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1. 发明授权

US08980631B2 High-throughput culture and transfer device and method 有权
标题翻译：高通量培养和转移装置及方法
公开(公告)号：US08980631B2
公开(公告)日：2015-03-17
申请号：US13381772
申请日：2010-06-30
申请人： Blair Taylor Stocks , Shayn Peirce Cottler , Adam J. Katz
发明人： Blair Taylor Stocks , Shayn Peirce Cottler , Adam J. Katz
IPC分类号： C12N5/02 , C12M1/12 , C12M1/32
CPC分类号： C12M25/01 , C12M21/08 , C12M23/12 , C12M25/00 , C12M41/00
摘要： A method and device for creating hanging drop cell aggregates. The method and device includes a plurality of pegs that allow for high throughput culture of aggregates. Also disclosed are means of transferring formed aggregates to various destinations, such as well plates, scaffolding, tissues, or wounds. Use of the device permits aggregates to be prepared or created in larger quantities than current methods, and allows for them to be transferred more efficiently.
摘要翻译：一种用于产生悬滴滴细胞聚集体的方法和装置。该方法和装置包括允许聚集体的高通量培养的多个栓钉。还公开了将形成的聚集体转移到各种目的地如孔板，脚手架，组织或伤口的手段。使用该设备可以使聚合体以比当前方法更大的量来制备或创建，并且允许其更有效地转移。

2. 发明授权

US08835170B2 Methods and compositions useful for diabetic wound healing 有权
标题翻译：用于糖尿病伤口愈合的方法和组合物
公开(公告)号：US08835170B2
公开(公告)日：2014-09-16
申请号：US12444412
申请日：2007-10-05
申请人： Adam J. Katz , Anna M. Parker
发明人： Adam J. Katz , Anna M. Parker
IPC分类号： C12N5/00 , C12N5/02 , C12N5/08 , C07K1/00 , C07K14/00 , A01N63/00 , A61K35/28 , A61K38/18 , A61K38/19
CPC分类号： A61K35/28 , A61K38/18 , A61K38/19 , A61K2300/00
摘要： The invention provides compositions and methods useful for treating wounds and enhancing wound healing, particularly for diabetic wound healing. One embodiment provides a method of treating a wound comprising administering to a subject in need thereof a therapeutically effective amount of adipose tissue derived stem cells to treat said wound, wherein the cells are cultured in the absence of serum prior to the administration to said subject. Another embodiment provides a method of treating a wound comprising administering to a subject in need thereof a therapeutically effective amount of adipose tissue derived stem cells to treat said wound, wherein the cells are cultured to induce the formation of at least one self-organizing mesenchymal blastema (SOMB) prior to the administration to said subject, wherein said SOMB is formed by culturing adipose tissue derived stem cells in hanging droplets.
摘要翻译：本发明提供了用于治疗伤口并增强伤口愈合的组合物和方法，特别是对于糖尿病伤口愈合。一个实施方案提供了治疗伤口的方法，其包括向有需要的受试者施用治疗有效量的脂肪组织来源的干细胞以治疗所述伤口，其中在给予所述受试者之前，在不存在血清的情况下培养细胞。另一个实施方案提供了一种治疗伤口的方法，其包括向有需要的受试者施用治疗有效量的脂肪组织来源的干细胞来治疗所述伤口，其中培养细胞以诱导形成至少一个自组织间充质胚乳（SOMB），其中所述SOMB通过以悬浮液滴培养脂肪组织来源的干细胞形成。

