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1. 发明授权

US08183272B2 Indanyl compounds 有权
标题翻译：茚满基化合物
公开(公告)号：US08183272B2
公开(公告)日：2012-05-22
申请号：US13167196
申请日：2011-06-23
申请人： Akira Nakao , Kentoku Gotanda , Kazumasa Aoki , Shimpei Hirano , Yoshiharu Hiruma , Takeshi Shiiki
发明人： Akira Nakao , Kentoku Gotanda , Kazumasa Aoki , Shimpei Hirano , Yoshiharu Hiruma , Takeshi Shiiki
IPC分类号： A61K31/41 , A61K31/18 , A61K31/192 , C07C53/134 , C07C311/25 , C07D257/04
CPC分类号： C07D257/04 , C07C217/28 , C07C255/57 , C07C2601/02 , C07C2602/08
摘要： Compounds exhibiting calcium receptor antagonist activity that are safe and orally administrable having Formula (I) or pharmaceutically acceptable salts thereof:
摘要翻译：表现出具有式（I）或其药学上可接受的盐的安全和口服给药的钙受体拮抗剂活性的化合物：

2. 发明授权

US08173631B2 Cyclic amine compounds 有权
标题翻译：环胺化合物
公开(公告)号：US08173631B2
公开(公告)日：2012-05-08
申请号：US13167443
申请日：2011-06-23
申请人： Akira Nakao , Kentoku Gotanda , Kazumasa Aoki , Shimpei Hirano , Yoshiharu Hiruma , Takeshi Shiiki
发明人： Akira Nakao , Kentoku Gotanda , Kazumasa Aoki , Shimpei Hirano , Yoshiharu Hiruma , Takeshi Shiiki
IPC分类号： A61K31/40 , A61K31/337 , C07D205/04 , C07D207/08
CPC分类号： C07D205/04 , C07D207/08 , C07D207/10 , C07D207/12 , C07D403/12 , C07D409/06 , C07D409/14
摘要： Compounds exhibiting calcium receptor antagonist activity that are safe and orally administrable having Formula (I) or pharmaceutically acceptable salts thereof
摘要翻译：表现出具有式（I）或其药学上可接受的盐的安全和口服给药的钙受体拮抗剂活性的化合物

3. 发明授权

US07907481B2 Optical disc drive device and tilt correction device 有权
标题翻译：光盘驱动装置和倾斜校正装置
公开(公告)号：US07907481B2
公开(公告)日：2011-03-15
申请号：US12337033
申请日：2008-12-17
申请人： Takashi Inoue , Hiroshi Shimada , Akira Nakao , Yasuhiro Hayashi
发明人： Takashi Inoue , Hiroshi Shimada , Akira Nakao , Yasuhiro Hayashi
IPC分类号： G11B7/00
CPC分类号： G11B7/0941 , G11B7/0901 , G11B7/0956
摘要： An optical disc drive device has an FE signal generator which generates a focus error signal, a TE signal generator which generates a tracking error signal, a return beam detector which detects a return beam reflected by an optical disc after irradiated by an optical pickup to generate a return beam level signal, a return beam gain setting part which sets amplitude adjustment amount of the return beam level signal so that a signal level of the return beam level signal generated by the return beam detector coincides with a predetermined reference level, an FE gain setting part which sets amplitude adjustment amount of the focus error signal in accordance with the signal level of the return beam level signal adjusted by the return beam gain setting part so that a signal amplitude of the focus error signal is constant, and a TE gain setting part which sets amplitude adjustment amount of the tracking error signal in accordance with the signal level of the return beam level signal adjusted by the return beam gain adjustment part so that a signal amplitude of the tracking error signal is constant.
摘要翻译：光盘驱动装置具有产生聚焦误差信号的FE信号发生器，产生跟踪误差信号的TE信号发生器，检测由光拾取器照射后由光盘反射的返回光束的返回光束检测器，以产生返回光束电平信号，返回光束增益设置部分，其设置返回光束电平信号的幅度调整量，使得由返回光束检测器产生的返回光束电平信号的信号电平与预定参考电平相符，FE增益设置部分，其根据由返回光束增益设置部分调整的返回光束电平信号的信号电平设置聚焦误差信号的幅度调整量，使得聚焦误差信号的信号幅度恒定，并且TE增益设置根据调整的返回光束电平信号的信号电平设定跟踪误差信号的幅度调整量的部分通过返回光束增益调整部分，使得跟踪误差信号的信号幅度恒定。

