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1. 发明授权

US6059913A Method for producing transdermal patches (TTS) 有权
标题翻译：生产透皮贴剂（TTS）的方法
公开(公告)号：US6059913A
公开(公告)日：2000-05-09
申请号：US091696
申请日：1998-10-30
申请人： Bodo Asmussen , Thomas Hille , Klaus Schumann , Peter Steinborn
发明人： Bodo Asmussen , Thomas Hille , Klaus Schumann , Peter Steinborn
IPC分类号： A61F13/02 , A61K9/70 , B44C1/165 , A61F13/00 , B23B31/00 , A61L13/00 , B32B4/00
CPC分类号： A61K9/7061 , A61K9/7084 , A61F2013/0296 , Y10T156/1967
摘要： A process for the continuous production of transdermal therapeutic patches, wherein a laminate of an auxiliary layer (3) siliconized at least on one side, an active substance-containing, pressure-sensitive adhesive layer (4), and a supporting layer (9) is prepared as a strip-shaped web (1) first, and the active substance-containing sections (4') obtained by punching said layers (3) and (4) across the web direction are intermittently transferred onto a second web (2), the punching procedure taking place in the rest phase between the cycles and the transfer procedure onto the second web (2) being carried out preferably at equal distances by means of a transfer device (11, 12), is characterized by the fact that the supporting layer (9) is stripped from the active substance-containing sections (4') during the transfer first, and that then the sections (3') of the auxiliary layer are removed with the aid of a process layer (5) which has been rendered pressure-sensitive adhesive.
摘要翻译： PCT No.PCT / EP96 / 05410 Sec。 371日期：1998年10月30日 102（e）1998年10月30日PCT PCT 1996年12月4日PCT公布。出版物WO97 / 22315 PCT 日期：1997年6月26日一种连续生产透皮治疗贴片的方法，其中至少在一侧硅化的辅助层（3），含活性物质的压敏粘合剂层（4）和首先将支撑层（9）作为带状网（1）制备，并且通过将幅材方向上的所述层（3）和（4）冲压而获得的含活性物质的部分（4'）被间歇地转移到其特征在于，在第二腹板（2）上，在循环之间的休息阶段中进行的穿孔步骤和通过转移装置（11,12）优选地以相等的距离进行到第二腹板（2）上的转移程序通过在第一次转移期间将支撑层（9）从含活性物质的部分（4'）剥离，然后借助于处理层去除辅助层的部分（3'）（5）已经压力敏感现在

2. 发明授权

US5802972A Tampon printing process 失效
标题翻译：棉塞印花工艺
公开(公告)号：US5802972A
公开(公告)日：1998-09-08
申请号：US966792
申请日：1997-11-10
申请人： Hans-Rainer Hoffmann , Bodo Asmussen , Klaus Schumann , Walter Muller
发明人： Hans-Rainer Hoffmann , Bodo Asmussen , Klaus Schumann , Walter Muller
IPC分类号： B41F16/00 , B05C3/20 , B41F1/00 , B41F1/40 , B41F17/00 , B41M1/00 , B41M1/10
CPC分类号： B41F17/00 , B05C3/20 , B41F1/40 , B41F17/001
摘要： A tampon printing process which uses a printing plate having at least one printing form at its surface, wherein the printing form is filled with printing medium at time intervals and the printing medium is subsequently transferred from the printing form onto a support by means of a tampon.
摘要翻译：一种棉塞印刷方法，其使用在其表面具有至少一种印刷形式的印刷版，其中印刷形式以时间间隔填充有印刷介质，并且打印介质随后通过棉条从印刷形式转印到支撑体上。

