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1. 发明授权

US06179586B2 Dual diaphragm, single chamber mesopump 有权
标题翻译：双隔膜，单室介孔泵
公开(公告)号：US06179586B2
公开(公告)日：2001-01-30
申请号：US09408651
申请日：1999-09-15
申请人： William R. Herb , J. David Zook , Cleopatra Cabuz
发明人： William R. Herb , J. David Zook , Cleopatra Cabuz
IPC分类号： F04B4300
CPC分类号： F04B43/043 , A61M5/14224 , A61M5/14276
摘要： A diaphragm pump, which is preferably electrostatically actuated, but which may be activated by other forces such as electromagnetic or piezoelectric actuation. The pump is formed by a pump body having a pump chamber formed therein. First and second diaphragms each having a set of valve holes in the diaphragm surface thereof are mounted in the chamber. Also provided are at least one inlet and at least one outlet port for communication with the pump chamber. The ports are positioned for sealing contact with the diaphragms at points that are not aligned with the holes in the diaphragms. A driver electrostatically actuates the diaphragms to cause diaphragm movement to a plurality of diaphragm positions to control flow of fluid through the pump. The first position is when the diaphragms are spaced from one another and from the ports to permit flow of fluid through the pump chamber. The second position is when the diaphragms are in diaphragm surface contact with the sets of holes mutually nonaligned to form a seal between the diaphragms. The third position is when a diaphragm is in diaphragm surface contact with the ports to form the sealing contact.
摘要翻译：隔膜泵优选是静电驱动的，但是可以通过诸如电磁或压电致动的其它力来激活。泵由具有形成在其中的泵室的泵体形成。在其隔膜表面中具有一组阀孔的第一和第二隔膜安装在腔室中。还设置有至少一个入口和至少一个用于与泵室连通的出口。端口被定位成在不与隔膜中的孔对准的点处与隔膜密封接触。驱动器静电地驱动隔膜以使隔膜移动到多个隔膜位置以控制通过泵的流体的流动。第一位置是当隔膜彼此间隔开并且从端口间隔开以允许流体流过泵室时。第二个位置是当隔膜与隔膜表面接触时，这些孔彼此不对齐，以形成隔膜之间的密封。第三个位置是当隔膜与隔膜表面接触时，形成密封接触。

2. 发明授权

US06549275B1 Optical detection system for flow cytometry 有权
标题翻译：流式细胞仪光学检测系统
公开(公告)号：US06549275B1
公开(公告)日：2003-04-15
申请号：US09630927
申请日：2000-08-02
申请人： Cleopatra Cabuz , J. David Zook , James Allen Cox , Aravind Padmanabhan , Teresa M. Marta
发明人： Cleopatra Cabuz , J. David Zook , James Allen Cox , Aravind Padmanabhan , Teresa M. Marta
IPC分类号： G01N3348
CPC分类号： G01N15/1456 , G01N15/1434 , G01N35/085 , G01N2015/0069 , G01N2015/0073 , G01N2015/008 , G01N2015/0238 , G01N2015/1075
摘要： An optical detection system for flow cytometry that uses two or more light sources positioned laterally at different distances from the central axis of the flow stream for providing light through different parts of the flow stream. By using two or more light sources, the particle position can be detected, and the alignment and width of the core stream can be monitored and controlled. In addition, the velocity and size of the particles can be more accurately determined than when only a single light source is used.
摘要翻译：一种用于流式细胞术的光学检测系统，其使用两个或更多个光源，其位于与流动流的中心轴线不同的距离处横向，用于通过流动流的不同部分提供光。通过使用两个或更多个光源，可以检测颗粒位置，并且可以监测和控制核心流的对准和宽度。此外，与仅使用单个光源相比，可以更准确地确定颗粒的速度和尺寸。

