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1. 发明授权

US08277846B2 Complexing agents for compositions containing inclusion complexes 有权
标题翻译：含有复合物的组合物的络合剂
公开(公告)号：US08277846B2
公开(公告)日：2012-10-02
申请号：US13107024
申请日：2011-05-13
申请人： Suzie Hwang Pun , Hector Gonzalez , Mark E. Davis , Nathalie C. Bellocq , Jianjun Cheng
发明人： Suzie Hwang Pun , Hector Gonzalez , Mark E. Davis , Nathalie C. Bellocq , Jianjun Cheng
IPC分类号： A61K31/74 , A61K9/14 , C12P19/30 , C12N15/63
CPC分类号： A61K47/48215 , A61K38/44 , A61K47/60 , A61K47/6949 , A61K47/6951 , A61K48/0041 , B82Y5/00 , C08B37/0012 , C08G65/33396 , C08G65/48 , C08G2650/04 , C08G2650/38 , C12Y113/12007
摘要： The invention provides a composition containing particulate composite of a polymer and a therapeutic agent. The composition also contains a complexing agent. The polymer interacts with the complexing agent in a host-guest or a guest-host interaction to form an inclusion complex. A therapeutic composition of the invention may be used to deliver the therapeutic agent and to treat various disorders. Both the polymer of the particulate composite and the complexing agent may be used to introduce functionality into the therapeutic composition. The invention also relates to a method of preparing a composition. The method combines a therapeutic agent, a polymer having host or guest functionality, and a complexing agent having guest or host functionality to form the therapeutic composition. The complexing agent forms an inclusion complex with the polymer. The invention also relates to a method of delivering a therapeutic agent. According to the method, a therapeutically effective amount of a therapeutic composition of the invention is administered to a mammal (e.g. person or animal) in recognized need of the therapeutic. Also disclosed are compounds having the formula:
摘要翻译：本发明提供了含有聚合物和治疗剂的颗粒复合物的组合物。该组合物还含有络合剂。聚合物与宿主客体或客体 - 宿主相互作用中的络合剂相互作用以形成包合物。本发明的治疗组合物可用于递送治疗剂并治疗各种疾病。颗粒复合材料的聚合物和络合剂都可用于将功能性引入治疗组合物中。本发明还涉及制备组合物的方法。该方法结合治疗剂，具有宿主或客体功能的聚合物和具有客体或宿主功能的络合剂以形成治疗组合物。络合剂与聚合物形成包合络合物。本发明还涉及递送治疗剂的方法。根据该方法，将治疗有效量的本发明的治疗组合物在公认的治疗需要中给予哺乳动物（例如人或动物）。还公开了具有下式的化合物：

2. 发明授权

US07968123B2 Complexing agents for compositions containing inclusion complexes 有权
标题翻译：含有复合物的组合物的络合剂
公开(公告)号：US07968123B2
公开(公告)日：2011-06-28
申请号：US11588033
申请日：2006-10-25
申请人： Suzie Hwang Pun , Hector Gonzalez , Mark E. Davis , Nathalie C. Bellocq , Jianjun Cheng
发明人： Suzie Hwang Pun , Hector Gonzalez , Mark E. Davis , Nathalie C. Bellocq , Jianjun Cheng
IPC分类号： A61K31/74 , A61K9/14 , C12P19/30 , C12N15/63
CPC分类号： A61K47/48215 , A61K38/44 , A61K47/60 , A61K47/6949 , A61K47/6951 , A61K48/0041 , B82Y5/00 , C08B37/0012 , C08G65/33396 , C08G65/48 , C08G2650/04 , C08G2650/38 , C12Y113/12007
摘要： The invention provides a composition containing particulate composite of a polymer and a therapeutic agent. The composition also contains a complexing agent. The polymer interacts with the complexing agent in a host-guest or a guest-host interaction to form an inclusion complex. A therapeutic composition of the invention may be used to deliver the therapeutic agent and to treat various disorders. Both the polymer of the particulate composite and the complexing agent may be used to introduce functionality into the therapeutic composition. The invention also relates to a method of preparing a composition. The method combines a therapeutic agent, a polymer having host or guest functionality, and a complexing agent having guest or host functionality to form the therapeutic composition. The complexing agent forms an inclusion complex with the polymer. The invention also relates to a method of delivering a therapeutic agent. According to the method, a therapeutically effective amount of a therapeutic composition of the invention is administered to a mammal (e.g. person or animal) in recognized need of the therapeutic. Also disclosed are compounds having the formula:
摘要翻译：本发明提供了含有聚合物和治疗剂的颗粒复合物的组合物。该组合物还含有络合剂。聚合物与宿主客体或客体 - 宿主相互作用中的络合剂相互作用以形成包合物。本发明的治疗组合物可用于递送治疗剂并治疗各种疾病。颗粒复合材料的聚合物和络合剂都可用于将功能性引入治疗组合物中。本发明还涉及制备组合物的方法。该方法结合治疗剂，具有宿主或客体功能的聚合物和具有客体或宿主功能的络合剂以形成治疗组合物。络合剂与聚合物形成包合络合物。本发明还涉及递送治疗剂的方法。根据该方法，将治疗有效量的本发明的治疗组合物在公认的治疗需要中给予哺乳动物（例如人或动物）。还公开了具有下式的化合物：

