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1. 发明授权

US06549275B1 Optical detection system for flow cytometry 有权
标题翻译：流式细胞仪光学检测系统
公开(公告)号：US06549275B1
公开(公告)日：2003-04-15
申请号：US09630927
申请日：2000-08-02
申请人： Cleopatra Cabuz , J. David Zook , James Allen Cox , Aravind Padmanabhan , Teresa M. Marta
发明人： Cleopatra Cabuz , J. David Zook , James Allen Cox , Aravind Padmanabhan , Teresa M. Marta
IPC分类号： G01N3348
CPC分类号： G01N15/1456 , G01N15/1434 , G01N35/085 , G01N2015/0069 , G01N2015/0073 , G01N2015/008 , G01N2015/0238 , G01N2015/1075
摘要： An optical detection system for flow cytometry that uses two or more light sources positioned laterally at different distances from the central axis of the flow stream for providing light through different parts of the flow stream. By using two or more light sources, the particle position can be detected, and the alignment and width of the core stream can be monitored and controlled. In addition, the velocity and size of the particles can be more accurately determined than when only a single light source is used.
摘要翻译：一种用于流式细胞术的光学检测系统，其使用两个或更多个光源，其位于与流动流的中心轴线不同的距离处横向，用于通过流动流的不同部分提供光。通过使用两个或更多个光源，可以检测颗粒位置，并且可以监测和控制核心流的对准和宽度。此外，与仅使用单个光源相比，可以更准确地确定颗粒的速度和尺寸。

2. 发明授权

US06597438B1 Portable flow cytometry 有权
标题翻译：便携式流式细胞仪
公开(公告)号：US06597438B1
公开(公告)日：2003-07-22
申请号：US09630924
申请日：2000-08-02
申请人： Cleopatra Cabuz , J. David Zook , James Allen Cox , Thomas Raymond Ohnstein , Ulrich Bonne , Eugen Loan Cabuz , Ernest Allen Satren , Aravind Padmanabhan , Teresa M. Marta
发明人： Cleopatra Cabuz , J. David Zook , James Allen Cox , Thomas Raymond Ohnstein , Ulrich Bonne , Eugen Loan Cabuz , Ernest Allen Satren , Aravind Padmanabhan , Teresa M. Marta
IPC分类号： G01N3349
CPC分类号： G01N15/1404 , A61B5/150022 , A61B5/15003 , A61B5/150221 , A61B5/150343 , A61B5/150351 , A61B5/150809 , A61B5/150824 , A61B5/157 , B01L3/5027 , G01N2015/1486 , Y10T436/101666
摘要： A portable or wearable cytometer that can be used at remote locations, such as in the field or at home. The flow cytometer of the present invention may help improve the healthcare of many weak, sick or elderly people by providing early detection of infection. By detecting the infection early, the infection may be more readily treatable. In military applications, the portable cytometer of the present invention may help save lives by providing early detection of infection due to biological agents.
摘要翻译：便携式或可穿戴式的血细胞计数仪，可在远程位置使用，如在野外或家中使用。本发明的流式细胞仪可以通过提供早期检测感染来帮助改善许多弱者，病人或老年人的医疗保健。通过早期检测感染，感染可能更容易治疗。在军事应用中，本发明的便携式血细胞计数器可以通过提供由于生物制剂引起的感染的早期检测来帮助挽救生命。