3. 发明授权

US06184608B2 Polymer microactuator array with macroscopic force and displacement 有权
公开(公告)号：US06184608B2
公开(公告)日：2001-02-06
申请号：US09223368
申请日：1998-12-29
申请人： Cleopatra Cabuz , Robert D. Horning , William R. Herb
发明人： Cleopatra Cabuz , Robert D. Horning , William R. Herb
IPC分类号： H02N100
CPC分类号： H02N1/006 , Y10T29/42
摘要： A microactuator array device, which includes a plurality of generally parallel thin flexible polymer sheets bonded together in a predetermined pattern to form an array of unit cells on at least one layer. Thin conductive and dielectric films are deposited on the sheets to form a plurality of electrodes associated with the array of unit cells. A source of electric potential operably connects the electrodes, whereby electrostatic forces are generated most intensely proximate the point where the gap between the sheets is smallest. Inlets and outlets for each cell permit displacement of fluid during generation of the electrostatic forces. In a preferred embodiment, the plurality of sheets forms a stack of layers of arrays of unit cells. The layers are configured such that bi-directional activation is caused by pairs of actuators working opposite each other. At least one of every pair of the sheets may be preformed into corrugations or into flaps to provide a predetermined mechanical bias between the pairs, or the sheets may form curved portions by an applied load to provide a displacement between the pairs. The sheets are preferably from about 1 &mgr;m to about 100 &mgr;m thick and the cells preferably have an individual displacement of from about 5 &mgr;m to about 200 &mgr;m.

4. 发明授权

US5901939A Buckled actuator with enhanced restoring force 失效
标题翻译：具有增强的恢复力的带扣致动器
公开(公告)号：US5901939A
公开(公告)日：1999-05-11
申请号：US948336
申请日：1997-10-09
申请人： Cleopatra Cabuz , Thomas R. Ohnstein , William R. Herb
发明人： Cleopatra Cabuz , Thomas R. Ohnstein , William R. Herb
IPC分类号： F15B11/042 , F15C5/00 , F16K31/02
CPC分类号： F15C5/00 , F15B11/0426 , Y10S251/901
摘要： An electrostatic actuator device including a stationary support and a buckled, moveable support mounted to enter into contact with the stationary support. At least three electrodes are employed. The first is mounted on the moveable support and a second electrode is on the stationary support. A third electrode is mounted on one of the supports such that the electrodes are positioned to form two pairs of electrodes for electrostatic attraction therebetween. The electrodes are powered by a voltage supply to provide electrostatic attraction between pairs of electrodes and move them into electrostatic contact. The buckled electrode has a shape configured to transmit a restoring force to its portion in contact with stationary support upon application of voltage to another pair of electrodes. The preferred voltage provides a two phase driving force including a voltage to the first pair of electrode for a period of time in a cycle of operation and a voltage to the second pair of electrodes for a period of time in the same cycle, preferably with an interim period of time with no voltage applied after each application of voltage. Various arrangements of three or more electrodes are disclosed, as is the use of the actuator in a microvalve having at least one valve opening. A three way microvalve is also shown, as are two forms of two dimensional valve arrays.
摘要翻译：一种静电致动器装置，包括固定支撑件和安装成与固定支架接触的带扣的可移动支撑件。至少使用三个电极。第一个安装在可移动支撑件上，第二个电极位于固定支架上。第三电极安装在一个支撑件上，使得电极被定位成形成两对电极，用于在它们之间静电吸引。电极由电压供电，以在电极对之间提供静电吸引并将它们移动成静电接触。带扣电极的形状被配置为当向另一对电极施加电压时将恢复力传递到与固定支架接触的部分。优选的电压在相同的周期中提供包括电压到第一对电极一段时间的相位驱动力，并且在相同的周期内将电压提供给第二对电极一段时间，优选地为每次施加电压后，不施加电压的中间时间段。公开了三个或更多个电极的各种布置，以及致动器在具有至少一个阀开口的微型阀中的使用。还示出了三路微型阀，两种形式的二维阀阵列也是如此。

