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1. 发明授权

US06597438B1 Portable flow cytometry 有权
标题翻译：便携式流式细胞仪
公开(公告)号：US06597438B1
公开(公告)日：2003-07-22
申请号：US09630924
申请日：2000-08-02
申请人： Cleopatra Cabuz , J. David Zook , James Allen Cox , Thomas Raymond Ohnstein , Ulrich Bonne , Eugen Loan Cabuz , Ernest Allen Satren , Aravind Padmanabhan , Teresa M. Marta
发明人： Cleopatra Cabuz , J. David Zook , James Allen Cox , Thomas Raymond Ohnstein , Ulrich Bonne , Eugen Loan Cabuz , Ernest Allen Satren , Aravind Padmanabhan , Teresa M. Marta
IPC分类号： G01N3349
CPC分类号： G01N15/1404 , A61B5/150022 , A61B5/15003 , A61B5/150221 , A61B5/150343 , A61B5/150351 , A61B5/150809 , A61B5/150824 , A61B5/157 , B01L3/5027 , G01N2015/1486 , Y10T436/101666
摘要： A portable or wearable cytometer that can be used at remote locations, such as in the field or at home. The flow cytometer of the present invention may help improve the healthcare of many weak, sick or elderly people by providing early detection of infection. By detecting the infection early, the infection may be more readily treatable. In military applications, the portable cytometer of the present invention may help save lives by providing early detection of infection due to biological agents.
摘要翻译：便携式或可穿戴式的血细胞计数仪，可在远程位置使用，如在野外或家中使用。本发明的流式细胞仪可以通过提供早期检测感染来帮助改善许多弱者，病人或老年人的医疗保健。通过早期检测感染，感染可能更容易治疗。在军事应用中，本发明的便携式血细胞计数器可以通过提供由于生物制剂引起的感染的早期检测来帮助挽救生命。

2. 发明授权

US06549275B1 Optical detection system for flow cytometry 有权
标题翻译：流式细胞仪光学检测系统
公开(公告)号：US06549275B1
公开(公告)日：2003-04-15
申请号：US09630927
申请日：2000-08-02
申请人： Cleopatra Cabuz , J. David Zook , James Allen Cox , Aravind Padmanabhan , Teresa M. Marta
发明人： Cleopatra Cabuz , J. David Zook , James Allen Cox , Aravind Padmanabhan , Teresa M. Marta
IPC分类号： G01N3348
CPC分类号： G01N15/1456 , G01N15/1434 , G01N35/085 , G01N2015/0069 , G01N2015/0073 , G01N2015/008 , G01N2015/0238 , G01N2015/1075
摘要： An optical detection system for flow cytometry that uses two or more light sources positioned laterally at different distances from the central axis of the flow stream for providing light through different parts of the flow stream. By using two or more light sources, the particle position can be detected, and the alignment and width of the core stream can be monitored and controlled. In addition, the velocity and size of the particles can be more accurately determined than when only a single light source is used.
摘要翻译：一种用于流式细胞术的光学检测系统，其使用两个或更多个光源，其位于与流动流的中心轴线不同的距离处横向，用于通过流动流的不同部分提供光。通过使用两个或更多个光源，可以检测颗粒位置，并且可以监测和控制核心流的对准和宽度。此外，与仅使用单个光源相比，可以更准确地确定颗粒的速度和尺寸。

3. 发明授权

US08071051B2 Portable sample analyzer cartridge 有权
标题翻译：便携式样品分析仪盒
公开(公告)号：US08071051B2
公开(公告)日：2011-12-06
申请号：US10908460
申请日：2005-05-12
申请人： Aravind Padmanabhan , James A. Cox , Cleopatra Cabuz
发明人： Aravind Padmanabhan , James A. Cox , Cleopatra Cabuz
IPC分类号： B01L3/00 , C12M1/34
CPC分类号： B01L3/502715 , B01L9/527 , B01L2200/027 , B01L2200/04 , B01L2200/0636 , B01L2200/146 , B01L2300/0672 , B01L2300/0816 , B01L2300/0877 , B01L2300/14 , B01L2400/0487 , G01N15/1484 , G01N35/00722 , G01N2015/0073 , G01N2015/0084 , G01N2015/0088 , G01N2015/1413 , G01N2015/1486 , G01N2035/00891
摘要： A sample analyzer cartridge for use at a point of care of a patient such as in a doctor's office, in the home, or elsewhere in the field. By providing a removable and/or disposable cartridge with all of the needed reagents and/or fluids, the sample analyzer can be reliably used outside of the laboratory environment, with little or no specialized training.
摘要翻译：在患者的护理点使用的样品分析器盒，例如在医生的办公室，家庭或现场的其他地方。通过提供具有所有需要的试剂和/或流体的可拆卸和/或一次性的筒，样品分析仪可以在实验室环境之外被可靠地使用，很少或没有专门的培训。