3. 发明授权

US08092833B2 Compositions containing inclusion complexes 有权
标题翻译：含有复合物的组合物
公开(公告)号：US08092833B2
公开(公告)日：2012-01-10
申请号：US12846344
申请日：2010-07-29
申请人： Suzie Hwang Pun , Hector Gonzalez , Mark E. Davis , Nathalie C. Bellocq , Jianjun Cheng
发明人： Suzie Hwang Pun , Hector Gonzalez , Mark E. Davis , Nathalie C. Bellocq , Jianjun Cheng
IPC分类号： A61K31/74 , A61K9/14 , C12P19/30 , C12N15/63
CPC分类号： A61K47/48215 , A61K38/44 , A61K47/60 , A61K47/6949 , A61K47/6951 , A61K48/0041 , B82Y5/00 , C08B37/0012 , C08G65/33396 , C08G65/48 , C08G2650/04 , C08G2650/38 , C12Y113/12007
摘要： The invention provides a composition containing particulate composite of a polymer and a therapeutic agent. The composition also contains a complexing agent. The polymer interacts with the complexing agent in a host-guest or a guest-host interaction to form an inclusion complex. A therapeutic composition of the invention may be used to deliver the therapeutic agent and to treat various disorders. Both the polymer of the particulate composite and the complexing agent may be used to introduce functionality into the therapeutic composition. The invention also relates to a method of preparing a composition. The method combines a therapeutic agent, a polymer having host or guest functionality, and a complexing agent having guest or host functionality to form the therapeutic composition. The complexing agent forms an inclusion complex with the polymer. The invention also relates to a method of delivering a therapeutic agent. According to the method, a therapeutically effective amount of a therapeutic composition of the invention is administered to a mammal (e.g. person or animal) in recognized need of the therapeutic. Also disclosed are compounds having the formula:
摘要翻译：本发明提供了含有聚合物和治疗剂的颗粒复合物的组合物。该组合物还含有络合剂。聚合物与宿主客体或客体 - 宿主相互作用中的络合剂相互作用以形成包合物。本发明的治疗组合物可用于递送治疗剂并治疗各种疾病。颗粒复合材料的聚合物和络合剂都可用于将功能性引入治疗组合物中。本发明还涉及制备组合物的方法。该方法结合治疗剂，具有宿主或客体功能的聚合物和具有客体或宿主功能的络合剂以形成治疗组合物。络合剂与聚合物形成包合络合物。本发明还涉及递送治疗剂的方法。根据该方法，将治疗有效量的本发明的治疗组合物在公认的治疗需要中给予哺乳动物（例如人或动物）。还公开了具有下式的化合物：