5. 发明授权

US07197949B2 Meso sniffer: a device and method for active gas sampling using alternating flow 有权
标题翻译： Meso嗅探器：用于使用交替流动态气体采样的装置和方法
公开(公告)号：US07197949B2
公开(公告)日：2007-04-03
申请号：US10115305
申请日：2002-04-02
申请人： J. David Zook , Cleopatra Cabuz
发明人： J. David Zook , Cleopatra Cabuz
IPC分类号： G01N1/00 , G01N1/22 , B32B5/02 , B32B27/04 , B32B27/12
CPC分类号： G01N33/0026 , G01N1/24 , G01N33/0011 , Y10T436/11 , Y10T436/25 , Y10T436/25375 , Y10T436/2575 , Y10T436/25875
摘要： A sampling system for detecting an analyte, comprising a diaphragm pump, a buffer chamber, a sensor head and intake port. The pump includes a chamber for receiving fluids via first and second ports. A buffer chamber is located at the second port for holding a quantity of air, and a sensor head is adapted to identify the presence of a desired analyte and produce a signal in response to the quantity identified. Preferably the diaphragm pump has a volume of gas per stroke capacity slightly larger than the volume of the sensor head such that the pump chamber has a greater volume than the buffer chamber and the buffer chamber has about the same volume as the sensor head. A sensor intake port intakes a sample potentially containing the analyte for contact with the sensor head upon operation of the diaphragm pump and out of the sensor head by jet-action caused by rapid movement of the diaphragm pump. A filter may be used for filtering air drawn through the pump chamber. The diaphragm pump may be either a single chamber pump or a multiple chamber diaphragm mesopump. In the purging mode, the system can also contain a pump for filling the system with clean air. When a mesopump is used, a single pumping channel can provide both AC and DC operation.
摘要翻译：一种用于检测分析物的采样系统，包括隔膜泵，缓冲室，传感头和进气口。泵包括用于经由第一和第二端口接收流体的室。缓冲室位于第二端口处，用于保持一定量的空气，并且传感器头适于识别所需分析物的存在并响应于所识别的量产生信号。优选地，隔膜泵具有稍微大于传感器头的体积的每行程容积的气体体积，使得泵室具有比缓冲室更大的体积，并且缓冲室具有与传感器头大致相同的体积。当隔膜泵工作时，传感器进气口进入可能含有分析物的样品，并通过由隔膜泵的快速运动引起的喷射作用而离开传感器头。过滤器可用于过滤通过泵室抽吸的空气。隔膜泵可以是单室泵或多室隔膜中孔泵。在清洗模式下，系统还可以包含用于用清洁空气填充系统的泵。当使用介质泵时，单个泵浦通道可以提供交流和直流操作。

6. 发明授权

US06597438B1 Portable flow cytometry 有权
标题翻译：便携式流式细胞仪
公开(公告)号：US06597438B1
公开(公告)日：2003-07-22
申请号：US09630924
申请日：2000-08-02
申请人： Cleopatra Cabuz , J. David Zook , James Allen Cox , Thomas Raymond Ohnstein , Ulrich Bonne , Eugen Loan Cabuz , Ernest Allen Satren , Aravind Padmanabhan , Teresa M. Marta
发明人： Cleopatra Cabuz , J. David Zook , James Allen Cox , Thomas Raymond Ohnstein , Ulrich Bonne , Eugen Loan Cabuz , Ernest Allen Satren , Aravind Padmanabhan , Teresa M. Marta
IPC分类号： G01N3349
CPC分类号： G01N15/1404 , A61B5/150022 , A61B5/15003 , A61B5/150221 , A61B5/150343 , A61B5/150351 , A61B5/150809 , A61B5/150824 , A61B5/157 , B01L3/5027 , G01N2015/1486 , Y10T436/101666
摘要： A portable or wearable cytometer that can be used at remote locations, such as in the field or at home. The flow cytometer of the present invention may help improve the healthcare of many weak, sick or elderly people by providing early detection of infection. By detecting the infection early, the infection may be more readily treatable. In military applications, the portable cytometer of the present invention may help save lives by providing early detection of infection due to biological agents.
摘要翻译：便携式或可穿戴式的血细胞计数仪，可在远程位置使用，如在野外或家中使用。本发明的流式细胞仪可以通过提供早期检测感染来帮助改善许多弱者，病人或老年人的医疗保健。通过早期检测感染，感染可能更容易治疗。在军事应用中，本发明的便携式血细胞计数器可以通过提供由于生物制剂引起的感染的早期检测来帮助挽救生命。

