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1. 发明公开

US20240366520A1 KIT FOR PREPARING NANOPARTICLES CONTAINING DRUG AND COMPRISING NO AMPHIPHILIC POLYMERS 审中-公开
公开(公告)号：US20240366520A1
公开(公告)日：2024-11-07
申请号：US18288677
申请日：2022-04-29
申请人： SAMYANG HOLDINGS CORPORATION
发明人： So Jin LEE , Go Eun KIM , Joon Young PARK
IPC分类号： A61K9/51 , A61K31/7088 , A61K35/76 , A61K38/00
CPC分类号： A61K9/5153 , A61K31/7088 , A61K35/76 , A61K38/00
摘要： The present invention relates to a kit for preparing nanoparticles containing a drug and, more specifically, to a kit for preparing drug-containing nanoparticles, the kit enabling a drug to be easily contained in nanoparticles by simple mixing only, preferably, in a specific weight ratio, the drug and nanoparticles containing a cationic compound and a polylactate, as kit constituent components comprising no amphiphilic polymers, and being designed to enable the efficiency of drug delivery into cells to be greater than that of a kit comprising an amphiphilic polymer.

2. 发明公开

US20240315984A1 MICROSPHERE-BASED DRUG DELIVERY PLATFORM FOR DELIVERY OF IMMUNOTHERAPEUTIC AGENTS 审中-公开
公开(公告)号：US20240315984A1
公开(公告)日：2024-09-26
申请号：US18612755
申请日：2024-03-21
申请人： Boston Scientific Scimed, Inc.
发明人： Bhanu Prasanth Koppolu , Philip David Dorgan , Rhiannon Johnson , Steven L. Kangas , Nivedita Swetha Ramkumar , Matthew R. Dreher
IPC分类号： A61K9/51 , A61K45/06
CPC分类号： A61K9/5153 , A61K9/5123 , A61K45/06
摘要： The present disclosure pertains to biodegradable polymeric microspheres that comprise a biodegradable polymer and an immunotherapeutic agent selected from an inhibitor of poly ADP ribose polymerase enzyme (PARP inhibitor) and/or a Toll-like receptor (TLR) agonist wherein (a) 50% of a total amount of the immunotherapeutic agent in the biodegradable polymeric microspheres is released from the biodegradable polymeric microspheres into a 37° C. solution of PBS Tween 20 (0.05%) at a point in time ranging from 3 days and 14 days; (b) between 1 mg and 100 mg of immunotherapeutic agent per 1 g dry weight of microspheres is released from the biodegradable polymeric microspheres into a 37° C. solution of PBS Tween 20 (0.05%) at a point in time ranging from 3 days and 14 days; or (c) both (a) and (b). Other aspects of the present disclosure pertain to methods of using such microparticles and kits that contain such microparticles.

3. 发明授权

US12083186B2 Methods for assembling scavenging particles 有权
公开(公告)号：US12083186B2
公开(公告)日：2024-09-10
申请号：US17344543
申请日：2021-06-10
申请人： NaNotics, LLC
发明人： Louis Hawthorne , John Dodgson
IPC分类号： A61K47/69 , A61K9/51 , A61K47/62
CPC分类号： A61K47/6929 , A61K9/5115 , A61K9/5153 , A61K47/62 , A61K47/6937
摘要： The disclosure provides, methods for preparing scavenging particles, as well as methods for attaching capture agents to the particles. The disclosure further provides compositions that bind to and inhibit the biological activity of soluble biomolecules, as well as pharmaceutical compositions thereof. The compositions may comprise a plurality of particles that specifically bind a target, such as a soluble biomolecule or a biomolecule on the surface of a pathogen, to inhibit the target (or pathogen) from interacting with other molecules or cells. Also provided herein are a number of applications (e.g., therapeutic applications) in which the compositions are useful.

4. 发明公开

US20240293334A1 NONVIRAL GENE TRANSFER TO THE SUPRACHOROIDAL SPACE 审中-公开
公开(公告)号：US20240293334A1
公开(公告)日：2024-09-05
申请号：US18535180
申请日：2023-12-11
申请人： The Johns Hopkins University
发明人： Peter A. Campochiaro , Jordan Green , Jayoung Kim , Jikui Shen
IPC分类号： A61K9/51 , A61K9/00 , A61K9/50 , A61K45/06 , B82Y5/00
CPC分类号： A61K9/5153 , A61K9/0051 , A61K9/5031 , A61K45/06 , B82Y5/00
摘要： The presently disclosed subject matter provides compositions and methods for administering a nanoparticle or microparticle and a therapeutic agent to the suprachoroidal space in the eye.