4. 发明申请

US20070049620A1 Cyclic tertiary amine compound 审中-公开
标题翻译：环状叔胺化合物
公开(公告)号：US20070049620A1
公开(公告)日：2007-03-01
申请号：US11301296
申请日：2005-12-12
申请人： Tomio Kimura , Nobuyuki Ohkawa , Akira Nakao , Takayoshi Nagasaki , Takaichi Shimozato
发明人： Tomio Kimura , Nobuyuki Ohkawa , Akira Nakao , Takayoshi Nagasaki , Takaichi Shimozato
IPC分类号： A61K31/444 , A61K31/4439 , C07D401/14 , C07D403/14
CPC分类号： C07D471/04 , A61K31/437 , A61K31/444
摘要： A cyclic tertiary amine compound which is capable of inhibiting the production of inflammatory cytoines. The compound having a structure represented by the following formula (I): wherein A represents an optionally substituted trivalent group which is benzene, pyrimidine, pyrrole, pyridine, pyridazine, furan, thiopene, pyrazole, imidazole, isoxazole or isothiazole; R1 represents an aryl or a heteroaryl group, which is unsubstituted or substituted; R2 represents a heteroaryl group which is unsubtituted or substituted; and R3 represents a cyclic tertiary amino group, or a pharmacologically acceptable salt of the compound.
摘要翻译：能够抑制炎性细胞因子产生的环状叔胺化合物。具有由下式（I）表示的结构的化合物：其中A表示任选取代的三价基团，其为苯，嘧啶，吡咯，吡啶，哒嗪，呋喃，噻吩，吡唑，咪唑，异恶唑或异噻唑; R 1表示未取代或取代的芳基或杂芳基; R 2表示未取代或取代的杂芳基; R 3表示化合物的环状叔氨基或药理学上可接受的盐。

5. 发明申请

US20060128756A1 Heteroaryl-substituted pyrrole derivatives, their preparation and their therapeutic uses 审中-公开
标题翻译：杂芳基取代的吡咯衍生物，其制备及其治疗用途
公开(公告)号：US20060128756A1
公开(公告)日：2006-06-15
申请号：US11339390
申请日：2006-01-25
申请人： Tomio Kimura , Kazumasa Aoki , Akira Nakao , Shigeru Ushiyama , Takaichi Shimozato , Nobuyuki Ohkawa
发明人： Tomio Kimura , Kazumasa Aoki , Akira Nakao , Shigeru Ushiyama , Takaichi Shimozato , Nobuyuki Ohkawa
IPC分类号： C07D401/02 , A61K31/444 , C07D401/14
CPC分类号： C07D451/02 , C07D401/04 , C07D401/14 , C07D453/02 , C07D455/02 , C07D471/04 , C07D487/04
摘要： Compounds having activity against production of an inflammatory cytokine of formula (I)′: A′ is pyrrole; R1′ is phenyl or naphthyl; R2′ is pyridyl or pyrimidinyl; R3′ is (IIa)′, (IIb)′ or (IIc)′: m′ is 1; E′ is nitrogen; D′ is >C(R5′), R5′ is hydrogen, Substituent α′ or Substituent β′; B′ is nitrogen-containing 5-membered heterocyclic; R4′ is 1 to 3 substituents from Substituent α′, Substituent β′ and Substituent γ′; R1′ and R3′ are bonded to two atoms of the pyrrole adjacent to the pyrrole atom bonded to R2′; Substituent α′ is hydroxyl, nitro, cyano, halogen, alkoxy, halogeno alkoxy, alkylthio, halogeno alkylthio or —NRa′Rb′; Ra′ and Rb′ are hydrogen, alkyl, alkenyl, alkynyl, aralkyl or alkylsulfonyl, or Ra′ and Rb′ with the nitrogen atom form a heterocyclyl; Substituent β′ is alkyl, alkenyl, alkynyl, aralkyl or cycloalkyl; Substituent γ′is oxo, hydroxyimino, alkoxyimino, alkylene, alkylenedioxy, alkylsulfinyl, alkylsulfonyl, aryl, aryloxy, alkylidenyl or aralkylidenyl.
摘要翻译：具有抗式产生式（I）的炎性细胞因子的活性化合物的化合物：A'是吡咯; R 1是苯基或萘基; R 2是吡啶基或嘧啶基; （IIa）'，（IIb）'或（IIc）'：m'为1; E'是氮; D'是> C（R 5'），R 5'是氢，取代基α'或取代基β'; B'是含氮5元杂环; R 4'是1至3个取代基α'，取代基β'和取代基γ'的取代基; R 1'和R 3'连接到与R 2'连接的吡咯原子相邻的吡咯的两个原子上; 取代基α'是羟基，硝基，氰基，卤素，烷氧基，卤代烷氧基，烷硫基，卤代烷硫基或-NR a R b B。 R a，O和R b'是氢，烷基，烯基，炔基，芳烷基或烷基磺酰基，或者R a'和R“ b'与氮原子形成杂环基; 取代基β'是烷基，烯基，炔基，芳烷基或环烷基; 取代基γ'是氧代，羟基亚氨基，烷氧基亚氨基，亚烷基，亚烷基二氧基，烷基亚磺酰基，烷基磺酰基，芳基，芳氧基，亚烷基或芳亚烷基。