3. 发明申请

US20130164731A1 APPARATUS AND METHODS RELATING TO COLLECTING AND PROCESSING HUMAN BIOLOGICAL MATERIAL CONTAINING ADIPOSE 有权
标题翻译：与收集和处理含有ADIPOSE的人体生物材料相关的装置和方法
公开(公告)号：US20130164731A1
公开(公告)日：2013-06-27
申请号：US13808550
申请日：2011-07-08
申请人： William W. Cimino , Adam J. Katz , Ramon Llull
发明人： William W. Cimino , Adam J. Katz , Ramon Llull
IPC分类号： C12N5/071
CPC分类号： C12N5/0653 , A61M1/0001 , A61M1/0094 , A61M1/0204 , A61M2202/08 , A61M2205/103 , C12M47/04
摘要： A portable apparatus for collection and processing of human biological material containing adipose, such as extracted during a lipoplasty procedure, is useful for multi-step processing to prepare a concentrated product (e.g., stromal vascular fraction) or a fat graft composition. The apparatus has a container with a containment volume with a tissue retention volume and a filtrate volume separated by a filter and with a tapered portion to a collection volume for collecting concentrate product. Inlet and suction ports provide access to the tissue retention volume and filtrate volume, respectively, and an extraction port provides versatile access for removal of target processed concentrate material or fat graft material, which access may be via a lumen through a rotatable mixer shaft. Access ports may be configured for access only from above the container. The apparatus is incorporatable into a variety of assemblies, systems, kits, methods and uses.
摘要翻译：用于收集和加工含有脂肪的人体生物材料的便携式装置，例如在脂肪成形术过程中提取的，可用于多步骤加工以制备浓缩产物（例如基质血管部分）或脂肪移植组合物。该装置具有容器，其具有容纳体积，具有组织保持体积，滤液体积由过滤器分离，并具有锥形部分，用于收集浓缩物产品的收集容积。入口和吸入口分别提供对组织保持体积和滤液体积的访问，并且提取端口提供用于去除目标处理的浓缩物质或脂肪移植材料的通用途径，其可通过可旋转的混合器轴通过管腔进入。访问端口可以被配置为仅从容器上方访问。该装置可并入各种组件，系统，套件，方法和用途中。

4. 发明申请

US20110318833A1 ADIPOSE-DERIVED STEM CELLS AND LATICCES 审中-公开
公开(公告)号：US20110318833A1
公开(公告)日：2011-12-29
申请号：US13226338
申请日：2011-09-06
申请人： Adam J. Katz , Ramon Llull , J. William Futrell , Marc H. Hedrick , Prosper Benhaim , Hermann Peter Lorenz , Min Zhu
发明人： Adam J. Katz , Ramon Llull , J. William Futrell , Marc H. Hedrick , Prosper Benhaim , Hermann Peter Lorenz , Min Zhu
IPC分类号： C12N5/0775
CPC分类号： C12N5/0667 , A61K35/12 , A61K48/00 , C12N5/0068 , C12N5/06 , C12N5/0647 , C12N5/0654 , C12N5/0655 , C12N5/0658 , C12N2500/25 , C12N2500/38 , C12N2500/42 , C12N2501/01 , C12N2501/33 , C12N2501/39 , C12N2502/1305 , C12N2506/1384 , C12N2510/00 , C12N2533/90
摘要： The present invention provides adipose-derived stem cells and lattices. In one aspect, the present invention provides a lipo-derived stem cell substantially free of adipocytes and red blood cells and clonal populations of connective tissue stem cells. The cells can be employed, alone or within biologically-compatible compositions, to generate differentiated tissues and structures, both in vivo and in vitro. Additionally, the cells can be expanded and cultured to produce hormones and to provide conditioned culture media for supporting the growth and expansion of other cell populations. In another aspect, the present invention provides a lipo-derived lattice substantially devoid of cells, which includes extracellular matrix material from adipose tissue. The lattice can be used as a substrate to facilitate the growth and differentiation of cells, whether in vivo or in vitro, into anlagen or even mature tissues or structures.
摘要翻译：本发明提供脂肪来源的干细胞和晶格。一方面，本发明提供了一种基本上不含脂肪细胞和结缔组织干细胞的红细胞和克隆群的脂衍生的干细胞。细胞可以单独使用或在生物相容性组合物内使用，以在体内和体外产生分化的组织和结构。此外，细胞可以扩增和培养以产生激素，并提供条件培养基以支持其他细胞群的生长和扩增。另一方面，本发明提供了一种基本上不含细胞的脂衍生晶格，其包括来自脂肪组织的细胞外基质材料。晶格可以用作底物，以促进细胞的生长和分化，无论是在体内还是在体外，成为成体组织或甚至成熟的组织或结构。

