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1. 发明申请

US20060175268A1 Plasma concentrator device 有权
公开(公告)号：US20060175268A1
公开(公告)日：2006-08-10
申请号：US11342982
申请日：2006-01-30
申请人： Randel Dorian , Michael Leach , Richard Storrs
发明人： Randel Dorian , Michael Leach , Richard Storrs
IPC分类号： C02F1/38
CPC分类号： A61M1/3679 , A61M1/0204 , A61M1/3693 , A61M2202/0415 , Y10T436/25375 , Y10T436/255
摘要： A plasma concentrator of this invention having a concentrator chamber, concentrator gel beads, a filter, and an agitator. The agitator has agitator blades extending outwardly from the lower end. The agitator end is positioned in the concentrator chamber and supported for rotation about its central axis and for reciprocal movement along its central axis. The concentrator has a top with an upper opening through which the upper end of the actuator stem extends, and a lower opening in which the filter is positioned. The concentrator chamber can have a cylindrical inner wall, and the agitator blades can have an outer edge in close proximity to the inner wall with the space between the outer edge and the inner wall being less than the diameter of the gel beads. The filter is selected to block effective flow of plasma therethrough under ambient gravity conditions and permit plasma and plasma concentrate flow therethrough under centrifugal forces of the separation gravity. The method concentrates plasma by removing water without significantly denaturing the fibrinogen in the plasma. The plasma is introduced into a concentration chamber containing a plurality of dehydrated concentrator gel beads and an agitator. Then water is removed from the plasma while stirring the beads to reduce plasma polarization and breaking up clumps of beads that form during the agitation. Then centrifugal force can be applied to the concentrated plasma in an amount sufficient to separate a substantial portion of the plasma concentrate from the beads.

2. 发明申请

US20050196874A1 Methods and apparatus for isolating platelets from blood 有权
标题翻译：从血液中分离血小板的方法和装置
公开(公告)号：US20050196874A1
公开(公告)日：2005-09-08
申请号：US11108387
申请日：2005-04-18
申请人： Randel Dorian , Scott King , Richard Storrs
发明人： Randel Dorian , Scott King , Richard Storrs
IPC分类号： A61M1/02 , A61K35/00 , B01D21/00 , B01D21/26 , B01L3/14 , B01L99/00 , B04B5/02 , G01N33/49 , B01L11/00
CPC分类号： A61M1/3693 , A61K35/00 , A61M2202/0427 , B01D21/0012 , B01D21/26 , B01D21/262 , B01D2221/10 , B01L3/50215 , B01L2200/026 , B01L2400/0633 , G01N33/49 , Y10T436/25375
摘要： A platelet collection device comprising a centrifugal spin-separator container with a cavity having a longitudinal inner surface. A float in the cavity has a base, a platelet collection surface above the base, an outer surface. The float density is below the density of erythrocytes and above the density of plasma. The platelet collection surface has a position on the float which places it below the level of platelets when the float is suspended in separated blood. During centrifugation, a layer of platelets or buffy coat collects closely adjacent the platelet collection surface. Platelets are then removed from the platelet collection surface. Movement of a float having a density greater than whole blood through the sedimenting erythrocytes releases entrapped platelets, increasing the platelet yield.
摘要翻译：一种血小板收集装置，其包括具有纵向内表面的空腔的离心旋转分离器容器。空腔中的浮子具有基部，基部上方的血小板收集表面，外表面。浮游密度低于红细胞密度，高于血浆密度。当血液悬浮在分离的血液中时，血小板收集表面具有在浮子上的位置，使其位于血小板的水平以下。在离心过程中，一层血小板或血沉棕黄层收集在血小板收集表面附近。然后从血小板收集表面除去血小板。具有大于全血的密度通过沉降的红细胞移动，释放截留的血小板，增加血小板产量。

3. 发明申请

US20070034579A1 Methods and apparatus for isolating platelets from blood 有权
公开(公告)号：US20070034579A1
公开(公告)日：2007-02-15
申请号：US11584414
申请日：2006-10-19
申请人： Randel Dorian , Scott King , Richard Storrs
发明人： Randel Dorian , Scott King , Richard Storrs
IPC分类号： C02F1/38
CPC分类号： A61M1/3693 , A61K35/00 , A61M2202/0427 , B01D21/0012 , B01D21/26 , B01D21/262 , B01D2221/10 , B01L3/50215 , B01L2200/026 , B01L2400/0633 , G01N33/49 , Y10T436/25375
摘要： A platelet collection device comprising a centrifugal spin-separator container with a cavity having a longitudinal inner surface. A float in the cavity has a base, a platelet collection surface above the base, an outer surface. The float density is below the density of erythrocytes and above the density of plasma. The platelet collection surface has a position on the float which places it below the level of platelets when the float is suspended in separated blood. During centrifugation, a layer of platelets or buffy coat collects closely adjacent the platelet collection surface. Platelets are then removed from the platelet collection surface. Movement of a float having a density greater than whole blood through the sedimenting erythrocytes releases entrapped platelets, increasing the platelet yield.