6. 发明授权

US5187857A Apparatus for manufacturing electronic parts wrapped with conductive foil 失效
标题翻译：用于制造带导电箔的电子部件的装置
公开(公告)号：US5187857A
公开(公告)日：1993-02-23
申请号：US859584
申请日：1992-03-27
申请人： Akira Nakao , Toyofusa Endo , Takeshi Ikeda
发明人： Akira Nakao , Toyofusa Endo , Takeshi Ikeda
IPC分类号： H01G4/40 , B31C11/00 , H01L21/00 , H03H3/00 , H03H7/01
CPC分类号： H01L21/67121 , B31C11/00 , H03H3/00 , Y10T29/435 , Y10T29/5143
摘要： The invention provides a novel apparatus for manufacturing electronic parts each incorporating a plurality of lead wires fully wrapped with conductive foil like noise filters for example. A turn table is intermittently shifted from the first work station to the seventh work station in the state in which an individual-unit lead-wire member is retained by a holding unit on the turn table. A predetermined lead wire is folded by respective work stations, whereas the remaining lead wires are adhered with conductive foil tapes via spot-welding process, and then these lead wires are fully wrapped with conductive foil tapes. Next, the predetermined lead wire is restored to the initial posture, and then all the lead wires are fully wrapped with insulation tapes. In this way, all the lead wires are properly processed so that they can be integrated in perfect alignment with constant pitches.

7. 发明授权

US08513235B2 Homocysteine synthase inhibitor 有权
标题翻译：同型半胱氨酸合酶抑制剂
公开(公告)号：US08513235B2
公开(公告)日：2013-08-20
申请号：US12937187
申请日：2009-04-10
申请人： Akira Nakao , Hiroko Suzuki , Ryo Tatsumi , Maki Seki , Minoru Tanaka , Tomofumi Setsuta , Hiroshi Iwasaki
发明人： Akira Nakao , Hiroko Suzuki , Ryo Tatsumi , Maki Seki , Minoru Tanaka , Tomofumi Setsuta , Hiroshi Iwasaki
IPC分类号： C07C237/10 , C07C237/12 , C07C255/60 , C07D209/44 , C07D271/06 , C07D295/22 , C07D295/32 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D487/04 , A61K31/55 , A61K31/4035 , A61K31/165 , A61K31/495 , A61K31/4245 , A61K31/454 , A61K31/4196 , A61K31/422 , A61K31/427 , A61K31/416 , A61K31/501 , A61P9/10
CPC分类号： C07D209/44 , C07C237/10 , C07C255/60 , C07C2602/08 , C07D271/06 , C07D295/22 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： The invention provides a homocysteine synthase inhibitor useful for the prophylaxis or treatment of diseases involving homocysteine synthase. The homocysteine synthase inhibitor is a compound of the formula (I) wherein each symbol is as defined herein, or a pharmacologically acceptable salt thereof, or a solvate thereof.
摘要翻译：本发明提供了可用于预防或治疗涉及同型半胱氨酸合酶的疾病的同型半胱氨酸合成酶抑制剂。同型半胱氨酸合成酶抑制剂是式（I）的化合物，其中每个符号如本文所定义，或其药理学上可接受的盐或其溶剂合物。