5. 发明授权

US07932084B2 Methods and compositions for growing adipose stem cells 有权
标题翻译：生长脂肪干细胞的方法和组合物
公开(公告)号：US07932084B2
公开(公告)日：2011-04-26
申请号：US12066348
申请日：2006-09-08
申请人： Adam J. Katz , Anna M. Parker
发明人： Adam J. Katz , Anna M. Parker
IPC分类号： C12N5/00 , C12N15/00
CPC分类号： C12N5/0667 , C12N2500/25 , C12N2500/42 , C12N2500/90 , C12N2501/10 , C12N2501/11 , C12N2501/135 , C12N2501/23 , C12N2501/25 , C12N2501/39 , C12N2501/392
摘要： The present invention relates to adipose tissue-derived stem cells and to methods and compositions for enhancing growth and differentiation of such cells. The invention further relates to growing such cells in serum-free or low serum growth medium, and formulations thereof.
摘要翻译：本发明涉及来自脂肪组织的干细胞以及用于增强这些细胞生长和分化的方法和组合物。本发明还涉及在无血清或低血清生长培养基中培养这些细胞及其制剂。

6. 发明申请

US20110027879A1 Adipose-derived stem cells and lattices 审中-公开
标题翻译：脂肪来源的干细胞和晶格
公开(公告)号：US20110027879A1
公开(公告)日：2011-02-03
申请号：US12657722
申请日：2010-01-26
申请人： Adam J. Katz , Ramon Llull , J. William Futrell , Marc H. Hedrick , Prosper Benhaim , Hermann Peter Lorenz , Min Zhu , Patricia Zuk , Peter H. Ashjian
发明人： Adam J. Katz , Ramon Llull , J. William Futrell , Marc H. Hedrick , Prosper Benhaim , Hermann Peter Lorenz , Min Zhu , Patricia Zuk , Peter H. Ashjian
IPC分类号： C12N5/0775
CPC分类号： C12N5/0653 , A61K35/12 , A61K48/00 , C12N5/0068 , C12N5/0607 , C12N5/0647 , C12N5/0654 , C12N5/0655 , C12N5/0658 , C12N5/0667 , C12N9/1276 , C12N2500/25 , C12N2500/38 , C12N2500/42 , C12N2501/01 , C12N2501/15 , C12N2501/33 , C12N2501/39 , C12N2510/00 , C12N2533/90 , C12Y207/07049
摘要： The present invention provides adipose-derived stem cells (ADSCs), adipose-derived stem cell-enriched fractions (ADSC-EF) and adipose-derived lattices, alone and combined with the ADSCs of the invention. In one aspect, the present invention provides an ADSC substantially free of adipocytes and red blood cells and clonal populations of connective tissue stem cells. The ADSCs can be employed, alone or within biologically-compatible compositions, to generate differentiated tissues and structures, both in vivo and in vitro. Additionally, the ADSCs can be expanded and cultured to produce molecules such as hormones, and to provide conditioned culture media for supporting the growth and expansion of other cell populations. In another aspect, the present invention provides a adipose-derived lattice substantially devoid of cells, which includes extracellular matrix material from adipose tissue. The lattice can be used as a substrate to facilitate the growth and differentiation of cells, whether in vivo or in vitro, into anlagen or even mature tissues or structures.
摘要翻译：本发明单独提供脂肪来源的干细胞（ADSCs），脂肪来源的干细胞富含级分（ADSC-EF）和脂肪衍生的格子，并与本发明的ADSC组合。一方面，本发明提供了基本上不含结缔组织干细胞的脂肪细胞和红细胞和克隆群体的ADSC。 ADSC可以单独使用或在生物相容性组合物内使用，以在体内和体外产生分化的组织和结构。另外，可以扩增和培养ADSC以产生分子如激素，并提供条件培养基以支持其它细胞群的生长和扩增。另一方面，本发明提供了一种基本上不含细胞的脂肪衍生的晶格，其包括来自脂肪组织的细胞外基质材料。晶格可以用作底物，以促进细胞的生长和分化，无论是在体内还是在体外，成为成体组织或甚至成熟的组织或结构。

