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1. 发明授权

US07598264B2 HIV integrase inhibitors 失效
标题翻译： HIV整合酶抑制剂
公开(公告)号：US07598264B2
公开(公告)日：2009-10-06
申请号：US10587682
申请日：2005-03-09
申请人： Wei Han , Melissa Egbertson , John S. Wai , Linghang Zhuang , Rowena D. Ruzek , Debra S. Perlow , Mark Cameron , Bruce S. Foster , Ulf H. Dolling , R. Scott Hoerrner , Philip J. Pye , Remy Angelaud , Danny E. Mancheno , David Askin
发明人： Wei Han , Melissa Egbertson , John S. Wai , Linghang Zhuang , Rowena D. Ruzek , Debra S. Perlow , Mark Cameron , Bruce S. Foster , Ulf H. Dolling , R. Scott Hoerrner , Philip J. Pye , Remy Angelaud , Danny E. Mancheno , David Askin
IPC分类号： A01N43/42 , A61K31/44 , C07D471/02 , C07D491/02 , C07D498/02 , C07D513/02
CPC分类号： C07D471/04
摘要： Hydroxy (tetra- or hexa-)hydronaphthyridine dione compounds of Formula I are inhibitors of HIV integrase and inhibitors of HIV replication: (I) wherein a, R1?, R2?, R3?, R4? and R5? are defined herein. The compounds are useful in the prevention and treatment of infection by HIV and in the prevention, delay in the onset, and treatment of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.
摘要翻译：式I的羟基（四或六） - 氢化萘啶二酮化合物是HIV整合酶和HIV复制抑制剂的抑制剂：（I）其中a，R 1？，R 2？，R 3 ?, R 4？并且R 5？在本文中定义。这些化合物可用于预防和治疗艾滋病毒感染以及预防，延迟艾滋病的发病和治疗。这些化合物用作抗感染和艾滋病作为化合物本身或以药学上可接受的盐的形式。化合物及其盐可以用作药物组合物中的成分，任选与其它抗病毒剂，免疫调节剂，抗生素或疫苗组合使用。

2. 发明申请

US20070179196A1 Hiv integrase inhibitors 失效
标题翻译： Hiv整合酶抑制剂
公开(公告)号：US20070179196A1
公开(公告)日：2007-08-02
申请号：US10587682
申请日：2005-03-09
申请人： Wei Han , Melissa Egbertson , John Wai , Linghang Zhuang , Rowena Ruzek , Debra Perlow , Richard Isaacs , Mark Cameron , Bruce Foster , Ulf Dolling , R. Hoermer , Vanessa Obligado , Lou Neilson , Boyoung Kim , Linda Payne , Matthew Morrissette , Peter Williams , Philip Pye , Remy Angelaud , Danny Mancheno , David Askin
发明人： Wei Han , Melissa Egbertson , John Wai , Linghang Zhuang , Rowena Ruzek , Debra Perlow , Richard Isaacs , Mark Cameron , Bruce Foster , Ulf Dolling , R. Hoermer , Vanessa Obligado , Lou Neilson , Boyoung Kim , Linda Payne , Matthew Morrissette , Peter Williams , Philip Pye , Remy Angelaud , Danny Mancheno , David Askin
IPC分类号： A01N37/08
CPC分类号： C07D471/04
摘要： Hydroxy (tetra- or hexa-)hydronaphthyridine dione compounds of Formula I are inhibitors of HIV integrase and inhibitors of HIV replication: (I) wherein a, R,1?, R,2?, R,3?, R,4? and R,5? are defined herein. The compounds are useful in the prevention and treatment of infection by HIV and in the prevention, delay in the onset, and treatment of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.
摘要翻译：式I的羟基（四或六） - 氢化萘啶二酮化合物是HIV整合酶和HIV复制抑制剂的抑制剂：（I）其中a，R ，1？，R 2？R ，3？，R ，4？并且R ，5？在本文中定义。这些化合物可用于预防和治疗艾滋病毒感染以及预防，延迟艾滋病的发病和治疗。这些化合物用作抗感染和艾滋病作为化合物本身或以药学上可接受的盐的形式。化合物及其盐可以用作药物组合物中的成分，任选与其它抗病毒剂，免疫调节剂，抗生素或疫苗组合使用。