3. 发明授权

US06382228B1 Fluid driving system for flow cytometry 有权
标题翻译：用于流式细胞仪的流体驱动系统
公开(公告)号：US06382228B1
公开(公告)日：2002-05-07
申请号：US09630923
申请日：2000-08-02
申请人： Cleopatra Cabuz , J. David Zook , Thomas Raymond Ohnstein , Ulrich Bonne , Eugen Loan Cabuz , Ernest Allen Satren
发明人： Cleopatra Cabuz , J. David Zook , Thomas Raymond Ohnstein , Ulrich Bonne , Eugen Loan Cabuz , Ernest Allen Satren
IPC分类号： G05D706
CPC分类号： G05D7/0694 , G01N15/1404 , Y10T137/0368 , Y10T137/0396 , Y10T137/7759 , Y10T137/7761 , Y10T137/87265
摘要： A fluid driving system for portable flow cytometers or other portable devices that accepts a less precise and less stable pressure source, and then adjusts the pressure in a closed-loop manner to maintain a constant, desired flow velocity. The fluid driving system may be used in portable or wearable cytometers for use in remote locations, such as at home or in the field.
摘要翻译：用于便携式流式细胞仪或其他便携式装置的流体驱动系统，其接受不太精确和不太稳定的压力源，然后以闭环方式调节压力以保持恒定的所需流速。流体驱动系统可以用于便携式或可穿戴式细胞仪中，用于远程位置，例如在家中或在现场。

4. 发明授权

US07197949B2 Meso sniffer: a device and method for active gas sampling using alternating flow 有权
标题翻译： Meso嗅探器：用于使用交替流动态气体采样的装置和方法
公开(公告)号：US07197949B2
公开(公告)日：2007-04-03
申请号：US10115305
申请日：2002-04-02
申请人： J. David Zook , Cleopatra Cabuz
发明人： J. David Zook , Cleopatra Cabuz
IPC分类号： G01N1/00 , G01N1/22 , B32B5/02 , B32B27/04 , B32B27/12
CPC分类号： G01N33/0026 , G01N1/24 , G01N33/0011 , Y10T436/11 , Y10T436/25 , Y10T436/25375 , Y10T436/2575 , Y10T436/25875
摘要： A sampling system for detecting an analyte, comprising a diaphragm pump, a buffer chamber, a sensor head and intake port. The pump includes a chamber for receiving fluids via first and second ports. A buffer chamber is located at the second port for holding a quantity of air, and a sensor head is adapted to identify the presence of a desired analyte and produce a signal in response to the quantity identified. Preferably the diaphragm pump has a volume of gas per stroke capacity slightly larger than the volume of the sensor head such that the pump chamber has a greater volume than the buffer chamber and the buffer chamber has about the same volume as the sensor head. A sensor intake port intakes a sample potentially containing the analyte for contact with the sensor head upon operation of the diaphragm pump and out of the sensor head by jet-action caused by rapid movement of the diaphragm pump. A filter may be used for filtering air drawn through the pump chamber. The diaphragm pump may be either a single chamber pump or a multiple chamber diaphragm mesopump. In the purging mode, the system can also contain a pump for filling the system with clean air. When a mesopump is used, a single pumping channel can provide both AC and DC operation.
摘要翻译：一种用于检测分析物的采样系统，包括隔膜泵，缓冲室，传感头和进气口。泵包括用于经由第一和第二端口接收流体的室。缓冲室位于第二端口处，用于保持一定量的空气，并且传感器头适于识别所需分析物的存在并响应于所识别的量产生信号。优选地，隔膜泵具有稍微大于传感器头的体积的每行程容积的气体体积，使得泵室具有比缓冲室更大的体积，并且缓冲室具有与传感器头大致相同的体积。当隔膜泵工作时，传感器进气口进入可能含有分析物的样品，并通过由隔膜泵的快速运动引起的喷射作用而离开传感器头。过滤器可用于过滤通过泵室抽吸的空气。隔膜泵可以是单室泵或多室隔膜中孔泵。在清洗模式下，系统还可以包含用于用清洁空气填充系统的泵。当使用介质泵时，单个泵浦通道可以提供交流和直流操作。

