01F11/0022 , B01F13/0052 , B01F2003/0035
摘要： A syringe for use with an injector includes a body comprising a distal discharge end, a plunger movably disposed within the body, and an agitation element disposed within the body between the plunger and the distal discharge end. A movement mechanism is operably associated with the injector to move the syringe in such a way that the at least one agitation element agitates a fluid contained in the syringe. Preferably, the syringe contains an ultrasound contrast agent that is agitated by the agitation element. An injector system and a method for agitating the contents of a syringe are also provided.
摘要翻译：用于注射器的注射器包括主体，其包括远端排出端，可移动地设置在主体内的柱塞，以及设置在柱塞和远侧排出端之间的主体内的搅动元件。移动机构与注射器可操作地相关联以使注射器以使得至少一个搅动元件搅动包含在注射器中的流体的方式移动。优选地，注射器包含由搅拌元件搅动的超声造影剂。还提供了一种用于搅拌注射器内容物的注射器系统和方法。

3. 发明授权

US4129131A Method and apparatus for defibrination of blood 失效
标题翻译：血液去纤颤的方法和装置
公开(公告)号：US4129131A
公开(公告)日：1978-12-12
申请号：US735173
申请日：1976-10-26
申请人： Henry Naftulin
发明人： Henry Naftulin
IPC分类号： A61M1/02 , A61M1/03
CPC分类号： A61M1/02 , A61M1/0204 , Y10S128/22 , Y10S604/903
摘要： A method and apparatus for collecting and defibrinating blood in a flexible container. The blood is collected in a flexible container of appropriate size into which is placed a sufficient quantity of glass beads or the like and a predetermined amount of gas. The flexible container is positioned within a vacuum chamber. The vacuum drawn in the chamber expands the gas within the flexible container to permit only about one half of the container to fill with blood. The flexible container is agitated causing the glass beads or the like to move rapidly through the blood and whip out the fibrin. An alternative embodiment substitutes a reticulated material in place of the glass beads positioned within the container.
摘要翻译：用于收集和去除柔性容器中的血液的方法和装置。将血液收集在适当尺寸的柔性容器中，其中放入足量的玻璃珠等和预定量的气体。柔性容器位于真空室内。在腔室中吸取的真空使柔性容器内的气体膨胀，从而仅允许容器的大约一半填充血液。搅动柔性容器，使玻璃珠等快速移动通过血液并将纤维蛋白鞭打出来。替代实施例代替网状材料代替位于容器内的玻璃珠。

4. 发明授权

US09260697B2 Apparatus and methods relating to collecting and processing human biological material containing adipose 有权
标题翻译：与收集和处理含有脂肪的人类生物材料有关的装置和方法
公开(公告)号：US09260697B2
公开(公告)日：2016-02-16
申请号：US13808550
申请日：2011-07-08
申请人： William W. Cimino , Adam J. Katz , Ramon Llull
发明人： William W. Cimino , Adam J. Katz , Ramon Llull
IPC分类号： A61M5/165 , C12N5/077 , A61M1/00 , C12M1/00
CPC分类号： C12N5/0653 , A61M1/0001 , A61M1/0094 , A61M1/0204 , A61M2202/08 , A61M2205/103 , C12M47/04
摘要： A portable apparatus for collection and processing of human biological material containing adipose, such as extracted during a lipoplasty procedure, is useful for multi-step processing to prepare a concentrated product (e.g., stromal vascular fraction) or a fat graft composition. The apparatus has a container with a containment volume with a tissue retention volume and a filtrate volume separated by a filter and with a tapered portion to a collection volume for collecting concentrate product. Inlet and suction ports provide access to the tissue retention volume and filtrate volume, respectively, and an extraction port provides versatile access for removal of target processed concentrate material or fat graft material, which access may be via a lumen through a rotatable mixer shaft. Access ports may be configured for access only from above the container. The apparatus is incorporatable into a variety of assemblies, systems, kits, methods and uses.
摘要翻译：用于收集和加工含有脂肪的人体生物材料的便携式装置，例如在脂肪成形术过程中提取的，可用于多步骤加工以制备浓缩产物（例如基质血管部分）或脂肪移植组合物。该装置具有容器，其具有容纳体积，具有组织保持体积，滤液体积由过滤器分离，并具有锥形部分，用于收集浓缩物产品的收集容积。入口和吸入口分别提供对组织保持体积和滤液体积的访问，并且提取端口提供用于去除目标处理的浓缩物质或脂肪移植材料的通用途径，其可通过可旋转的混合器轴通过管腔进入。访问端口可以被配置为仅从容器上方访问。该装置可并入各种组件，系统，套件，方法和用途中。