4. 发明申请

US20120172525A1 COMPOSITIONS CONTAINING INCLUSION COMPLEXES 审中-公开
标题翻译：包含复合物的组合物
公开(公告)号：US20120172525A1
公开(公告)日：2012-07-05
申请号：US13305592
申请日：2011-11-28
申请人： Suzie Hwang Pun , Hector Gonzalez , Mark E. Davis , Nathalie C. Bellocq , Jianjun Cheng
发明人： Suzie Hwang Pun , Hector Gonzalez , Mark E. Davis , Nathalie C. Bellocq , Jianjun Cheng
IPC分类号： C08G65/48 , C08G12/00
CPC分类号： A61K48/0041 , A61K38/44 , A61K47/555 , A61K47/6949 , A61K47/6951 , B82Y5/00 , C08B37/0012 , C08B37/0015 , C08G65/33396 , C08G65/48 , C08G2650/04 , C08G2650/38 , C12N15/87 , C12Y113/12007
摘要： The invention provides a composition containing particulate composite of a polymer and a therapeutic agent. The composition also contains a complexing agent. The polymer interacts with the complexing agent in a host-guest or a guest-host interaction to form an inclusion complex. A therapeutic composition of the invention may be used to deliver the therapeutic agent and to treat various disorders. Both the polymer of the particulate composite and the complexing agent may be used to introduce functionality into the therapeutic composition. The invention also relates to a method of preparing a composition. The method combines a therapeutic agent, a polymer having host or guest functionality, and a complexing agent having guest or host functionality to form the therapeutic composition. The complexing agent forms an inclusion complex with the polymer. The invention also relates to a method of delivering a therapeutic agent. According to the method, a therapeutically effective amount of a therapeutic composition of the invention is administered to a mammal (e.g. person or animal) in recognized need of the therapeutic. Also disclosed are compounds having the formula:
摘要翻译：本发明提供了含有聚合物和治疗剂的颗粒复合物的组合物。该组合物还含有络合剂。聚合物与宿主客体或客体 - 宿主相互作用中的络合剂相互作用以形成包合物。本发明的治疗组合物可用于递送治疗剂并治疗各种疾病。颗粒复合材料的聚合物和络合剂都可用于将功能性引入治疗组合物中。本发明还涉及制备组合物的方法。该方法结合治疗剂，具有宿主或客体功能的聚合物和具有客体或宿主功能的络合剂以形成治疗组合物。络合剂与聚合物形成包合络合物。本发明还涉及递送治疗剂的方法。根据该方法，将治疗有效量的本发明的治疗组合物在公认的治疗需要中给予哺乳动物（例如人或动物）。还公开了具有下式的化合物：

5. 发明申请

US20110182864A1 COMPOSITIONS CONTAINING INCLUSION COMPLEXES 有权
标题翻译：包含复合物的组合物
公开(公告)号：US20110182864A1
公开(公告)日：2011-07-28
申请号：US12846344
申请日：2010-07-29
申请人： Suzie Hwang Pun , Hector Gonzalez , Mark E. Davis , Nathalie C. Bellocq , Jianjun Cheng
发明人： Suzie Hwang Pun , Hector Gonzalez , Mark E. Davis , Nathalie C. Bellocq , Jianjun Cheng
IPC分类号： A61K48/00 , C07K5/072 , C07K14/79 , A61K35/76 , A61K38/02 , A61K31/56 , C07K7/06 , C12N5/00
CPC分类号： A61K47/48215 , A61K38/44 , A61K47/60 , A61K47/6949 , A61K47/6951 , A61K48/0041 , B82Y5/00 , C08B37/0012 , C08G65/33396 , C08G65/48 , C08G2650/04 , C08G2650/38 , C12Y113/12007
摘要： The invention provides a composition containing particulate composite of a polymer and a therapeutic agent. The composition also contains a complexing agent. The polymer interacts with the complexing agent in a host-guest or a guest-host interaction to form an inclusion complex. A therapeutic composition of the invention may be used to deliver the therapeutic agent and to treat various disorders. Both the polymer of the particulate composite and the complexing agent may be used to introduce functionality into the therapeutic composition. The invention also relates to a method of preparing a composition. The method combines a therapeutic agent, a polymer having host or guest functionality, and a complexing agent having guest or host functionality to form the therapeutic composition. The complexing agent forms an inclusion complex with the polymer. The invention also relates to a method of delivering a therapeutic agent. According to the method, a therapeutically effective amount of a therapeutic composition of the invention is administered to a mammal (e.g. person or animal) in recognized need of the therapeutic. Also disclosed are compounds having the formula:
摘要翻译：本发明提供了含有聚合物和治疗剂的颗粒复合物的组合物。该组合物还含有络合剂。聚合物与宿主客体或客体 - 宿主相互作用中的络合剂相互作用以形成包合物。本发明的治疗组合物可用于递送治疗剂并治疗各种疾病。颗粒复合材料的聚合物和络合剂都可用于将功能性引入治疗组合物中。本发明还涉及制备组合物的方法。该方法结合治疗剂，具有宿主或客体功能的聚合物和具有客体或宿主功能的络合剂以形成治疗组合物。络合剂与聚合物形成包合络合物。本发明还涉及递送治疗剂的方法。根据该方法，将治疗有效量的本发明的治疗组合物在公认的治疗需要中给予哺乳动物（例如人或动物）。还公开了具有下式的化合物：