5. 发明授权

US06432721B1 Meso sniffer: a device and method for active gas sampling using alternating flow 有权
标题翻译： Meso嗅探器：用于使用交替流动态气体采样的装置和方法
公开(公告)号：US06432721B1
公开(公告)日：2002-08-13
申请号：US09430425
申请日：1999-10-29
申请人： J. David Zook , Cleopatra Cabuz
发明人： J. David Zook , Cleopatra Cabuz
IPC分类号： G01N122
CPC分类号： G01N33/0026 , G01N1/24 , G01N33/0011 , Y10T436/11 , Y10T436/25 , Y10T436/25375 , Y10T436/2575 , Y10T436/25875
摘要： A sampling system for detecting an analyte, comprising a diaphragm pump, a buffer chamber, a sensor head and intake port. The pump includes a chamber for receiving fluids via first and second ports. A buffer chamber is located at the second port for holding a quantity of air, and a sensor head is adapted to identify the presence of a desired analyte and produce a signal in response to the quantity identified. Preferably the diaphragm pump has a volume of gas per stroke capacity slightly larger than the volume of the sensor head such that the pump chamber has a greater volume than the buffer chamber and the buffer chamber has about the same volume as the sensor head. A sensor intake port intakes a sample potentially containing the analyte for contact with the sensor head upon operation of the diaphragm pump and out of the sensor head by jet-action caused by rapid movement of the diaphragm pump. A filter may be used for filtering air drawn through the pump chamber. The diaphragm pump may be either a single chamber pump or a multiple chamber diaphragm mesopump. In the purging mode, the system can also contain a pump for filling the system with cleaned air. When a mesopump is used, a single pumping channel can provide both AC and DC operation.
摘要翻译：一种用于检测分析物的采样系统，包括隔膜泵，缓冲室，传感头和进气口。泵包括用于经由第一和第二端口接收流体的室。缓冲室位于第二端口处，用于保持一定量的空气，并且传感器头适于识别所需分析物的存在并响应于所识别的量产生信号。优选地，隔膜泵具有稍微大于传感器头的体积的每行程容积的气体体积，使得泵室具有比缓冲室更大的体积，并且缓冲室具有与传感器头大致相同的体积。当隔膜泵工作时，传感器进气口进入可能含有分析物的样品，并通过由隔膜泵的快速运动引起的喷射作用而离开传感器头。过滤器可用于过滤通过泵室抽吸的空气。隔膜泵可以是单室泵或多室隔膜中孔泵。在清洗模式中，系统还可以包含用于用清洁空气填充系统的泵。当使用介质泵时，单个泵浦通道可以提供交流和直流操作。

6. 发明授权

US06179586B2 Dual diaphragm, single chamber mesopump 有权
标题翻译：双隔膜，单室介孔泵
公开(公告)号：US06179586B2
公开(公告)日：2001-01-30
申请号：US09408651
申请日：1999-09-15
申请人： William R. Herb , J. David Zook , Cleopatra Cabuz
发明人： William R. Herb , J. David Zook , Cleopatra Cabuz
IPC分类号： F04B4300
CPC分类号： F04B43/043 , A61M5/14224 , A61M5/14276
摘要： A diaphragm pump, which is preferably electrostatically actuated, but which may be activated by other forces such as electromagnetic or piezoelectric actuation. The pump is formed by a pump body having a pump chamber formed therein. First and second diaphragms each having a set of valve holes in the diaphragm surface thereof are mounted in the chamber. Also provided are at least one inlet and at least one outlet port for communication with the pump chamber. The ports are positioned for sealing contact with the diaphragms at points that are not aligned with the holes in the diaphragms. A driver electrostatically actuates the diaphragms to cause diaphragm movement to a plurality of diaphragm positions to control flow of fluid through the pump. The first position is when the diaphragms are spaced from one another and from the ports to permit flow of fluid through the pump chamber. The second position is when the diaphragms are in diaphragm surface contact with the sets of holes mutually nonaligned to form a seal between the diaphragms. The third position is when a diaphragm is in diaphragm surface contact with the ports to form the sealing contact.
摘要翻译：隔膜泵优选是静电驱动的，但是可以通过诸如电磁或压电致动的其它力来激活。泵由具有形成在其中的泵室的泵体形成。在其隔膜表面中具有一组阀孔的第一和第二隔膜安装在腔室中。还设置有至少一个入口和至少一个用于与泵室连通的出口。端口被定位成在不与隔膜中的孔对准的点处与隔膜密封接触。驱动器静电地驱动隔膜以使隔膜移动到多个隔膜位置以控制通过泵的流体的流动。第一位置是当隔膜彼此间隔开并且从端口间隔开以允许流体流过泵室时。第二个位置是当隔膜与隔膜表面接触时，这些孔彼此不对齐，以形成隔膜之间的密封。第三个位置是当隔膜与隔膜表面接触时，形成密封接触。

