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1. 发明授权

US07598264B2 HIV integrase inhibitors 失效
标题翻译： HIV整合酶抑制剂
公开(公告)号：US07598264B2
公开(公告)日：2009-10-06
申请号：US10587682
申请日：2005-03-09
申请人： Wei Han , Melissa Egbertson , John S. Wai , Linghang Zhuang , Rowena D. Ruzek , Debra S. Perlow , Mark Cameron , Bruce S. Foster , Ulf H. Dolling , R. Scott Hoerrner , Philip J. Pye , Remy Angelaud , Danny E. Mancheno , David Askin
发明人： Wei Han , Melissa Egbertson , John S. Wai , Linghang Zhuang , Rowena D. Ruzek , Debra S. Perlow , Mark Cameron , Bruce S. Foster , Ulf H. Dolling , R. Scott Hoerrner , Philip J. Pye , Remy Angelaud , Danny E. Mancheno , David Askin
IPC分类号： A01N43/42 , A61K31/44 , C07D471/02 , C07D491/02 , C07D498/02 , C07D513/02
CPC分类号： C07D471/04
摘要： Hydroxy (tetra- or hexa-)hydronaphthyridine dione compounds of Formula I are inhibitors of HIV integrase and inhibitors of HIV replication: (I) wherein a, R1?, R2?, R3?, R4? and R5? are defined herein. The compounds are useful in the prevention and treatment of infection by HIV and in the prevention, delay in the onset, and treatment of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.
摘要翻译：式I的羟基（四或六） - 氢化萘啶二酮化合物是HIV整合酶和HIV复制抑制剂的抑制剂：（I）其中a，R 1？，R 2？，R 3 ?, R 4？并且R 5？在本文中定义。这些化合物可用于预防和治疗艾滋病毒感染以及预防，延迟艾滋病的发病和治疗。这些化合物用作抗感染和艾滋病作为化合物本身或以药学上可接受的盐的形式。化合物及其盐可以用作药物组合物中的成分，任选与其它抗病毒剂，免疫调节剂，抗生素或疫苗组合使用。

2. 发明申请

US20070179196A1 Hiv integrase inhibitors 失效
标题翻译： Hiv整合酶抑制剂
公开(公告)号：US20070179196A1
公开(公告)日：2007-08-02
申请号：US10587682
申请日：2005-03-09
申请人： Wei Han , Melissa Egbertson , John Wai , Linghang Zhuang , Rowena Ruzek , Debra Perlow , Richard Isaacs , Mark Cameron , Bruce Foster , Ulf Dolling , R. Hoermer , Vanessa Obligado , Lou Neilson , Boyoung Kim , Linda Payne , Matthew Morrissette , Peter Williams , Philip Pye , Remy Angelaud , Danny Mancheno , David Askin
发明人： Wei Han , Melissa Egbertson , John Wai , Linghang Zhuang , Rowena Ruzek , Debra Perlow , Richard Isaacs , Mark Cameron , Bruce Foster , Ulf Dolling , R. Hoermer , Vanessa Obligado , Lou Neilson , Boyoung Kim , Linda Payne , Matthew Morrissette , Peter Williams , Philip Pye , Remy Angelaud , Danny Mancheno , David Askin
IPC分类号： A01N37/08
CPC分类号： C07D471/04
摘要： Hydroxy (tetra- or hexa-)hydronaphthyridine dione compounds of Formula I are inhibitors of HIV integrase and inhibitors of HIV replication: (I) wherein a, R,1?, R,2?, R,3?, R,4? and R,5? are defined herein. The compounds are useful in the prevention and treatment of infection by HIV and in the prevention, delay in the onset, and treatment of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.
摘要翻译：式I的羟基（四或六） - 氢化萘啶二酮化合物是HIV整合酶和HIV复制抑制剂的抑制剂：（I）其中a，R ，1？，R 2？R ，3？，R ，4？并且R ，5？在本文中定义。这些化合物可用于预防和治疗艾滋病毒感染以及预防，延迟艾滋病的发病和治疗。这些化合物用作抗感染和艾滋病作为化合物本身或以药学上可接受的盐的形式。化合物及其盐可以用作药物组合物中的成分，任选与其它抗病毒剂，免疫调节剂，抗生素或疫苗组合使用。

3. 发明授权

US06060607A Process for synthesizing carbapenem side chain intermediates 失效
公开(公告)号：US06060607A
公开(公告)日：2000-05-09
申请号：US334398
申请日：1999-06-16
申请人： Karel M. J. Brands , John M. Williams , Ulf H. Dolling , Ronald B. Jobson , Antony J. Davies , Ian F. Cottrell , Mark Cameron , Michael S. Ashwood
发明人： Karel M. J. Brands , John M. Williams , Ulf H. Dolling , Ronald B. Jobson , Antony J. Davies , Ian F. Cottrell , Mark Cameron , Michael S. Ashwood
IPC分类号： C07D207/16 , C07D409/12 , C07F9/572 , C07D207/10
CPC分类号： C07D409/12 , C07D207/16 , C07F9/5721 , C07F9/5722
摘要： A process of synthesizing a compound of the formula 1: ##STR1## is described. A compound of the formula 2: ##STR2## is reacted with diphenylphosphinic chloride to activate the carboxylic acid group, and then reacted with methanesulfonyl chloride to produce a compound of formula 4: ##STR3## Compound 4 is then reacted with a group II metal sulfide source in water to produce a compound of formula 1.