3. 发明授权

US07175172B2 Method and device for inserting a plurality of individual sheetlike forms of administration in a dispenser by forming a multilayer pile 有权
标题翻译：通过形成多层桩将多个单独的片状给药形式插入分配器中的方法和装置
公开(公告)号：US07175172B2
公开(公告)日：2007-02-13
申请号：US10658027
申请日：2003-09-09
申请人： Peter Steinborn , Horst Dzekan , Klaus Schumann , Wolfgang Laux , Michael Horstmann
发明人： Peter Steinborn , Horst Dzekan , Klaus Schumann , Wolfgang Laux , Michael Horstmann
IPC分类号： B65H39/16
CPC分类号： B65H35/06 , A61K9/006 , B65H39/16 , B65H2701/1752 , B65H2701/176 , Y10T83/2042 , Y10T83/2046 , Y10T83/222
摘要： A process for introducing a plurality of segregated sheet-like administration forms into a dispenser under formation of a multilayered stack for individually dosable removal, with sheet-like tapes wound-up on rolls being present as starting material, utilizes the following steps. In a first step, a number of sheet-like layers of said tapes, which number corresponds to the stack, is simultaneously drawn from a plurality of rolls. In a further step, the individual tapes are united, using guide means, to form a multilayered strand, which in yet another step, is drawn forward to a cutting station where one length of stack is severed at a time, and wherein a length segment of the multilayered strand corresponding to the stack is substantially in the dispenser prior to being severed from a remainder of the multilayered strand by the cutting device.
摘要翻译：一种将多个分离的片状给药形式引入到分配器中的方法，该分配器形成多层堆叠以进行单独的剂量去除，卷材卷绕在辊上作为起始材料，利用以下步骤。在第一步骤中，从多个辊同时拉出数个对应于堆叠的所述带的多个片状层。在另一步骤中，使用引导装置将各个带组合在一起形成多层股线，该多股股票在另一个步骤中被向前拉到切割站，其中一次堆叠被一次切断，并且其中长度段对应于堆叠的多层股线在通过切割装置从剩余的多层股线切断之前基本上在分配器中。

4. 发明授权

US06659442B1 Method and device for inserting a plurality of individual sheetlike forms of administration in a dispenser by forming a multilayer pile 有权
标题翻译：通过形成多层桩将多个单独的片状给药形式插入分配器中的方法和装置
公开(公告)号：US06659442B1
公开(公告)日：2003-12-09
申请号：US09622562
申请日：2000-09-20
申请人： Peter Steinborn , Horst Dzekan , Klaus Schumann , Wolfgang Laux , Michael Horstmann
发明人： Peter Steinborn , Horst Dzekan , Klaus Schumann , Wolfgang Laux , Michael Horstmann
IPC分类号： B65H3916
CPC分类号： B65H35/06 , A61K9/006 , B65H39/16 , B65H2701/1752 , B65H2701/176 , Y10T83/2042 , Y10T83/2046 , Y10T83/222
摘要： A process for introducing a plurality of segregated sheet-like administration forms into a dispenser under formation of a multilayered stack for individually dosable removal, with sheet-like tapes wound-up on rolls being present as starting material, utilizes the following steps. In a first step, a number of sheet-like layers of said tapes, which number corresponds to the stack, is simultaneously drawn from a plurality of rolls. In a further step, the individual tapes are united, using guide means, to form a multilayered strand, which in yet another step, is drawn forward to a cutting station where one length of stack is severed at a time, and wherein a length segment of the multilayered strand corresponding to the stack is substantially in the dispenser prior to being severed from a remainder of the multilayered strand by the cutting device.
摘要翻译：一种将多个分离的片状给药形式引入到分配器中的方法，该分配器形成多层堆叠以进行单独的剂量去除，卷材卷绕在辊上作为起始材料，利用以下步骤。在第一步骤中，从多个辊同时拉出数个对应于堆叠的所述带的多个片状层。在另一步骤中，使用引导装置将各个带组合在一起形成多层股线，该多股股票在另一个步骤中被向前拉到切割站，其中一次堆叠被一次切断，并且其中长度段对应于堆叠的多层股线在通过切割装置从剩余的多层股线切断之前基本上在分配器中。

5. 发明授权

US07029549B1 Method and device for dispensing adhesive laminate segments 有权
标题翻译：用于分配粘合剂层压片段的方法和装置
公开(公告)号：US07029549B1
公开(公告)日：2006-04-18
申请号：US10089187
申请日：2000-09-13
申请人： Christian Von Falkenhausen , Klaus Schumann , Peter Steinborn , Frank Theobald
发明人： Christian Von Falkenhausen , Klaus Schumann , Peter Steinborn , Frank Theobald
IPC分类号： B32B31/00 , B44C1/00 , B65G59/00
CPC分类号： A61F13/0276 , A61F2013/0296 , A61K9/7023 , B65H35/02 , B65H37/002 , Y10T156/1085 , Y10T156/1348 , Y10T156/1705
摘要： A process for dispensing pressure-sensitive adhesive laminates (3) or laminate sections from a movable primary (1) onto a movable secondary carrier band (2), the laminates (3), upon deflection of the primary band (1) around a dispenser edge (4), being detached and dispensed onto the secondary band (2), is characterized in that the primary band (1) is provided with at least one separation line or predetermined breaking line, thus subdividing it into at least two strips (5, 5′), and that the strips are individually drawn from separate sections (4′, 4″) of the dispenser edge (4).
摘要翻译：一种用于将压敏粘合剂层（3）或层压体部分从可移动的初级（1）分配到可移动的第二载体带（2）上的方法，所述层压体（3）在主带（1）绕着分配器边缘（4）被分离并分配到次级带（2）上的特征在于，主带（1）设置有至少一个分隔线或预定的断裂线，从而将其细分成至少两个条（5 ，5'），并且条带分别从分配器边缘（4）的分开的部分（4'，4“）拉出。

