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1. 发明授权

US06063782A Pyrrolopyridazine derivatives 失效
标题翻译：吡咯并哒嗪衍生物
公开(公告)号：US06063782A
公开(公告)日：2000-05-16
申请号：US676375
申请日：1996-07-17
申请人： Tomio Kimura , Nobuhiko Shibakawa , Hiroshi Fujiwara , Etsuro Itoh , Keiji Matsunobu , Keiichi Tabata , Hiroshi Yasuda , Yoshimi Fujihara, deceased
发明人： Tomio Kimura , Nobuhiko Shibakawa , Hiroshi Fujiwara , Etsuro Itoh , Keiji Matsunobu , Keiichi Tabata , Hiroshi Yasuda , Yoshimi Fujihara, deceased
IPC分类号： E04F13/08 , A61K31/5025 , A61P1/04 , C07D487/04 , E04F13/073 , E04F13/26 , E04F19/02
CPC分类号： C07D487/04
摘要： Pyrrolopyridazine derivatives having the general formula. ##STR1## In the above formula, R.sup.1 represents a C.sub.2 -C.sub.6 alkenyl-group, a halogeno-C.sub.2 -C.sub.6 -alkenyl group, a C.sub.6 -C.sub.10 aryl-C.sub.2 -C.sub.6 -alkenyl group, a C.sub.2 -C.sub.6 alkynyl group, a C.sub.3 -C.sub.7 cycloalkyl group, a C.sub.3 -C.sub.7 cycloalkyl-C.sub.1 -C.sub.6 -alkyl group, a C.sub.5 -C.sub.7 cycloalkenyl-C.sub.1 -C.sub.6 -alkyl group or a halogeno-C.sub.1 -C.sub.6 -alkyl group; R.sup.2 and R.sup.3 are the same or different and each represents a hydrogen atom, a C.sub.1 -C.sub.6 alkyl group or a C.sub.6 -C.sub.10 aryl group; R.sup.4 represents a hydrogen atom or a C.sub.1 -C.sub.6 alkyl group; R.sup.5 represents a C.sub.6 -C.sub.10 aryl group or a 5-10 membered heteroaryl group comtaining heteroatom(s) selected from nitrogen, oxygen and sulfur;
摘要翻译：具有通式的吡咯并哒嗪衍生物。在上式中，R 1表示C 2 -C 6链烯基，卤代-C 2 -C 6 - 烯基，C 6 -C 10芳基-C 2 -C 6 - 烯基，C 2 -C 6炔基，C 3 -C 7环烷基 C 3 -C 7环烷基-C 1 -C 6烷基，C 5 -C 7环烯基-C 1 -C 6烷基或卤代-C 1 -C 6烷基; R2和R3相同或不同，各自表示氢原子，C1-C6烷基或C6-C10芳基; R4表示氢原子或C1-C6烷基; R5表示C6-C10芳基或含有选自氮，氧和硫的杂原子的5-10元杂芳基;

2. 发明授权

US5591752A Quinoline derivative 失效
标题翻译：喹啉衍生物
公开(公告)号：US5591752A
公开(公告)日：1997-01-07
申请号：US505172
申请日：1995-08-16
申请人： Tomio Kimura , Yoshio Kaku , Takashi Ikuta , Hiroshi Fujiwara , Hitoshi Ueno , Eiji Okanari
发明人： Tomio Kimura , Yoshio Kaku , Takashi Ikuta , Hiroshi Fujiwara , Hitoshi Ueno , Eiji Okanari
IPC分类号： C07D405/12 , C07D405/14 , C07D403/10 , A61K31/47 , C07D407/10
CPC分类号： C07D405/12 , C07D405/14
摘要： This invention relates to a compound (a quinoline derivative) represented by the formula (I): ##STR1## The quinoline derivative of this invention has a strong leukotriene antagonistic action and is extremely useful as an antiallergic medicine and an anti-inflammatory medicine.
摘要翻译： PCT No.PCT / JP94 / 00234 Sec。 371日期：1995年8月16日 102（e）日期1995年8月16日PCT 1994年2月16日PCT PCT。 WO94 / 19345 PCT公开号 1994年9月1日本发明涉及由式（I）表示的化合物（喹啉衍生物）：本发明具有强烈的白三烯拮抗作用，作为抗过敏药和抗炎药非常有用。

