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1. 发明授权

US5990229A Adhesives with low level of residual monomers and process for manufacturing same 失效
标题翻译：具有低水平残留单体的粘合剂及其制造方法
公开(公告)号：US5990229A
公开(公告)日：1999-11-23
申请号：US928313
申请日：1997-09-12
申请人： Thomas Hille , Paul M. Petersen , James Burkert , Paul B. Foreman
发明人： Thomas Hille , Paul M. Petersen , James Burkert , Paul B. Foreman
IPC分类号： A61K8/02 , A61K8/81 , A61L15/58 , A61Q19/00 , C08F2/06 , C08F8/04 , C09J125/06 , C09J131/04 , C09J133/00 , C09J133/08 , C09J133/10 , C08F8/42
CPC分类号： A61L15/58 , A61K8/0208 , A61K8/8152 , A61L15/585 , A61Q19/00 , C08F8/04
摘要： An adhesive, which contains olefinic polymers and less than 1% by weight of free monomers, is manufactured via catalytic hydrogenation. It is preferably used in the area of cosmetics, in the foods sector, in medicinal plasters and transdermal systems.
摘要翻译：通过催化氢化制造含有烯属聚合物和小于1重量％游离单体的粘合剂。它优选用于化妆品，食品领域，医药膏和透皮系统领域。

2. 发明授权

US09308202B2 Transdermal therapeutic system for administering the active substance buprenorphine 有权
标题翻译：用于施用活性物质丁丙诺啡的透皮治疗系统
公开(公告)号：US09308202B2
公开(公告)日：2016-04-12
申请号：US12515848
申请日：2007-11-07
申请人： Thomas Hille , Michael Horstmann , Walter Mueller
发明人： Thomas Hille , Michael Horstmann , Walter Mueller
IPC分类号： A61K31/485 , A61K9/70
CPC分类号： A61K31/485 , A61K9/7053 , A61K9/7069 , A61K9/7084 , A61K9/7092 , A61K47/12 , A61M37/00
摘要： The invention relates to a transdermal therapeutic system for administering the active substance buprenorphine. Said system comprises at least one carboxylic acid that determines the solubility of buprenorphine in the matrix layer and that can likewise be absorbed. The transdermal therapeutic system according to the invention is used in the treatment of pain and is characterized by a considerably increased utilization of the active substance.
摘要翻译：本发明涉及一种用于施用活性物质丁丙诺啡的透皮治疗系统。所述系统包含至少一种羧酸，其确定丁丙诺啡在基质层中的溶解度，同样可以被吸收。根据本发明的透皮治疗系统用于治疗疼痛，其特征在于活性物质的利用率显着增加。

3. 发明申请

US20070066790A1 Method for continuous production of high-molecular weight polyesters and device for implementation of the method 有权
公开(公告)号：US20070066790A1
公开(公告)日：2007-03-22
申请号：US11373937
申请日：2006-03-13
申请人： Eike Schulz Van Endert , Rainer Hagen , Thomas Hille , Christian Atlas , Ulrich Thiele
发明人： Eike Schulz Van Endert , Rainer Hagen , Thomas Hille , Christian Atlas , Ulrich Thiele
IPC分类号： C08G63/02
CPC分类号： C08G63/785 , B01J19/1887 , B01J2219/00085 , B01J2219/00087 , B01J2219/0011 , B01J2219/00166 , C08G63/78
摘要： The invention relates to a method for producing high-molecular weight polyesters, such as e.g. polyethylene terephthalate (PET), polybutylene terephthalate (PBT), polynaphthalene terephthalate (PEN), polytrimethylene terephthalate (PTT) and/or polyesters of other dicarboxylic acids and diols including copolymers thereof. The invention relates likewise to a device for implementing this method. The latter concerns a single-stage tower reactor with which a method, comprising only two reactors, is made available for the total process.

