专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20120149894A1 NOVEL CATIONIC LIPIDS WITH VARIOUS HEAD GROUPS FOR OLIGONUCLEOTIDE DELIVERY 有权
标题翻译：具有各种头发交付的各种头巾组
公开(公告)号：US20120149894A1
公开(公告)日：2012-06-14
申请号：US13390702
申请日：2010-08-18
申请人： Mark Cameron , Jennifer R. Davis , Andrea R. Geiser , Matthew G. Stanton , Vladislav V. Telyatnikov , Lu Tian , Weimin Wang
发明人： Mark Cameron , Jennifer R. Davis , Andrea R. Geiser , Matthew G. Stanton , Vladislav V. Telyatnikov , Lu Tian , Weimin Wang
IPC分类号： C07J9/00 , C07J43/00
CPC分类号： A61K9/1272 , A61K31/7088 , C07J41/0055 , C07J43/003
摘要： The instant invention provides for novel cationic lipids that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with siRNA, to facilitate the cellular uptake and endosomal escape, and to knockdown target mRNA both in vitro and in vivo.
摘要翻译：本发明提供了可以与其它脂质组分如胆固醇和PEG-脂质组合使用以与siRNA形成脂质纳米颗粒以促进细胞摄取和内体逃逸以及在体外和体内。

2. 发明授权

US09181295B2 Cationic lipids with various head groups for oligonucleotide delivery 有权
标题翻译：具有各种头基的阳离子脂质用于寡核苷酸递送
公开(公告)号：US09181295B2
公开(公告)日：2015-11-10
申请号：US13390702
申请日：2010-08-18
申请人： Mark Cameron , Jennifer R. Davis , Andrea R. Geiser , Matthew G. Stanton , Vladislav V. Telyatnikov , Lu Tian , Weimin Wang
发明人： Mark Cameron , Jennifer R. Davis , Andrea R. Geiser , Matthew G. Stanton , Vladislav V. Telyatnikov , Lu Tian , Weimin Wang
IPC分类号： C07J41/00 , A61K9/127 , C07J43/00
CPC分类号： A61K9/1272 , A61K31/7088 , C07J41/0055 , C07J43/003
摘要： The instant invention provides for novel cationic lipids that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with siRNA, to facilitate the cellular uptake and endosomal escape, and to knockdown target mRNA both in vitro and in vivo.
摘要翻译：本发明提供了可以与其它脂质组分如胆固醇和PEG-脂质组合使用以与siRNA形成脂质纳米颗粒以促进细胞摄取和内体逃逸以及在体外和体内。

3. 发明授权

US07230005B2 Compounds and methods for lowering the abuse potential and extending the duration of action of a drug 有权
标题翻译：用于降低滥用潜力并延长药物作用时间的化合物和方法
公开(公告)号：US07230005B2
公开(公告)日：2007-06-12
申请号：US10800898
申请日：2004-03-15
申请人： Jules A. Shafer , Vladislav V. Telyatnikov , Zhiwei Guo
发明人： Jules A. Shafer , Vladislav V. Telyatnikov , Zhiwei Guo
IPC分类号： A61K31/485 , C07D489/02
CPC分类号： C07D489/08 , A61K47/555 , A61K47/60
摘要： The abuse potential of a bioavailable drug such as an opiate analgesic agent is reduced and its duration of action is extended by converting it to a poorly absorbed ester prodrug or other prodrug derivative prior to formulation. Unlike many existing sustained release formulations of active pharmaceutical agents wherein an active pharmaceutical agent can be released by chewing, crushing, or otherwise breaking tablets or capsule beads containing the active pharmaceutical agent, such mechanical processing of tablets or capsule beads containing a prodrug of this invention neither releases the active drug nor compromises the controlled conversion of prodrug to drug. Moreover, tablets and capsule beads containing prodrugs of this invention or other drugs can be formulated with a sufficient amount of a thickening agent such as hydroxypropylmethylcellulose or carboxymethylcellulose to impede inappropriate intravenous and nasal administration of formulations that are not indicated for these modes of administration.
摘要翻译：降低生物可利用药物如鸦片止痛剂的滥用潜力，并且通过在制剂前将其转化为不良吸收的酯前药或其它前药衍生物来延长其作用时间。与活性药物的许多现有持续释放制剂不同，其中通过咀嚼，破碎或以其它方式破坏含有活性药剂的片剂或胶囊珠可以释放活性药剂，这种包含本发明前药的片剂或胶囊珠粒的机械加工既不释放活性药物也不妥协药物对药物的受控转化。此外，含有本发明前药或其他药物的片剂和胶囊珠可以用足量的增稠剂如羟丙基甲基纤维素或羧甲基纤维素配制，以阻止对这些给药模式未注明的制剂的不适当的静脉内和鼻内施用。