6. 发明授权

US07807198B2 Compositions containing inclusion complexes 有权
标题翻译：含有复合物的组合物
公开(公告)号：US07807198B2
公开(公告)日：2010-10-05
申请号：US11321441
申请日：2005-12-28
申请人： Suzie Hwang Pun , Hector Gonzalez , Mark E. Davis , Nathalie C. Bellocq , Jianjun Cheng
发明人： Suzie Hwang Pun , Hector Gonzalez , Mark E. Davis , Nathalie C. Bellocq , Jianjun Cheng
IPC分类号： A61K9/14 , A61K31/74
CPC分类号： A61K47/48215 , A61K38/44 , A61K47/60 , A61K47/6949 , A61K47/6951 , A61K48/0041 , B82Y5/00 , C08B37/0012 , C08G65/33396 , C08G65/48 , C08G2650/04 , C08G2650/38 , C12Y113/12007
摘要： The invention provides a composition containing particulate composite of a polymer and a therapeutic agent. The composition also contains a complexing agent. The polymer interacts with the complexing agent in a host-guest or a guest-host interaction to form an inclusion complex. A therapeutic composition of the invention may be used to deliver the therapeutic agent and to treat various disorders. Both the polymer of the particulate composite and the complexing agent may be used to introduce functionality into the therapeutic composition. The invention also relates to a method of preparing a composition. The method combines a therapeutic agent, a polymer having host or guest functionality, and a complexing agent having guest or host functionality to form the therapeutic composition. The complexing agent forms an inclusion complex with the polymer. The invention also relates to a method of delivering a therapeutic agent. According to the method, a therapeutically effective amount of a therapeutic composition of the invention is administered to a mammal (e.g. person or animal) in recognized need of the therapeutic. Also disclosed are compounds having the formula:
摘要翻译：本发明提供了含有聚合物和治疗剂的颗粒复合物的组合物。该组合物还含有络合剂。聚合物与宿主客体或客体 - 宿主相互作用中的络合剂相互作用以形成包合物。本发明的治疗组合物可用于递送治疗剂并治疗各种疾病。颗粒复合材料的聚合物和络合剂都可用于将功能性引入治疗组合物中。本发明还涉及制备组合物的方法。该方法结合治疗剂，具有宿主或客体功能的聚合物和具有客体或宿主功能的络合剂以形成治疗组合物。络合剂与聚合物形成包合络合物。本发明还涉及递送治疗剂的方法。根据该方法，将治疗有效量的本发明的治疗组合物在公认的治疗需要中给予哺乳动物（例如人或动物）。还公开了具有下式的化合物：

