专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08709483B2 System for targeted delivery of therapeutic agents 有权
标题翻译：用于靶向递送治疗剂的系统
公开(公告)号：US08709483B2
公开(公告)日：2014-04-29
申请号：US12239136
申请日：2008-09-26
申请人： Omid C. Farokhzad , Jianjun Cheng , Benjamin A. Teply , Robert S. Langer , Stephen E. Zale
发明人： Omid C. Farokhzad , Jianjun Cheng , Benjamin A. Teply , Robert S. Langer , Stephen E. Zale
IPC分类号： A61K9/14 , A61K38/00 , C12N15/11
CPC分类号： A61K47/4813 , A61K9/5031 , A61K9/5153 , A61K9/5192 , A61K31/337 , A61K47/482 , A61K47/48215 , A61K47/549 , A61K47/555 , A61K47/593 , A61K47/60 , A61K47/6935 , A61K47/6937 , A61K51/0417 , A61K51/0491 , A61K51/0495 , A61K51/065
摘要： The present invention provides a drug delivery system for targeted delivery of therapeutic agent-containing particles to tissues, cells, and intracellular compartments. The invention provides targeted particles comprising a particle, one or more targeting moieties, and one or more therapeutic agents to be delivered and pharmaceutical compositions comprising inventive targeted particles. The present invention provides methods of designing, manufacturing, and using inventive targeted particles and pharmaceutical compositions thereof.
摘要翻译：本发明提供了用于将组合物，细胞和细胞内区室靶向递送含治疗剂的颗粒的药物递送系统。本发明提供了包含颗粒，一种或多种靶向部分和一种或多种待递送治疗剂和包含本发明靶向颗粒的药物组合物的靶向颗粒。本发明提供了设计，制造和使用本发明的靶向颗粒及其药物组合物的方法。

2. 发明申请

US20100323199A1 POLYMERS FOR FUNCTIONAL PARTICLES 有权
标题翻译：功能颗粒聚合物
公开(公告)号：US20100323199A1
公开(公告)日：2010-12-23
申请号：US12873692
申请日：2010-09-01
申请人： Frank X. Gu , Benjamin A. Teply , Robert S. Langer , Omid C. Farokhzad
发明人： Frank X. Gu , Benjamin A. Teply , Robert S. Langer , Omid C. Farokhzad
IPC分类号： B32B5/00
CPC分类号： C08G63/912 , A61K9/5153 , A61K47/549 , A61K47/593 , A61K47/60 , A61K47/6935 , A61K47/6937 , A61K49/00 , A61K51/1244 , B82Y5/00 , Y10S977/773 , Y10S977/906 , Y10S977/915 , Y10T428/2982
摘要： The present invention generally relates to polymers and macromolecules, in particular, to block polymers useful in particles such as nanoparticles. One aspect of the invention is directed to a method of developing nanoparticles with desired properties. In one set of embodiments, the method includes producing libraries of nanoparticles having highly controlled properties, which can be formed by mixing together two or more macromolecules in different ratios. One or more of the macromolecules may be a polymeric conjugate of a moiety to a biocompatible polymer. In some cases, the nanoparticle may contain a drug. The moiety, in some embodiments, may have a molecular weight greater than about 1000 Da; for example, the moiety may include a polypeptide or a polynucleotide, such as an aptamer. The moiety may also be a targeting moiety, an imaging moiety, a chelating moiety, a charged moiety, or a therapeutic moiety. Another aspect of the invention is directed to systems and methods of producing such polymeric conjugates. In some embodiments, a solution containing a polymer is contacted with a liquid, such as an immiscible liquid, to form nanoparticles containing the polymeric conjugate. Other aspects of the invention are directed to methods using such libraries, methods of using or administering such polymeric conjugates, methods of promoting the use of such polymeric conjugates, kits involving such polymeric conjugates, or the like.
摘要翻译：本发明一般涉及聚合物和大分子，特别是阻止可用于颗粒如纳米颗粒的聚合物。本发明的一个方面涉及一种开发具有所需性质的纳米颗粒的方法。在一组实施方案中，该方法包括制备具有高度控制性质的纳米颗粒的文库，其可通过将两种或多种不同比例的大分子混合在一起形成。一个或多个大分子可以是部分与生物相容性聚合物的聚合物缀合物。在一些情况下，纳米颗粒可以含有药物。在一些实施方案中，该部分可具有大于约1000Da的分子量; 例如，该部分可以包括多肽或多核苷酸，例如适体。该部分还可以是靶向部分，成像部分，螯合部分，带电部分或治疗部分。本发明的另一方面涉及制备这种聚合物缀合物的系统和方法。在一些实施方案中，将含有聚合物的溶液与诸如不混溶液体的液体接触以形成含有聚合物缀合物的纳米颗粒。本发明的其它方面涉及使用这种文库的方法，使用或施用这种聚合物缀合物的方法，促进使用这种聚合物缀合物的方法，涉及这种聚合物缀合物的试剂盒等。

