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1. 发明授权

US06784423B2 Characterization of individual particle atomic composition by aerosol mass spectrometry 有权
标题翻译：通过气溶胶质谱法对单个颗粒原子组成进行表征
公开(公告)号：US06784423B2
公开(公告)日：2004-08-31
申请号：US10251352
申请日：2002-09-20
申请人： William David Reents, Jr. , Michael J Schabel
发明人： William David Reents, Jr. , Michael J Schabel
IPC分类号： H01J4900
CPC分类号： H01J49/161 , H01J49/40
摘要： A method for determining the shape and size of particles and their constituent elements is disclosed. Particle ions are accelerated through a mass spectrometer useful in identifying the source particle of the resulting ions. By measuring the time-varying intensity of the identified ions as they strike a detector, a plot of the intensity of the ions over time is obtained for each ionized particle. The size of each ionized particle is determined by measuring a time span corresponding to the width of the peak of this plot. If the detector is a phosphor detector, the shape of the particle may be determined by using a high-speed camera to capture cross-section images of the ion-induced light pattern at closely-spaced successive moments in time. Alternatively, the intensity of ions striking the detector along at least one lateral dimension may be detected. By combining the multiple cross section images or the multiple lateral direction intensity profiles that are thus captured, an actual image of the shape of the original particle can be obtained.
摘要翻译：公开了一种用于确定颗粒及其构成元件的形状和尺寸的方法。通过可用于鉴定所得离子的源粒子的质谱仪加速粒子离子。通过测量所鉴定的离子随着检测器的时变强度，每个电离粒子获得离子强度随时间的变化图。通过测量对应于该图的峰的宽度的时间跨度来确定每个电离粒子的尺寸。如果检测器是磷光体检测器，则可以通过使用高速摄像机来确定颗粒的形状，以在紧密间隔的连续时刻捕获离子诱导的光图案的横截面图像。或者，可以检测沿着至少一个横向尺寸撞击检测器的离子的强度。通过组合由此捕获的多个横截面图像或多个横向强度分布，可以获得原始粒子的形状的实际图像。

2. 发明授权

US07048889B2 Dynamically controllable biological/chemical detectors having nanostructured surfaces 有权
标题翻译：具有纳米结构表面的动态可控生物/化学检测器
公开(公告)号：US07048889B2
公开(公告)日：2006-05-23
申请号：US10806543
申请日：2004-03-23
申请人： Susanne Arney , Timofei Nikita Kroupenkine , Alan Michael Lyons , Mary Louise Mandich , Michael J Schabel , Joseph Ashley Taylor
发明人： Susanne Arney , Timofei Nikita Kroupenkine , Alan Michael Lyons , Mary Louise Mandich , Michael J Schabel , Joseph Ashley Taylor
IPC分类号： G01N15/06
CPC分类号： B01L3/5088 , B01L3/508 , B01L2300/089 , B01L2300/161 , B01L2400/0406 , B01L2400/0421 , B01L2400/0427 , B01L2400/0436
摘要： A biological/chemical detector is disclosed that is capable of manipulating liquids, such as reagent droplets, without relying on microchannels. In a first embodiment, fluid flow is passed through the detector, thus causing particles wholly or partially containing an illustrative chemical compound or biological species to be collected on the tips of nanostructures in the detector. A droplet of liquid is moved across the tips of the nanostructures, thus absorbing the particles into the liquid. The droplet is caused to penetrate the nanostructures in a desired location, thus causing the chemical compound or biological species in said liquid droplet to come into contact with, for example, a reagent. In another embodiment, a fluid flow is passed through the nanostructured surfaces of the detector such that the chemical compound and/or biological species are deposited between the nanoposts of a desired pixel. A droplet of liquid is moved across the surface to that desired pixel and is caused to penetrate the nanostructures of the pixel, thus contacting a reagent.
摘要翻译：公开了一种生物/化学检测器，其能够在不依赖微通道的情况下操纵诸如试剂液滴的液体。在第一实施例中，流体流动通过检测器，从而使完全或部分含有说明性化学化合物或生物物质的颗粒收集在检测器中的纳米结构的末端上。液滴流过纳米结构的尖端，从而将颗粒吸收到液体中。使液滴在期望的位置穿透纳米结构，从而使所述液滴中的化合物或生物物质与例如试剂接触。在另一个实施方案中，流体流动通过检测器的纳米结构化表面，使得化学化合物和/或生物物质沉积在期望像素的纳米孔之间。一滴液体通过表面移动到该期望的像素，并且被引导穿透像素的纳米结构，从而使试剂接触。

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