7. 发明申请

US20090181456A1 Adipose-derived stem cells and lattices 审中-公开
标题翻译：脂肪来源的干细胞和晶格
公开(公告)号：US20090181456A1
公开(公告)日：2009-07-16
申请号：US12315967
申请日：2008-12-08
申请人： Marc H. Hedrick , Adam J. Katz , Ramon Lluil , J. William Futrell , Prosper Benhaim , Hermann Peter Lorenz , Min Zhu
发明人： Marc H. Hedrick , Adam J. Katz , Ramon Lluil , J. William Futrell , Prosper Benhaim , Hermann Peter Lorenz , Min Zhu
IPC分类号： C12N5/08
CPC分类号： C12N5/0667 , A61K35/12 , A61K48/00 , C12N5/0068 , C12N2500/25 , C12N2500/38 , C12N2500/42 , C12N2501/01 , C12N2501/15 , C12N2501/33 , C12N2501/39 , C12N2510/00 , C12N2533/90
摘要： The present invention provides adipose-derived stem cells (ADSCs), adipose-derived stem cell-enriched fractions (ADSC-EF) and adipose-derived lattices, alone and combined with the ADSCs of the invention. In one aspect, the present invention provides an ADSC substantially free of adipocytes and red blood cells and clonal populations of connective tissue stem cells. The ADSCs can be employed, alone or within biologically-compatible compositions, to generate differentiated tissues and structures, both in vivo and in vitro. Additionally, the ADSCs can be expanded and cultured to produce molecules such as hormones, and to provide conditioned culture media for supporting the growth and expansion of other cell populations. In another aspect the present invention provides a adipose-derived lattice substantially devoid of cells, which includes extracellular matrix material from adipose tissue. The lattice can be used as a substrate to facilitate the growth and differentiation of cells, whether in vivo or in vitro, into anlagen or even mature tissues or structures.
摘要翻译：本发明单独提供脂肪来源的干细胞（ADSCs），脂肪来源的干细胞富含级分（ADSC-EF）和脂肪衍生的格子，并与本发明的ADSC组合。一方面，本发明提供了基本上不含结缔组织干细胞的脂肪细胞和红细胞和克隆群体的ADSC。 ADSC可以单独使用或在生物相容性组合物内使用，以在体内和体外产生分化的组织和结构。另外，可以扩增和培养ADSC以产生分子如激素，并提供条件培养基以支持其它细胞群的生长和扩增。在另一方面，本发明提供了一种基本上不含细胞的脂肪衍生的晶格，其包括来自脂肪组织的细胞外基质材料。晶格可以用作底物，以促进细胞的生长和分化，无论是在体内还是在体外，成为成体组织或甚至成熟的组织或结构。

8. 发明申请

US20080248003A1 Methods and Compositions for Growing Adipose Stem Cells 有权
标题翻译：生长脂肪干细胞的方法和组合
公开(公告)号：US20080248003A1
公开(公告)日：2008-10-09
申请号：US12066348
申请日：2006-09-08
申请人： Adam J. Katz , Anna M. Parker
发明人： Adam J. Katz , Anna M. Parker
IPC分类号： A61K35/12 , C12N5/06 , A61P43/00
CPC分类号： C12N5/0667 , C12N2500/25 , C12N2500/42 , C12N2500/90 , C12N2501/10 , C12N2501/11 , C12N2501/135 , C12N2501/23 , C12N2501/25 , C12N2501/39 , C12N2501/392
摘要： The present invention relates to adipose tissue-derived stem cells and to methods and compositions for enhancing growth and differentiation of such cells. The invention further relates to growing such cells in serum-free or low serum growth medium, and formulations thereof.
摘要翻译：本发明涉及来自脂肪组织的干细胞以及用于增强这些细胞生长和分化的方法和组合物。本发明还涉及在无血清或低血清生长培养基中培养这些细胞及其制剂。

