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1. 发明申请

US20220378774A1 METHOD OF PROMOTING CELLULAR HYDRATION BY ENHANCING INTRACELLULAR PERMEATION 有权
公开(公告)号：US20220378774A1
公开(公告)日：2022-12-01
申请号：US17884516
申请日：2022-08-09
申请人： Eastpond Laboratories Limited
发明人： Lajos SZENTE
IPC分类号： A61K31/455 , A61K31/198 , A61K9/00 , A23L2/58 , A23L2/56 , A23L2/38 , A23L29/212 , A23L33/175 , A23L33/15 , C08L5/16 , A23L2/52 , A23L2/66 , A61K47/61
摘要： A method of promoting increased cellular hydration in a multicellular organism that is capable of intracellular water permeation includes the step of causing the multicellular organism to ingest an aqueous solution that contains an amount of a carbohydrate clathrate component. There is also a step of enhancing the intracellular permeation. The multicellular organism contains aquaporins, and the causing step involves interaction of the composition with the aquaporins. The cellular hydration promoted and caused by the method is corroborated by a test that uses human-aquaporin-expressed frog oocytes. The test uses single cell Xenopus laevis frog oocytes having expressed human aquaporin AGP1 water channels. There is also a beverage composition that increases lifespan in the multicellular organism, and a beverage composition that promotes cellular hydration when ingested by a multicellular organism.

2. 发明申请

US20220089873A1 HYDROPHILIC CYCLODEXTRIN-CONTAINING SILICONE GELS 有权
公开(公告)号：US20220089873A1
公开(公告)日：2022-03-24
申请号：US17419323
申请日：2018-12-29
申请人： WACKER CHEMIE AG
发明人： Amitabha MITRA , Sarah BURKE , Feng WANG , Christian HARTMAN , Margaret WHITTON , Chelsea GRIMM
IPC分类号： C08L83/06 , C08G77/20 , C08B37/16 , C08J3/075 , C08G77/12 , C08L5/16
摘要： Solvent-swollen crosslinked silicone gels containing covalently bonded cyclodextrin groups are prepared by hydrosilylation. The swollen gels are storage stable, compatible with water and polar solvents, and display a significant water break effect.

3. 发明申请

US20220064446A1 ADDITION-CURABLE SILICONE RUBBER COMPOSITION AND METHOD FOR PRODUCING SAME 有权
公开(公告)号：US20220064446A1
公开(公告)日：2022-03-03
申请号：US17415360
申请日：2019-12-10
申请人： SHIN-ETSU CHEMICAL CO., LTD.
发明人： Nobu KATO
IPC分类号： C08L83/04 , C08G77/12 , C08G77/20 , C08G77/08 , C08L5/16
摘要： An addition-curable silicone rubber composition which contains: 100 parts by mass of (A) an organopolysiloxane that has at least two alkenyl groups, each of which is bonded to a silicon atom, in each molecule, and wherein an alkenyl group is bonded to a silicon atom at one end or both ends of the molecular chain; 1-80 parts by mass of (B) γ-cyclodextrin; (C) an organohydrogen polysiloxane that has at least two hydrogen atoms, each of which is bonded to a silicon atom, in each molecule in such an amount that the molar ratio of the hydrogen atoms bonded to silicon atoms (Si—H groups) to the total amount of the alkenyl groups bonded to silicon atoms in the entire composition, namely (Si—H groups)/(Si-alkenyl groups) is from 0.5 to 5.0; and a catalytic amount of (D) an addition reaction catalyst.