3. 发明授权

US5610303A Arylamino pyrimidine compound 失效
标题翻译：芳基嘧啶化合物
公开(公告)号：US5610303A
公开(公告)日：1997-03-11
申请号：US411838
申请日：1995-04-03
申请人： Tomio Kimura , Yoshiaki Kuroki , Hiroshi Fujiwara , Shigeharu Anpeiji
发明人： Tomio Kimura , Yoshiaki Kuroki , Hiroshi Fujiwara , Shigeharu Anpeiji
IPC分类号： A61K31/00 , A61K31/505 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D401/10
CPC分类号： C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14
摘要： A pyrimidine derivative represented by the formula (II) or (III): ##STR1## (wherein R.sup.1 and R.sup.2 each represent H, a halogen, amino, nitro, an unsubstituted or substituted alkyl, an alkoxy or an alkoxycarbonyl, or R.sup.1 and R.sup.2 are bonded together to form an unsubstituted or substituted alkylene; R.sup.3 represents an aralkyl or a hetero aromatic ring type-alkyl, R.sup.4 represents H or acyl, R.sup.5 represents H, OH or an alkoxy, R.sup.6 represents H, a halogen, an alkyl or an alkoxy, X represents --CH=, --CH=CH--(CH.sub.2).sub.p --, --CH.sub.2 -- or --CH.sub.2 CH.sub.2 --(CH.sub.2).sub.p --, Y represents =CH-- (CH.sub.2).sub.p --, --CH.sub.2 --(CH.sub.2).sub.p --, a single bond or a double bond, p represents 0 or 1, and . . . represents a single bond or a double bond),and a salt thereof have selective acetylcholinesterase-inhibiting activities and selective A type monoamine oxidase-inhibiting activities, and are useful as an antidepressant and an agent for curing senile dementia.
摘要翻译： PCT No.PCT / JP93 / 01412 Sec。 371日期：1995年4月3日 102（e）日期1995年4月3日PCT提交1993年10月1日PCT公布。出版物WO94 / 07890 日本时间1994年04月14日由式（II）或（III）表示的嘧啶衍生物：其中R1和R2各自表示H，卤素，氨基，硝基，未取代的或取代的烷基，烷氧基或烷氧基羰基，或R 1和R 2结合在一起形成未取代或取代的亚烷基; R 3表示芳烷基或杂芳环型烷基，R 4表示H或酰基，R 5表示H，OH或烷氧基，卤素，烷基或烷氧基，X代表-CH =， - CH = CH-（CH2）p-，-CH2-或-CH2CH2-（CH2）p-，Y代表= CH - （CH 2）p - ， - CH 2 - （CH 2）p - ，单键或双键，p表示0或1，+ E，ov ... + EE表示单键或双键）其盐具有选择性的乙酰胆碱酯酶抑制活性和选择性A型单胺氧化酶抑制活性，并且可用作抗抑郁药和用于治疗老年痴呆的药剂。

