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1. 外观设计

USD1028760S1 Intelligent spectral analysis pencil 有权
公开(公告)号：USD1028760S1
公开(公告)日：2024-05-28
申请号：US29841505
申请日：2022-06-07
申请人： Wei Liu , Han Zhang , Jianjun Cheng , Liguo Huang
设计人： Wei Liu , Han Zhang , Jianjun Cheng , Liguo Huang
摘要： FIG. 1 is a perspective view of an intelligent spectral analysis pencil showing our new design;
FIG. 2 is a front view thereof;
FIG. 3 is a rear view thereof;
FIG. 4 is a left side view thereof;
FIG. 5 is a right side view thereof;
FIG. 6 is a top view thereof;
FIG. 7 is a bottom view thereof; and,
FIG. 8 is a top side perspective view thereof.
The broken lines in the drawings depict portions of the intelligent spectral analysis pencil that form no part of the claimed design.

2. 发明申请

US20140206679A1 HETEROCYCLIC PYRIDONE COMPOUND, AND INTERMEDIATE, PREPARATION METHOD AND USE THEREOF 有权
标题翻译：杂环吡啶类化合物及其中间体，制备方法及其用途
公开(公告)号：US20140206679A1
公开(公告)日：2014-07-24
申请号：US14124628
申请日：2012-05-28
申请人： Jianjun Cheng , Jihong Qin , Bin Ye
发明人： Jianjun Cheng , Jihong Qin , Bin Ye
IPC分类号： C07D513/04 , C07D498/04 , C07D471/04
CPC分类号： C07D513/04 , C07D471/04 , C07D498/04
摘要： The present invention relates to a heterocyclic pyridone compound represented by General Formula (I), where the heterocyclic pyridone compound is used as a tyrosine kinase inhibitor, and particularly a c-Met inhibitor. The present invention also relates to intermediates for preparing heterocyclic pyridone compound and a preparation method. The present invention further relates to a pharmaceutical composition containing the heterocyclic pyridone compound as an active ingredient, and a use of the pharmaceutical composition in treatment of diseases associated with tyrosine kinase c-Met, especially cancer associated with c-Met, as a medicament.
摘要翻译：本发明涉及由通式（I）表示的杂环吡啶酮化合物，其中杂环吡啶酮化合物用作酪氨酸激酶抑制剂，特别是c-Met抑制剂。本发明还涉及制备杂环吡啶酮化合物的中间体及其制备方法。本发明还涉及含有杂环吡啶酮化合物作为活性成分的药物组合物，以及该药物组合物用于治疗与酪氨酸激酶c-Met相关疾病，特别是与c-Met相关的癌症作为药物的用途。

3. 发明授权

US08680202B2 Cyclodextrin-based polymers for therapeutics delivery 有权
标题翻译：用于治疗输送的基于环糊精的聚合物
公开(公告)号：US08680202B2
公开(公告)日：2014-03-25
申请号：US13572294
申请日：2012-08-10
申请人： Jianjun Cheng , Mark E. Davis , Kay T. Khin
发明人： Jianjun Cheng , Mark E. Davis , Kay T. Khin
IPC分类号： A61K47/48 , C08B37/16 , A61K9/51 , A61P35/00
CPC分类号： C08G69/44 , A61K31/337 , A61K31/7048 , A61K47/48176 , A61K47/48192 , A61K47/482 , A61K47/48215 , A61K47/4823 , A61K47/48338 , A61K47/48969 , A61K47/58 , A61K47/59 , A61K47/60 , A61K47/61 , A61K47/6951 , B82Y5/00 , C08B30/00 , C08B31/00 , C08B37/0012 , C08F220/28 , C08F220/58 , C08F222/22 , C08F2220/282 , C08G81/02 , G06F19/00 , G06F19/3456 , G06Q50/22 , Y02A90/22 , Y02A90/26
摘要： The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug stability and solubility, and reduce toxicity of the small molecule therapeutic when used in vivo. Furthermore, by selecting from a variety of linker groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein. The invention further relates to methods for conducting pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the polymeric compounds described herein.
摘要翻译：本发明涉及设计为小分子治疗剂递送载体的治疗性环糊精含有聚合物的组合物及其药物组合物。这些含环糊精的聚合物改善药物稳定性和溶解性，并且在体内使用时降低小分子治疗剂的毒性。此外，通过从各种接头基团和靶向配体中选择，聚合物呈现用于治疗剂的受控递送的方法。本发明还涉及用本文所述的治疗组合物治疗受试者的方法。本发明还涉及用于进行药物业务的方法，包括制造，许可或分发包含或涉及本文所述的聚合物的试剂盒。