4. 发明授权

US6063931A Process for synthesizing carbapenem side chain intermediates 失效
标题翻译：合成碳青霉烯侧链中间体的方法
公开(公告)号：US6063931A
公开(公告)日：2000-05-16
申请号：US106297
申请日：1998-06-29
申请人： Karel M. J. Brands , John M. Williams , Ulf H. Dolling , Ronald B. Jobson , Antony J. Davies , Ian F. Cottrell , Mark Cameron , Michael S. Ashwood
发明人： Karel M. J. Brands , John M. Williams , Ulf H. Dolling , Ronald B. Jobson , Antony J. Davies , Ian F. Cottrell , Mark Cameron , Michael S. Ashwood
IPC分类号： C07D207/16 , C07D409/12 , C07D495/08 , C07F9/572 , C07F9/32
CPC分类号： C07D409/12 , C07D207/16 , C07D495/08 , C07F9/5721 , C07F9/5722
摘要： A process of synthesizing a compound of the formula 1: ##STR1## is described. A compound of the formula 2: ##STR2## is reacted with diphenylphosphinic chloride to activate the carboxylic acid group, and then reacted with methanesulfonyl chloride to produce a compound of formula 4: ##STR3## Compound 4 is then reacted with a group II metal sulfide source in water to produce a compound of formula 1.
摘要翻译：描述了合成式1化合物的方法。式2的化合物与二苯基次氯化氯反应以活化羧酸基团，然后与甲磺酰氯反应生成式4的化合物：然后使化合物4与第II族金属硫化物源在水中反应，产生式1的化合物。

5. 发明申请

US20060211063A1 Phosphokinase assay 审中-公开
标题翻译：磷酸激酶测定
公开(公告)号：US20060211063A1
公开(公告)日：2006-09-21
申请号：US10549078
申请日：2004-03-12
申请人： Jon Supernault , Mark Cameron , Sara Brien
发明人： Jon Supernault , Mark Cameron , Sara Brien
IPC分类号： G01N33/53
CPC分类号： G01N33/573 , G01N2333/91205
摘要： A method of detecting protein kinases in a sample by coating a solid surface with a buffer containing protease and phosphatase inhibitors and immobilizing a labeled antibody to the coated solid surface, whereby protein kinases react with the antibody, thereby detecting a presence of the protein kinases. Also provided is an assay and kit for detecting protein kinases having antibodies specific to a phosphorylation site of the protein kinase and a label bound to the antibodies.
摘要翻译：一种通过用含有蛋白酶和磷酸酶抑制剂的缓冲液包被固体表面并将标记的抗体固定在包被的固体表面上从而检测蛋白激酶的存在，从而检测样品中蛋白激酶的方法。还提供了用于检测具有对蛋白激酶的磷酸化位点特异性抗体的蛋白激酶和与抗体结合的标记的测定和试剂盒。

6. 发明授权

US09181295B2 Cationic lipids with various head groups for oligonucleotide delivery 有权
标题翻译：具有各种头基的阳离子脂质用于寡核苷酸递送
公开(公告)号：US09181295B2
公开(公告)日：2015-11-10
申请号：US13390702
申请日：2010-08-18
申请人： Mark Cameron , Jennifer R. Davis , Andrea R. Geiser , Matthew G. Stanton , Vladislav V. Telyatnikov , Lu Tian , Weimin Wang
发明人： Mark Cameron , Jennifer R. Davis , Andrea R. Geiser , Matthew G. Stanton , Vladislav V. Telyatnikov , Lu Tian , Weimin Wang
IPC分类号： C07J41/00 , A61K9/127 , C07J43/00
CPC分类号： A61K9/1272 , A61K31/7088 , C07J41/0055 , C07J43/003
摘要： The instant invention provides for novel cationic lipids that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with siRNA, to facilitate the cellular uptake and endosomal escape, and to knockdown target mRNA both in vitro and in vivo.
摘要翻译：本发明提供了可以与其它脂质组分如胆固醇和PEG-脂质组合使用以与siRNA形成脂质纳米颗粒以促进细胞摄取和内体逃逸以及在体外和体内。

