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1. 发明申请

US20060270704A1 Isoquinolinone potassium channel inhibitors 有权
标题翻译：异喹啉酮钾通道抑制剂
公开(公告)号：US20060270704A1
公开(公告)日：2006-11-30
申请号：US10572343
申请日：2004-09-22
申请人： Richard Isaacs , Christopher Dinsmore , Charles McIntyre , Linda Payne , David Claremon
发明人： Richard Isaacs , Christopher Dinsmore , Charles McIntyre , Linda Payne , David Claremon
IPC分类号： C07D217/22 , A61K31/4704
CPC分类号： C07D217/26 , C07D217/24 , C07D401/04 , C07D401/06 , C07D417/04
摘要： The present invention relates to compounds having the structure formula (I) useful as potassium channel inhibitors to treat cardiac arrhythmias, and the like.
摘要翻译：本发明涉及具有结构式（I）的化合物，其可用作治疗心律失常的钾通道抑制剂等。

2. 发明申请

US20080090794A1 Potassium Channel Inhibitors 有权
标题翻译：钾通道抑制剂
公开(公告)号：US20080090794A1
公开(公告)日：2008-04-17
申请号：US11658114
申请日：2005-07-27
申请人： Christoph Dinsmore , Jeffrey Bergman , Douglas Beshore , B. Wesley Trotter , Kausik Nanda , Richard Isaacs , Linda Payne , Lou Anne Neilson , Zhicai Wu , Mark Bilodeau , Peter Manley , Adrianne Balitza
发明人： Christoph Dinsmore , Jeffrey Bergman , Douglas Beshore , B. Wesley Trotter , Kausik Nanda , Richard Isaacs , Linda Payne , Lou Anne Neilson , Zhicai Wu , Mark Bilodeau , Peter Manley , Adrianne Balitza
IPC分类号： A61K31/5377 , A61K31/397 , A61K31/438 , A61K31/4412 , A61K31/4439 , A61P9/04 , C07D213/04 , C07D221/20 , C07D401/14 , C07D413/02 , C07D413/00 , C07D401/02 , C07D213/63 , A61P9/06 , A61P9/00 , A61K31/444 , A61K31/497 , A61K31/506
CPC分类号： C07D213/36 , C07D213/30 , C07D213/32 , C07D213/38 , C07D213/40 , C07D213/42 , C07D213/55 , C07D213/56 , C07D213/64 , C07D401/06 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/08 , C07D491/08
摘要： The present invention relates to compounds having the structure useful as potassium channel inhibitors to treat cardiac arrhythmias, and the like.
摘要翻译：本发明涉及具有用作治疗心律失常的钾通道抑制剂的结构的化合物等。

3. 发明申请

US20070179196A1 Hiv integrase inhibitors 失效
标题翻译： Hiv整合酶抑制剂
公开(公告)号：US20070179196A1
公开(公告)日：2007-08-02
申请号：US10587682
申请日：2005-03-09
申请人： Wei Han , Melissa Egbertson , John Wai , Linghang Zhuang , Rowena Ruzek , Debra Perlow , Richard Isaacs , Mark Cameron , Bruce Foster , Ulf Dolling , R. Hoermer , Vanessa Obligado , Lou Neilson , Boyoung Kim , Linda Payne , Matthew Morrissette , Peter Williams , Philip Pye , Remy Angelaud , Danny Mancheno , David Askin
发明人： Wei Han , Melissa Egbertson , John Wai , Linghang Zhuang , Rowena Ruzek , Debra Perlow , Richard Isaacs , Mark Cameron , Bruce Foster , Ulf Dolling , R. Hoermer , Vanessa Obligado , Lou Neilson , Boyoung Kim , Linda Payne , Matthew Morrissette , Peter Williams , Philip Pye , Remy Angelaud , Danny Mancheno , David Askin
IPC分类号： A01N37/08
CPC分类号： C07D471/04
摘要： Hydroxy (tetra- or hexa-)hydronaphthyridine dione compounds of Formula I are inhibitors of HIV integrase and inhibitors of HIV replication: (I) wherein a, R,1?, R,2?, R,3?, R,4? and R,5? are defined herein. The compounds are useful in the prevention and treatment of infection by HIV and in the prevention, delay in the onset, and treatment of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.
摘要翻译：式I的羟基（四或六） - 氢化萘啶二酮化合物是HIV整合酶和HIV复制抑制剂的抑制剂：（I）其中a，R ，1？，R 2？R ，3？，R ，4？并且R ，5？在本文中定义。这些化合物可用于预防和治疗艾滋病毒感染以及预防，延迟艾滋病的发病和治疗。这些化合物用作抗感染和艾滋病作为化合物本身或以药学上可接受的盐的形式。化合物及其盐可以用作药物组合物中的成分，任选与其它抗病毒剂，免疫调节剂，抗生素或疫苗组合使用。