5. 发明授权

US07901584B2 Plasma concentration 有权
标题翻译：血浆浓度
公开(公告)号：US07901584B2
公开(公告)日：2011-03-08
申请号：US12476838
申请日：2009-06-02
申请人： Randel Dorian , Michael D. Leach , Richard W. Storrs
发明人： Randel Dorian , Michael D. Leach , Richard W. Storrs
IPC分类号： B01D15/02 , B01D33/27 , B01D37/00
CPC分类号： A61M1/3679 , A61M1/0204 , A61M1/3693 , A61M2202/0415 , Y10T436/25375 , Y10T436/255
摘要： A plasma concentrator having a concentrator chamber, concentrator gel beads, a filter, and an agitator. The agitator end is positioned in the concentrator chamber and supported for rotation about its central axis and for reciprocal movement along its central axis. A filter is selected to block effective flow of plasma therethrough under ambient gravity conditions and permit plasma and plasma concentrate flow therethrough under centrifugal forces of the separation gravity. A method concentrates plasma by removing water without significantly denaturing the fibrinogen in the plasma. Then centrifugal force can be applied to the concentrated plasma in an amount sufficient to separate a substantial portion of the plasma concentrate from the beads.
摘要翻译：具有浓缩器室，浓缩器凝胶珠，过滤器和搅拌器的等离子体浓缩器。搅拌器端部定位在聚光器室中并被支撑以围绕其中心轴线旋转并且用于沿其中心轴线往复运动。选择过滤器以阻止等离子体在环境重力条件下的有效流动，并允许等离子体和等离子体浓缩物在分离重力的离心力下流过其中。方法通过除去水而不使血浆中的纤维蛋白原显着变性来浓缩血浆。然后可以将离心力施加到浓缩的等离子体中，其量足以将大部分等离子体浓缩物与珠粒分离。