4. 发明申请

US20050186120A1 Methods and apparatus for isolating platelets from blood 审中-公开
公开(公告)号：US20050186120A1
公开(公告)日：2005-08-25
申请号：US11108378
申请日：2005-04-18
申请人： Randel Dorian , Scott King , Richard Storrs
发明人： Randel Dorian , Scott King , Richard Storrs
IPC分类号： A61M1/02 , A61K35/00 , B01D21/00 , B01D21/26 , B01L3/14 , B01L99/00 , B04B5/02 , G01N33/49 , B01L11/00
CPC分类号： A61M1/3693 , A61K35/00 , A61M2202/0427 , B01D21/0012 , B01D21/26 , B01D21/262 , B01D2221/10 , B01L3/50215 , B01L2200/026 , B01L2400/0633 , G01N33/49 , Y10T436/25375
摘要： A platelet collection device comprising a centrifugal spin-separator container with a cavity having a longitudinal inner surface. A float in the cavity has a base, a platelet collection surface above the base, an outer surface. The float density is below the density of erythrocytes and above the density of plasma. The platelet collection surface has a position on the float which places it below the level of platelets when the float is suspended in separated blood. During centrifugation, a layer of platelets or buffy coat collects closely adjacent the platelet collection surface. Platelets are then removed from the platelet collection surface. Movement of a float having a density greater than whole blood through the sedimenting erythrocytes releases entrapped platelets, increasing the platelet yield.

5. 发明申请

US20080011684A1 APPARATUS AND METHOD FOR PREPARING PLATELET RICH PLASMA AND CONCENTRATES THEREOF 有权
标题翻译：制备稀土等离子体及其浓度的装置和方法
公开(公告)号：US20080011684A1
公开(公告)日：2008-01-17
申请号：US11831605
申请日：2007-07-31
申请人： Randel Dorian , Michael Leach
发明人： Randel Dorian , Michael Leach
IPC分类号： B01D35/00 , B01D24/32 , B01D33/067
CPC分类号： A61M1/3496 , A61M1/3482 , A61M1/3633 , A61M1/3679 , A61M1/3693 , A61M1/3696 , A61M2202/0415 , B04B5/0442 , B04B2005/0478
摘要： A Platelet Rich Plasma separator assembly is disclosed. The assembly can include a cylindrical outer wall closed at the top by an upper plate and closed at the bottom. A bottom plate having an upper surface sloped down to a central opening. The top edge of the inner wall terminates at a distance from the upper plate to define an annular erythrocyte passageway therebetween. The inner wall has an outer surface and an inner surface that slopes radially inward from its top edge to its bottom at an angle of from 0.2 to 5 degrees with a central axis of the inner wall. A cylindrical depth filter is positioned between the inner surface of the outer wall and the outer surface of the inner wall in communication with the inner wall through the erythrocyte passageway.
摘要翻译：公开了一种富血小板血浆分离器组件。组件可以包括在顶部由上板封闭并在底部封闭的圆柱形外壁。底板，其具有向下倾斜到中心开口的上表面。内壁的顶边缘终止于距上板一定距离处，以在其间限定环形红细胞通道。内壁具有外表面和内表面，内表面与内壁的中心轴线以从0.2到5度的角度从其顶部边缘到其底部向内径向倾斜。圆柱形深度过滤器位于外壁的内表面和内壁的外表面之间，通过红细胞通道与内壁连通。