7. 发明授权

US07166302B2 Complexing agents for compositions containing inclusion complexes 有权
公开(公告)号：US07166302B2
公开(公告)日：2007-01-23
申请号：US10021294
申请日：2001-12-19
申请人： Suzie Hwang Pun , Hector Gonzalez , Mark E. Davis , Nathalie Bellocq , Jianjun Cheng
发明人： Suzie Hwang Pun , Hector Gonzalez , Mark E. Davis , Nathalie Bellocq , Jianjun Cheng
IPC分类号： A61K9/14 , A61K31/74 , C12P19/30 , C12N15/63
CPC分类号： A61K47/48215 , A61K38/44 , A61K47/60 , A61K47/6949 , A61K47/6951 , A61K48/0041 , B82Y5/00 , C08B37/0012 , C08G65/33396 , C08G65/48 , C08G2650/04 , C08G2650/38 , C12Y113/12007
摘要： The invention provides a composition containing particulate composite of a polymer and a therapeutic agent. The composition also contains a complexing agent. The polymer interacts with the complexing agent in a host-guest or a guest-host interaction to form an inclusion complex. A therapeutic composition of the invention may be used to deliver the therapeutic agent and to treat various disorders. Both the polymer of the particulate composite and the complexing agent may be used to introduce functionality into the therapeutic composition. The invention also relates to a method of preparing a composition. The method combines a therapeutic agent, a polymer having host or guest functionality, and a complexing agent having guest or host functionality to form the therapeutic composition. The complexing agent forms an inclusion complex with the polymer. The invention also relates to a method of delivering a therapeutic agent. According to the method, a therapeutically effective amount of a therapeutic composition of the invention is administered to a mammal (e.g. person or animal) in recognized need of the therapeutic. Also disclosed are compounds having the formula:

8. 发明申请

US20110256104A1 COMPLEXING AGENTS FOR COMPOSITIONS CONTAINING INCLUSION COMPLEXES 有权
标题翻译：包含复合物的组合物的复合剂
公开(公告)号：US20110256104A1
公开(公告)日：2011-10-20
申请号：US13107024
申请日：2011-05-13
申请人： Suzie Hwang Pun , Hector Gonzalez , Mark E. Davis , Nathalie Bellocq , Jianjun Cheng
发明人： Suzie Hwang Pun , Hector Gonzalez , Mark E. Davis , Nathalie Bellocq , Jianjun Cheng
IPC分类号： A61K35/76 , C12N9/96 , C12N7/00 , C12N15/63 , A61K38/14 , A61K31/7088 , A61K31/718 , C07K9/00 , C07K19/00 , C07K14/00 , C08B37/16 , A61P21/00 , A61P35/04 , A61P9/00 , A61P31/12 , A61K38/54
CPC分类号： A61K47/48215 , A61K38/44 , A61K47/60 , A61K47/6949 , A61K47/6951 , A61K48/0041 , B82Y5/00 , C08B37/0012 , C08G65/33396 , C08G65/48 , C08G2650/04 , C08G2650/38 , C12Y113/12007
摘要： The invention provides a composition containing particulate composite of a polymer and a therapeutic agent. The composition also contains a complexing agent. The polymer interacts with the complexing agent in a host-guest or a guest-host interaction to form an inclusion complex. A therapeutic composition of the invention may be used to deliver the therapeutic agent and to treat various disorders. Both the polymer of the particulate composite and the complexing agent may be used to introduce functionality into the therapeutic composition. The invention also relates to a method of preparing a composition. The method combines a therapeutic agent, a polymer having host or guest functionality, and a complexing agent having guest or host functionality to form the therapeutic composition. The complexing agent forms an inclusion complex with the polymer. The invention also relates to a method of delivering a therapeutic agent. According to the method, a therapeutically effective amount of a therapeutic composition of the invention is administered to a mammal (e.g. person or animal) in recognized need of the therapeutic. Also disclosed are compounds having the formula:
摘要翻译：本发明提供了含有聚合物和治疗剂的颗粒复合物的组合物。该组合物还含有络合剂。聚合物与宿主客体或客体 - 宿主相互作用中的络合剂相互作用以形成包合物。本发明的治疗组合物可用于递送治疗剂并治疗各种疾病。颗粒复合材料的聚合物和络合剂都可用于将功能性引入治疗组合物中。本发明还涉及制备组合物的方法。该方法结合治疗剂，具有宿主或客体功能的聚合物和具有客体或宿主功能的络合剂以形成治疗组合物。络合剂与聚合物形成包合络合物。本发明还涉及递送治疗剂的方法。根据该方法，将治疗有效量的本发明的治疗组合物在公认的治疗需要中给予哺乳动物（例如人或动物）。还公开了具有下式的化合物：