6. 发明授权

US07553413B2 Plasma concentrator device 有权
标题翻译：等离子体浓缩装置
公开(公告)号：US07553413B2
公开(公告)日：2009-06-30
申请号：US11342982
申请日：2006-01-30
申请人： Randel Dorian , Michael D. Leach , Richard Wood Storrs
发明人： Randel Dorian , Michael D. Leach , Richard Wood Storrs
IPC分类号： B01D15/02 , B01D24/00 , B01D29/00
CPC分类号： A61M1/3679 , A61M1/0204 , A61M1/3693 , A61M2202/0415 , Y10T436/25375 , Y10T436/255
摘要： A plasma concentrator of this invention having a concentrator chamber, concentrator gel beads, a filter, and an agitator. The agitator has agitator blades extending outwardly from the lower end. The agitator end is positioned in the concentrator chamber and supported for rotation about its central axis and for reciprocal movement along its central axis. The concentrator has a top with an upper opening through which the upper end of the actuator stem extends, and a lower opening in which the filter is positioned. The concentrator chamber can have a cylindrical inner wall, and the agitator blades can have an outer edge in close proximity to the inner wall with the space between the outer edge and the inner wall being less than the diameter of the gel beads. The filter is selected to block effective flow of plasma therethrough under ambient gravity conditions and permit plasma and plasma concentrate flow therethrough under centrifugal forces of the separation gravity. The method concentrates plasma by removing water without significantly denaturing the fibrinogen in the plasma. The plasma is introduced into a concentration chamber containing a plurality of dehydrated concentrator gel beads and an agitator. Then water is removed from the plasma while stirring the beads to reduce plasma polarization and breaking up clumps of beads that form during the agitation. Then centrifugal force can be applied to the concentrated plasma in an amount sufficient to separate a substantial portion of the plasma concentrate from the beads.
摘要翻译：本发明的等离子体浓缩器具有浓缩器室，浓缩器凝胶珠，过滤器和搅拌器。搅拌器具有从下端向外延伸的搅拌器叶片。搅拌器端部定位在聚光器室中并被支撑以围绕其中心轴线旋转并且用于沿其中心轴线往复运动。集中器具有顶部，其具有上部开口，致动器杆的上端延伸穿过该上部开口，以及下部开口，过滤器定位在该开口中。浓缩器室可以具有圆柱形内壁，并且搅拌器叶片可以具有紧邻内壁的外边缘，外边缘和内壁之间的空间小于凝胶珠的直径。选择过滤器以在环境重力条件下阻止等离子体的有效流动，并允许等离子体和等离子体浓缩物在分离重力的离心力下流过其中。该方法通过除去水而不使血浆中的纤维蛋白原显着变性来浓缩血浆。将等离子体引入含有多个脱水浓缩器凝胶珠和搅拌器的浓缩室中。然后在搅拌珠子的同时从等离子体中除去水，以减少等离子极化并破坏在搅拌过程中形成的珠粒团块。然后可以将离心力施加到浓缩的等离子体中，其量足以将大部分等离子体浓缩物与珠粒分离。

7. 发明申请

US20060175268A1 Plasma concentrator device 有权
公开(公告)号：US20060175268A1
公开(公告)日：2006-08-10
申请号：US11342982
申请日：2006-01-30
申请人： Randel Dorian , Michael Leach , Richard Storrs
发明人： Randel Dorian , Michael Leach , Richard Storrs
IPC分类号： C02F1/38
CPC分类号： A61M1/3679 , A61M1/0204 , A61M1/3693 , A61M2202/0415 , Y10T436/25375 , Y10T436/255
摘要： A plasma concentrator of this invention having a concentrator chamber, concentrator gel beads, a filter, and an agitator. The agitator has agitator blades extending outwardly from the lower end. The agitator end is positioned in the concentrator chamber and supported for rotation about its central axis and for reciprocal movement along its central axis. The concentrator has a top with an upper opening through which the upper end of the actuator stem extends, and a lower opening in which the filter is positioned. The concentrator chamber can have a cylindrical inner wall, and the agitator blades can have an outer edge in close proximity to the inner wall with the space between the outer edge and the inner wall being less than the diameter of the gel beads. The filter is selected to block effective flow of plasma therethrough under ambient gravity conditions and permit plasma and plasma concentrate flow therethrough under centrifugal forces of the separation gravity. The method concentrates plasma by removing water without significantly denaturing the fibrinogen in the plasma. The plasma is introduced into a concentration chamber containing a plurality of dehydrated concentrator gel beads and an agitator. Then water is removed from the plasma while stirring the beads to reduce plasma polarization and breaking up clumps of beads that form during the agitation. Then centrifugal force can be applied to the concentrated plasma in an amount sufficient to separate a substantial portion of the plasma concentrate from the beads.

8. 发明授权

US1614337A Method of separating fibrinous material from fluids 失效
标题翻译：从流体中分离纤维蛋白质材料的方法
公开(公告)号：US1614337A
公开(公告)日：1927-01-11
申请号：US2630425
申请日：1925-04-27
申请人： COMSTOCK & WESCOTT
发明人： CLARKE ATWOOD FRANCIS
IPC分类号： A23J1/06 , A61M1/02
CPC分类号： A61M1/02 , A23J1/06 , A61M1/0204 , Y10S128/22