5. 发明公开

US20240122866A1 CATIONIC POLYMER-FORMULATED NANOPARTICLES AND METHODS OF USE 审中-公开
公开(公告)号：US20240122866A1
公开(公告)日：2024-04-18
申请号：US18547669
申请日：2022-02-23
申请人： Ann and Robert H. Lurie Children's Hospital of Chicago
发明人： Youyang Zhao
IPC分类号： A61K9/51 , A61K45/06
CPC分类号： A61K9/5153 , A61K45/06
摘要： Disclosed herein is a composition comprising a nanoparticle which comprises polyethylene glycol (PEG)-b-poly (D,L-lactide) (PLA) (PEG-b-PLA) co-polymer formulated with polyethylenimine (PEI) or other cationic polymers and one or more cargo molecules associated with the nanoparticle such as nucleic acids. Also provided are methods for delivering a cargo molecule to a cell in vitro and in vivo using the disclosed compositions.

6. 发明授权

US11931466B2 Process for the preparation of drug loaded microparticles 有权
公开(公告)号：US11931466B2
公开(公告)日：2024-03-19
申请号：US17510330
申请日：2021-10-25
申请人： FERRING B.V.
发明人： Celal Albayrak
IPC分类号： A61K9/51 , A61K9/00 , A61K9/16 , A61K9/50 , A61K31/519 , B82Y5/00
CPC分类号： A61K9/5153 , A61K9/0019 , A61K9/1647 , A61K9/1694 , A61K9/5031 , A61K9/5089 , A61K9/5192 , A61K31/519 , B82Y5/00
摘要： Provided is a process for the production of nano- and/or microparticles containing a therapeutically active agent embedded in a polymer matrix or encapsulated by a polymer shell, and nano- and/or microparticles obtainable by the process, said process comprising the steps of:

a) providing a solution of a polymer selected from polylactide, polyglycolide, and polyester copolymers comprising copolymerized units of lactic acid and/or glycolic acid in an organic solvent S1 having limited water solubility;
b) providing a solution or dispersion of a therapeutically active agent in as solvent or mixture of organic solvents S2 comprising at least 50 vol. % benzyl alcohol,
c) combining the solution or the solution and suspension provided in step a) and step b) to provide an organic phase which comprises dissolved polymer and dissolved therapeutically active agent in a mixture of the organic solvents S1 and S2;
d) agitating the organic phase provided in step c) in a vessel and adding an aqueous surfactant solution to the agitated organic phase in a volume ratio of at least 2:1 in terms of the total volume of the aqueous surfactant solution to the total volume of the organic phase as provided in step c), thus causing the formation of a dispersion containing a continuous aqueous phase and a discontinuous organic phase; and
e) allowing the spontaneous formation of the nano- and/or microparticles via transfer of organic solvent from the discontinuous organic phase into the continuous aqueous phase directly after the dispersion has been formed.

7. 发明授权

US11918695B2 Topical formulation of hyperbranched polymer-coated particles 有权
公开(公告)号：US11918695B2
公开(公告)日：2024-03-05
申请号：US15573807
申请日：2016-05-11
申请人： Yale University
发明人： Yang Deng , Asiri Ediriwickrema , William M. Saltzman , Michael Girardi
IPC分类号： A61K31/337 , A61K8/02 , A61K8/11 , A61K8/34 , A61K8/81 , A61K8/86 , A61K8/92 , A61K9/00 , A61K9/50 , A61K9/51 , A61K31/00 , A61K31/7076 , A61K47/69 , A61P35/00 , A61Q17/00 , A61Q17/04 , A61Q19/00
CPC分类号： A61K9/5153 , A61K8/0241 , A61K8/11 , A61K8/345 , A61K8/8147 , A61K8/86 , A61K8/922 , A61K9/0019 , A61K9/5031 , A61K31/00 , A61K31/7076 , A61K47/6935 , A61K47/6937 , A61P35/00 , A61Q17/005 , A61Q17/04 , A61Q19/00 , A61K2800/624 , A61K2800/654
摘要： Core-shell particles have a hydrophobic core and a shell formed of o containing hyperbranched polymers (HP). The HP can be covalently bound to the one or more materials that form the core or coated thereon. The HP coating can be modified to adjust the properties of the particles. For example, unmodified HP coatings resist non-specific protein absorption. Alternatively, the hydroxyl groups on the HP coating can be chemically modified to form functional groups that react with functional groups on tissue to adhere the particles to the tissue, cells, or extracellular materials, such as proteins. Such functional groups include, but not limited to, aldehydes, amines, and O-substituted oximes. Topical formulation for application to the skin contain these HP coated nanoparticles. In some embodiments, the particles include cosmetic, therapeutic, diagnostic, nutraceutical, and/or prophylactic agents, such as those used as sunblock compositions.