7. 发明授权

US06432721B1 Meso sniffer: a device and method for active gas sampling using alternating flow 有权
标题翻译： Meso嗅探器：用于使用交替流动态气体采样的装置和方法
公开(公告)号：US06432721B1
公开(公告)日：2002-08-13
申请号：US09430425
申请日：1999-10-29
申请人： J. David Zook , Cleopatra Cabuz
发明人： J. David Zook , Cleopatra Cabuz
IPC分类号： G01N122
CPC分类号： G01N33/0026 , G01N1/24 , G01N33/0011 , Y10T436/11 , Y10T436/25 , Y10T436/25375 , Y10T436/2575 , Y10T436/25875
摘要： A sampling system for detecting an analyte, comprising a diaphragm pump, a buffer chamber, a sensor head and intake port. The pump includes a chamber for receiving fluids via first and second ports. A buffer chamber is located at the second port for holding a quantity of air, and a sensor head is adapted to identify the presence of a desired analyte and produce a signal in response to the quantity identified. Preferably the diaphragm pump has a volume of gas per stroke capacity slightly larger than the volume of the sensor head such that the pump chamber has a greater volume than the buffer chamber and the buffer chamber has about the same volume as the sensor head. A sensor intake port intakes a sample potentially containing the analyte for contact with the sensor head upon operation of the diaphragm pump and out of the sensor head by jet-action caused by rapid movement of the diaphragm pump. A filter may be used for filtering air drawn through the pump chamber. The diaphragm pump may be either a single chamber pump or a multiple chamber diaphragm mesopump. In the purging mode, the system can also contain a pump for filling the system with cleaned air. When a mesopump is used, a single pumping channel can provide both AC and DC operation.
摘要翻译：一种用于检测分析物的采样系统，包括隔膜泵，缓冲室，传感头和进气口。泵包括用于经由第一和第二端口接收流体的室。缓冲室位于第二端口处，用于保持一定量的空气，并且传感器头适于识别所需分析物的存在并响应于所识别的量产生信号。优选地，隔膜泵具有稍微大于传感器头的体积的每行程容积的气体体积，使得泵室具有比缓冲室更大的体积，并且缓冲室具有与传感器头大致相同的体积。当隔膜泵工作时，传感器进气口进入可能含有分析物的样品，并通过由隔膜泵的快速运动引起的喷射作用而离开传感器头。过滤器可用于过滤通过泵室抽吸的空气。隔膜泵可以是单室泵或多室隔膜中孔泵。在清洗模式中，系统还可以包含用于用清洁空气填充系统的泵。当使用介质泵时，单个泵浦通道可以提供交流和直流操作。

8. 发明授权

US06382228B1 Fluid driving system for flow cytometry 有权
标题翻译：用于流式细胞仪的流体驱动系统
公开(公告)号：US06382228B1
公开(公告)日：2002-05-07
申请号：US09630923
申请日：2000-08-02
申请人： Cleopatra Cabuz , J. David Zook , Thomas Raymond Ohnstein , Ulrich Bonne , Eugen Loan Cabuz , Ernest Allen Satren
发明人： Cleopatra Cabuz , J. David Zook , Thomas Raymond Ohnstein , Ulrich Bonne , Eugen Loan Cabuz , Ernest Allen Satren
IPC分类号： G05D706
CPC分类号： G05D7/0694 , G01N15/1404 , Y10T137/0368 , Y10T137/0396 , Y10T137/7759 , Y10T137/7761 , Y10T137/87265
摘要： A fluid driving system for portable flow cytometers or other portable devices that accepts a less precise and less stable pressure source, and then adjusts the pressure in a closed-loop manner to maintain a constant, desired flow velocity. The fluid driving system may be used in portable or wearable cytometers for use in remote locations, such as at home or in the field.
摘要翻译：用于便携式流式细胞仪或其他便携式装置的流体驱动系统，其接受不太精确和不太稳定的压力源，然后以闭环方式调节压力以保持恒定的所需流速。流体驱动系统可以用于便携式或可穿戴式细胞仪中，用于远程位置，例如在家中或在现场。