4. 发明授权

US06868286B1 Device for a transdermal and phonophoretic combination therapy and the use thereof in a method for medical application 有权
标题翻译：用于透皮和声学组合疗法的装置及其在医疗应用方法中的应用
公开(公告)号：US06868286B1
公开(公告)日：2005-03-15
申请号：US09830780
申请日：1999-10-23
申请人： Thomas Hille , Bernhard Hehn
发明人： Thomas Hille , Bernhard Hehn
IPC分类号： A61K9/70 , A61L15/44 , A61M37/00 , A61N1/30
CPC分类号： A61M37/0092
摘要： The invention relates to a combination therapy by TTS and simultaneous initial ultrasound treatment and the subsequent use of the TTS without additional ultrasound treatment. The treatment is characterized in that it shows an effect without or with only little delay. This form of therapy is especially advantageous for treating strong or chronic pains. The invention relates to a corresponding device and the use of suitable pharmaceutical substances.
摘要翻译：本发明涉及通过TTS的联合治疗和同时初始超声治疗，并且随后使用TTS而无需额外的超声治疗。治疗的特征在于它没有或只有很小的延迟显示效果。这种治疗方式对于治疗强或慢性疼痛尤为有利。本发明涉及相应的装置和合适的药物物质的用途。

5. 发明授权

US06548510B1 Pharmaceutical composition containing deoxypeganine for the treatment of nicotine dependence 失效
标题翻译：含有脱氧胆碱的药物组合物用于治疗尼古丁依赖
公开(公告)号：US06548510B1
公开(公告)日：2003-04-15
申请号：US09889650
申请日：2001-07-19
申请人： Bodo Asmussen , Thomas Hille , Hans-Rainer Hoffmann , Klaus Opitz
发明人： Bodo Asmussen , Thomas Hille , Hans-Rainer Hoffmann , Klaus Opitz
IPC分类号： A61K31505
CPC分类号： A61K31/517 , Y10S514/813
摘要： Desoxypeganine and its pharmaceutically acceptable acid addition salts are useful in treating nicotine dependence.
摘要翻译：脱氧胆碱及其药学上可接受的酸加成盐可用于治疗尼古丁依赖。

6. 发明授权

US06315854B1 Transdermal therapeutic plaster 失效
标题翻译：透皮治疗膏药
公开(公告)号：US06315854B1
公开(公告)日：2001-11-13
申请号：US08531890
申请日：1995-09-22
申请人： Dieter Anhauser , Lothar Deurer , Thomas Hille , Peter Steinborn
发明人： Dieter Anhauser , Lothar Deurer , Thomas Hille , Peter Steinborn
IPC分类号： B32B3110
CPC分类号： A61K9/7061 , A61F2013/0296 , A61K9/7084 , Y10T156/1052 , Y10T156/108 , Y10T156/1085 , Y10T156/1095
摘要： A process for continuously manufacturing transdermal therapeutic patches having a backing layer, a pressure-sensitive adhesive drug reservoir layer, and a removable protective layer, whereby loss of active substances during fabrication of the patches is minimized, said process being characterized in that, in a tape-like laminate having a pressure-sensitive adhesive backing layer (1) and a removable protective layer (3), single quadrangular pressure-sensitive adhesive drug reservoir sections (2) are inserted one after the other in the longitudinal direction between the layers (2,3); the clearance between said drug reservoir sections remains constant in the longitudinal direction; their width is calculated such that the backing layer (1) and the removable protective layer (3) project beyond both sides of said sections; the pressure-sensitive adhesive backing layer (1) is first cut by punching in such a way that the punching line (1a) surrounds the individual drug reservoir sections (2) at an evident distance from their outer dimensions; the the resulting lattice-type refuse of the drug-free pressure-sensitive adhesive backing layer (1) is removed; and subsequently the protective layer (3) is cut in the resultant spaces between the drug reservoir sections (2).
摘要翻译：一种用于连续制造具有背衬层，压敏粘合剂药物储存层和可移除保护层的透皮治疗贴片的方法，由此在贴片制造过程中活性物质的损失最小化，所述方法的特征在于，具有压敏粘合剂背衬层（1）和可移除保护层（3）的带状层压体，单个四边形压敏粘合剂药物储存部分（2）沿着纵向方向一个接一个地插入在层之间 2,3）; 所述药物储存部之间的间隙在长度方向保持恒定; 计算它们的宽度，使得背衬层（1）和可移除保护层（3）突出超出所述部分的两侧; 首先通过冲压来切割压敏粘合剂背衬层（1），使冲孔线（1a）以与其外部尺寸明显的距离围绕各个药物储存部分（2）; 除去无药物粘合剂背衬层（1）的所得晶格型垃圾; 随后在药物储存部分（2）之间的合成空间中切割保护层（3）。