8. 发明公开

US20240024334A1 NOVEL METHODS 审中-公开
公开(公告)号：US20240024334A1
公开(公告)日：2024-01-25
申请号：US18481168
申请日：2023-10-04
申请人： INTRA-CELLULAR THERAPIES, INC.
发明人： Kimberly VANOVER , Peng LI , Sharon MATES , Robert DAVIS , Lawrence P. WENNOGLE
IPC分类号： A61K31/5383 , A61K31/4985 , A61K45/06 , A61K9/00 , A61K9/51
CPC分类号： A61K31/5383 , A61K31/4985 , A61K45/06 , A61K9/0024 , A61K9/5153 , A61K9/0019
摘要： The disclosure provides the use of particular substituted heterocycle fused gamma-carboline compounds as pharmaceuticals for the treatment of residual symptoms of psychosis or schizophrenia. The disclosure also provides novel long acting injectable formulations of particular substituted heterocycle fused gamma-carboline compounds and use of such long acting injectable formulations for the treatment of residual symptoms of psychosis or schizophrenia.

9. 发明授权

US11826087B2 Compositions and methods for thermal skin treatment with metal nanoparticles 有权
公开(公告)号：US11826087B2
公开(公告)日：2023-11-28
申请号：US15267656
申请日：2016-09-16
申请人： Coronado Aesthetics, LLC
发明人： Todd James Harris , Alice Ann Chen Kim
IPC分类号： A61B18/06 , A61K8/19 , A61K8/02 , A61Q9/04 , A61K9/00 , A61K9/51 , A61K8/29 , A61B17/50 , A61B18/20 , A61N5/06 , A61B18/18 , A61K8/11 , A61K41/00 , A61Q9/00 , A61Q19/00 , A61B18/00 , A61N7/00 , A61N5/067 , A61Q19/08 , A61Q19/06 , B82Y5/00
CPC分类号： A61B18/06 , A61B17/50 , A61B18/18 , A61B18/203 , A61K8/0241 , A61K8/0245 , A61K8/0283 , A61K8/11 , A61K8/19 , A61K8/29 , A61K9/0014 , A61K9/5115 , A61K9/5123 , A61K9/5146 , A61K9/5153 , A61K41/0052 , A61K41/0057 , A61N5/062 , A61N5/0616 , A61Q9/00 , A61Q9/04 , A61Q19/00 , A61B2018/0047 , A61B2018/00452 , A61B2018/00458 , A61B2018/00476 , A61B2018/00577 , A61B2018/00791 , A61B2018/00809 , A61B2018/068 , A61K9/0009 , A61K9/009 , A61K2800/413 , A61K2800/621 , A61K2800/622 , A61K2800/624 , A61K2800/81 , A61N5/067 , A61N5/0617 , A61N5/0624 , A61N5/0625 , A61N7/00 , A61N2005/0659 , A61N2007/0034 , A61Q19/06 , A61Q19/08 , B82Y5/00
摘要： Treatment of skin tissue with photoactive materials and light, such as nanoparticles and formulations which are useful for cosmetic, diagnostic and therapeutic applications to mammals such as humans. In particular, embodiments of thermal treatment of the skin surface with metal nanoparticles in surfactant containing solutions are disclosed.

10. 发明公开

US20230372377A1 COMPOSITIONS AND METHODS FOR TREATING AND AMELIORATING RESPIRATORY CONDITIONS AND INFLAMMATION OF MUCOSA 审中-公开
公开(公告)号：US20230372377A1
公开(公告)日：2023-11-23
申请号：US18138671
申请日：2023-04-24
申请人： ATOPIC MEDICAL, INC.
发明人： Thomas J. Borody , Debra A. Peattie
IPC分类号： A61K31/7048 , A61K45/06 , A61K9/127 , A61K9/107 , A61K9/00 , A61P31/16 , A61K9/51 , A61P11/02 , A61P11/06 , A61P11/12 , A61P11/08
CPC分类号： A61K31/7048 , A61K45/06 , A61K9/1274 , A61K9/1075 , A61K9/008 , A61P31/16 , A61K9/51 , A61P11/02 , A61P11/06 , A61P11/12 , A61P11/08 , A61K9/0075 , A61K9/5153 , A61K9/0078 , A61K9/5146
摘要： Disclosed are compositions and methods for treating, amelioriating, reversing and/or preventing (acting as a prophylaxis): a respiratory condition involving an infection or an inflammation, or any lung condition involving inflammation or infection, e.g., of a respiratory mucosa, and/or an infection or an inflammation of an underlying muscle of the respiratory tract; or, an asthma; a bronchitis; a sinusitis or rhinosinusitis; an infection of a sinus; chronic obstructive airway disease; emphysema; chronic bronchitis; pneumonia; or, a bronchiectasis. In alternative embodiments, the therapeutic combination comprises an orally administered Amphotericin B or equivalent antifungal alone, or a combination of Amphotericin B and: one antibiotic; two antibiotics; three antibiotics; or, four or more antibiotics. In alternative embodiments, these compositions and methods are dosaged and administered to children in need thereof. In alternative embodiments, compositions and methods of the invention are dosaged, formulated and dosaged as tablet, capsule, liquid, powder or aerosol preparations or formulations, or preparations or formulations for oral delivery or inhalation.

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