3. 发明授权

US07323460B2 N-(substituted benzyl)-8-hydroxy-1,6-naphthyridine-7-carboxamides useful as HIV integrase inhibitors 失效
标题翻译：可用作HIV整合酶抑制剂的N-（取代苄基）-8-羟基-1,6-萘啶-7-甲酰胺
公开(公告)号：US07323460B2
公开(公告)日：2008-01-29
申请号：US10508094
申请日：2003-03-12
申请人： Melissa Egbertson , H. Marie Langford , Jeffrey Y. Melamed , John S. Wai , Wei Han , Debbie S. Perlow , Linghang Zhuang , Mark Embrey
发明人： Melissa Egbertson , H. Marie Langford , Jeffrey Y. Melamed , John S. Wai , Wei Han , Debbie S. Perlow , Linghang Zhuang , Mark Embrey
IPC分类号： C07D401/02 , A61K31/4375
CPC分类号： C07D471/04
摘要： N-(Substituted benzyl)-8-hydroxy-1,6-naphthyridine-7-carboxamides are inhibitors of HIV integrase and inhibitors of HIV replication. The naphthyridine carboxamides are of Formula (I): wherein R1′, R2′ and R3′ are defined herein. The compounds are useful in the prevention and treatment of infection by HIV and in the prevention, delay in the onset, and treatment of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of preventing, treating or delaying the onset of AIDS and methods of preventing or treating infection by HIV are described.
摘要翻译： N-（取代的苄基）-8-羟基-1,6-萘啶-7-甲酰胺是HIV整合酶和HIV复制抑制剂的抑制剂。萘啶甲酰胺具有式（I）：其中R 1，R 2，R 3和R 3'在本文中定义。这些化合物可用于预防和治疗艾滋病毒感染以及预防，延迟艾滋病的发病和治疗。这些化合物用作抗感染和艾滋病作为化合物本身或以药学上可接受的盐的形式。化合物及其盐可以用作药物组合物中的成分，任选与其它抗病毒剂，免疫调节剂，抗生素或疫苗组合使用。描述了预防，治疗或延缓AIDS发病的方法以及预防或治疗HIV感染的方法。

4. 发明申请

US20050176955A1 N-(substituted benzyl)-8-hydroxy-1,6-naphthyridine-7-carboxamides useful as hiv integrase inhibitors 失效
标题翻译：可用作hiv整合酶抑制剂的N-（取代的苄基）-8-羟基-1,6-萘啶-7-甲酰胺
公开(公告)号：US20050176955A1
公开(公告)日：2005-08-11
申请号：US10508094
申请日：2003-03-12
申请人： Melissa Egbertson , H. Marie Langford , Jeffrey Melamed , John Wai , Wei Han , Debbie Perlow , Linghang Zhuang , Mark Embrey , Steven Young
发明人： Melissa Egbertson , H. Marie Langford , Jeffrey Melamed , John Wai , Wei Han , Debbie Perlow , Linghang Zhuang , Mark Embrey , Steven Young
IPC分类号： A61K31/4375 , A61K31/541 , A61K31/549 , A61K45/00 , A61P31/18 , A61P43/00 , C07D471/02 , C07D471/04
CPC分类号： C07D471/04
摘要： N-(Substituted benzyl)-8-hydroxy-1,6-naphthyridine-7-carboxamides are inhibitors of HIV integrase and inhibitors of HIV replication. The naphthyridine carboxamides are of Formula (I): wherein R1′, R2′ and R3′ are defined herein. The compounds are useful in the prevention and treatment of infection by HIV and in the prevention, delay in the onset, and treatment of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of preventing, treating or delaying the onset of AIDS and methods of preventing or treating infection by HIV are described.
摘要翻译： N-（取代的苄基）-8-羟基-1,6-萘啶-7-甲酰胺是HIV整合酶和HIV复制抑制剂的抑制剂。萘啶甲酰胺具有式（I）：其中R 1，R 2和R 3'在本文中定义。这些化合物可用于预防和治疗艾滋病毒感染以及预防，延迟艾滋病的发病和治疗。这些化合物用作抗感染和艾滋病作为化合物本身或以药学上可接受的盐的形式。化合物及其盐可以用作药物组合物中的成分，任选与其它抗病毒剂，免疫调节剂，抗生素或疫苗组合使用。描述了预防，治疗或延缓AIDS发病的方法以及预防或治疗HIV感染的方法。