9. 发明申请

US20130164731A1 APPARATUS AND METHODS RELATING TO COLLECTING AND PROCESSING HUMAN BIOLOGICAL MATERIAL CONTAINING ADIPOSE 有权
标题翻译：与收集和处理含有ADIPOSE的人体生物材料相关的装置和方法
公开(公告)号：US20130164731A1
公开(公告)日：2013-06-27
申请号：US13808550
申请日：2011-07-08
申请人： William W. Cimino , Adam J. Katz , Ramon Llull
发明人： William W. Cimino , Adam J. Katz , Ramon Llull
IPC分类号： C12N5/071
CPC分类号： C12N5/0653 , A61M1/0001 , A61M1/0094 , A61M1/0204 , A61M2202/08 , A61M2205/103 , C12M47/04
摘要： A portable apparatus for collection and processing of human biological material containing adipose, such as extracted during a lipoplasty procedure, is useful for multi-step processing to prepare a concentrated product (e.g., stromal vascular fraction) or a fat graft composition. The apparatus has a container with a containment volume with a tissue retention volume and a filtrate volume separated by a filter and with a tapered portion to a collection volume for collecting concentrate product. Inlet and suction ports provide access to the tissue retention volume and filtrate volume, respectively, and an extraction port provides versatile access for removal of target processed concentrate material or fat graft material, which access may be via a lumen through a rotatable mixer shaft. Access ports may be configured for access only from above the container. The apparatus is incorporatable into a variety of assemblies, systems, kits, methods and uses.
摘要翻译：用于收集和加工含有脂肪的人体生物材料的便携式装置，例如在脂肪成形术过程中提取的，可用于多步骤加工以制备浓缩产物（例如基质血管部分）或脂肪移植组合物。该装置具有容器，其具有容纳体积，具有组织保持体积，滤液体积由过滤器分离，并具有锥形部分，用于收集浓缩物产品的收集容积。入口和吸入口分别提供对组织保持体积和滤液体积的访问，并且提取端口提供用于去除目标处理的浓缩物质或脂肪移植材料的通用途径，其可通过可旋转的混合器轴通过管腔进入。访问端口可以被配置为仅从容器上方访问。该装置可并入各种组件，系统，套件，方法和用途中。

10. 发明申请

US20090236297A1 Plasma Concentrator Device 有权
标题翻译：等离子集中器
公开(公告)号：US20090236297A1
公开(公告)日：2009-09-24
申请号：US12476838
申请日：2009-06-02
申请人： Randel Dorian , Michael D. Leach , Richard Wood Storrs
发明人： Randel Dorian , Michael D. Leach , Richard Wood Storrs
IPC分类号： B01D33/27
CPC分类号： A61M1/3679 , A61M1/0204 , A61M1/3693 , A61M2202/0415 , Y10T436/25375 , Y10T436/255
摘要： A plasma concentrator having a concentrator chamber, concentrator gel beads, a filter, and an agitator. The agitator end is positioned in the concentrator chamber and supported for rotation about its central axis and for reciprocal movement along its central axis. A filter is selected to block effective flow of plasma therethrough under ambient gravity conditions and permit plasma and plasma concentrate flow therethrough under centrifugal forces of the separation gravity. A method concentrates plasma by removing water without significantly denaturing the fibrinogen in the plasma. Then centrifugal force can be applied to the concentrated plasma in an amount sufficient to separate a substantial portion of the plasma concentrate from the beads.
摘要翻译：具有浓缩器室，浓缩器凝胶珠，过滤器和搅拌器的等离子体浓缩器。搅拌器端部定位在聚光器室中并被支撑以围绕其中心轴线旋转并且用于沿其中心轴线往复运动。选择过滤器以阻止等离子体在环境重力条件下的有效流动，并允许等离子体和等离子体浓缩物在分离重力的离心力下流过其中。方法通过除去水而不使血浆中的纤维蛋白原显着变性来浓缩血浆。然后可以将离心力施加到浓缩的等离子体中，其量足以将大部分等离子体浓缩物与珠粒分离。

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