9. 发明授权

US06316247B1 System and method for refining liposuctioned adipose tissue 失效
标题翻译：脂肪抽吸脂肪组织的系统和方法
公开(公告)号：US06316247B1
公开(公告)日：2001-11-13
申请号：US09333532
申请日：1999-06-15
申请人： Adam J. Katz , Ramon Llull , J. William Futrell , Marc H. Hedrick , Frank R. Walters
发明人： Adam J. Katz , Ramon Llull , J. William Futrell , Marc H. Hedrick , Frank R. Walters
IPC分类号： C07G1700
CPC分类号： A61L27/3604 , A61L27/3683
摘要： A device and method for producing refined adipose tissue for use in autologous adipose transplantation or research wherein a sterile environment is maintained. More particularly, a system for refining tissue comprising a first flexible container, a second flexible container having a plurality of pores providing for fluid communication between the interior of the first flexible container and the interior of the first enveloping flexible container, a first port that provides communication between the exterior environment and the interior of the first flexible container and thereby provides a means for introducing fluids into the interior of the first flexible container and allowing waste effluent to exit the first container, a second flexible container, a second port for inserting tissue into the second container and expressing refined tissue out of the container, and a means for controlling the opening and closing of the first and second ports. The method comprises introducing a tissue sample into the system and subjecting it to a washing phase wherein the tissue is agitated, the waste effluent is allowed to exit the system through the first port, and the refined tissue is expressed out the second port for further refinement or transplantation.
摘要翻译：用于生产用于自体脂肪移植或研究的精制脂肪组织的装置和方法，其中保持无菌环境。更具体地，涉及一种用于精制组织的系统，包括第一柔性容器，具有多个孔的第二柔性容器，所述第二柔性容器提供用于在第一柔性容器的内部与第一包封柔性容器的内部之间的流体连通;第一端口，外部环境和第一柔性容器的内部之间的连通，从而提供用于将流体引入第一柔性容器的内部并允许废物流出物离开第一容器，第二柔性容器，用于插入组织的第二端口进入第二容器并从容器中表达精制的组织，以及用于控制第一和第二端口的打开和关闭的装置。该方法包括将组织样品引入系统并使其进行洗涤阶段，其中组织被搅动，允许废物流出物通过第一端口离开系统，并且精制组织被表达出第二端口用于进一步细化或移植。

10. 发明申请

US20150376572A1 ADIPOSE-DERIVED STEM CELLS AND LATTICES 审中-公开
公开(公告)号：US20150376572A1
公开(公告)日：2015-12-31
申请号：US14581956
申请日：2014-12-23
申请人： Adam J. Katz , Ramon Llull , J. William Futrell , Marc H. Hedrick , Prosper Benhaim , Hermann Peter Lorenz , Min Zhu , Patricia Zuk , Peter H. Ashjian
发明人： Adam J. Katz , Ramon Llull , J. William Futrell , Marc H. Hedrick , Prosper Benhaim , Hermann Peter Lorenz , Min Zhu , Patricia Zuk , Peter H. Ashjian
IPC分类号： C12N5/077 , C12N9/12
CPC分类号： C12N5/0653 , A61K35/12 , A61K48/00 , C12N5/0068 , C12N5/0607 , C12N5/0647 , C12N5/0654 , C12N5/0655 , C12N5/0658 , C12N5/0667 , C12N9/1276 , C12N2500/25 , C12N2500/38 , C12N2500/42 , C12N2501/01 , C12N2501/15 , C12N2501/33 , C12N2501/39 , C12N2510/00 , C12N2533/90 , C12Y207/07049
摘要： The present invention provides adipose-derived stem cells (ADSCs), adipose-derived stem cell-enriched fractions (ADSC-EF) and adipose-derived lattices, alone and combined with the ADSCs of the invention. In one aspect, the present invention provides an ADSC substantially free of adipocytes and red blood cells and clonal populations of connective tissue stem cells. The ADSCs can be employed, alone or within biologically-compatible compositions, to generate differentiated tissues and structures, both in vivo and in vitro. Additionally, the ADSCs can be expanded and cultured to produce molecules such as hormones, and to provide conditioned culture media for supporting the growth and expansion of other cell populations. In another aspect, the present invention provides a adipose-derived lattice substantially devoid of cells, which includes extracellular matrix material from adipose tissue. The lattice can be used as a substrate to facilitate the growth and differentiation of cells, whether in vivo or in vitro, into anlagen or even mature tissues or structures.
摘要翻译：本发明单独提供脂肪来源的干细胞（ADSCs），脂肪来源的干细胞富含级分（ADSC-EF）和脂肪衍生的格子，并与本发明的ADSC组合。一方面，本发明提供了基本上不含结缔组织干细胞的脂肪细胞和红细胞和克隆群体的ADSC。 ADSC可以单独使用或在生物相容性组合物内使用，以在体内和体外产生分化的组织和结构。另外，可以扩增和培养ADSC以产生分子如激素，并提供条件培养基以支持其它细胞群的生长和扩增。另一方面，本发明提供了一种基本上不含细胞的脂肪衍生的晶格，其包括来自脂肪组织的细胞外基质材料。晶格可以用作底物，以促进细胞的生长和分化，无论是在体内还是在体外，成为成体组织或甚至成熟的组织或结构。

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