9. 发明授权

US06255758B1 Polymer microactuator array with macroscopic force and displacement 失效
标题翻译：聚合物微致动器阵列具有宏观力和位移
公开(公告)号：US06255758B1
公开(公告)日：2001-07-03
申请号：US09609726
申请日：2000-07-03
申请人： Cleopatra Cabuz , Robert D. Horning , William R. Herb
发明人： Cleopatra Cabuz , Robert D. Horning , William R. Herb
IPC分类号： H02N100
CPC分类号： H02N1/006 , Y10T29/42
摘要： A microactuator array device, which includes a plurality of generally parallel thin flexible polymer sheets bonded together in a predetermined pattern to form an array of unit cells on at least one layer. Thin conductive and dielectric films are deposited on the sheets to form a plurality of electrodes associated with the array of unit cells. A source of electric potential operably connects the electrodes, whereby electrostatic forces are generated most intensely proximate the point where the gap between the sheets is smallest. Inlets and outlets for each cell permit displacement of fluid during generation of the electrostatic forces. In a preferred embodiment, the plurality of sheets forms a stack of layers of arrays of unit cells. The layers are configured such that bi-directional activation is caused by pairs of actuators working opposite each other. At least one of every pair of the sheets may be preformed into corrugations or into flaps to provide a predetermined mechanical bias between the pairs, or the sheets may form curved portions by an applied load to provide a displacement between the pairs. The sheets are preferably from about 1 &mgr;m to about 100 &mgr;m thick and the cells preferably have an individual displacement of from about 5 &mgr;m to about 200 &mgr;m.
摘要翻译：一种微致动器阵列装置，其包括以预定图案结合在一起以在至少一个层上形成单元电池阵列的多个大致平行的薄柔性聚合物片。薄片导电和介电薄膜沉积在薄片上以形成与单元阵列阵列相关联的多个电极。电位源可操作地连接电极，由此静电力最强烈地产生在板之间的间隙最小的点附近。每个细胞的入口和出口允许在产生静电力期间排出流体。在优选实施例中，多个片材形成一组单元阵列阵列。这些层被配置成使得双向激活由彼此相对工作的成对的致动器引起。每对片材中的至少一个可以被预成形为波纹或折片以在对之间提供预定的机械偏置，或者片材可以通过施加的载荷形成弯曲部分，以在对之间提供位移。片材优选为约1μm至约100μm厚，并且细胞优选具有约5μm至约200μm的单个位移。

10. 发明申请

US20130038446A1 LOCATOR SYSTEM USING DISPARATE LOCATOR SIGNALS 有权
标题翻译：定位器系统使用不同的定位器信号
公开(公告)号：US20130038446A1
公开(公告)日：2013-02-14
申请号：US13207247
申请日：2011-08-10
申请人： Steve Huseth , Cleopatra Cabuz
发明人： Steve Huseth , Cleopatra Cabuz
IPC分类号： G08B1/08
CPC分类号： G08B21/0202 , G08B29/183
摘要： The present disclosure relates generally to locating systems, and more particularly, to handheld locator systems for locating personnel or other objects in buildings or other environments. In one illustrative embodiment, a tag is attached to an object to be located (e.g. firefighter). The tag may be configured to emit a first signal and a second signal, where the first signal and the second signal having disparate propagation characteristics in the environment. In some cases, the first signal may be an acoustic signal and the second signal may be an RF signal, but this is not required in all embodiments. By using a first signal or set of signals, and then automatically switching to another signal or set of signal(s) when the first signal or set of signals are not received clearly, the tag/receiver system may help mitigate the failure modes/weaknesses of any single technology, and may provide advantages over use of any of the technologies used singly.
摘要翻译：本公开一般涉及定位系统，更具体地，涉及用于在人造建筑物或其他环境中定位人员或其他物体的手持定位器系统。在一个说明性实施例中，标签附接到要定位的对象（例如消防员）。标签可以被配置为发射第一信号和第二信号，其中第一信号和第二信号在环境中具有不同的传播特性。在一些情况下，第一信号可以是声信号，第二信号可以是RF信号，但是在所有实施例中不是必需的。通过使用第一信号或一组信号，然后当第一信号或一组信号没有被清楚地接收时，自动切换到另一个信号或一组信号，标签/接收机系统可以帮助减轻故障模式/弱点任何单一技术，并且可以提供优于使用单独使用的任何技术的优点。

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