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1. 发明申请

US20090221075A1 System And Process For Separating A Material 有权
标题翻译：用于分离材料的系统和过程
公开(公告)号：US20090221075A1
公开(公告)日：2009-09-03
申请号：US12395085
申请日：2009-02-27
申请人： Randel Dorian , Michael D. Leach , Richard W. Storrs , Jason Chavarria
发明人： Randel Dorian , Michael D. Leach , Richard W. Storrs , Jason Chavarria
IPC分类号： C12N5/00 , C12M1/00
CPC分类号： C12M47/04 , B01L3/5021 , B01L3/50825 , B01L3/5635 , B01L2200/026 , B01L2300/046 , C12M47/02 , G01N1/286 , G01N1/4077
摘要： Disclosed is a system to separate, enrich, and/or purify a cellular population from a biological tissue, such as a tissue sample. For example, an adipose tissue sample can be acquired and disrupted. The disrupted tissue sample can then be separated and purified. The separated components can include multipotent, pluripotent, or other cell populations.
摘要翻译：公开了从生物组织如组织样品分离，富集和/或纯化细胞群的系统。例如，可以获取并破坏脂肪组织样品。然后可以分离和纯化破碎的组织样品。分离的组分可以包括多能，多能或其他细胞群体。

2. 发明授权

US07901584B2 Plasma concentration 有权
标题翻译：血浆浓度
公开(公告)号：US07901584B2
公开(公告)日：2011-03-08
申请号：US12476838
申请日：2009-06-02
申请人： Randel Dorian , Michael D. Leach , Richard W. Storrs
发明人： Randel Dorian , Michael D. Leach , Richard W. Storrs
IPC分类号： B01D15/02 , B01D33/27 , B01D37/00
CPC分类号： A61M1/3679 , A61M1/0204 , A61M1/3693 , A61M2202/0415 , Y10T436/25375 , Y10T436/255
摘要： A plasma concentrator having a concentrator chamber, concentrator gel beads, a filter, and an agitator. The agitator end is positioned in the concentrator chamber and supported for rotation about its central axis and for reciprocal movement along its central axis. A filter is selected to block effective flow of plasma therethrough under ambient gravity conditions and permit plasma and plasma concentrate flow therethrough under centrifugal forces of the separation gravity. A method concentrates plasma by removing water without significantly denaturing the fibrinogen in the plasma. Then centrifugal force can be applied to the concentrated plasma in an amount sufficient to separate a substantial portion of the plasma concentrate from the beads.
摘要翻译：具有浓缩器室，浓缩器凝胶珠，过滤器和搅拌器的等离子体浓缩器。搅拌器端部定位在聚光器室中并被支撑以围绕其中心轴线旋转并且用于沿其中心轴线往复运动。选择过滤器以阻止等离子体在环境重力条件下的有效流动，并允许等离子体和等离子体浓缩物在分离重力的离心力下流过其中。方法通过除去水而不使血浆中的纤维蛋白原显着变性来浓缩血浆。然后可以将离心力施加到浓缩的等离子体中，其量足以将大部分等离子体浓缩物与珠粒分离。

3. 发明授权

US08337711B2 System and process for separating a material 有权
标题翻译：用于分离材料的系统和过程
公开(公告)号：US08337711B2
公开(公告)日：2012-12-25
申请号：US12395085
申请日：2009-02-27
申请人： Randel Dorian , Michael D. Leach , Richard W. Storrs , Jason Chavarria
发明人： Randel Dorian , Michael D. Leach , Richard W. Storrs , Jason Chavarria
IPC分类号： B01D21/26 , B04B3/00
CPC分类号： C12M47/04 , B01L3/5021 , B01L3/50825 , B01L3/5635 , B01L2200/026 , B01L2300/046 , C12M47/02 , G01N1/286 , G01N1/4077
摘要： Disclosed is a system to separate, enrich, and/or purify a cellular population from a biological tissue, such as a tissue sample. For example, an adipose tissue sample can be acquired and disrupted. The disrupted tissue sample can then be separated and purified. The separated components can include multipotent, pluripotent, or other cell populations.
摘要翻译：公开了从生物组织如组织样品分离，富集和/或纯化细胞群的系统。例如，可以获取并破坏脂肪组织样品。然后可以分离和纯化破碎的组织样品。分离的组分可以包括多能，多能或其他细胞群体。