4. 发明授权

US11248092B2 Method of preparing a polyrotaxane and polyrotaxane 有权
公开(公告)号：US11248092B2
公开(公告)日：2022-02-15
申请号：US16472266
申请日：2017-12-21
申请人： UNIVERSITAET DES SAARLANDES
发明人： Budiman Ali , Carsten Becker-Willinger , Gisela Heppe , Nina Mueller , Peter-William De Oliveira , Gerhard Wenz , Gergely Kali , Harley Eisenbarth , Devid Hero , David Hafner , Jessica Hilschmann
IPC分类号： C08F2/16 , C08F2/38 , C08G83/00 , C08F212/08 , C08F220/44 , C08K5/14 , C08K5/23 , C08L5/16
摘要： In one embodiment the invention relates to a method of preparing a polyrotaxane, said method comprising: performing a radical copolymerization of at least (a) a first polymerizable monomer having a stopper group, and of at least (b) a second polymerizable hydrophobic monomer, wherein said second monomer is complexed by a ring-shaped molecule, and of at least (c) a third polymerizable hydrophilic monomer; wherein during said copolymerization a copolymer threading said ring-shaped molecule is formed, wherein during said copolymerization said first monomer having a stopper group is incorporated into the chain of said copolymer at least partially between the ends thereof, and wherein said stopper groups prevent said ring-shaped molecule from disassembling from the copolymer; and wherein the amount of said first monomer having a stopper group is of from 0.1 mol % to 20 mol % based on 100 mol % of the total amount of polymerizable monomers. In another embodiment the invention relates to a method of preparing a polyrotaxane, said method comprising: performing a radical copolymerization of at least (a) a first polymerizable monomer having a stopper group, and of at least (b) a second polymerizable partially hydrophilic monomer, wherein said second monomer is complexed by a ring-shaped molecule, and wherein said second monomer has a solubility in water at 20° C. of from 5 g/L to 40 g/L; wherein during said copolymerization a copolymer threading said ring-shaped molecule is formed, wherein during said copolymerization said first monomer having a stopper group is incorporated into the chain of said copolymer at least partially between the ends thereof, and wherein said stopper groups prevent said ring-shaped molecule from disassembling from the copolymer; and wherein the amount of said first monomer having a stopper group is of from 0.1 mol % to 20 mol % based on 100 mol % of the total amount of polymerizable monomers. Furthermore, the present invention relates to methods of preparing cross-linked polyrotaxanes and cross-linked polyrotaxanes which can be prepared using such methods. Thus, the present invention also relates to polyrotaxane and crosslinked polyrotaxanes. The invention also relates to products which contain the polyrotaxanes or cross-linked polyrotaxanes or which can be prepared from the polyrotaxanes or the cross-linked polyrotaxanes. The present invention further relates to the use of polyrotaxanes or cross-linked polyrotaxanes in various applications, such as the use as a self-healing material.

5. 发明申请

US20220017650A1 NOVEL PROCESS FOR THE PURIFICATION OF SUGAMMADEX SODIUM 有权
公开(公告)号：US20220017650A1
公开(公告)日：2022-01-20
申请号：US17312382
申请日：2019-12-11
申请人： Biophore India Pharmaceuticals PVT. Ltd.
发明人： Manik Reddy PULLAGURLA , Bhaskar Reddy PITTA , Suresh Babu NAMANA , Maheswara Rao GOKADA , Jagadeesh Babu RANGISETTY
IPC分类号： C08B37/16 , C08L5/16
摘要： The present invention relates to an improved process for the preparation of Sugammadex sodium (1). It further relates to a novel process for the purification of Sugammadex sodium (1) having impurity A less than 2% (w/w) and impurity E less than 0.1% (w/w)

6. 发明申请

US20210379000A1 INJECTABLE MELPHALAN COMPOSITIONS COMPRISING A CYCLODEXTRIN DERIVATIVE AND METHODS OF MAKING AND USING THE SAME 有权
公开(公告)号：US20210379000A1
公开(公告)日：2021-12-09
申请号：US17194980
申请日：2021-03-08
申请人： Cydex Pharmaceuticals, Inc.
发明人： James D. Pipkin , Stephen G. Machatha
IPC分类号： A61K31/198 , A61K9/00 , B82Y5/00 , A61K47/69 , C08B37/16 , C08L5/16 , A61K47/40
摘要： The present invention is directed to pharmaceutical compositions comprising melphalan and a cyclodextrin derivative, and methods of making and using the same.