3. 发明授权

US08367113B2 Polymers for functional particles 有权
标题翻译：功能颗粒聚合物
公开(公告)号：US08367113B2
公开(公告)日：2013-02-05
申请号：US11803843
申请日：2007-05-15
申请人： Frank X. Gu , Benjamin A. Teply , Robert S. Langer , Omid C. Farokhzad
发明人： Frank X. Gu , Benjamin A. Teply , Robert S. Langer , Omid C. Farokhzad
IPC分类号： A61K9/14 , A61K9/51
CPC分类号： C08G63/912 , A61K9/5153 , A61K47/549 , A61K47/593 , A61K47/60 , A61K47/6935 , A61K47/6937 , A61K49/00 , A61K51/1244 , B82Y5/00 , Y10S977/773 , Y10S977/906 , Y10S977/915 , Y10T428/2982
摘要： The present invention generally relates to polymers and macromolecules, in particular, to block polymers useful in particles such as nanoparticles. One aspect of the invention is directed to a method of developing nanoparticles with desired properties. In one set of embodiments, the method includes producing libraries of nanoparticles having highly controlled properties, which can be formed by mixing together two or more macromolecules in different ratios. One or more of the macromolecules may be a polymeric conjugate of a moiety to a biocompatible polymer. In some cases, the nanoparticle may contain a drug. The moiety, in some embodiments, may have a molecular weight greater than about 1000 Da; for example, the moiety may include a polypeptide or a polynucleotide, such as an aptamer. The moiety may also be a targeting moiety, an imaging moiety, a chelating moiety, a charged moiety, or a therapeutic moiety. Another aspect of the invention is directed to systems and methods of producing such polymeric conjugates. In some embodiments, a solution containing a polymer is contacted with a liquid, such as an immiscible liquid, to form nanoparticles containing the polymeric conjugate. Other aspects of the invention are directed to methods using such libraries, methods of using or administering such polymeric conjugates, methods of promoting the use of such polymeric conjugates, kits involving such polymeric conjugates, or the like.
摘要翻译：本发明一般涉及聚合物和大分子，特别是阻止可用于颗粒如纳米颗粒的聚合物。本发明的一个方面涉及一种开发具有所需性质的纳米颗粒的方法。在一组实施方案中，该方法包括制备具有高度控制性质的纳米颗粒的文库，其可通过将两种或多种不同比例的大分子混合在一起形成。一个或多个大分子可以是部分与生物相容性聚合物的聚合物缀合物。在一些情况下，纳米颗粒可以含有药物。在一些实施方案中，该部分可具有大于约1000Da的分子量; 例如，该部分可以包括多肽或多核苷酸，例如适体。该部分还可以是靶向部分，成像部分，螯合部分，带电部分或治疗部分。本发明的另一方面涉及制备这种聚合物缀合物的系统和方法。在一些实施方案中，将含有聚合物的溶液与诸如不混溶液体的液体接触以形成含有聚合物缀合物的纳米颗粒。本发明的其它方面涉及使用这种文库的方法，使用或施用这种聚合物缀合物的方法，促进使用这种聚合物缀合物的方法，涉及这种聚合物缀合物的试剂盒等。

4. 发明授权

US08323698B2 Polymers for functional particles 有权
标题翻译：功能颗粒聚合物
公开(公告)号：US08323698B2
公开(公告)日：2012-12-04
申请号：US12873692
申请日：2010-09-01
申请人： Frank X. Gu , Omid C. Farokhzad , Robert S. Langer , Benjamin A. Teply
发明人： Frank X. Gu , Omid C. Farokhzad , Robert S. Langer , Benjamin A. Teply
IPC分类号： A61K9/14 , A61K9/51
CPC分类号： C08G63/912 , A61K9/5153 , A61K47/549 , A61K47/593 , A61K47/60 , A61K47/6935 , A61K47/6937 , A61K49/00 , A61K51/1244 , B82Y5/00 , Y10S977/773 , Y10S977/906 , Y10S977/915 , Y10T428/2982
摘要： The present invention generally relates to polymers and macromolecules, in particular, to block polymers useful in particles such as nanoparticles. One aspect of the invention is directed to a method of developing nanoparticles with desired properties. In one set of embodiments, the method includes producing libraries of nanoparticles having highly controlled properties, which can be formed by mixing together two or more macromolecules in different ratios. One or more of the macromolecules may be a polymeric conjugate of a moiety to a biocompatible polymer. In some cases, the nanoparticle may contain a drug. The moiety, in some embodiments, may have a molecular weight greater than about 1000 Da; for example, the moiety may include a polypeptide or a polynucleotide, such as an aptamer. The moiety may also be a targeting moiety, an imaging moiety, a chelating moiety, a charged moiety, or a therapeutic moiety. Another aspect of the invention is directed to systems and methods of producing such polymeric conjugates. In some embodiments, a solution containing a polymer is contacted with a liquid, such as an immiscible liquid, to form nanoparticles containing the polymeric conjugate. Other aspects of the invention are directed to methods using such libraries, methods of using or administering such polymeric conjugates, methods of promoting the use of such polymeric conjugates, kits involving such polymeric conjugates, or the like.
摘要翻译：本发明一般涉及聚合物和大分子，特别是阻止可用于颗粒如纳米颗粒的聚合物。本发明的一个方面涉及一种开发具有所需性质的纳米颗粒的方法。在一组实施方案中，该方法包括制备具有高度控制性质的纳米颗粒的文库，其可通过将两种或多种不同比例的大分子混合在一起形成。一个或多个大分子可以是部分与生物相容性聚合物的聚合物缀合物。在一些情况下，纳米颗粒可以含有药物。在一些实施方案中，该部分可具有大于约1000Da的分子量; 例如，该部分可以包括多肽或多核苷酸，例如适体。该部分还可以是靶向部分，成像部分，螯合部分，带电部分或治疗部分。本发明的另一方面涉及制备这种聚合物缀合物的系统和方法。在一些实施方案中，将含有聚合物的溶液与诸如不混溶液体的液体接触以形成含有聚合物缀合物的纳米颗粒。本发明的其它方面涉及使用这种文库的方法，使用或施用这种聚合物缀合物的方法，促进使用这种聚合物缀合物的方法，涉及这种聚合物缀合物的试剂盒等。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式