4. 发明授权

US07829580B2 Cyclic amine derivative having heteroaryl ring 失效
标题翻译：具有杂芳基环的环胺衍生物
公开(公告)号：US07829580B2
公开(公告)日：2010-11-09
申请号：US11442429
申请日：2006-05-26
申请人： Tomio Kimura , Naoki Tanaka , Atsuhiro Sugidachi , Toshiyuki Konosu
发明人： Tomio Kimura , Naoki Tanaka , Atsuhiro Sugidachi , Toshiyuki Konosu
IPC分类号： A61K31/445 , C07D211/54
CPC分类号： C07D211/72 , C07D401/06 , C07D401/14 , C07D405/06 , C07D409/06 , C07D413/06 , C07D417/06
摘要： A compound having the general formula (I) wherein R1 represents C1-C6 alkyl, etc., R2 represents hydrogen, C2-C7 alkanoyl, C7-C11 arylcarbonyl, the formula R4—(CH2)l—, etc., R3 represents C6-C10 aryl, etc., X1, X2, X3, X4 and X5 each independently represents hydrogen, halogen, etc., and n represents an integer of 0 to 2, pharmacologically acceptable salts thereof or prodrugs thereof. They have excellent inhibition of platelet activation, etc. and are useful as a prophylactic or therapeutic agents for diseases related to thrombus or embolus formation.
摘要翻译：具有通式（I）的化合物，其中R1表示C1-C6烷基等，R2表示氢，C2-C7烷酰基，C7-C11芳基羰基，式R4-（CH2）-1-等，R3表示C6 -C 10芳基等，X 1，X 2，X 3，X 4和X 5各自独立地表示氢，卤素等，n表示0〜2的整数，其药理学上可接受的盐或其前药。它们具有优异的血小板活化抑制等，并且可用作与血栓或栓塞形成有关的疾病的预防或治疗剂。

5. 发明申请

US20100201810A1 IMAGE DISPLAY APPARATUS AND IMAGE DISPLAY METHOD 审中-公开
标题翻译：图像显示装置和图像显示方法
公开(公告)号：US20100201810A1
公开(公告)日：2010-08-12
申请号：US12676063
申请日：2008-10-06
申请人： Kazunori Shimazaki , Tomio Kimura , Yutaka Nakashima , Masami Tomioka
发明人： Kazunori Shimazaki , Tomio Kimura , Yutaka Nakashima , Masami Tomioka
IPC分类号： H04N7/18
CPC分类号： B60R1/00 , B60R11/04 , B60R2300/30 , B60R2300/301 , B60R2300/303 , B60R2300/607 , B60R2300/806 , G06T7/73 , G06T2207/30204 , G06T2207/30264
摘要： Images are taken by a fixed camera and a moving camera, and a relative position calculation unit recognizes a current position and orientation of the moving object based on a detection signal that is input from a sensor for obtaining positional information of a moving object and calculates a relative positional relationship of the moving camera with respect to the fixed camera by comparing the current position and orientation of the moving object with a given position at which the fixed camera is installed. Based on the relative positional relationship, the image taken by the fixed camera and the image taken by the moving camera are synthesized into one image by an image composition unit, and a composite image viewed from a virtual viewpoint is displayed on a monitor.
摘要翻译：图像由固定摄像机和移动摄像机拍摄，相对位置计算单元基于从用于获取移动物体的位置信息的传感器输入的检测信号来识别移动物体的当前位置和姿态，并且计算出通过将移动物体的当前位置和姿态与安装固定照相机的给定位置进行比较，移动摄像机相对于固定照相机的相对位置关系。基于相对位置关系，通过图像合成单元将由固定摄像机拍摄的图像和由移动摄像机拍摄的图像合成为一个图像，并且将从虚拟视点观看的合成图像显示在监视器上。