5. 发明申请

US20090054399A1 HIV INTEGRASE INHIBITORS 失效
标题翻译：艾滋病毒整合抑制剂
公开(公告)号：US20090054399A1
公开(公告)日：2009-02-26
申请号：US11920032
申请日：2006-05-05
申请人： Joseph P. Vacca , John S. Wai , Linda S. Payne , Richard C.A. Isaacs , Wei Han , Melissa Egbertson , Richard Pracitto
发明人： Joseph P. Vacca , John S. Wai , Linda S. Payne , Richard C.A. Isaacs , Wei Han , Melissa Egbertson , Richard Pracitto
IPC分类号： A61K31/5383 , C07D471/14 , A61K31/551 , A61K31/4985 , A61K31/4375 , C07D498/14
CPC分类号： C07D471/14 , A61K31/4353 , A61K31/4375 , C07D498/14
摘要： Tricyclic compounds of Formula (I) are inhibitors of HIV integrase and inhibitors of HIV replication: wherein bond a, ring A, R1, R2 and R3 are defined herein. The compounds are useful for the prophylaxis or treatment of infection by HIV and the prophylaxis, treatment, or delay in the onset of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.
摘要翻译：式（I）的三环化合物是HIV整合酶和HIV复制抑制剂的抑制剂：其中键A，环A，R 1，R 2和R 3在本文中定义。该化合物可用于预防或治疗艾滋病毒感染以及艾滋病的预防，治疗或延迟。这些化合物用作抗感染和艾滋病作为化合物本身或以药学上可接受的盐的形式。化合物及其盐可以用作药物组合物中的成分，任选与其它抗病毒剂，免疫调节剂，抗生素或疫苗组合使用。

6. 发明申请

US20130178468A1 HIV INTEGRASE INHIBITORS 审中-公开
标题翻译：艾滋病毒整合抑制剂
公开(公告)号：US20130178468A1
公开(公告)日：2013-07-11
申请号：US13606929
申请日：2012-09-07
申请人： Joseph P. Vacca , John S. Wai , Linda S. Payne , Richard C. A. Isaccs , Wei Han , Melissa Egbertson , Richard Pracitto
发明人： Joseph P. Vacca , John S. Wai , Linda S. Payne , Richard C. A. Isaccs , Wei Han , Melissa Egbertson , Richard Pracitto
IPC分类号： C07D471/14 , C07D498/14
CPC分类号： C07D471/14 , A61K31/4353 , A61K31/4375 , C07D498/14
摘要： Tricyclic compounds of Formula I are inhibitors of HIV integrase and inhibitors of HIV replication: wherein bond a, ring A, R1, R2 and R3 are defined herein. The compounds are useful for the prophylaxis or treatment of infection by HIV and the prophylaxis, treatment, or delay in the onset of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.
摘要翻译：式I的三环化合物是HIV整合酶和HIV复制抑制剂的抑制剂：其中键A，环A，R 1，R 2和R 3在本文中定义。该化合物可用于预防或治疗艾滋病毒感染以及艾滋病的预防，治疗或延迟。这些化合物用作抗感染和艾滋病作为化合物本身或以药学上可接受的盐的形式。化合物及其盐可以用作药物组合物中的成分，任选与其它抗病毒剂，免疫调节剂，抗生素或疫苗组合使用。

7. 外观设计

USD1011634S1 Fire extinguisher 有权
公开(公告)号：USD1011634S1
公开(公告)日：2024-01-16
申请号：US29895406
申请日：2023-06-21
申请人： Wei Han
设计人： Wei Han
摘要： FIG. 1 is a front, right and top perspective view of a fire extinguisher, showing my design.
FIG. 2 is a rear, left and bottom perspective view thereof.
FIG. 3 is a front elevation view thereof.
FIG. 4 is a rear elevation view thereof.
FIG. 5 is a left side elevation view thereof.
FIG. 6 is a right side elevation view thereof.
FIG. 7 is a top plan view thereof; and,
FIG. 8 is a bottom plan view thereof.
The broken lines depict portions of the fire extinguisher that form no part of the claimed design.

