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    • 3. 发明申请
    • NANOCONJUGATES AND NANOCONJUGATE FORMULATIONS
    • 纳米结晶和纳米结晶配方
    • US20130101672A1
    • 2013-04-25
    • US13518836
    • 2010-12-23
    • Jianjun ChengRong Tong
    • Jianjun ChengRong Tong
    • A61K9/16
    • A61K9/1658A61K9/0019A61K9/5169A61K47/593A61K47/60A61K47/6935
    • The invention provides a drug-polymer nanoconjugate that includes a drug covalently bonded to a polymer. The nanoconjugate can include a block copolymer coating and/or an albumin coating. The drug of the drug-polymer nanoconjugate can be one or more of a variety of therapeutic agents linked to the polymer through ether or thioether linkages formed from hydroxyl or thiol groups of the drug. The albumin coating can substantially or completely retard or prevent aggregation of the nanoconjugates in solid form or in solution. The invention further provides compositions that include a plurality of drug-polymer nanoconjugates, as well as methods for using the drug-polymer nanoconjugates, such as in therapeutic or diagnostic applications.
    • 本发明提供药物 - 聚合物纳米缀合物,其包括共价键合到聚合物上的药物。 纳米缀合物可以包括嵌段共聚物涂层和/或白蛋白涂层。 药物 - 聚合物纳米缀合物的药物可以是通过由药物的羟基或硫醇基团形成的醚或硫醚键与聚合物连接的各种治疗剂中的一种或多种。 白蛋白涂层可以基本上或完全地延迟或阻止纳米缀合物以固体形式或溶液中的聚集。 本发明还提供了包括多种药物 - 聚合物纳米缀合物的组合物,以及用于使用药物 - 聚合物纳米缀合物的方法,例如在治疗或诊断应用中。
    • 6. 发明授权
    • Nanoconjugates and nanoconjugate formulations
    • 纳米缀合物和纳米缀合物配方
    • US09295651B2
    • 2016-03-29
    • US13518836
    • 2010-12-23
    • Jianjun ChengRong Tong
    • Jianjun ChengRong Tong
    • A61K9/14A61K38/38A61K47/30A61K47/42A61K47/48A61K9/16A61K9/00A61K9/51
    • A61K9/1658A61K9/0019A61K9/5169A61K47/593A61K47/60A61K47/6935
    • The invention provides a drug-polymer nanoconjugate that includes a drug covalently bonded to a polymer. The nanoconjugate can include a block copolymer coating and/or an albumin coating. The drug of the drug-polymer nanoconjugate can be one or more of a variety of therapeutic agents linked to the polymer through ether or thioether linkages formed from hydroxyl or thiol groups of the drug. The albumin coating can substantially or completely retard or prevent aggregation of the nanoconjugates in solid form or in solution. The invention further provides compositions that include a plurality of drug-polymer nanoconjugates, as well as methods for using the drug-polymer nanoconjugates, such as in therapeutic or diagnostic applications.
    • 本发明提供药物 - 聚合物纳米缀合物,其包括共价键合到聚合物上的药物。 纳米缀合物可以包括嵌段共聚物涂层和/或白蛋白涂层。 药物 - 聚合物纳米缀合物的药物可以是通过由药物的羟基或硫醇基团形成的醚或硫醚键与聚合物连接的各种治疗剂中的一种或多种。 白蛋白涂层可以基本上或完全地延迟或阻止纳米缀合物以固体形式或溶液中的聚集。 本发明还提供了包括多种药物 - 聚合物纳米缀合物的组合物,以及用于使用药物 - 聚合物纳米缀合物的方法,例如在治疗或诊断应用中。
    • 8. 发明授权
    • Data recovery system and the method thereof
    • 数据恢复系统及其方法
    • US07242735B2
    • 2007-07-10
    • US10632925
    • 2003-08-04
    • Chao-Hsin LuYi-Shu ChangShiu-Rong TongKuang-Hsi Hsieh
    • Chao-Hsin LuYi-Shu ChangShiu-Rong TongKuang-Hsi Hsieh
    • H04L7/02
    • H04L7/0338
    • A data recovery system and method is disclosed, which comprises an oversampler, a phase detection circuit, a data pick circuit, a data overlap/skip detection circuit and a data correction circuit. The oversampler oversamples an input signal and thus generates oversampled signals. The phase detection circuit receives for detecting transitions of the oversampled signals and outputting a phase signal. The data pick circuit receives the phase signal, accordingly groups the oversampled signals into n groups and picks one group as an output data. The data overlap/skip detection circuit determines if data is overlapped or skipped according to the phase signal and the last phase signal. The data correction circuit corrects data when data is overlapped or skipped and outputs an accurate output data.
    • 公开了一种数据恢复系统和方法,其包括过采样器,相位检测电路,数据拾取电路,数据重叠/跳过检测电路和数据校正电路。 过采样器过采样输入信号,从而产生过采样信号。 相位检测电路接收用于检测过采样信号的转变并输出相位信号。 数据采集​​电路接收相位信号,相应地将过采样信号分组为n组,并选择一组作为输出数据。 数据重叠/跳跃检测电路根据相位信号和最后的相位信号确定数据是否重叠或跳过。 当数据重叠或跳过时,数据校正电路校正数据,并输出准确的输出数据。