6. 再颁专利

USRE39420E1 1,2-Diphenylpyrrole derivatives, their preparation and their therapeutic uses 有权
标题翻译： 1,2-二苯基吡咯衍生物及其制备方法及其治疗用途
公开(公告)号：USRE39420E1
公开(公告)日：2006-12-05
申请号：US09678218
申请日：2000-09-29
申请人： Tomio Kimura , Yasuo Noguchi , Akira Nakao , Keisuke Suzuki , Shigeru Ushiyama , Akihiro Kawara , Masaaki Miyamoto
发明人： Tomio Kimura , Yasuo Noguchi , Akira Nakao , Keisuke Suzuki , Shigeru Ushiyama , Akihiro Kawara , Masaaki Miyamoto
IPC分类号： A61K31/40 , C07D207/333 , C07D207/335 , C07D207/337
CPC分类号： C07D207/333 , C07D207/335 , C07D207/337
摘要： Compounds of formula (I) and (II): [wherein R is hydrogen, halogen or alkyl; R1 is alkyl, amino or substituted amino; R2 is optionally substituted phenyl; R3 is hydrogen, halogen or optionally substituted alkyl; R4 is hydrogen, optionally substituted alkyl, cycloalkyl, aryl, or aralkyl] have valuable analgesic, anti-inflammatory, anti-pyretic and anti-allergic activities and have the ability to inhibit the production of leukotrienes and to inhibit bone resorption. They are relatively free from the side effects which generally result from the administration of compounds having these kinds of activities.
摘要翻译：式（I）和（II）的化合物：[其中R是氢，卤素或烷基; R 1是烷基，氨基或取代的氨基; R 2是任选取代的苯基; R 3是氢，卤素或任选取代的烷基; R 4是氢，任选取代的烷基，环烷基，芳基或芳烷基]具有有价值的镇痛，抗炎，抗裂解和抗过敏活性，并且具有抑制白三烯生产的能力和以抑制骨吸收。它们相对没有通常由施用具有这些活性的化合物引起的副作用。

7. 发明授权

US07091352B2 Compounds substituted with bicyclic amino groups 失效
标题翻译：被双环氨基取代的化合物
公开(公告)号：US07091352B2
公开(公告)日：2006-08-15
申请号：US10625024
申请日：2003-07-22
申请人： Tomio Kimura , Akira Nakao
发明人： Tomio Kimura , Akira Nakao
IPC分类号： C07D221/02
CPC分类号： C07D471/04 , C07D455/02 , C07D487/04
摘要： Compounds of the formula (I) below, or pharmacologically acceptable salts, esters or other derivatives thereof: wherein A is furan, thiophene, pyrazole, imidazole, isoxazole or isothiazole; R1 is a substituted or unsubstituted aryl or a substituted or unsubstituted heteroaryl; R2 is a substituted or unsubstituted heteroaryl; and R3 is a bicyclic amino group; provided that the substituents R1 and R2 are bonded to the two atoms of the cyclic group A which are adjacent to the atom of the cyclic group A to which the substituent R2 is bonded. The compounds inhibit the production of inflammatory cytokines.
摘要翻译：式（I）的化合物或其药理学上可接受的盐，酯或其衍生物：其中A为呋喃，噻吩，吡唑，咪唑，异恶唑或异噻唑; R 1是取代或未取代的芳基或取代或未取代的杂芳基; R 2是取代或未取代的杂芳基; R 3是双环氨基; 条件是取代基R 1和R 2与键合在与环状基团A的原子相邻的环状基团A的两个原子上，取代基R ^{2 键合。这些化合物抑制炎性细胞因子的产生。}