4. 发明授权

US06794981B2 Integratable-fluid flow and property microsensor assembly 失效
标题翻译：可积分流体流量和性能微传感器组件
公开(公告)号：US06794981B2
公开(公告)日：2004-09-21
申请号：US10150851
申请日：2002-05-16
申请人： Aravind Padmanabhan , Jay G. Schwichtenberg , Cleopatra Cabuz , Ernest Satren
发明人： Aravind Padmanabhan , Jay G. Schwichtenberg , Cleopatra Cabuz , Ernest Satren
IPC分类号： H01C304
CPC分类号： G01F1/6842 , G01F1/6845 , G01F5/00 , G01N1/2247 , G01N25/18 , G01N25/488 , G01N33/0014 , G01N2001/2285
摘要： An integratable fluid flow and property microsensor assembly is configured to be operably embedded in a microfluidic cartridge of the type used in lab-on-a-chip systems. The assembly is a robust package having a microstructure flow sensor contained within a housing in order to achieve a robust sensing device. The cartridge provides a flow path to the assembly, which directs the fluid across the flow sensor and returns the fluid to the cartridge flow path. The flow sensor monitors the controlled flow of fluid and transmits signals indicative of that flow. The assembly structure provides a robust sensor that is operable and accurate in many different applications.
摘要翻译：可整合的流体流动和性质微传感器组件被配置为可操作地嵌入在芯片实验室系统中使用的类型的微流体盒中。该组件是具有包含在壳体内的微结构流量传感器的鲁棒封装，以便实现鲁棒的感测装置。墨盒提供到组件的流动路径，其引导流体穿过流量传感器并将流体返回到墨盒流动路径。流量传感器监测流体的受控流动并传输指示该流量的信号。组装结构提供了一个鲁棒的传感器，在许多不同的应用中可操作和准确。

5. 发明授权

US08383043B2 Analyzer system 有权
标题翻译：分析仪系统
公开(公告)号：US08383043B2
公开(公告)日：2013-02-26
申请号：US11615884
申请日：2006-12-22
申请人： Aravind Padmanabhan , James A. Cox , Bernard S. Fritz , Tom M. Rezachek , Peter L. Reutiman , Ron L. Bardell , Cleopatra Cabuz
发明人： Aravind Padmanabhan , James A. Cox , Bernard S. Fritz , Tom M. Rezachek , Peter L. Reutiman , Ron L. Bardell , Cleopatra Cabuz
IPC分类号： G01N33/00 , G01N33/48
CPC分类号： G01N35/00603 , B01L3/502715 , B01L3/502723 , B01L3/50273 , B01L3/502746 , B01L9/527 , B01L2200/027 , B01L2200/04 , B01L2200/0636 , B01L2200/0684 , B01L2200/143 , B01L2200/146 , B01L2300/021 , B01L2300/044 , B01L2300/0627 , B01L2300/0672 , B01L2300/0816 , B01L2300/0877 , B01L2300/14 , B01L2400/0406 , B01L2400/0481 , B01L2400/0487 , G01N15/1404 , G01N15/1459 , G01N15/1484 , G01N21/53 , G01N29/032 , G01N33/5094 , G01N35/00663 , G01N2015/0069 , G01N2015/0073 , G01N2015/008 , G01N2015/0084 , G01N2015/1452 , G01N2015/1486 , G01N2035/00148 , G01N2035/00158 , G01N2035/00247 , G01N2035/1034 , G01N2035/1053 , G01N2291/02433 , G01N2291/02836 , G01N2291/02872
摘要： A system relating to sample analyzers, and more particular, to sample analyzers that are simple to operate and have a reduce risk of providing an erroneous result to a user. In some cases, the sample analyzer may be a portable sample analyzer that includes a disposable fluidic cartridge. The operators of the analyzers need not be trained.
摘要翻译：与样品分析仪相关的系统，更具体地，涉及操作简单且降低向用户提供错误结果的风险的样品分析仪。在一些情况下，样品分析仪可以是便携式样品分析仪，其包括一次性流体盒。不需要对分析仪的操作员进行培训。