6. 发明申请

US20060175242A1 Method and apparatus for preparing platelet rich plasma and concentrates thereof 有权
标题翻译：制备富血小板血浆及其浓缩物的方法和装置
公开(公告)号：US20060175242A1
公开(公告)日：2006-08-10
申请号：US11342761
申请日：2006-01-30
申请人： Randel Dorian , Michael Leach
发明人： Randel Dorian , Michael Leach
IPC分类号： B01D63/00
CPC分类号： B01D63/02 , A61M1/0281 , A61M1/3482 , A61M1/3496 , A61M1/3633 , A61M1/3679 , A61M1/3693 , A61M1/3696 , A61M2202/0415 , A61M2202/0427 , B01D2313/44 , B01D2313/58 , B01F11/0005 , B01F13/0052 , B04B5/0442 , B04B2005/0478
摘要： The PRP separator-concentrator of this invention is suitable for office use or emergency use for trauma victims. The PRP separator comprises a motorized centrifugal separation assembly, and a concentrator assembly. The centrifugal separator assembly comprises a centrifugal drum separator that includes an erythrocyte capture module and a motor having a drive axis connected to the centrifugal drum separator. The concentrator assembly comprises a water-removal module for preparing PRP concentrate. The centrifugal drum separator has an erythrocyte trap. The water removal module can be a syringe device with water absorbing beads or it can be a pump-hollow fiber cartridge assembly. The hollow fibers are membranes with pores that allow the flow of water through the fiber membrane while excluding flow of clotting factors useful for sealing and adhering tissue and growth factors helpful for healing while avoiding activation of platelets and disruption of any trace erythrocytes present in the PRP.
摘要翻译：本发明的PRP分离器集中器适用于创伤受害者的办公用途或紧急用途。 PRP分离器包括电动离心分离组件和集中器组件。离心分离器组件包括离心鼓分离器，其包括红细胞捕获模块和具有连接到离心鼓分离器的驱动轴的马达。浓缩器组件包括用于制备PRP浓缩物的去水模块。离心鼓分离器具有红细胞捕集器。除水模块可以是具有吸水珠的注射器装置，或者其可以是泵中空纤维筒组件。中空纤维是具有孔的膜，其允许水流过纤维膜，同时排除可用于密封和粘附组织的凝血因子的流动和有助于愈合的生长因子，同时避免血小板的活化和PRP中存在的任何痕量红细胞的破坏。

7. 发明申请

US20060175244A1 Apparatus and method for preparing platelet rich plasma and concentrates thereof 有权
标题翻译：制备富血小板血浆及其浓缩物的装置及方法
公开(公告)号：US20060175244A1
公开(公告)日：2006-08-10
申请号：US11342749
申请日：2006-01-30
申请人： Randel Dorian , Michael Leach
发明人： Randel Dorian , Michael Leach
IPC分类号： B01D35/00
CPC分类号： B01D63/02 , A61M1/0281 , A61M1/3482 , A61M1/3496 , A61M1/3633 , A61M1/3679 , A61M1/3693 , A61M1/3696 , A61M2202/0415 , A61M2202/0427 , B01D2313/44 , B01D2313/58 , B04B5/0442 , B04B2005/0478
摘要： A PRP separator-concentrator comprising a housing, a separation assembly, and a concentration assembly. The concentration assembly has a concentration sump. An axially concentric rigid stationary outlet tube is secured to the housing and extends through the separation assembly to the sump. The separation assembly is attached to and positioned above the concentration assembly to form a combined separator-concentrator assemblage that is rotatable about the outlet tube. The separation assembly includes a separation chamber lined with a depth filter having pores and passageways that are sized to receive and entrap erythrocytes during centrifuging. The concentration chamber has a floor for supporting desiccated beads and a wall with at least one opening closed with a screen. The concentrator can have a distribution of upright screen supports, the upright screen supports having an inner surface and an outer surface, the cylindrical screen being supported on the outer surface of the upright screen supports. A stationary bead rake can be secured to the stationary tube and extend outward therefrom, the rake having distal ends that are spaced at a distance from the upright screen supports. The rake can comprise a longitudinal body, the center of which is secured to the rigid outlet tube. The separator-concentrator includes a valve assembly connecting the separation chamber and the concentration chamber. PRP concentrate is produced by contacting PRP with desiccated beads while the beads are stirred with a stationary rake, and rotating the concentration chamber at centrifugal speeds to separate PRP concentrate from the beads.
摘要翻译： PRP分离器集中器，其包括壳体，分离组件和浓缩组件。浓缩组件具有浓缩池。轴向同心的刚性固定出口管固定到壳体并且延伸穿过分离组件到达贮槽。分离组件附接到并定位在浓度组件上方，以形成围绕出口管可旋转的组合的分离器 - 集中器组合件。分离组件包括分隔室，内部具有深度过滤器，该深度过滤器具有孔和通道，其尺寸适于在离心过程中接收和捕获红细胞。浓缩室具有用于支撑干燥珠粒的底板和具有至少一个开口的屏幕的壁。集中器可以具有直立屏幕支撑件的分布，直立屏幕支撑件具有内表面和外表面，圆柱形屏幕支撑在直立屏幕支撑件的外表面上。固定的胎圈耙子可以固定到固定管并从其向外延伸，耙子具有与立式筛网支撑件间隔一定距离的远端。耙子可以包括纵向主体，其中心固定到刚性出口管。分离器集中器包括连接分离室和浓缩室的阀组件。 PRP浓缩物通过使PRP与干燥的珠粒接触而产生，同时将珠粒与固定的耙子一起搅拌，并且以离心速度旋转浓缩室以将PRP浓缩物与珠粒分离。