7. 发明申请

US20120063142A1 Illuminating and Targeting Systems and Methods Having Variable Liquid Lens 失效
标题翻译：具有可变液晶透镜的照明和瞄准系统和方法
公开(公告)号：US20120063142A1
公开(公告)日：2012-03-15
申请号：US12882472
申请日：2010-09-15
申请人： Mark Cameron , Thomas R. Luce
发明人： Mark Cameron , Thomas R. Luce
IPC分类号： F21V17/02 , F21V5/00 , F21S6/00
CPC分类号： F41G1/35 , G01J5/0806 , G01J5/089 , G02B3/14 , G02B19/0052 , G02B26/005 , G02B26/0875
摘要： Systems and methods that incorporate a variable liquid lens are disclosed. In at least some embodiments, a light projecting system includes a light source, and a light processing assembly configured to receive a light beam from the light source and to project an output field. The light processing assembly includes at least one liquid lens configured to controllably process the light beam such that the output field is variable between a relatively-broader illuminating field and a relatively-narrower targeting field. In some embodiments, a controller may controllably adjust the at least one liquid lens to alternately provide the illuminating field and the targeting field, and may controllably adjust at least one dwell time to adjust a brightness of at least one of the illuminating and targeting fields, respectively.
摘要翻译：公开了包含可变液体透镜的系统和方法。在至少一些实施例中，光投射系统包括光源，以及配置成从光源接收光束并投影输出场的光处理组件。光处理组件包括至少一个配置成可控制地处理光束的液体透镜，使得输出场在相对较宽的照明场和相对较窄的目标场之间是可变的。在一些实施例中，控制器可以可控制地调节至少一个液体透镜以交替地提供照明场和瞄准场，并且可以可控地调节至少一个驻留时间以调节照明和瞄准场中的至少一个的亮度，分别。

8. 发明授权

US08408745B2 Illuminating and targeting systems and methods having variable liquid lens 失效
标题翻译：具有可变液体透镜的照明和瞄准系统和方法
公开(公告)号：US08408745B2
公开(公告)日：2013-04-02
申请号：US12882472
申请日：2010-09-15
申请人： Mark Cameron , Thomas R. Luce
发明人： Mark Cameron , Thomas R. Luce
IPC分类号： F21S8/00
CPC分类号： F41G1/35 , G01J5/0806 , G01J5/089 , G02B3/14 , G02B19/0052 , G02B26/005 , G02B26/0875
摘要： Systems and methods that incorporate a variable liquid lens are disclosed. In at least some embodiments, a light projecting system includes a light source, and a light processing assembly configured to receive a light beam from the light source and to project an output field. The light processing assembly includes at least one liquid lens configured to controllably process the light beam such that the output field is variable between a relatively-broader illuminating field and a relatively-narrower targeting field. In some embodiments, a controller may controllably adjust the at least one liquid lens to alternately provide the illuminating field and the targeting field, and may controllably adjust at least one dwell time to adjust a brightness of at least one of the illuminating and targeting fields, respectively.
摘要翻译：公开了包含可变液体透镜的系统和方法。在至少一些实施例中，光投射系统包括光源，以及配置成从光源接收光束并投影输出场的光处理组件。光处理组件包括至少一个配置成可控制地处理光束的液体透镜，使得输出场在相对较宽的照明场和相对较窄的目标场之间是可变的。在一些实施例中，控制器可以可控制地调节至少一个液体透镜以交替地提供照明场和瞄准场，并且可以可控地调节至少一个驻留时间以调节照明和瞄准场中的至少一个的亮度，分别。

9. 发明申请

US20060040329A1 CXCL10-based diagnosis and treatment of respiratory illnesses 有权
标题翻译：基于CXCL10的呼吸系统疾病诊断与治疗
公开(公告)号：US20060040329A1
公开(公告)日：2006-02-23
申请号：US10920055
申请日：2004-08-17
申请人： David Kelvin , Mark Cameron , Desmond Persad
发明人： David Kelvin , Mark Cameron , Desmond Persad
IPC分类号： C12Q1/70 , G01N33/567 , G01N33/53
CPC分类号： G01N33/56983
摘要： Elevated blood levels of the chemokine CXCL10 polypeptide are associated with respiratory illnesses (e.g. SARS, influenza and community-acquired pneumonia) and are useful in diagnosis of patients. Methods are provided for diagnosis and treatment of patients suffering from respiratory illnesses. Methods are provided for identifying inhibitors of the CXCL10:CXCR3 axis, for use in treating patients suffering from respiratory illnesses.
摘要翻译：趋化因子CXCL10多肽的血液水平升高与呼吸系统疾病（如SARS，流行性感冒和社区获得性肺炎）有关，可用于诊断患者。提供了诊断和治疗患有呼吸系统疾病的患者的方法。提供了用于鉴定CXCL10：CXCR3轴抑制剂的方法，用于治疗患有呼吸系统疾病的患者。

10. 发明授权

US06708597B2 Weapon aiming 失效
标题翻译：武器瞄准
公开(公告)号：US06708597B2
公开(公告)日：2004-03-23
申请号：US10228760
申请日：2002-08-26
申请人： Brad E. Meyers , Mark Cameron
发明人： Brad E. Meyers , Mark Cameron
IPC分类号： F41G314
CPC分类号： F41G1/35 , F41G3/04 , F41G3/323 , F41G11/00
摘要： An aiming system for a trajectory weapon such as a ground launcher, machine gun, mortar, or the like. The aiming system is attached to a conventional mount for the involved weapon. Also disclosed is a method of sighting in a weapon which employs the aiming system.
摘要翻译：用于诸如地面发射器，机枪，迫击炮等的轨迹武器的瞄准系统。瞄准系统连接到用于所涉武器的常规安装座。还公开了一种在使用瞄准系统的武器中瞄准的方法。

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