9. 发明申请

US20130197210A1 COMPLEXING AGENTS FOR COMPOSITIONS CONTAINING INCLUSION COMPLEXES 审中-公开
标题翻译：包含复合物的组合物的复合剂
公开(公告)号：US20130197210A1
公开(公告)日：2013-08-01
申请号：US13586328
申请日：2012-08-15
申请人： Suzie Hwang Pun , Hector Gonzalez , Mark E. Davis , Nathalie Bellocq , Jianjun Cheng
发明人： Suzie Hwang Pun , Hector Gonzalez , Mark E. Davis , Nathalie Bellocq , Jianjun Cheng
IPC分类号： C08B37/16
CPC分类号： A61K48/0041 , A61K38/44 , A61K47/555 , A61K47/6949 , A61K47/6951 , B82Y5/00 , C08B37/0012 , C08B37/0015 , C08G65/33396 , C08G65/48 , C08G2650/04 , C08G2650/38 , C12N15/87 , C12Y113/12007
摘要： The invention provides a composition containing particulate composite of a polymer and a therapeutic agent. The composition also contains a complexing agent. The polymer interacts with the complexing agent in a host-guest or a guest-host interaction to form an inclusion complex. Both the polymer of the particulate composite and the complexing agent may be used to introduce functionality into the therapeutic composition. A therapeutic composition of the invention may be used to deliver the therapeutic agent and to treat various disorders. The invention also relates to a method of preparing a composition of the present disclosure. The invention further relates to a method of delivering a therapeutic agent, using the composition of the present disclosure, where a therapeutically effective amount of a therapeutic composition of the invention may be administered to a mammal (e.g. person or animal) in recognized need of the therapeutic.
摘要翻译：本发明提供了含有聚合物和治疗剂的颗粒复合物的组合物。该组合物还含有络合剂。聚合物与宿主客体或客体 - 宿主相互作用中的络合剂相互作用以形成包合物。颗粒复合材料的聚合物和络合剂都可用于将功能性引入治疗组合物中。本发明的治疗组合物可用于递送治疗剂并治疗各种疾病。本发明还涉及制备本公开的组合物的方法。本发明还涉及使用本公开内容的组合物递送治疗剂的方法，其中治疗有效量的本发明的治疗组合物可以以公认的需要施用于哺乳动物（例如人或动物）治疗。

10. 发明授权

US07018609B2 Compositions containing inclusion complexes 有权
公开(公告)号：US07018609B2
公开(公告)日：2006-03-28
申请号：US10021312
申请日：2001-12-19
申请人： Suzie Hwang Pun , Hector Gonzalez , Mark E. Davis , Nathalie Bellocq , Jianjun Cheng
发明人： Suzie Hwang Pun , Hector Gonzalez , Mark E. Davis , Nathalie Bellocq , Jianjun Cheng
IPC分类号： A61K51/00
CPC分类号： A61K47/48215 , A61K38/44 , A61K47/60 , A61K47/6949 , A61K47/6951 , A61K48/0041 , B82Y5/00 , C08B37/0012 , C08G65/33396 , C08G65/48 , C08G2650/04 , C08G2650/38 , C12Y113/12007
摘要： The invention provides a composition containing particulate composite of a polymer and a therapeutic agent. The composition also contains a complexing agent. The polymer interacts with the complexing agent in a host-guest or a guest-host interaction to form an inclusion complex. A therapeutic composition of the invention may be used to deliver the therapeutic agent and to treat various disorders. Both the polymer of the particulate composite and the complexing agent may be used to introduce functionality into the therapeutic composition. The invention also relates to a method of preparing a composition. The method combines a therapeutic agent, a polymer having host or guest functionality, and a complexing agent having guest or host functionality to form the therapeutic composition. The complexing agent forms an inclusion complex with the polymer. The invention also relates to a method of delivering a therapeutic agent. According to the method, a therapeutically effective amount of a therapeutic composition of the invention is administered to a mammal (e.g. person or animal) in recognized need of the therapeutic. Also disclosed are compounds having the formula:

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