4. 发明申请

US20120027746A1 METHOD FOR GENERATING THROMBIN 审中-公开
标题翻译：生产THROMBIN的方法
公开(公告)号：US20120027746A1
公开(公告)日：2012-02-02
申请号：US12846944
申请日：2010-07-30
申请人： Randel DORIAN , Richard W. Storrs , Michael D. Leach
发明人： Randel DORIAN , Richard W. Storrs , Michael D. Leach
IPC分类号： A61K38/48 , A61P7/00 , C12N9/74
CPC分类号： C12N9/6429 , A61K38/00 , A61K38/4833 , C12Y304/21005
摘要： Methods of generating thrombin and methods of applying a clotting tissue sealant to a site on a subject are provided. A blood component comprising platelets can be obtained from the subject. A hypotonic composition is contacted with a solid matrix to form a thrombin-containing liquid, where the hypotonic composition includes water, calcium, a blood component comprising platelets, and optionally a chelator. Calcium is present in the hypotonic composition in an amount greater than the amount of calcium that can be complexed by the chelator. Thrombin-containing liquid is then separated from the hypotonic composition and can be applied to the site on the subject to form a clot, for example, by combination with fibrinogen.
摘要翻译：提供产生凝血酶的方法和将凝结组织密封剂施用于受试者的部位的方法。可以从受试者获得包含血小板的血液成分。低渗组合物与固体基质接触以形成含凝血酶的液体，其中低渗组合物包括水，钙，包含血小板的血液成分和任选的螯合剂。钙在低渗组合物中的存在量大于可由螯合剂络合的钙的量。然后将含凝血酶的液体与低渗组合物分离，并且可以应用于受试者的位点以形成凝块，例如通过与纤维蛋白原组合。

5. 发明授权

US08328024B2 Buoy suspension fractionation system 有权
$Buoy suspension fractionation system$
标题翻译：浮标分离系统
公开(公告)号：US08328024B2
公开(公告)日：2012-12-11
申请号：US13198038
申请日：2011-08-04
申请人： Michael D. Leach , Randel Dorian , Jacy C. Hoeppner
发明人： Michael D. Leach , Randel Dorian , Jacy C. Hoeppner
IPC分类号： B01D21/26 , B01D45/12 , B04B5/02 , B04B7/00
CPC分类号： B01D21/262 , A61M1/029 , A61M1/3693 , A61M2202/0427 , B01L3/50215 , B01L2200/026
摘要： A separator that uses centrifugation to fractionate a suspension such as blood comprises a separation container and a buoy. The buoy is carried in the separation container and has a tuned density that is configured to reach an equilibrium position in a suspension. The guide surface is carried on the buoy upper surface and is inclined to an accumulation position near a buoy perimeter. The buoy suspension fractionation system can be used in a method of isolating a fraction from a suspension, and in a method for re-suspending particulates for withdrawal.
摘要翻译：使用离心分离悬浮液如血液的分离器包括分离容器和浮标。浮标被携带在分离容器中并且具有被配置为在悬浮液中达到平衡位置的调节密度。引导表面承载在浮标上表面上，并且倾斜于靠近浮标周界的积聚位置。浮标分级分离系统可用于从悬浮液中分离馏分的方法，以及用于再悬浮颗粒以进行萃取的方法。

6. 发明授权

US08096422B2 Apparatus and method for preparing platelet rich plasma and concentrates thereof 有权
标题翻译：制备富血小板血浆及其浓缩物的装置及方法
公开(公告)号：US08096422B2
公开(公告)日：2012-01-17
申请号：US12917055
申请日：2010-11-01
申请人： Randel Dorian , Michael D. Leach
发明人： Randel Dorian , Michael D. Leach
IPC分类号： B01D33/067 , B01D35/00 , B01D24/32 , B04B3/00
CPC分类号： B01D63/02 , A61M1/0281 , A61M1/3482 , A61M1/3496 , A61M1/3633 , A61M1/3679 , A61M1/3693 , A61M1/3696 , A61M2202/0415 , A61M2202/0427 , B01D2313/44 , B01D2313/58 , B04B5/0442 , B04B2005/0478
摘要： Disclosed is a separator-concentrator, such as for separating and concentrating platelet-rich-plasma (PRP) from whole blood that is suitable for office use or emergency use for trauma victims. The PRP separator comprises a motorized centrifugal separation assembly and a concentrator assembly. The centrifugal separation assembly comprises a centrifugal drum separator and a motor having a drive axis connected to the centrifugal drum separator. The concentrator assembly comprises a water-removal module for preparing PRP concentrate.
摘要翻译：公开了一种分离器收集器，例如用于分离和浓缩富血小板血浆（PRP），全血适用于办公用途或紧急用于创伤受害者。 PRP分离器包括电动离心分离组件和集中器组件。离心分离组件包括离心鼓分离器和具有连接到离心鼓分离器的驱动轴的马达。浓缩器组件包括用于制备PRP浓缩物的去水模块。

