会员体验
专利管家（专利管理）
工作空间（专利管理）
风险监控（情报监控）
数据分析（专利分析）
侵权分析（诉讼无效）
联系我们
交流群
官方交流：
QQ群： 891211   
微信请扫码    >>>
现在联系顾问~
下载
著录项
PDF全文
热词
    • 3. 发明申请
      US20090306059A1 CYCLIC AMINE DERIVATIVE HAVING SUBSTITUTED ALKYL GROUP 审中-公开
    • CYCLIC AMINE DERIVATIVE HAVING SUBSTITUTED ALKYL GROUP
    • 具有取代的烷基的环胺衍生物
    • US20090306059A1
    • 2009-12-10
    • US11915522
    • 2006-05-26
    • Tomio Kimura , Naoki Tanaka , Hiroyuki Kobayashi , Atsuhiro Sugidachi
    • Tomio Kimura , Naoki Tanaka , Hiroyuki Kobayashi , Atsuhiro Sugidachi
    • A61K31/541 , C07D413/06 , A61K31/5377 , C07D417/06 , C07D401/06 , A61K31/4545 , A61P7/02
    • F16D3/2233 , F16D2003/22309 , Y10T403/32655
    • A compound having the general formula (I), pharmacologically acceptable salts thereof or prodrugs thereof: [wherein R1 represents a hydrogen atom, a C1-C6 alkyl group which may be substituted, a C3-C6 cycloalkyl group which may be substituted, a C1-C6 alkoxy group which may be substituted or a C6-C10 aryl group which may be substituted; R2 represents a hydrogen atom, a halogen atom, a carboxy group, a C2-C7 alkoxycarbonyl group, a carbamoyl group, a cyano group, a C1-C6 alkyl group, a halogeno C1-C6 alkyl group, a C1-C6 alkyl group substituted by a heteroaryl group, a C1-C6 alkoxy group, a halogeno C1-C6 alkoxy group, a hydroxy C1-C6 alkyl group, a C2-C12 alkoxyalkyl group, a formyl group, a C2-C7 alkanoyl group, a C4-C7 cycloalkylcarbonyl group, a C2-C7 alkylcarbamoyl group, a di(C1-C6 alkyl)carbamoyl group, a group of formula R4—CO—CR5R6—(CH2)m—, a group of formula R7—CO—(CH2)l—N(R8)— or a sulfamoyl C1-C6 alkyl group; R3 represents a substituted C1-C6 alkyl group, a heterocyclyl group or a heterocyclyl group substituted with 1 to 5 substituents; X1, X2, X3, X4 and X5 each independently represents a hydrogen atom, a halogen atom, an amino group, a carboxy group, a carbamoyl group, a cyano group, a nitro group, a C1-C6 alkyl group, a halogeno C1-C6 alkyl group, a C1-C6 alkoxy group, or a halogeno C1-C6 alkoxy group; and n represents an integer of 0 to 2].
    • 具有通式（I）的化合物，其药学上可接受的盐或其前药：其中R1表示氢原子，可被取代的C1-C6烷基，可被取代的C3-C6环烷基，C1 可被取代的-C6烷氧基或可被取代的C6-C10芳基; R2表示氢原子，卤素原子，羧基，C2-C7烷氧基羰基，氨基甲酰基，氰基，C1-C6烷基，卤代C1-C6烷基，C1-C6烷基 被杂芳基，C 1 -C 6烷氧基，卤代C 1 -C 6烷氧基，羟基C 1 -C 6烷基，C 2 -C 12烷氧基烷基，甲酰基，C 2 -C 7烷酰基， C7环烷基羰基，C2-C7烷基氨基甲酰基，二（C1-C6烷基）氨基甲酰基，式R4-CO-CR5R6-（CH2）m-的基团，式R7-CO-（CH2） （R8） - 或氨磺酰基C1-C6烷基; R 3表示取代的C 1 -C 6烷基，杂环基或被1至5个取代基取代的杂环基; X1，X2，X3，X4和X5各自独立地表示氢原子，卤素原子，氨基，羧基，氨基甲酰基，氰基，硝基，C1-C6烷基，卤代C1 C 1-6烷基，C 1 -C 6烷氧基或卤代C 1 -C 6烷氧基; n表示0〜2的整数]。
    • 基本信息 添加关注 加入工作空间 PDF全文 PDF下载 全文下载 相似专利 双屏查看 权利要求书 说明书全文 Global Dossier Espacenet 法律信息 同族专利 专利引用
    • 4. 发明申请
      US20090233952A1 SUBSTITUTED CYCLOALKENE DERIVATIVE 有权
    • SUBSTITUTED CYCLOALKENE DERIVATIVE
    • US20090233952A1
    • 2009-09-17
    • US12066813
    • 2006-09-13
    • Tomio Kimura , Nobuyuki Ohkawa , Takayoshi Nagasaki , Atsuhiro Sugidachi , Osamu Ando
    • Tomio Kimura , Nobuyuki Ohkawa , Takayoshi Nagasaki , Atsuhiro Sugidachi , Osamu Ando
    • A61K31/443 , C07D317/72 , A61K31/357 , C07D405/08 , A61K31/4025 , C07D319/04 , C07D405/10
    • C07C311/14 , C07C2601/16 , C07C2602/50 , C07D303/38 , C07D307/94 , C07D317/72 , C07D319/08 , C07D321/10 , C07D327/04 , C07D339/06 , C07D339/08 , C07D493/04 , C07D493/10