4. 发明申请

US20130101672A1 NANOCONJUGATES AND NANOCONJUGATE FORMULATIONS 有权
标题翻译：纳米结晶和纳米结晶配方
公开(公告)号：US20130101672A1
公开(公告)日：2013-04-25
申请号：US13518836
申请日：2010-12-23
申请人： Jianjun Cheng , Rong Tong
发明人： Jianjun Cheng , Rong Tong
IPC分类号： A61K9/16
CPC分类号： A61K9/1658 , A61K9/0019 , A61K9/5169 , A61K47/593 , A61K47/60 , A61K47/6935
摘要： The invention provides a drug-polymer nanoconjugate that includes a drug covalently bonded to a polymer. The nanoconjugate can include a block copolymer coating and/or an albumin coating. The drug of the drug-polymer nanoconjugate can be one or more of a variety of therapeutic agents linked to the polymer through ether or thioether linkages formed from hydroxyl or thiol groups of the drug. The albumin coating can substantially or completely retard or prevent aggregation of the nanoconjugates in solid form or in solution. The invention further provides compositions that include a plurality of drug-polymer nanoconjugates, as well as methods for using the drug-polymer nanoconjugates, such as in therapeutic or diagnostic applications.
摘要翻译：本发明提供药物 - 聚合物纳米缀合物，其包括共价键合到聚合物上的药物。纳米缀合物可以包括嵌段共聚物涂层和/或白蛋白涂层。药物 - 聚合物纳米缀合物的药物可以是通过由药物的羟基或硫醇基团形成的醚或硫醚键与聚合物连接的各种治疗剂中的一种或多种。白蛋白涂层可以基本上或完全地延迟或阻止纳米缀合物以固体形式或溶液中的聚集。本发明还提供了包括多种药物 - 聚合物纳米缀合物的组合物，以及用于使用药物 - 聚合物纳米缀合物的方法，例如在治疗或诊断应用中。

5. 发明授权

US08404662B2 Cyclodextrin-based polymers for therapeutics delivery 有权
公开(公告)号：US08404662B2
公开(公告)日：2013-03-26
申请号：US13572283
申请日：2012-08-10
申请人： Jianjun Cheng , Mark Davis , Kay T. Khin
发明人： Jianjun Cheng , Mark Davis , Kay T. Khin
IPC分类号： A61K31/337 , A61K31/4745 , C08G2/30 , C08G69/08 , C08L5/16
CPC分类号： C08G69/44 , A61K31/337 , A61K31/7048 , A61K47/48176 , A61K47/48192 , A61K47/482 , A61K47/48215 , A61K47/4823 , A61K47/48338 , A61K47/48969 , A61K47/58 , A61K47/59 , A61K47/60 , A61K47/61 , A61K47/6951 , B82Y5/00 , C08B30/00 , C08B31/00 , C08B37/0012 , C08F220/28 , C08F220/58 , C08F222/22 , C08F2220/282 , C08G81/02 , G06F19/00 , G06F19/3456 , G06Q50/22 , Y02A90/22 , Y02A90/26
摘要： The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug stability and solubility, and reduce toxicity of the small molecule therapeutic when used in vivo. Furthermore, by selecting from a variety of linker groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein. The invention further relates to methods for conducting pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the polymeric compounds described herein.

6. 发明授权

US08389499B2 Cyclodextrin-based polymers for therapeutics delivery 有权
公开(公告)号：US08389499B2
公开(公告)日：2013-03-05
申请号：US13553400
申请日：2012-07-19
申请人： Jianjun Cheng , Mark E. Davis , Kay T. Khin
发明人： Jianjun Cheng , Mark E. Davis , Kay T. Khin
IPC分类号： A61K31/337 , C08G2/30 , C08G69/08 , C08G69/10 , C08L5/16
CPC分类号： C08G69/44 , A61K31/337 , A61K31/7048 , A61K47/48176 , A61K47/48192 , A61K47/482 , A61K47/48215 , A61K47/4823 , A61K47/48338 , A61K47/48969 , A61K47/58 , A61K47/59 , A61K47/60 , A61K47/61 , A61K47/6951 , B82Y5/00 , C08B30/00 , C08B31/00 , C08B37/0012 , C08F220/28 , C08F220/58 , C08F222/22 , C08F2220/282 , C08G81/02 , G06F19/00 , G06F19/3456 , G06Q50/22 , Y02A90/22 , Y02A90/26
摘要： The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug stability and solubility, and reduce toxicity of the small molecule therapeutic when used in vivo. Furthermore, by selecting from a variety of linker groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein. The invention further relates to methods for conducting pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the polymeric compounds described herein.