4. 发明授权

US07234634B1 Mail box guard locking insert 失效
标题翻译：邮箱保护锁定插入
公开(公告)号：US07234634B1
公开(公告)日：2007-06-26
申请号：US11594616
申请日：2006-11-07
申请人： Calvin Payne , Linda Payne
发明人： Calvin Payne , Linda Payne
IPC分类号： B65G11/04
CPC分类号： A47G29/1209
摘要： A unit is located inside a mailbox which prevents access to the mailbox through the door of the mailbox when the unit is in place. The unit includes a fence-like portion that is attached to the mailbox body by an arm that is locked to the mailbox in the rear of the mailbox. The fence-like portion is locked to the arm and is attached to the mailbox by a hinge. When unlocked, the fence can be pivoted out of the way to allow access to inside of the mailbox.
摘要翻译：一个单元位于邮箱内，当本机在适当位置时，可以阻止通过邮箱门进入邮箱。该单元包括通过被锁定到邮箱后部的邮箱的臂连接到邮箱主体的栅栏状部分。栅栏状部分被锁定到臂上，并通过铰链附接到邮箱。当解锁时，围栏可以摆脱方式，以允许访问邮箱内部。

5. 发明申请

US20050010048A1 Aza-and polyaza-naphthalenly ketones useful as hiv integrase inhibitors 审中-公开
标题翻译：可用作hiv整合酶抑制剂的氮杂和多氮萘酮
公开(公告)号：US20050010048A1
公开(公告)日：2005-01-13
申请号：US10398929
申请日：2001-10-09
申请人： Linghang Zhuang , John Wai , Linda Payne , Steven Young , Thorsten Fisher , Mark Embrey , James Guare
发明人： Linghang Zhuang , John Wai , Linda Payne , Steven Young , Thorsten Fisher , Mark Embrey , James Guare
IPC分类号： C07D215/26 , A61K31/4375 , A61K31/444 , A61K31/4545 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/513 , A61K31/5377 , A61P31/18 , A61P43/00 , C07D215/04 , C07D401/06 , C07D401/10 , C07D471/04 , C07D521/00 , C07D471/02 , C07D487/02
CPC分类号： C07D215/04 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/06 , C07D471/04
摘要： Certain aza- and polyaza-naphthalenyl ketones including certain quinolinyl and naphthyridinyl ketones are described as inhibitors of HIV integrase and inhibitors of HIV replication. These compounds are useful in the prevention or treatment of infection by HIV and the treatment or the delay in the onset of AIDS, as compounds or pharmaceutically acceptable salts, or as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating or delaying the onset of AIDS and methods of preventing or treating infection by HIV are also described.
摘要翻译：包括某些喹啉基和萘啶基酮的某些氮杂和多氮萘基酮被描述为HIV整合酶的抑制剂和HIV复制抑制剂。这些化合物可用于预防或治疗艾滋病毒感染以及作为化合物或药学上可接受的盐或作为药物组合物中的成分治疗或延迟发作的AIDS，任选地与其它抗病毒剂，免疫调节剂，抗生素或其它抗生素组合疫苗。还描述了治疗或延缓AIDS发病的方法以及预防或治疗HIV感染的方法。

6. 发明授权

US06319932B1 Oxazolidinones useful as alpha 1A adrenoceptor antagonists 失效
标题翻译：可用作α1A肾上腺素受体拮抗剂的恶唑烷酮
公开(公告)号：US06319932B1
公开(公告)日：2001-11-20
申请号：US09438006
申请日：1999-11-10
申请人： Jennie B. Nerenberg , Mark G. Bock , Harold G. Selnick , Linda Payne
发明人： Jennie B. Nerenberg , Mark G. Bock , Harold G. Selnick , Linda Payne
IPC分类号： A61K31445
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D413/12
摘要： Novel oxazolidinone compounds and pharmaceutically acceptable salts thereof are disclosed. The synthesis of these compounds and their use as alpha 1a adrenergic receptor antagonists is also described. One application of these compounds is in the treatment of benign prostatic hyperplasia. These compounds are selective in their ability to relax smooth muscle tissue enriched in the alpha 1a receptor subtype without at the same time inducing hypotension. One such tissue is found surrounding the urethral lining. Therefore, one utility of the instant compounds is to provide acute relief to males suffering from benign prostatic hyperplasia, by permitting less hindered urine flow. Another utility of the instant compounds is provided by combination with a human 5-alpha reductase inhibitory compound, such that both acute and chronic relief from the effects of benign prostatic hyperplasia can be achieved.
摘要翻译：公开了新的恶唑烷酮化合物及其药学上可接受的盐。还描述了这些化合物的合成及其作为α1a肾上腺素能受体拮抗剂的用途。这些化合物的一个应用是治疗良性前列腺增生。这些化合物具有选择性地放松富集α1a受体亚型的平滑肌组织的能力，而不会同时引起低血压。发现一个这样的组织围绕尿道衬里。因此，本发明化合物的一个用途是通过允许较少的受阻尿流量来对患有良性前列腺增生的男性提供急性缓解。通过与人类5-α还原酶抑制化合物的组合提供本发明化合物的另一种用途，使得可以实现急性和慢性缓解来自良性前列腺增生的作用。

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