7. 发明授权

US06194404B1 Process for the isolation of galanthamine 有权
标题翻译：加兰他敏分离方法
公开(公告)号：US06194404B1
公开(公告)日：2001-02-27
申请号：US09130883
申请日：1998-08-07
申请人： Thomas Hille , Hans-Rainer Hoffmann , Mirko Kreh , Rudolf Matusch
发明人： Thomas Hille , Hans-Rainer Hoffmann , Mirko Kreh , Rudolf Matusch
IPC分类号： A01N4346
CPC分类号： C07D491/04
摘要： The subject matter of the present invention concerns a process for the isolation of the alkaloid galanthamine; the galanthamine itself which has been produced according to this process; the use of the galanthamine thus produced in galenic preparations; and the galanthamine thus produced for treating narrow-angle glaucoma, Alzheimer's disease, as well as alcohol and nicotine dependence.
摘要翻译：本发明的主题涉及分离生物碱雪花胺的方法; 根据该方法生产的雪花胺本身; 使用如此在galenic制剂中产生的雪花胺; 和由此产生的雪花胺用于治疗狭窄的青光眼，阿尔茨海默病以及酒精和尼古丁依赖。

8. 发明授权

US6059913A Method for producing transdermal patches (TTS) 有权
标题翻译：生产透皮贴剂（TTS）的方法
公开(公告)号：US6059913A
公开(公告)日：2000-05-09
申请号：US091696
申请日：1998-10-30
申请人： Bodo Asmussen , Thomas Hille , Klaus Schumann , Peter Steinborn
发明人： Bodo Asmussen , Thomas Hille , Klaus Schumann , Peter Steinborn
IPC分类号： A61F13/02 , A61K9/70 , B44C1/165 , A61F13/00 , B23B31/00 , A61L13/00 , B32B4/00
CPC分类号： A61K9/7061 , A61K9/7084 , A61F2013/0296 , Y10T156/1967
摘要： A process for the continuous production of transdermal therapeutic patches, wherein a laminate of an auxiliary layer (3) siliconized at least on one side, an active substance-containing, pressure-sensitive adhesive layer (4), and a supporting layer (9) is prepared as a strip-shaped web (1) first, and the active substance-containing sections (4') obtained by punching said layers (3) and (4) across the web direction are intermittently transferred onto a second web (2), the punching procedure taking place in the rest phase between the cycles and the transfer procedure onto the second web (2) being carried out preferably at equal distances by means of a transfer device (11, 12), is characterized by the fact that the supporting layer (9) is stripped from the active substance-containing sections (4') during the transfer first, and that then the sections (3') of the auxiliary layer are removed with the aid of a process layer (5) which has been rendered pressure-sensitive adhesive.
摘要翻译： PCT No.PCT / EP96 / 05410 Sec。 371日期：1998年10月30日 102（e）1998年10月30日PCT PCT 1996年12月4日PCT公布。出版物WO97 / 22315 PCT 日期：1997年6月26日一种连续生产透皮治疗贴片的方法，其中至少在一侧硅化的辅助层（3），含活性物质的压敏粘合剂层（4）和首先将支撑层（9）作为带状网（1）制备，并且通过将幅材方向上的所述层（3）和（4）冲压而获得的含活性物质的部分（4'）被间歇地转移到其特征在于，在第二腹板（2）上，在循环之间的休息阶段中进行的穿孔步骤和通过转移装置（11,12）优选地以相等的距离进行到第二腹板（2）上的转移程序通过在第一次转移期间将支撑层（9）从含活性物质的部分（4'）剥离，然后借助于处理层去除辅助层的部分（3'）（5）已经压力敏感现在