7. 发明授权

US08092833B2 Compositions containing inclusion complexes 有权
标题翻译：含有复合物的组合物
公开(公告)号：US08092833B2
公开(公告)日：2012-01-10
申请号：US12846344
申请日：2010-07-29
申请人： Suzie Hwang Pun , Hector Gonzalez , Mark E. Davis , Nathalie C. Bellocq , Jianjun Cheng
发明人： Suzie Hwang Pun , Hector Gonzalez , Mark E. Davis , Nathalie C. Bellocq , Jianjun Cheng
IPC分类号： A61K31/74 , A61K9/14 , C12P19/30 , C12N15/63
CPC分类号： A61K47/48215 , A61K38/44 , A61K47/60 , A61K47/6949 , A61K47/6951 , A61K48/0041 , B82Y5/00 , C08B37/0012 , C08G65/33396 , C08G65/48 , C08G2650/04 , C08G2650/38 , C12Y113/12007
摘要： The invention provides a composition containing particulate composite of a polymer and a therapeutic agent. The composition also contains a complexing agent. The polymer interacts with the complexing agent in a host-guest or a guest-host interaction to form an inclusion complex. A therapeutic composition of the invention may be used to deliver the therapeutic agent and to treat various disorders. Both the polymer of the particulate composite and the complexing agent may be used to introduce functionality into the therapeutic composition. The invention also relates to a method of preparing a composition. The method combines a therapeutic agent, a polymer having host or guest functionality, and a complexing agent having guest or host functionality to form the therapeutic composition. The complexing agent forms an inclusion complex with the polymer. The invention also relates to a method of delivering a therapeutic agent. According to the method, a therapeutically effective amount of a therapeutic composition of the invention is administered to a mammal (e.g. person or animal) in recognized need of the therapeutic. Also disclosed are compounds having the formula:
摘要翻译：本发明提供了含有聚合物和治疗剂的颗粒复合物的组合物。该组合物还含有络合剂。聚合物与宿主客体或客体 - 宿主相互作用中的络合剂相互作用以形成包合物。本发明的治疗组合物可用于递送治疗剂并治疗各种疾病。颗粒复合材料的聚合物和络合剂都可用于将功能性引入治疗组合物中。本发明还涉及制备组合物的方法。该方法结合治疗剂，具有宿主或客体功能的聚合物和具有客体或宿主功能的络合剂以形成治疗组合物。络合剂与聚合物形成包合络合物。本发明还涉及递送治疗剂的方法。根据该方法，将治疗有效量的本发明的治疗组合物在公认的治疗需要中给予哺乳动物（例如人或动物）。还公开了具有下式的化合物：

8. 发明授权

US07166302B2 Complexing agents for compositions containing inclusion complexes 有权
公开(公告)号：US07166302B2
公开(公告)日：2007-01-23
申请号：US10021294
申请日：2001-12-19
申请人： Suzie Hwang Pun , Hector Gonzalez , Mark E. Davis , Nathalie Bellocq , Jianjun Cheng
发明人： Suzie Hwang Pun , Hector Gonzalez , Mark E. Davis , Nathalie Bellocq , Jianjun Cheng
IPC分类号： A61K9/14 , A61K31/74 , C12P19/30 , C12N15/63
CPC分类号： A61K47/48215 , A61K38/44 , A61K47/60 , A61K47/6949 , A61K47/6951 , A61K48/0041 , B82Y5/00 , C08B37/0012 , C08G65/33396 , C08G65/48 , C08G2650/04 , C08G2650/38 , C12Y113/12007
摘要： The invention provides a composition containing particulate composite of a polymer and a therapeutic agent. The composition also contains a complexing agent. The polymer interacts with the complexing agent in a host-guest or a guest-host interaction to form an inclusion complex. A therapeutic composition of the invention may be used to deliver the therapeutic agent and to treat various disorders. Both the polymer of the particulate composite and the complexing agent may be used to introduce functionality into the therapeutic composition. The invention also relates to a method of preparing a composition. The method combines a therapeutic agent, a polymer having host or guest functionality, and a complexing agent having guest or host functionality to form the therapeutic composition. The complexing agent forms an inclusion complex with the polymer. The invention also relates to a method of delivering a therapeutic agent. According to the method, a therapeutically effective amount of a therapeutic composition of the invention is administered to a mammal (e.g. person or animal) in recognized need of the therapeutic. Also disclosed are compounds having the formula:

