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    • 8. 发明授权
    • Transdermal therapeutic plaster
    • 透皮治疗膏药
    • US06315854B1
    • 2001-11-13
    • US08531890
    • 1995-09-22
    • Dieter AnhauserLothar DeurerThomas HillePeter Steinborn
    • Dieter AnhauserLothar DeurerThomas HillePeter Steinborn
    • B32B3110
    • A61K9/7061A61F2013/0296A61K9/7084Y10T156/1052Y10T156/108Y10T156/1085Y10T156/1095
    • A process for continuously manufacturing transdermal therapeutic patches having a backing layer, a pressure-sensitive adhesive drug reservoir layer, and a removable protective layer, whereby loss of active substances during fabrication of the patches is minimized, said process being characterized in that, in a tape-like laminate having a pressure-sensitive adhesive backing layer (1) and a removable protective layer (3), single quadrangular pressure-sensitive adhesive drug reservoir sections (2) are inserted one after the other in the longitudinal direction between the layers (2,3); the clearance between said drug reservoir sections remains constant in the longitudinal direction; their width is calculated such that the backing layer (1) and the removable protective layer (3) project beyond both sides of said sections; the pressure-sensitive adhesive backing layer (1) is first cut by punching in such a way that the punching line (1a) surrounds the individual drug reservoir sections (2) at an evident distance from their outer dimensions; the the resulting lattice-type refuse of the drug-free pressure-sensitive adhesive backing layer (1) is removed; and subsequently the protective layer (3) is cut in the resultant spaces between the drug reservoir sections (2).
    • 一种用于连续制造具有背衬层,压敏粘合剂药物储存层和可移除保护层的透皮治疗贴片的方法,由此在贴片制造过程中活性物质的损失最小化,所述方法的特征在于, 具有压敏粘合剂背衬层(1)和可移除保护层(3)的带状层压体,单个四边形压敏粘合剂药物储存部分(2)沿着纵向方向一个接一个地插入在层之间 2,3); 所述药物储存部之间的间隙在长度方向保持恒定; 计算它们的宽度,使得背衬层(1)和可移除保护层(3)突出超出所述部分的两侧; 首先通过冲压来切割压敏粘合剂背衬层(1),使冲孔线(1a)以与其外部尺寸明显的距离围绕各个药物储存部分(2); 除去无药物粘合剂背衬层(1)的所得晶格型垃圾; 随后在药物储存部分(2)之间的合成空间中切割保护层(3)。
    • 10. 发明授权
    • Method for producing transdermal patches (TTS)
    • 生产透皮贴剂(TTS)的方法
    • US6059913A
    • 2000-05-09
    • US091696
    • 1998-10-30
    • Bodo AsmussenThomas HilleKlaus SchumannPeter Steinborn
    • Bodo AsmussenThomas HilleKlaus SchumannPeter Steinborn
    • A61F13/02A61K9/70B44C1/165A61F13/00B23B31/00A61L13/00B32B4/00
    • A61K9/7061A61K9/7084A61F2013/0296Y10T156/1967
    • A process for the continuous production of transdermal therapeutic patches, wherein a laminate of an auxiliary layer (3) siliconized at least on one side, an active substance-containing, pressure-sensitive adhesive layer (4), and a supporting layer (9) is prepared as a strip-shaped web (1) first, and the active substance-containing sections (4') obtained by punching said layers (3) and (4) across the web direction are intermittently transferred onto a second web (2), the punching procedure taking place in the rest phase between the cycles and the transfer procedure onto the second web (2) being carried out preferably at equal distances by means of a transfer device (11, 12), is characterized by the fact that the supporting layer (9) is stripped from the active substance-containing sections (4') during the transfer first, and that then the sections (3') of the auxiliary layer are removed with the aid of a process layer (5) which has been rendered pressure-sensitive adhesive.
    • PCT No.PCT / EP96 / 05410 Sec。 371日期:1998年10月30日 102(e)1998年10月30日PCT PCT 1996年12月4日PCT公布。 出版物WO97 / 22315 PCT 日期:1997年6月26日一种连续生产透皮治疗贴片的方法,其中至少在一侧硅化的辅助层(3),含活性物质的压敏粘合剂层(4)和 首先将支撑层(9)作为带状网(1)制备,并且通过将幅材方向上的所述层(3)和(4)冲压而获得的含活性物质的部分(4')被间歇地转移到 其特征在于,在第二腹板(2)上,在循环之间的休息阶段中进行的穿孔步骤和通过转移装置(11,12)优选地以相等的距离进行到第二腹板(2)上的转移程序 通过在第一次转移期间将支撑层(9)从含活性物质的部分(4')剥离,然后借助于处理层去除辅助层的部分(3') (5)已经压力敏感 现在