8. 发明申请

US20090161504A1 OPTICAL DISC DRIVE DEVICE AND TILT CORRECTION DEVICE 有权
标题翻译：光盘驱动装置和倾斜校正装置
公开(公告)号：US20090161504A1
公开(公告)日：2009-06-25
申请号：US12337033
申请日：2008-12-17
申请人： Takashi Inoue , Hiroshi Shimada , Akira Nakao , Yasuhiro Hayashi
发明人： Takashi Inoue , Hiroshi Shimada , Akira Nakao , Yasuhiro Hayashi
IPC分类号： G11B7/00
CPC分类号： G11B7/0941 , G11B7/0901 , G11B7/0956
摘要： An optical disc drive device has an FE signal generator which generates a focus error signal, a TE signal generator which generates a tracking error signal, a return beam detector which detects a return beam reflected by an optical disc after irradiated by an optical pickup to generate a return beam level signal, a return beam gain setting part which sets amplitude adjustment amount of the return beam level signal so that a signal level of the return beam level signal generated by the return beam detector coincides with a predetermined reference level, an FE gain setting part which sets amplitude adjustment amount of the focus error signal in accordance with the signal level of the return beam level signal adjusted by the return beam gain setting part so that a signal amplitude of the focus error signal is constant, and a TE gain setting part which sets amplitude adjustment amount of the tracking error signal in accordance with the signal level of the return beam level signal adjusted by the return beam gain adjustment part so that a signal amplitude of the tracking error signal is constant.
摘要翻译：光盘驱动装置具有产生聚焦误差信号的FE信号发生器，产生跟踪误差信号的TE信号发生器，检测由光拾取器照射后由光盘反射的返回光束的返回光束检测器，返回光束电平信号，返回光束增益设置部分，其设置返回光束电平信号的幅度调整量，使得由返回光束检测器产生的返回光束电平信号的信号电平与预定参考电平相符，FE增益设置部分，其根据由返回光束增益设置部分调整的返回光束电平信号的信号电平设置聚焦误差信号的幅度调整量，使得聚焦误差信号的信号幅度恒定，并且TE增益设置根据调整的返回光束电平信号的信号电平设定跟踪误差信号的幅度调整量的部分通过返回光束增益调整部分，使得跟踪误差信号的信号幅度恒定。

9. 发明授权

US06998715B1 Grid array electronic component, wire reinforcing method for the same, and method of manufacturing the same 有权
标题翻译：网格阵列电子元件，线材加强方法及其制造方法
公开(公告)号：US06998715B1
公开(公告)日：2006-02-14
申请号：US10088086
申请日：2000-09-21
申请人： Shouichi Fuji , Akira Nakao
发明人： Shouichi Fuji , Akira Nakao
IPC分类号： H01L23/48
CPC分类号： H01L23/49838 , H01L2224/0554 , H01L2224/05568 , H01L2224/05573 , H01L2224/16 , H01L2224/16225 , H01L2924/00014 , H01L2924/01019 , H01L2924/15311 , H01L2924/3511 , H05K1/111 , H05K2201/094 , H05K2201/10734 , Y02P70/611 , H01L2224/05599 , H01L2224/0555 , H01L2224/0556
摘要： Grid array electronic component, wiring-strengthening method and producing method wherein a grid array electronic component in which a grid array LSI chip 2 having a large number of lands 3 connected to a large number of lands 13 through connecting means 30, the lands 13 are connected to a wire 4 of a printed wiring board 1, an auxiliary land 5 is formed at a connection portion 31 of the lands 13 on the printed wiring board 1 corresponding to the lands 3 of a corner portion of the grid array LSI chip 2 connecting the wire 4 and the concentration of stress of the connection portion 31 is moderated, thereby providing the effect that the brake of the wire in the connection portion 31 is prevented.
摘要翻译：格栅阵列电子元件，布线强化法及其制造方法，其中格栅阵列电子元件，其中具有大量接地片3的栅格阵列LSI芯片2，通过连接装置30连接到大量的焊盘13，焊盘13为连接到印刷电路板1的导线4上的辅助焊盘5形成在印刷电路板1上的焊盘13的连接部分31上，对应于连接在栅极阵列LSI芯片2的角部的焊盘3上线4和连接部31的应力集中受到缓和，从而提供防止连接部31中的线的制动的效果。