7. 发明申请

US20110030925A1 APPARATUS AND METHOD FOR THERMAL MANAGEMENT USING VAPOR CHAMBER 有权
标题翻译：用于使用蒸气室进行热管理的装置和方法
公开(公告)号：US20110030925A1
公开(公告)日：2011-02-10
申请号：US12909669
申请日：2010-10-21
申请人： Wei Yang , Steven J. Eickhoff , Chunbo Zhang , Alex Gu , J. David Zook
发明人： Wei Yang , Steven J. Eickhoff , Chunbo Zhang , Alex Gu , J. David Zook
IPC分类号： F28D15/04
CPC分类号： F28D15/046 , F28D15/0233 , H01L23/427 , H01L2924/0002 , H01L2924/00
摘要： An apparatus includes a plurality of islands each carrying multiple cantilevers. The apparatus also includes a fluidic network having a plurality of channels separating the islands. The channels are configured to provide fluid to the islands, and the fluid at least partially fills spaces between the cantilevers and the islands. Heat from the islands vaporizes the fluid filling the spaces between the cantilevers and the islands to transfer the heat away from the islands while driving the cantilevers into oscillation. The apparatus may also include a casing configured to surround the islands and the fluidic network to create a vapor chamber, where the vapor chamber is configured to retain the vaporized fluid. The islands and the fluidic network could be formed in a single substrate, or the islands could be separate and attached together by a binder located within the channels of the fluidic network.
摘要翻译：一种装置包括多个岛，每个岛承载多个悬臂。该装置还包括具有分离岛的多个通道的流体网络。通道被配置成向岛提供流体，并且流体至少部分地填充悬臂和岛之间的空间。来自岛屿的热量使填充悬臂和岛屿之间的空间的流体蒸发，以将散热物从岛屿转移，同时驱动悬臂进入振荡。该装置还可以包括被配置成围绕岛和流体网络以形成蒸汽室的壳体，其中蒸气室被配置为保持蒸发的流体。岛和流体网络可以形成在单个基底中，或者岛可以分开并通过位于流体网络的通道内的粘合剂附着在一起。

8. 发明授权

US4252861A Growth technique for silicon-on-ceramic 失效
标题翻译：硅陶瓷生长技术
公开(公告)号：US4252861A
公开(公告)日：1981-02-24
申请号：US79844
申请日：1979-09-28
申请人： J. Don Heaps , J. David Zook
发明人： J. Don Heaps , J. David Zook
IPC分类号： H01L31/04 , C04B41/50 , C04B41/85 , C30B15/00 , C30B29/64 , H01L21/208 , H01L31/18 , B05D1/18 , H01L31/00
CPC分类号： C04B41/009 , C04B41/50 , C04B41/85 , C30B15/00 , C30B15/007 , C30B29/605 , H01L31/182 , Y02E10/546 , Y02P70/521
摘要： The present invention is an improvement to the method of growing silicon films on a substrate by bringing the substrate in contact with molten silicon. The improved growth technique may be classified as an asymmetric mode of growth of silicon on the substrate and is characterized by the substrate being maintained at a higher temperature than the solidification of silicon in the area of the substrate where the silicon layer growth is taking place, that is in the area of the liquid-solid interface. The higher temperature of the substrate causes the liquid-solid interface to be tilted to be nearly parallel to the substrate surface but inclined at a reentrant angle, so that the leading edge of the crystallization front is away from the substrate. This provides several advantages including increased growth speed, a nonhomogeneous doping of the silicon layer, that is an impurity concentration gradient and results in a high-low junction at the back surface and gives the back surface field effect.
摘要翻译：本发明是通过使衬底与熔融硅接触而在衬底上生长硅膜的方法的改进。改进的生长技术可以被分类为在衬底上的硅的不对称生长模式，其特征在于衬底被保持在比在硅层生长发生的衬底的区域中的硅的固化更高的温度，即在液固界面的区域。基板的较高温度使得液 - 固界面倾斜成几乎平行于基板表面，但以折入角倾斜，使得结晶前沿的前缘远离基板。这提供了几个优点，包括增加生长速度，硅层的非均匀掺杂，即杂质浓度梯度，并导致后表面的高低接合并给出背面场效应。