8. 发明授权

US07000586B2 Control device for compression ignition operation of internal combustion engine 失效
标题翻译：内燃机压缩点火运行控制装置
公开(公告)号：US07000586B2
公开(公告)日：2006-02-21
申请号：US10851648
申请日：2004-05-24
申请人： Akira Kato , Toru Kitamura , Tomio Kimura , Shohei Okazaki , Toshihiro Yamaki , Katsura Okubo
发明人： Akira Kato , Toru Kitamura , Tomio Kimura , Shohei Okazaki , Toshihiro Yamaki , Katsura Okubo
IPC分类号： F02B5/00 , F02M25/07 , F02D41/04
CPC分类号： F01N3/0842 , F01N3/0807 , F01N2430/085 , F02B1/12 , F02D41/006 , F02D41/3035 , F02D41/401 , F02D2200/703 , Y02T10/44
摘要： A controller for an internal combustion engine capable of performing a compression ignition operation. The internal combustion engine includes a combustion chamber, and a fuel injector for injecting fuel directly in the combustion chamber. The controller includes: an air pressure detecting unit configured to detect at least one of an air pressure and an exhaust air pressure; and a fuel injection control unit configured to actuate the fuel injector to control a fuel injection timing according to a detected result by the air pressure detecting unit. The fuel injection control unit puts the fuel injection timing forward as the detected result by the air pressure detecting unit is lowered.
摘要翻译：一种用于执行压缩点火操作的内燃机的控制器。内燃机包括燃烧室和用于直接在燃烧室中喷射燃料的燃料喷射器。控制器包括：气压检测单元，被配置为检测空气压力和排气压力中的至少一个; 以及燃料喷射控制单元，其构造成根据气压检测单元的检测结果致动燃料喷射器以控制燃料喷射正时。燃料喷射控制单元随着气压检测单元的检测结果降低而将燃料喷射正时向前。

9. 发明授权

US06711473B2 Parking assisting device 失效
标题翻译：停车辅助装置
公开(公告)号：US06711473B2
公开(公告)日：2004-03-23
申请号：US10176459
申请日：2002-06-21
申请人： Kazunori Shimazaki , Tomio Kimura , Satoshi Yamada
发明人： Kazunori Shimazaki , Tomio Kimura , Satoshi Yamada
IPC分类号： G06F700
CPC分类号： B62D15/028 , B60T2201/10
摘要： A parking assisting device is provided with: a yaw rate sensor for detecting a yaw angle of a vehicle; a controller having a navigation function control unit and a parking assisting function control unit; a function selecting switch for determining switching to a parking assisting mode from a navigation mode; a monitor for providing navigation information, as well as for setting the reference position of the yaw angle and selecting a parking mode; and a speaker for providing parking assisting information to a driver in accordance with a vehicle position specified on the basis of the yaw angle.
摘要翻译：一种停车辅助装置设置有用于检测车辆的偏航角的偏航率传感器; 控制器，具有导航功能控制单元和停车辅助功能控制单元; 功能选择开关，用于确定从导航模式切换到驻车辅助模式; 用于提供导航信息的监视器，以及用于设置偏航角的参考位置并选择停车模式; 以及扬声器，用于根据基于偏航角指定的车辆位置向驾驶员提供停车辅助信息。

10. 发明授权

US4997943A Quinoline-3-carboxylic acid derivatives 失效
标题翻译：喹啉-3-羧酸衍生物
公开(公告)号：US4997943A
公开(公告)日：1991-03-05
申请号：US33066
申请日：1987-03-31
申请人： Masayuki Iwata , Tomio Kimura , Yoshimi Fujihara , Tetsushi Katsube
发明人： Masayuki Iwata , Tomio Kimura , Yoshimi Fujihara , Tetsushi Katsube
IPC分类号： A61K31/47 , A61K31/495 , A61K31/535 , A61K31/54 , A61P31/04 , C07D215/56 , C07D215/58 , C07D401/04 , C07D521/00
CPC分类号： C07D215/56 , C07D215/58 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/04
摘要： Compounds of formula (I): ##STR1## (in which R.sup.1 is alkoxy, R is alkyl, haloalkyl, alkylamino, cycloalkyl or optionally substituted phenyl, X is chlorine or fluorine and Y is selected from certain specific heterocycles) have excellent antibacterial activity. They may be prepared by introducing the group represented by Y into the corresponding compound in which Y is replaced by a halogen atom.
摘要翻译：式（I）化合物：其中R 1为烷氧基，R为烷基，卤代烷基，烷基氨基，环烷基或任意取代的苯基，X为氯或氟，Y为某些特定杂环）抗菌活性。它们可以通过将由Y表示的基团引入到其中Y被卤素原子代替的相应化合物中来制备。

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