10. 发明申请

US20050283006A1 Heteroaryl-substituted pyrrole derivatives, their preparation and their therapeutic uses 审中-公开
标题翻译：杂芳基取代的吡咯衍生物，其制备及其治疗用途
公开(公告)号：US20050283006A1
公开(公告)日：2005-12-22
申请号：US10411061
申请日：2003-04-10
申请人： Tomio Kimura , Kazumasa Aoki , Akira Nakao , Shigeru Ushiyama , Takaichi Shimozato , Nobuyuki Ohkawa , Takayoshi Nagasaki , Takanori Yamazaki
发明人： Tomio Kimura , Kazumasa Aoki , Akira Nakao , Shigeru Ushiyama , Takaichi Shimozato , Nobuyuki Ohkawa , Takayoshi Nagasaki , Takanori Yamazaki
IPC分类号： C07D401/04 , C07D401/14 , C07D451/02 , C07D453/02 , C07D455/02 , C07D471/04 , C07D487/04 , C07D491/20 , C07D41/14 , C07D43/02
CPC分类号： C07D451/02 , C07D401/04 , C07D401/14 , C07D453/02 , C07D455/02 , C07D471/04 , C07D487/04
摘要： Compounds having activity against production of inflammatory cytokines of formula (I)′: A′ is pyrrole; R1′ is aryl or heteroaryl; R2′ is heteroaryl having at least one nitrogen atom; R3′ is (IIa)′, (IIb)′ or (IIc)′: m′ is 1 or 2; one of D′ and E′ is nitrogen and the other is >C(R5′)—, R5′ is hydrogen, Substituent α′ or Substituent β′; B′ is nitrogen-containing 4- to 7-membered heterocyclic; R4′ is 1 to 3 substituents from Substituent α′, Substituent β′ and Substituent γ′; R1′ and R3′ are bonded to two atoms of the pyrrole adjacent to the pyrrole atom bonded to R2′; Substituent α′: hydroxyl, nitro, cyano, halogen, alkoxy, halogeno alkoxy, alkylthio, halogeno alkylthio or —NRa′Rb′; Ra′ and Rb′ are hydrogen, alkyl, alkenyl, alkynyl, aralkyl or alkylsulfonyl, or Ra′ and Rb′ with the nitrogen atom form a heterocyclyl; Substituent β′: alkyl, alkenyl, alkynyl, aralkyl or cycloalkyl; Substituent γ′: oxo, hydroxyimino, alkoxyimino, alkylene, alkylenedioxy, alkylsulfinyl, alkylsulfonyl, aryl, aryloxy, alkylidenyl or aralkylidenyl.
摘要翻译：具有抗式产生式（I）的炎性细胞因子的化合物的化合物：A'是吡咯; R 1是芳基或杂芳基; R 2是具有至少一个氮原子的杂芳基; （IIa）'，（IIb）'或（IIc）'：m'为1或2; D'和E'之一是氮，另一个是> C（R 5'） - ，R 5'是氢，取代基α'或取代基β'; B'是含氮的4-至7-元杂环; R 4'是1至3个取代基α'，取代基β'和取代基γ'的取代基; R 1'和R 3'连接到与R 2'连接的吡咯原子相邻的吡咯的两个原子上; 取代基α'：羟基，硝基，氰基，卤素，烷氧基，卤代烷氧基，烷硫基，卤代烷硫基或-NR a R b b。 R a，O和R b'是氢，烷基，烯基，炔基，芳烷基或烷基磺酰基，或者R a'和R“ b'与氮原子形成杂环基; 取代基β'：烷基，烯基，炔基，芳烷基或环烷基; 取代基γ'：氧代，羟基亚氨基，烷氧基亚氨基，亚烷基，亚烷基二氧基，烷基亚磺酰基，烷基磺酰基，芳基，芳氧基，亚烷基或芳烷基。

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