6. 发明授权

US07333197B2 Raman detection based flow cytometer 有权
标题翻译：基于拉曼检测的流式细胞仪
公开(公告)号：US07333197B2
公开(公告)日：2008-02-19
申请号：US10991001
申请日：2004-11-17
申请人： Bernard S. Fritz , Aravind Padmanabhan , Cleopatra Cabuz
发明人： Bernard S. Fritz , Aravind Padmanabhan , Cleopatra Cabuz
IPC分类号： G01N21/00
CPC分类号： G01N21/658 , G01N15/147
摘要： A method and apparatus for enabling chemical identification of individual particles, cells of molecules by obtaining a Raman spectrum of a particle, cell or molecule as it flows past a sensing point in a flow cytometer. The particles, which may be cells or molecules, are associated with a suitable noble metal colloid or colloidal aggregate. Cellular particles may be associated with gold or silver colloidal particles by ultra-sonic sonification while in a sample preparation reservoir containing the gold or silver colloidal suspension. The colloid associated particles are then hydrodynamically focused into a single file by a fluid control module. The surface-enhance Raman Spectrum of individual particles are obtained by illuminating the particle with a laser as the particle flows past a sensing point and gathering the light that is non-elastically scattered (Raman scattered) by the particle. The surface-enhanced Raman spectrum is then analyzed to identify the particle.
摘要翻译：一种方法和装置，用于通过在流式细胞计数器中流过感测点时获得粒子，细胞或分子的拉曼光谱，从而能够化学鉴定单个颗粒，分子细胞。可以是细胞或分子的颗粒与合适的贵金属胶体或胶体聚集体相关联。在含有金或银胶体悬浮液的样品制备储存器中，细胞颗粒可以通过超声波超声处理与金或银胶体颗粒结合。然后通过流体控制模块将胶体相关颗粒流体动力聚焦成单个文件。当颗粒流过感测点并通过颗粒收集非弹性散射（拉曼散射）的光时，通过用激光照射颗粒来获得单个颗粒的表面增强拉曼光谱。然后分析表面增强拉曼光谱以鉴定颗粒。

7. 发明申请

US20070172388A1 PORTABLE SAMPLE ANALYZER SYSTEM 有权
标题翻译：便携式样品分析仪系统
公开(公告)号：US20070172388A1
公开(公告)日：2007-07-26
申请号：US11615874
申请日：2006-12-22
申请人： Aravind Padmanabhan , James Cox , Bernard Fritz , Tom Rezachek , Peter Reutiman , Ron Bardell , Cleopatra Cabuz
发明人： Aravind Padmanabhan , James Cox , Bernard Fritz , Tom Rezachek , Peter Reutiman , Ron Bardell , Cleopatra Cabuz
IPC分类号： G01N31/22
CPC分类号： G01N35/00603 , B01L3/502715 , B01L3/502723 , B01L3/50273 , B01L3/502746 , B01L9/527 , B01L2200/027 , B01L2200/04 , B01L2200/0636 , B01L2200/0684 , B01L2200/143 , B01L2200/146 , B01L2300/021 , B01L2300/0627 , B01L2300/0672 , B01L2300/0816 , B01L2300/0877 , B01L2300/14 , B01L2400/0487 , G01N15/1404 , G01N15/1459 , G01N15/1484 , G01N21/53 , G01N29/032 , G01N35/00663 , G01N2015/0069 , G01N2015/0073 , G01N2015/008 , G01N2015/0084 , G01N2015/1452 , G01N2015/1486 , G01N2035/00148 , G01N2035/00247 , G01N2035/1034 , G01N2035/1053 , G01N2291/02433 , G01N2291/02836 , G01N2291/02872
摘要： A system relating to sample analyzers, and more particular, to sample analyzers that are simple to operate and have a reduced risk of providing an erroneous result to a user. In some cases, the sample analyzer may be a portable sample analyzer that includes a disposable fluidic cartridge. The operators of the analyzers need not be trained.
摘要翻译：与样品分析仪有关的系统，更具体地说，涉及操作简单且降低向用户提供错误结果的风险的样品分析仪。在一些情况下，样品分析仪可以是便携式样品分析仪，其包括一次性流体盒。不需要对分析仪的操作员进行培训。