8. 发明授权

US09283300B2 Use of midkine protein and the protein-containing medical device 有权
标题翻译：使用中期蛋白和含蛋白质的医疗器械
公开(公告)号：US09283300B2
公开(公告)日：2016-03-15
申请号：US13322443
申请日：2010-05-25
申请人： Wei Han , Zhonghui Zhang
发明人： Wei Han , Zhonghui Zhang
IPC分类号： A61K38/17 , A61P19/02 , A61L27/54 , A61L27/24 , A61L27/22 , A61K38/18 , A61F2/30
CPC分类号： A61L27/227 , A61F2/30756 , A61F2002/30677 , A61K38/18 , A61L27/54 , A61L2300/252 , A61L2300/414 , A61L2430/06
摘要： The applications and medical devices of Midkine in the field of biotechnology are described in this invention. This invention describes the applications of the protein as follow in (a) or (b) in preparing drugs for promoting cartilage growth or treating cartilage diseases, the protein as a growth factor for promoting chondrocyte proliferation, or medical devices containing this protein: (a) the protein whose amino acid sequence is shown as SEQ ID NO.1; (b) the proteins whose amino acid sequence have at least 60% homology comparing with amino acid sequence described in (a). The present invention is different from the present knowledge of MK and its related proteins. The experimental results demonstrated that MK promotes proliferation of three types of chondrocytes and is used for preparing drugs for treating cartilage disease. It may provide new therapy for treating cartilage diseases clinically, and new technology for expansion of chondrocytes in vitro for cartilage tissue engineering.
摘要翻译：本发明描述了Midkine在生物技术领域的应用和医疗设备。本发明描述了如下（a）或（b）中的蛋白质在制备用于促进软骨生长或治疗软骨疾病的药物中的应用，所述蛋白质作为促进软骨细胞增殖的生长因子，或含有该蛋白质的医学装置：（a ）其氨基酸序列显示为SEQ ID NO.1的蛋白质; （b）与（a）中所述的氨基酸序列相比，其氨基酸序列具有至少60％同源性的蛋白质。本发明与MK及其相关蛋白质的现有知识不同。实验结果表明，MK促进三种软骨细胞增殖，用于制备治疗软骨疾病的药物。可能提供临床治疗软骨疾病的新疗法，软骨组织工程体外软骨细胞扩增的新技术。

9. 发明申请

US20150204993A1 DEVICES AND METHODS FOR DOWNHOLE ACOUSTIC IMAGING 有权
标题翻译：用于卧室声学成像的装置和方法
公开(公告)号：US20150204993A1
公开(公告)日：2015-07-23
申请号：US14587251
申请日：2014-12-31
申请人： James V. Leggett, III , Roger R. Steinsiek , Wei Han , Kamalesh Chatterjee
发明人： James V. Leggett, III , Roger R. Steinsiek , Wei Han , Kamalesh Chatterjee
IPC分类号： G01V1/44 , E21B47/01 , G01V1/16
CPC分类号： E21B47/01 , B06B1/0207 , B06B2201/70 , E21B47/011 , E21B47/101 , G01V1/40
摘要： An acoustic transducer assembly includes: a carrier configured to be disposed in an earth formation, the carrier having a carrier axis; an array of transducer elements forming at least a semicircular shape, the array configured to emit acoustic signals in a radial direction relative to the carrier axis; and a circuit coupled to the array and configured to actuate a subset of the transducer elements and emit an acoustic beam therefrom, the circuit configured to actuate the subsets as a phased array to electronically rotate the acoustic beam about the carrier axis.
摘要翻译：声学换能器组件包括：被配置为设置在地层中的载体，载体具有载体轴线; 形成至少半圆形的换能器元件的阵列，所述阵列被配置为相对于所述载体轴沿径向方向发射声信号; 以及耦合到所述阵列并且被配置为致动所述换能器元件的子集并且从其发射声束的电路，所述电路被配置为致动所述子集作为相控阵列以电子地绕所述载体轴线旋转所述声束。

10. 发明授权

US08466295B2 Thiophene derivatives as factor XIa inhibitors 有权
标题翻译：噻吩衍生物作为因子XIa抑制剂
公开(公告)号：US08466295B2
公开(公告)日：2013-06-18
申请号：US12097068
申请日：2006-12-13
申请人： Wei Han
发明人： Wei Han
IPC分类号： C07D231/56 , C07D333/22 , A61K31/415 , A61K31/38
CPC分类号： C07D333/24 , C07D333/28 , C07D409/04
摘要： The present invention provides compounds of Formula (I): or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein the variables A, L1, R3, and R11 are as defined herein. The compounds of Formula (I) are useful as selective inhibitors of serine protease enzymes of the coagulation cascade and/or contact activation system; for example thrombin, factor Xa, factor XIa, factor IXa, factor VIIa and/or plasma kallikrein. In particular, it relates to compounds that are selective factor XIa inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.
摘要翻译：本发明提供式（I）的化合物或其立体异构体，互变异构体，药学上可接受的盐，溶剂合物或前药，其中变量A，L1，R3和R11如本文所定义。式（I）的化合物可用作凝血级联和/或接触激活系统的丝氨酸蛋白酶的选择性抑制剂; 例如凝血酶，因子Xa，因子XIa，因子IXa，因子VIIa和/或血浆激肽释放酶。特别地，它涉及作为选择性因子XIa抑制剂的化合物。本发明还涉及包含这些化合物的药物组合物和使用其制备血栓栓塞和/或炎症性疾病的方法。

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