9. 发明申请

US20060182795A1 Compositions containing inclusion complexes 有权
标题翻译：含有复合物的组合物
公开(公告)号：US20060182795A1
公开(公告)日：2006-08-17
申请号：US11321441
申请日：2005-12-28
申请人： Suzie Pun , Hector Gonzalez , Mark Davis , Nathalie Bellocq , Jianjun Cheng
发明人： Suzie Pun , Hector Gonzalez , Mark Davis , Nathalie Bellocq , Jianjun Cheng
IPC分类号： A61K48/00 , C07F9/02 , A61K9/127 , C07J9/00
CPC分类号： A61K47/48215 , A61K38/44 , A61K47/60 , A61K47/6949 , A61K47/6951 , A61K48/0041 , B82Y5/00 , C08B37/0012 , C08G65/33396 , C08G65/48 , C08G2650/04 , C08G2650/38 , C12Y113/12007
摘要： The invention provides a composition containing particulate composite of a polymer and a therapeutic agent. The composition also contains a complexing agent. The polymer interacts with the complexing agent in a host-guest or a guest-host interaction to form an inclusion complex. A therapeutic composition of the invention may be used to deliver the therapeutic agent and to treat various disorders. Both the polymer of the particulate composite and the complexing agent may be used to introduce functionality into the therapeutic composition. The invention also relates to a method of prepariing a composition. The method combines a therapeutic agent, a polymer having host or guest functionality, and a complexing agent having guest or host functionality to form the therapeutic composition. The complexing agent forms an inclusion complex with the polymer. The invention also relates to a method of delivering a therapeutic agent. According to the method, a therapeutically effective amount of a therapeutic composition of the invention is administered to a mammal (e.g. person or animal) in recognized need of the therapeutic. Also disclosed are compounds having the formula:
摘要翻译：本发明提供了含有聚合物和治疗剂的颗粒复合物的组合物。该组合物还含有络合剂。聚合物与宿主客体或客体 - 宿主相互作用中的络合剂相互作用以形成包合物。本发明的治疗组合物可用于递送治疗剂并治疗各种疾病。颗粒复合材料的聚合物和络合剂都可用于将功能性引入治疗组合物中。本发明还涉及制备组合物的方法。该方法结合治疗剂，具有宿主或客体功能的聚合物和具有客体或宿主功能的络合剂以形成治疗组合物。络合剂与聚合物形成包合络合物。本发明还涉及递送治疗剂的方法。根据该方法，将治疗有效量的本发明的治疗组合物在公认的治疗需要中给予哺乳动物（例如人或动物）。还公开了具有下式的化合物：

10. 发明授权

US08709483B2 System for targeted delivery of therapeutic agents 有权
标题翻译：用于靶向递送治疗剂的系统
公开(公告)号：US08709483B2
公开(公告)日：2014-04-29
申请号：US12239136
申请日：2008-09-26
申请人： Omid C. Farokhzad , Jianjun Cheng , Benjamin A. Teply , Robert S. Langer , Stephen E. Zale
发明人： Omid C. Farokhzad , Jianjun Cheng , Benjamin A. Teply , Robert S. Langer , Stephen E. Zale
IPC分类号： A61K9/14 , A61K38/00 , C12N15/11
CPC分类号： A61K47/4813 , A61K9/5031 , A61K9/5153 , A61K9/5192 , A61K31/337 , A61K47/482 , A61K47/48215 , A61K47/549 , A61K47/555 , A61K47/593 , A61K47/60 , A61K47/6935 , A61K47/6937 , A61K51/0417 , A61K51/0491 , A61K51/0495 , A61K51/065
摘要： The present invention provides a drug delivery system for targeted delivery of therapeutic agent-containing particles to tissues, cells, and intracellular compartments. The invention provides targeted particles comprising a particle, one or more targeting moieties, and one or more therapeutic agents to be delivered and pharmaceutical compositions comprising inventive targeted particles. The present invention provides methods of designing, manufacturing, and using inventive targeted particles and pharmaceutical compositions thereof.
摘要翻译：本发明提供了用于将组合物，细胞和细胞内区室靶向递送含治疗剂的颗粒的药物递送系统。本发明提供了包含颗粒，一种或多种靶向部分和一种或多种待递送治疗剂和包含本发明靶向颗粒的药物组合物的靶向颗粒。本发明提供了设计，制造和使用本发明的靶向颗粒及其药物组合物的方法。

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