9. 发明授权

US08241919B2 Gas pulse generator for baseline drift correction and related system and method 有权
标题翻译：气体脉冲发生器，用于基线漂移校正及相关系统及方法
公开(公告)号：US08241919B2
公开(公告)日：2012-08-14
申请号：US12260007
申请日：2008-10-28
申请人： Adam Dewey McBrady , J. David Zook , Alex Gu , Michael L. Rhodes
发明人： Adam Dewey McBrady , J. David Zook , Alex Gu , Michael L. Rhodes
IPC分类号： G01N33/00
CPC分类号： G01N33/0011 , G01N2030/122 , G01N2030/623 , Y10T436/25 , Y10T436/25375 , Y10T436/255
摘要： A method includes acquiring a chemical sample and modulating the chemical sample at a frequency greater than a drift frequency of a sensor. The method also includes determining at least one of a presence and a concentration of the analyte within the modulated chemical sample using the sensor. Modulating the chemical sample could include alternately absorbing at least some of the analyte into a sorbent material and releasing at least some of the analyte from the sorbent material. Modulating the chemical sample could also include heating the sorbent material, absorbing part of the analyte into the sorbent material, and passing a remaining portion of the analyte into the sensor. Modulating the chemical sample could further include stopping the heating of the sorbent material, releasing the part of the analyte from the sorbent material, and passing the sample with the released part of the analyte into the sensor.
摘要翻译：一种方法包括获取化学样品并以大于传感器的漂移频率的频率调制化学样品。该方法还包括使用传感器确定调制的化学样品中的分析物的存在和浓度中的至少一种。调制化学样品可以包括交替地将至少一些分析物吸收到吸附材料中并从吸附剂材料中释放至少一些分析物。调制化学样品还可以包括加热吸附剂材料，将分析物的一部分吸收到吸附剂材料中，并将分析物的剩余部分传递到传感器中。调制化学样品可进一步包括停止吸附剂材料的加热，将分析物的一部分从吸附剂材料中释放出来，并将样品与分析物的释放部分一起传递到传感器中。

10. 发明授权

US07612871B2 Frequency-multiplexed detection of multiple wavelength light for flow cytometry 有权
标题翻译：用于流式细胞术的多波长光的多路复用检测
公开(公告)号：US07612871B2
公开(公告)日：2009-11-03
申请号：US10931686
申请日：2004-09-01
申请人： James A. Cox , J. David Zook
发明人： James A. Cox , J. David Zook
IPC分类号： G01C3/08 , G01N21/00
CPC分类号： G01N15/1459 , G01N2015/1438 , G01N2015/1477 , G01N2015/1486 , G01N2201/0691
摘要： A multiplexed set of light sources having outputs of light with various wavelengths which are combined into one beam. The beam may impinge a particle in a flow channel of a cytometer. The light leaving the flow channel may be sensed by a detector and the light distinguished according to wavelength.
摘要翻译：具有组合成一个光束的具有各种波长的光的输出的多路复用光源组。光束可能会在细胞仪的流动通道中撞击颗粒。离开流动通道的光可以由检测器感测，并且根据波长区分出的光。

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