7. 发明授权

US07987995B2 Method and apparatus for preparing platelet rich plasma and concentrates thereof 有权
标题翻译：制备富血小板血浆及其浓缩物的方法和装置
公开(公告)号：US07987995B2
公开(公告)日：2011-08-02
申请号：US12772497
申请日：2010-05-03
申请人： Randel Dorian , Michael D. Leach
发明人： Randel Dorian , Michael D. Leach
IPC分类号： B01D15/02 , B01D21/26 , B01D33/00 , B04B3/00 , B04B7/08
CPC分类号： B01D63/02 , A61M1/0281 , A61M1/3482 , A61M1/3496 , A61M1/3633 , A61M1/3679 , A61M1/3693 , A61M1/3696 , A61M2202/0415 , A61M2202/0427 , B01D2313/44 , B01D2313/58 , B01F11/0005 , B01F13/0052 , B04B5/0442 , B04B2005/0478
摘要： The PRP separator-concentrator of this invention is suitable for office use or emergency use for trauma victims. The PRP separator comprises a motorized centrifugal separation assembly, and a concentrator assembly. The centrifugal separator assembly comprises a centrifugal drum separator that includes an erythrocyte capture module and a motor having a drive axis connected to the centrifugal drum separator. The concentrator assembly comprises a water-removal module for preparing PRP concentrate. The centrifugal drum separator has an erythrocyte trap. The water removal module can be a syringe device with water absorbing beads or it can be a pump-hollow fiber cartridge assembly. The hollow fibers are membranes with pores that allow the flow of water through the fiber membrane while excluding flow of clotting factors useful for sealing and adhering tissue and growth factors helpful for healing while avoiding activation of platelets and disruption of any trace erythrocytes present in the PRP.
摘要翻译：本发明的PRP分离器集中器适用于创伤受害者的办公用途或紧急用途。 PRP分离器包括电动离心分离组件和集中器组件。离心分离器组件包括离心鼓分离器，其包括红细胞捕获模块和具有连接到离心鼓分离器的驱动轴的马达。浓缩器组件包括用于制备PRP浓缩物的去水模块。离心鼓分离器具有红细胞捕集器。除水模块可以是具有吸水珠的注射器装置，或者其可以是泵中空纤维筒组件。中空纤维是具有孔的膜，其允许水流过纤维膜，同时排除可用于密封和粘附组织的凝血因子的流动和有助于愈合的生长因子，同时避免血小板的活化和PRP中存在的任何痕量红细胞的破坏。

8. 发明申请

US20110021334A1 Buoy Suspension Fractionation System 有权
标题翻译：浮标分离系统
公开(公告)号：US20110021334A1
公开(公告)日：2011-01-27
申请号：US12897401
申请日：2010-10-04
申请人： Michael D. Leach , Randel Dorian , Jacy C. Hoeppner
发明人： Michael D. Leach , Randel Dorian , Jacy C. Hoeppner
IPC分类号： B01D21/26
CPC分类号： B01D21/262 , A61M1/029 , A61M1/3693 , B01D21/26 , B01L3/50215 , B01L2200/026 , B01L2400/0409 , G01N33/491
摘要： A separator that uses centrifugation to fractionate a suspension such as blood comprises a separation container and a buoy. The buoy is carried in the separation container and has a tuned density that is configured to reach an equilibrium position in a suspension. The guide surface is carried on the buoy upper surface and is inclined to an accumulation position near a buoy perimeter. The buoy suspension fractionation system can be used in a method of isolating a fraction from a suspension, and in a method for re-suspending particulates for withdrawal.
摘要翻译：使用离心分离悬浮液如血液的分离器包括分离容器和浮标。浮标被携带在分离容器中并且具有被配置为在悬浮液中达到平衡位置的调节密度。引导表面承载在浮标上表面上，并且倾斜于靠近浮标周界的积聚位置。浮标分级分离系统可用于从悬浮液中分离馏分的方法，以及用于再悬浮颗粒以进行萃取的方法。