8. 发明授权

US08596470B2 Buoy fractionation system 有权
$Buoy fractionation system$
公开(公告)号：US08596470B2
公开(公告)日：2013-12-03
申请号：US13400188
申请日：2012-02-20
申请人： Michael D. Leach , Randel Dorian , Jacy C. Hoeppner
发明人： Michael D. Leach , Randel Dorian , Jacy C. Hoeppner
IPC分类号： B01D21/26
CPC分类号： B01D21/262 , A61M1/029 , A61M1/3693 , B01D21/26 , B01L3/50215 , B01L2200/026 , B01L2400/0409 , G01N33/491
摘要： A separator system operable to use centrifugation to fractionate a multiple component material, such as a suspension including blood, comprises a buoy. The buoy can be carried in a separation container and has a tuned density that is configured to reach an equilibrium position in the multiple component material. A guide surface is carried on a buoy upper surface and is inclined to an accumulation position near a buoy perimeter. The buoy suspension fractionation system can be used in a method of isolating a fraction from a suspension, and in a method for re-suspending particulates for withdrawal.

9. 发明申请

US20120145652A1 Method of Separating a Selected Component from a Multiple Component Material 有权
标题翻译：从多组分材料中分离所选组分的方法
公开(公告)号：US20120145652A1
公开(公告)日：2012-06-14
申请号：US13400188
申请日：2012-02-20
申请人： Michael D. Leach , Randel Dorian , Jacy C. Hoeppner
发明人： Michael D. Leach , Randel Dorian , Jacy C. Hoeppner
IPC分类号： B01D43/00
CPC分类号： B01D21/262 , A61M1/029 , A61M1/3693 , B01D21/26 , B01L3/50215 , B01L2200/026 , B01L2400/0409 , G01N33/491
摘要： A separator system operable to use centrifugation to fractionate a multiple component material, such as a suspension including blood, comprises a buoy. The buoy can be carried in a separation container and has a tuned density that is configured to reach an equilibrium position in the multiple component material. A guide surface is carried on a buoy upper surface and is inclined to an accumulation position near a buoy perimeter. The buoy suspension fractionation system can be used in a method of isolating a fraction from a suspension, and in a method for re-suspending particulates for withdrawal.
摘要翻译：可操作以使用离心分离多组分材料（例如包括血液的悬浮液）的分离器系统包括浮标。浮标可以携带在分离容器中，并且具有被配置为在多组分材料中达到平衡位置的调节密度。引导表面承载在浮标上表面上并且倾斜于靠近浮标周界的堆积位置。浮标分级分离系统可用于从悬浮液中分离馏分的方法，以及用于再悬浮颗粒以进行萃取的方法。

10. 发明授权

US08119013B2 Method of separating a selected component from a multiple component material 有权
标题翻译：将选择的组分与多组分材料分离的方法
公开(公告)号：US08119013B2
公开(公告)日：2012-02-21
申请号：US12897401
申请日：2010-10-04
申请人： Michael D. Leach , Randel Dorian , Jacy C. Hoeppner
发明人： Michael D. Leach , Randel Dorian , Jacy C. Hoeppner
IPC分类号： B01D21/26
CPC分类号： B01D21/262 , A61M1/029 , A61M1/3693 , B01D21/26 , B01L3/50215 , B01L2200/026 , B01L2400/0409 , G01N33/491
摘要： A separator that uses centrifugation to fractionate a suspension such as blood comprises a separation container and a buoy. The buoy is carried in the separation container and has a tuned density that is configured to reach an equilibrium position in a suspension. The guide surface is carried on the buoy upper surface and is inclined to an accumulation position near a buoy perimeter. The buoy suspension fractionation system can be used in a method of isolating a fraction from a suspension, and in a method for re-suspending particulates for withdrawal.
摘要翻译：使用离心分离悬浮液如血液的分离器包括分离容器和浮标。浮标被携带在分离容器中并且具有被配置为在悬浮液中达到平衡位置的调节密度。引导表面承载在浮标上表面上，并且倾斜于靠近浮标周界的积聚位置。浮标分级分离系统可用于从悬浮液中分离馏分的方法，以及用于再悬浮颗粒以进行萃取的方法。

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