7. 发明授权

US11179481B2 Tricarbocyanine-cyclodextrin(s) conjugates and use thereof 有权
公开(公告)号：US11179481B2
公开(公告)日：2021-11-23
申请号：US16557162
申请日：2019-08-30
申请人： CYANAGEN S.R.L.
发明人： Leopoldo Della Ciana , Norbert Gretz , Rossana Perciaccante , Federica Rodeghiero , Stefania Geraci , Jiaguo Huang , Zeneida Herrera Pérez , Johannes Pill , Stefanie Weinfurter
IPC分类号： A61K49/00 , A61M36/14 , C09B69/10 , C08B37/16 , C08L5/16
摘要： The present invention relates to novel tricarbocyanine-cyclodextrin(s) conjugates useful as markers in the diagnosis of kidney diseases, a diagnostic composition comprising said conjugates, their use and their production.

8. 发明授权

US11149135B2 Application of cyclodextrins (CDS) for remediation of perfluoroalkyl substances (PFASS) 有权
公开(公告)号：US11149135B2
公开(公告)日：2021-10-19
申请号：US15944359
申请日：2018-04-03
申请人： Kevin E. O'Shea , Mary Joelle Weiss-Errico
发明人： Kevin E. O'Shea , Mary Joelle Weiss-Errico
IPC分类号： C02F1/28 , C08L5/16 , C08B37/16 , B08B3/08 , B09C1/08 , A01K61/10 , G01N21/64 , A01K97/04 , C02F1/68 , C02F101/30 , C02F101/36
摘要： A system for remediation of perfluoroalkyl substances (PFASs) has a multiplicity of β-cyclodextrins (β-CDs) and/or modified β-CDs combined with a vehicle additive, and a delivery device. Modified β-CDs can contain a single amine functionality at a single primary carbon or single secondary carbon of the β-CD. The vehicle additive can be powdered activated carbon (PAC). The delivery device is a column, a pouch, a packet, or a sheet that can permit the contacting of a fluid environment with the β-CDs and vehicle additive. The system of remediation can be used for a fluid environment or for biological organisms. CD-based fluorescent sensors can detect PFASs in the environment.

9. 发明申请

US20210147582A1 FRACTIONATED ALKYLATED CYCLODEXTRIN COMPOSITIONS AND PROCESSES FOR PREPARING AND USING THE SAME 有权
公开(公告)号：US20210147582A1
公开(公告)日：2021-05-20
申请号：US17103328
申请日：2020-11-24
申请人： CyDex Pharmaceuticals, Inc.
发明人： Vincent D. Antle , Charles Alan Watson , David W. Miles
IPC分类号： C08B37/00 , C08L5/16 , B01D15/32 , C08B37/16 , A61K47/69 , A61K47/40
摘要： The present invention relates to compositions comprising fractionated alkylated cyclodextrin compositions having a single degree of substitution, and processes for preparing and using the same.

10. 发明授权

US10851223B2 Use of a cyclodextrin polycondensate or a composition comprising such a polycondensate, as a capturing agent 有权
公开(公告)号：US10851223B2
公开(公告)日：2020-12-01
申请号：US16075454
申请日：2017-02-03
申请人： Bertrand Duval , Fabrice Grenard , Jean-Baptiste Loiseau , Bernard Rougier
发明人： Bertrand Duval , Fabrice Grenard , Jean-Baptiste Loiseau , Bernard Rougier
IPC分类号： C08L5/16 , C08B37/16 , C02F1/70 , B01D53/64 , B01J20/24 , C02F1/28 , C08K5/092 , C08L29/04 , C02F101/30 , C02F101/32 , C02F101/34 , C02F101/36 , C02F101/20 , C02F101/22
摘要： The use of a cyclodextrin polycondensate or a composition comprising at least one cyclodextrin polycondensate, as an agent for capturing at least one substance chosen from a metal element and an organic molecule having an octanol/water partition coefficient, referred to as Log Kow, greater than or equal to 2, the cyclodextrin polycondensate being obtained by reacting the following compounds (A) to (C): (A) at least one cyclodextrin, (B) at least one linear, branched or cyclic polycarboxylic acid, that is saturated, unsaturated or aromatic, and (C) at least one ethylene vinyl alcohol copolymer (EVOH).

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