9. 发明授权

US07824559B2 Apparatus and method for preparing platelet rich plasma and concentrates thereof 有权
标题翻译：制备富血小板血浆及其浓缩物的装置及方法
公开(公告)号：US07824559B2
公开(公告)日：2010-11-02
申请号：US11342749
申请日：2006-01-30
申请人： Randel Dorian , Michael D. Leach
发明人： Randel Dorian , Michael D. Leach
IPC分类号： B01D21/26 , B01D33/00 , B01D35/00 , B01D37/00 , B04B1/04 , B04B3/00
CPC分类号： B01D63/02 , A61M1/0281 , A61M1/3482 , A61M1/3496 , A61M1/3633 , A61M1/3679 , A61M1/3693 , A61M1/3696 , A61M2202/0415 , A61M2202/0427 , B01D2313/44 , B01D2313/58 , B04B5/0442 , B04B2005/0478
摘要： A PRP separator-concentrator comprising a housing, a separation assembly, and a concentration assembly. The concentration assembly has a concentration sump. An axially concentric rigid stationary outlet tube is secured to the housing and extends through the separation assembly to the sump. The separation assembly is attached to and positioned above the concentration assembly to form a combined separator-concentrator assemblage that is rotatable about the outlet tube. The separation assembly includes a separation chamber lined with a depth filter having pores and passageways that are sized to receive and entrap erythrocytes during centrifuging. The concentration chamber has a floor for supporting desiccated beads and a wall with at least one opening closed with a screen. The concentrator can have a distribution of upright screen supports, the upright screen supports having an inner surface and an outer surface, the cylindrical screen being supported on the outer surface of the upright screen supports. A stationary bead rake can be secured to the stationary tube and extend outward therefrom, the rake having distal ends that are spaced at a distance from the upright screen supports. The rake can comprise a longitudinal body, the center of which is secured to the rigid outlet tube. The separator-concentrator includes a valve assembly connecting the separation chamber and the concentration chamber. PRP concentrate is produced by contacting PRP with desiccated beads while the beads are stirred with a stationary rake, and rotating the concentration chamber at centrifugal speeds to separate PRP concentrate from the beads.
摘要翻译： PRP分离器集中器，其包括壳体，分离组件和浓缩组件。浓缩组件具有浓缩池。轴向同心的刚性固定出口管固定到壳体并且延伸穿过分离组件到达贮槽。分离组件附接到并定位在浓度组件上方，以形成围绕出口管可旋转的组合的分离器 - 集中器组合件。分离组件包括分隔室，内部具有深度过滤器，该深度过滤器具有孔和通道，其尺寸适于在离心过程中接收和捕获红细胞。浓缩室具有用于支撑干燥珠粒的底板和具有至少一个开口的屏幕的壁。集中器可以具有直立屏幕支撑件的分布，直立屏幕支撑件具有内表面和外表面，圆柱形屏幕支撑在直立屏幕支撑件的外表面上。固定的胎圈耙子可以固定到固定管并从其向外延伸，耙子具有与立式筛网支撑件间隔一定距离的远端。耙子可以包括纵向主体，其中心固定到刚性出口管。分离器集中器包括连接分离室和浓缩室的阀组件。 PRP浓缩物通过使PRP与干燥的珠粒接触而产生，同时将珠粒与固定的耙子一起搅拌，并且以离心速度旋转浓缩室以将PRP浓缩物与珠粒分离。

10. 发明申请

US20100206798A1 Method And Apparatus For Preparing Platelet Rich Plasma And Concentrates Thereof 有权
标题翻译：制备富血小板血浆及其浓缩物的方法和装置
公开(公告)号：US20100206798A1
公开(公告)日：2010-08-19
申请号：US12772497
申请日：2010-05-03
申请人： Randel Dorian , Michael D. Leach
发明人： Randel Dorian , Michael D. Leach
IPC分类号： B01D15/02
CPC分类号： B01D63/02 , A61M1/0281 , A61M1/3482 , A61M1/3496 , A61M1/3633 , A61M1/3679 , A61M1/3693 , A61M1/3696 , A61M2202/0415 , A61M2202/0427 , B01D2313/44 , B01D2313/58 , B01F11/0005 , B01F13/0052 , B04B5/0442 , B04B2005/0478
摘要： The PRP separator-concentrator of this invention is suitable for office use or emergency use for trauma victims. The PRP separator comprises a motorized centrifugal separation assembly, and a concentrator assembly. The centrifugal separator assembly comprises a centrifugal drum separator that includes an erythrocyte capture module and a motor having a drive axis connected to the centrifugal drum separator. The concentrator assembly comprises a water-removal module for preparing PRP concentrate. The centrifugal drum separator has an erythrocyte trap. The water removal module can be a syringe device with water absorbing beads or it can be a pump-hollow fiber cartridge assembly. The hollow fibers are membranes with pores that allow the flow of water through the fiber membrane while excluding flow of clotting factors useful for sealing and adhering tissue and growth factors helpful for healing while avoiding activation of platelets and disruption of any trace erythrocytes present in the PRP.
摘要翻译：本发明的PRP分离器集中器适用于创伤受害者的办公用途或紧急用途。 PRP分离器包括电动离心分离组件和集中器组件。离心分离器组件包括离心鼓分离器，其包括红细胞捕获模块和具有连接到离心鼓分离器的驱动轴的马达。浓缩器组件包括用于制备PRP浓缩物的去水模块。离心鼓分离器具有红细胞捕集器。除水模块可以是具有吸水珠的注射器装置，或者其可以是泵中空纤维筒组件。中空纤维是具有孔的膜，其允许水流过纤维膜，同时排除可用于密封和粘附组织的凝血因子的流动和有助于愈合的生长因子，同时避免血小板活化和破坏PRP中存在的任何痕量红细胞。

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