9. 发明授权

US5700480A Transdermal therapeutic system comprising galanthamine as active component 失效
标题翻译：透皮治疗系统，其包含加兰他敏作为活性成分
公开(公告)号：US5700480A
公开(公告)日：1997-12-23
申请号：US495609
申请日：1995-09-29
申请人： Thomas Hille , Lothar Deurer
发明人： Thomas Hille , Lothar Deurer
IPC分类号： A61L15/00 , A61K9/70 , A61K31/55 , A61M37/00 , A61F13/02 , A61K9/14 , A61L15/16
CPC分类号： A61K9/7061 , A61K31/55
摘要： A transdermal therapeutic system (TTS) for the administration of galanthamine to the skin each system having a backing layer which is impermeable to active substances and a pressure sensitive adhesive reservoir layer, wherein the reservoir layer comprises 40-80% wt. polymeric material selected from the group consisting of polyacrylates, 0.1-30%-wt. plasticizers, and 0.1-30%-wt. galanthamine base or one of its pharmaceutically acceptable salts.
摘要翻译： PCT No.PCT / EP94 / 00054 Sec。 371 1995年9月29日第 102（e）1995年9月29日PCT PCT 1994年1月10日PCT公布。 WO94 / 16707 PCT出版物日期1994年8月4日一种用于向皮肤施用雪花胺的透皮治疗系统（TTS），每个系统具有不可渗透活性物质的背衬层和压敏粘合剂储存层，其中储存层包含40-80重量％。选自聚丙烯酸酯，0.1-30重量％增塑剂和0.1-30％重量。雪花胺碱或其药学上可接受的盐之一。

10. 发明授权

US08883198B2 Transdermal rivastigmine therapeutic system 有权
标题翻译：经皮拉伐他汀治疗系统
公开(公告)号：US08883198B2
公开(公告)日：2014-11-11
申请号：US13405689
申请日：2012-02-27
申请人： Thomas Hille , Lothar Deurer
发明人： Thomas Hille , Lothar Deurer
IPC分类号： A61F13/02 , A61K9/70 , A61K31/485
CPC分类号： A61K31/381 , A61K9/0014 , A61K9/7023 , A61K9/7038 , A61K9/7053 , A61K9/7061 , A61K9/7069 , A61K9/7084 , A61K31/485
摘要： The invention relates to transdermal therapeutic systems (TTS) comprising a backing, a reservoir layer containing at least one pharmaceutical active ingredient, and an adhesive. Said transdermal therapeutic systems are characterized in that they are able to continuously adhere to the surface of the skin over a long period of time. During said long period of time, a) there is at least one time interval during which the TTS adhering to the surface of the skin is intensively exposed to water, and b) the active ingredient is transdermally released. The invention also relates to a method for the continuous transdermal release of at least one pharmaceutical active ingredient over a long period of time.
摘要翻译：本发明涉及包含背衬，含有至少一种药物活性成分的储库层和粘合剂的透皮治疗系统（TTS）。所述透皮治疗系统的特征在于它们能够长时间连续地粘附到皮肤表面。在长时间内，a）至少有一段时间间隔，其中附着在皮肤表面的TTS集中暴露于水中，b）活性成分被透皮释放。本发明还涉及一种用于在长时间内连续透皮释放至少一种药物活性成分的方法。

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