8. 发明申请

US20070003434A1 FLOW METERED ANALYZER 有权
标题翻译：流量计分析仪
公开(公告)号：US20070003434A1
公开(公告)日：2007-01-04
申请号：US11428332
申请日：2006-06-30
申请人： Aravind Padmanabhan , Cleopatra Cabuz
发明人： Aravind Padmanabhan , Cleopatra Cabuz
IPC分类号： G01N21/00
CPC分类号： B01L3/502746 , B01L3/50273 , B01L9/527 , B01L2200/14 , B01L2200/146 , B01L2200/147 , B01L2300/14 , B01L2300/1838 , B01L2400/0487 , B01L2400/082 , G01N15/1484 , G01N2015/0073 , G01N2015/008 , G01N2015/0084 , G01N2015/1486
摘要： A hematology analyzer or cytometer cartridge system having flow metering. It may have on- or off-cartridge flow metering and control. The system may have local and direct flow measurement to provide accurate counts per unit volume. There may be numerous arrangements for fluidic circuit checks of the cartridge. Examples may include checks pertaining to zero flow, interface, pressure, flow rate, fluid type and quality, backflow, dry qualification, temperature exposure limits, and so on, of the circuits and cartridge associated items.
摘要翻译：具有流量计量的血液分析仪或血细胞计数器系统。它可以具有开/关流量计量和控制。该系统可以具有本地和直接流量测量，以提供每单位体积的精确计数。可能存在许多针对盒的流体回路检查的布置。示例可以包括关于电路和盒相关物品的零流量，界面，压力，流速，流体类型和质量，回流，干质量鉴定，温度暴露限制等的检查。

9. 发明申请

US20050243304A1 CYTOMETER ANALYSIS CARTRIDGE OPTICAL CONFIGURATION 有权
标题翻译： CYTOMETER ANALYSIC CARTRIDGE光学配置
公开(公告)号：US20050243304A1
公开(公告)日：2005-11-03
申请号：US10908543
申请日：2005-05-16
申请人： Aravind Padmanabhan , Jay Schwichtenberg , Bernard Fritz , Cleopatra Cabuz , Ernest Satren
发明人： Aravind Padmanabhan , Jay Schwichtenberg , Bernard Fritz , Cleopatra Cabuz , Ernest Satren
IPC分类号： B01L3/00 , B01L9/00 , G01N15/00 , G01N15/14 , G01N33/48
CPC分类号： G01N15/1459 , B01L3/502715 , B01L9/527 , B01L2200/025 , B01L2200/027 , B01L2200/0636 , B01L2200/0689 , B01L2300/0645 , B01L2300/0654 , B01L2400/0487 , B01L2400/0633 , G01N15/1456 , G01N15/1484 , G01N2015/008 , G01N2015/1452 , G01N2015/1486
摘要： A medium having microfluidic circuitry for sampling and analyses. The medium may be a cartridge having a window countersunk into it and containing a flow channel. The flow channel may have items of interest flowing through it. Analyses of these items may be optical involving one or more light sources emanating light to and one or more light detectors receiving light from the channel. There are various configurations so that source and detector light cones may reach the flow channel without obscuration or interference of the light to and from the flow channel in the window.
摘要翻译：具有用于取样和分析的微流体电路的介质。该介质可以是具有一个窗口沉入其中并包含流动通道的盒。流动通道可以具有流过其的兴趣物品。这些项目的分析可以是光学的，涉及发射光的一个或多个光源和从该通道接收光的一个或多个光检测器。存在各种配置，使得源和检测器光锥可以到达流动通道而不会使光在窗口中的流动通道的光线不受干扰或干扰。

10. 发明授权

US08361410B2 Flow metered analyzer 有权
标题翻译：流量计分析仪
公开(公告)号：US08361410B2
公开(公告)日：2013-01-29
申请号：US11428332
申请日：2006-06-30
申请人： Aravind Padmanabhan , Cleopatra Cabuz
发明人： Aravind Padmanabhan , Cleopatra Cabuz
IPC分类号： G01N21/00
CPC分类号： B01L3/502746 , B01L3/50273 , B01L9/527 , B01L2200/14 , B01L2200/146 , B01L2200/147 , B01L2300/14 , B01L2300/1838 , B01L2400/0487 , B01L2400/082 , G01N15/1484 , G01N2015/0073 , G01N2015/008 , G01N2015/0084 , G01N2015/1486
摘要： A hematology analyzer or cytometer cartridge system having flow metering. It may have on- or off-cartridge flow metering and control. The system may have local and direct flow measurement to provide accurate counts per unit volume. There may be numerous arrangements for fluidic circuit checks of the cartridge. Examples may include checks pertaining to zero flow, interface, pressure, flow rate, fluid type and quality, backflow, dry qualification, temperature exposure limits, and so on, of the circuits and cartridge associated items.
摘要翻译：具有流量计量的血液分析仪或血细胞计数器系统。它可以具有开/关流量计量和控制。该系统可以具有本地和直接流量测量，以提供每单位体积的精确计数。可能存在许多针对盒的流体回路检查的布置。示例可以包括关于电路和盒相关物品的零流量，界面，压力，流速，流体类型和质量，回流，干质量鉴定，温度暴露限制等的检查。

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