    • [Object] To provide a substituted cycloalkene derivative having an action to suppress intracellular signal transduction or cell activation induced by endotoxin and to suppress cell responses due to the intracellular signal transduction and cell activation such as an excess generation of inflammatory mediators such as TNF-α, pharmacologically acceptable salts therefor, a medicament containing them as an active ingredient, a preparation method therefor, and a medicament containing the aforementioned substituted cycloalkene derivative as an active ingredient which is superior in prophylaxis and/or treatment of diseases such as sepsis (septic shock, disseminated intravascular coagulation, multiple organ failure and the like), that are associated with intracellular signal transduction or cell activation induced by endotoxin and to cell responses to the intracellular signal transduction and cell activation.[Solution] A compound represented by the general formula (I): {whereinX and Y represent a group in which X and Y together with a carbon atom to which they are bound form ring A (the ring is 3- to 7-membered heterocyclyl ring or 3- to 7-membered cycloalkyl ring), each represents a hydrogen atom, or X and Y together represent a substituent of ring B. l and m, independently from each other, represent an integer of 0 to 3, and l+m is 1 to 3. R1 is an aliphatic hydrocarbon group and the like which may be substituted with a group selected from Substituent group β and Substituent group γ. n represents an integer of 0 to 3. R2 is a C1-C6 alkyl group and the like which may be substituted with a group selected from a hydrogen atom and Substituent group β. R3 is a phenyl group, 5- to 6-membered heteroaryl group and the like which may be substituted with a group selected from Substituent group ε. R5 is a C1-C6 alkyl group and the like which may be substituted with a group selected from a hydrogen atom and Substituent group β. Provided that in the case where R3 is a phenyl group which may be substituted with a group selected from Substituent group ε, X and Y represent a group in which X and Y together with a carbon atom to which they are bound form ring A, or X and Y together represent a substituent of ring B.
    • 基本信息 添加关注 加入工作空间 PDF全文 PDF下载 全文下载 相似专利 双屏查看 权利要求书 说明书全文 Global Dossier Espacenet 法律信息 同族专利 专利引用
    • 6. 再颁专利
      USRE43858E1 Substituted cycloalkene derivative 有权
    • Substituted cycloalkene derivative
    • 取代的环烯烃衍生物
    • USRE43858E1
    • 2012-12-11
    • US13224745
    • 2006-09-13
    • Tomio Kimura , Nobuyuki Ohkawa , Takayoshi Nagasaki , Atsuhiro Sugidachi , Osamu Ando
    • Tomio Kimura , Nobuyuki Ohkawa , Takayoshi Nagasaki , Atsuhiro Sugidachi , Osamu Ando
    • A61K31/335 , C07D317/72
    • A compound of formula (I) Wherein X, Y, ring A, ring B, l, m, R1, R2, R4 and R5 are as defined herein, to supress intracellular signal transduction or cell activation induced by endotoxin and to suppress cell responses due to the intracellular signal transduction and cell activation such as an excess generation of inflammatory mediators such as TNF-α, pharmacologically acceptable salts therefor, a preparation method therefor, and a medicament containing the aforementioned substituted cycloalkene derivative as an active ingredient which is superior in prophylaxis and/or treatment of diseases such as sepsis (septic shock, disseminated intravascular coagulation, multiple organ failure and the like), that are associated with intracellular signal transduction or cell activation induced by endotoxin and to cell responses to the intracellular signal transduction and cell activation.
    • 式（I）化合物其中X，Y，环A，环B，l，m，R 1，R 2，R 4和R 5如本文所定义，以抑制由内毒素诱导的细胞内信号转导或细胞活化并抑制细胞反应 由于细胞内信号转导和细胞活化，例如过量产生炎症介质如TNF-α，其药理学上可接受的盐，其制备方法，以及含有上述取代的环烯烃衍生物作为活性成分的药物，其优于 与细胞内信号转导或由内毒素诱导的细胞活化以及对细胞内信号转导和细胞的细胞反应相关的诸如败血症（败血症休克，弥散性血管内凝血，多器官功能衰竭等）的疾病的预防和/或治疗 激活。
    • 基本信息 添加关注 加入工作空间 PDF全文 PDF下载 全文下载 相似专利 双屏查看 权利要求书 说明书全文 Global Dossier Espacenet 法律信息 同族专利 专利引用
每页展示10个专利
每页展示10个专利
每页展示20个专利
每页展示50个专利
每页展示100个专利

IPRDB

最新中国发明专利 最新美国发明专利 技术领域 专利库 专利分类库 国际专利分类库

热门服务

会员版试用 API 数据接口 找代理 知嘟嘟专利交易 排行榜 大学排行榜 专利百科

关于我们

平台介绍 战略合作 网站地图

友情链接

知嘟嘟专利交易 国家知识产权局 中国商标网

联系方式


©2019-2023 上海吉码数字技术有限公司 版权所有，并保留所有权利 沪ICP备20016256号-6 沪公网安备31011702005475号