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1. 发明申请

US20060175268A1 Plasma concentrator device 有权
公开(公告)号：US20060175268A1
公开(公告)日：2006-08-10
申请号：US11342982
申请日：2006-01-30
申请人： Randel Dorian , Michael Leach , Richard Storrs
发明人： Randel Dorian , Michael Leach , Richard Storrs
IPC分类号： C02F1/38
CPC分类号： A61M1/3679 , A61M1/0204 , A61M1/3693 , A61M2202/0415 , Y10T436/25375 , Y10T436/255
摘要： A plasma concentrator of this invention having a concentrator chamber, concentrator gel beads, a filter, and an agitator. The agitator has agitator blades extending outwardly from the lower end. The agitator end is positioned in the concentrator chamber and supported for rotation about its central axis and for reciprocal movement along its central axis. The concentrator has a top with an upper opening through which the upper end of the actuator stem extends, and a lower opening in which the filter is positioned. The concentrator chamber can have a cylindrical inner wall, and the agitator blades can have an outer edge in close proximity to the inner wall with the space between the outer edge and the inner wall being less than the diameter of the gel beads. The filter is selected to block effective flow of plasma therethrough under ambient gravity conditions and permit plasma and plasma concentrate flow therethrough under centrifugal forces of the separation gravity. The method concentrates plasma by removing water without significantly denaturing the fibrinogen in the plasma. The plasma is introduced into a concentration chamber containing a plurality of dehydrated concentrator gel beads and an agitator. Then water is removed from the plasma while stirring the beads to reduce plasma polarization and breaking up clumps of beads that form during the agitation. Then centrifugal force can be applied to the concentrated plasma in an amount sufficient to separate a substantial portion of the plasma concentrate from the beads.

2. 发明申请

US20070034579A1 Methods and apparatus for isolating platelets from blood 有权
公开(公告)号：US20070034579A1
公开(公告)日：2007-02-15
申请号：US11584414
申请日：2006-10-19
申请人： Randel Dorian , Scott King , Richard Storrs
发明人： Randel Dorian , Scott King , Richard Storrs
IPC分类号： C02F1/38
CPC分类号： A61M1/3693 , A61K35/00 , A61M2202/0427 , B01D21/0012 , B01D21/26 , B01D21/262 , B01D2221/10 , B01L3/50215 , B01L2200/026 , B01L2400/0633 , G01N33/49 , Y10T436/25375
摘要： A platelet collection device comprising a centrifugal spin-separator container with a cavity having a longitudinal inner surface. A float in the cavity has a base, a platelet collection surface above the base, an outer surface. The float density is below the density of erythrocytes and above the density of plasma. The platelet collection surface has a position on the float which places it below the level of platelets when the float is suspended in separated blood. During centrifugation, a layer of platelets or buffy coat collects closely adjacent the platelet collection surface. Platelets are then removed from the platelet collection surface. Movement of a float having a density greater than whole blood through the sedimenting erythrocytes releases entrapped platelets, increasing the platelet yield.

3. 发明申请

US20050186120A1 Methods and apparatus for isolating platelets from blood 审中-公开
公开(公告)号：US20050186120A1
公开(公告)日：2005-08-25
申请号：US11108378
申请日：2005-04-18
申请人： Randel Dorian , Scott King , Richard Storrs
发明人： Randel Dorian , Scott King , Richard Storrs
IPC分类号： A61M1/02 , A61K35/00 , B01D21/00 , B01D21/26 , B01L3/14 , B01L99/00 , B04B5/02 , G01N33/49 , B01L11/00
CPC分类号： A61M1/3693 , A61K35/00 , A61M2202/0427 , B01D21/0012 , B01D21/26 , B01D21/262 , B01D2221/10 , B01L3/50215 , B01L2200/026 , B01L2400/0633 , G01N33/49 , Y10T436/25375
摘要： A platelet collection device comprising a centrifugal spin-separator container with a cavity having a longitudinal inner surface. A float in the cavity has a base, a platelet collection surface above the base, an outer surface. The float density is below the density of erythrocytes and above the density of plasma. The platelet collection surface has a position on the float which places it below the level of platelets when the float is suspended in separated blood. During centrifugation, a layer of platelets or buffy coat collects closely adjacent the platelet collection surface. Platelets are then removed from the platelet collection surface. Movement of a float having a density greater than whole blood through the sedimenting erythrocytes releases entrapped platelets, increasing the platelet yield.

4. 发明申请

US20050196874A1 Methods and apparatus for isolating platelets from blood 有权
标题翻译：从血液中分离血小板的方法和装置
公开(公告)号：US20050196874A1
公开(公告)日：2005-09-08
申请号：US11108387
申请日：2005-04-18
申请人： Randel Dorian , Scott King , Richard Storrs
发明人： Randel Dorian , Scott King , Richard Storrs
IPC分类号： A61M1/02 , A61K35/00 , B01D21/00 , B01D21/26 , B01L3/14 , B01L99/00 , B04B5/02 , G01N33/49 , B01L11/00
CPC分类号： A61M1/3693 , A61K35/00 , A61M2202/0427 , B01D21/0012 , B01D21/26 , B01D21/262 , B01D2221/10 , B01L3/50215 , B01L2200/026 , B01L2400/0633 , G01N33/49 , Y10T436/25375
摘要： A platelet collection device comprising a centrifugal spin-separator container with a cavity having a longitudinal inner surface. A float in the cavity has a base, a platelet collection surface above the base, an outer surface. The float density is below the density of erythrocytes and above the density of plasma. The platelet collection surface has a position on the float which places it below the level of platelets when the float is suspended in separated blood. During centrifugation, a layer of platelets or buffy coat collects closely adjacent the platelet collection surface. Platelets are then removed from the platelet collection surface. Movement of a float having a density greater than whole blood through the sedimenting erythrocytes releases entrapped platelets, increasing the platelet yield.
摘要翻译：一种血小板收集装置，其包括具有纵向内表面的空腔的离心旋转分离器容器。空腔中的浮子具有基部，基部上方的血小板收集表面，外表面。浮游密度低于红细胞密度，高于血浆密度。当血液悬浮在分离的血液中时，血小板收集表面具有在浮子上的位置，使其位于血小板的水平以下。在离心过程中，一层血小板或血沉棕黄层收集在血小板收集表面附近。然后从血小板收集表面除去血小板。具有大于全血的密度通过沉降的红细胞移动，释放截留的血小板，增加血小板产量。

5. 发明申请

US20070254864A1 CHROMIUM COMPLEXES 审中-公开
标题翻译：铬复合物
公开(公告)号：US20070254864A1
公开(公告)日：2007-11-01
申请号：US11740803
申请日：2007-04-26
申请人： Richard Storrs , Scott King
发明人： Richard Storrs , Scott King
IPC分类号： A61K31/555 , C07F11/00
CPC分类号： C07D215/48 , C07D213/79 , C07D213/80
摘要： The invention provides a complex which comprises at least one chromium ion and at least one pyridyl carboxylic acid moiety. The compounds of the invention are of use in controlling body mass and treating diseases caused by or characterized by deficiency of chromium metabolism, e.g., type 2 Diabetes, obesity, vascular disease and metabolic syndromes.
摘要翻译：本发明提供了一种复合物，其包括至少一种铬离子和至少一个吡啶羧酸部分。本发明的化合物可用于控制体重和治疗由铬代谢缺乏引起或特征的疾病，例如2型糖尿病，肥胖，血管疾病和代谢综合征。

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