4. 发明授权

US09034893B2 Process for reducing contaminating michael acceptor levels in oxycodone and other compositions 有权
标题翻译：用于减少羟考酮和其他组合物中污染的迈克尔受体水平的方法
公开(公告)号：US09034893B2
公开(公告)日：2015-05-19
申请号：US12960991
申请日：2010-12-06
申请人： Jules A. Shafer , Vladislav V. Telyatnikov , Hao Wang
发明人： Jules A. Shafer , Vladislav V. Telyatnikov , Hao Wang
IPC分类号： A61K31/485 , C07D489/08 , C07D489/02
CPC分类号： A23L5/27 , A23V2002/00 , C07D489/02 , C07D489/08 , G01N30/74 , G01N33/02 , G01N33/15 , G01N2030/027
摘要： The present invention relates to processes for removal of Michael acceptors from certain compositions wherein the composition is treated with a thiol-containing compound under conditions sufficient to remove Michael acceptors and the resulting thiol-Michael adducts. Certain embodiments of the present invention enable quantification and/or removal of Michael acceptors and/or Michael acceptor precursors.
摘要翻译：本发明涉及从某些组合物中除去迈克尔受体的方法，其中组合物在足以除去迈克尔受体和所得到的硫醇 - 迈克尔加合物的条件下用含硫醇的化合物处理。本发明的某些实施方案能够定量和/或去除迈克尔受体和/或迈克尔受体前体。

5. 发明申请

US20110136849A1 PROCESS FOR REDUCING CONTAMINATING MICHAEL ACCEPTOR LEVELS IN OXYCODONE AND OTHER COMPOSITIONS 有权
标题翻译：氧化剂和其他组合物中降低敏感性MICHAEL接收剂含量的方法
公开(公告)号：US20110136849A1
公开(公告)日：2011-06-09
申请号：US12960991
申请日：2010-12-06
申请人： Jules A. Shafer , Vladislav V. Telyatnikov , Hao Wang
发明人： Jules A. Shafer , Vladislav V. Telyatnikov , Hao Wang
IPC分类号： A61K31/4355 , A61P25/04
CPC分类号： A23L5/27 , A23V2002/00 , C07D489/02 , C07D489/08 , G01N30/74 , G01N33/02 , G01N33/15 , G01N2030/027
摘要： The present invention relates to processes for removal of Michael acceptors from certain compositions wherein the composition is treated with a thiol-containing compound under conditions sufficient to remove Michael acceptors and the resulting thiol-Michael adducts. Certain embodiments of the present invention enable quantification and/or removal of Michael acceptors and/or Michael acceptor precursors.
摘要翻译：本发明涉及从某些组合物中除去迈克尔受体的方法，其中组合物在足以除去迈克尔受体和所得到的硫醇 - 迈克尔加合物的条件下用含硫醇的化合物处理。本发明的某些实施方案能够定量和/或去除迈克尔受体和/或迈克尔受体前体。

6. 发明授权

US07875623B2 Process for reducing contaminating Michael acceptor levels in oxycodone and other compositions 有权
标题翻译：用于减少羟考酮和其他组合物中污染的Michael受体水平的方法
公开(公告)号：US07875623B2
公开(公告)日：2011-01-25
申请号：US11603956
申请日：2006-11-22
申请人： Jules A. Shafer , Vladislav V. Telyatnikov , Hao Wang
发明人： Jules A. Shafer , Vladislav V. Telyatnikov , Hao Wang
IPC分类号： A61K31/485 , C07D489/08
CPC分类号： A23L5/27 , A23V2002/00 , C07D489/02 , C07D489/08 , G01N30/74 , G01N33/02 , G01N33/15 , G01N2030/027
摘要： The present invention relates to processes for removal of Michael acceptors from certain compositions wherein the composition is treated with a thiol-containing compound under conditions sufficient to remove Michael acceptors and the resulting thiol-Michael adducts. Certain embodiments of the present invention enable quantification and/or removal of Michael acceptors and/or Michael acceptor precursors.
摘要翻译：本发明涉及从某些组合物中除去迈克尔受体的方法，其中组合物在足以除去迈克尔受体和所得到的硫醇 - 迈克尔加合物的条件下用含硫醇的化合物处理。本发明的某些实施方案能够定量和/或去除迈克尔受体和/或迈克尔受体前体。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式