6. 发明授权

US06655112B1 Primary packaging unit for film-like or oblate-like administered shapes 有权
标题翻译：初级包装单元，用于膜状或扁扁状施用形状
公开(公告)号：US06655112B1
公开(公告)日：2003-12-02
申请号：US09582889
申请日：2000-09-12
申请人： Karsten Cremer , Karin Ludwig , Dieter Anhäuser , Klaus Schumann , Peter Steinborn , Uwe Bungarten
发明人： Karsten Cremer , Karin Ludwig , Dieter Anhäuser , Klaus Schumann , Peter Steinborn , Uwe Bungarten
IPC分类号： B65B900
CPC分类号： B65D75/527 , B65B9/02 , Y10T156/1095
摘要： A primary packaging unit for film-like or wafer-like administration forms for oral application with an off-cut of an upper web of packaging material and of an lower web of packaging material is characterized in that a plurality of dosage units of a film-like or wafer-like administration form, individually sealed in flat compartments formed without cold or hot forming of the packaging material and spaced at a distance to one another, are present in a primary packaging unit, and there are perforations between the compartments which enable the separation of individual compartments, if necessary.
摘要翻译：用于通过包装材料的上腹板和包装材料的下腹板的切口进行口腔应用的用于膜状或晶片状施用形式的初级包装单元的特征在于，多个剂量单位的膜 - 单独密封在形成为没有冷或热成型的包装材料并且彼此间隔开的距离的平坦隔室中，存在于初级包装单元中，并且在隔室之间存在穿孔，如果有必要，分隔个别舱室。

7. 发明授权

US06797105B1 Method for producing heat bonded packages and tool for implementing said method 有权
标题翻译：用于制造热粘封包装的方法和用于实施所述方法的工具
公开(公告)号：US06797105B1
公开(公告)日：2004-09-28
申请号：US09763267
申请日：2001-04-16
申请人： Klaus Schumann , Frank Seibertz , Peter Steinborn
发明人： Klaus Schumann , Frank Seibertz , Peter Steinborn
IPC分类号： B32B3108
CPC分类号： B29C66/8432 , B29C65/18 , B29C65/7891 , B29C66/0242 , B29C66/1122 , B29C66/43 , B29C66/71 , B29C66/72321 , B29C66/72328 , B29C66/83221 , B29C66/849 , B29C66/91423 , B29C66/91645 , B29K2033/20 , B29K2023/065
摘要： The invention relates to a process for producing hot-seal packs, in particular for transdermal therapeutic systems, by welding to one another, at predetermined linear regions and at polymer layers facing towards one another, two laps of continuous pack material composed of two or more layers. To this end, one (or two) sealing tool(s) are used to bring the pack material into contact with pressure and heat. To improve the quality of the welded seams without altering the cycle rate, according to the invention the sealing time is doubled and the temperature of the sealing tool(s) (1, 2) is reduced so that there is a considerable reduction in the temperature reached within the pack material (3, 4), this temperature then being only slightly above the melting point of the polymer used. An example of a sealing tool (1, 2) is given (FIG. 1).
摘要翻译：本发明涉及一种用于生产热封包装，特别是用于透皮治疗系统的方法，其通过彼此相互焊接，在预定的线性区域和在彼此面对的聚合物层处彼此焊接，由两个或更多个组成的两圈连续包装材料层。为此，使用一个（或两个）密封工具使包装材料与压力和热量接触。为了提高焊缝的质量而不改变循环速率，根据本发明，密封时间加倍，并且密封工具（1,2）的温度降低，使得温度显着降低达到包装材料（3,4）内，该温度仅略高于所用聚合物的熔点。给出了密封工具（1,2）的示例（图1）。

8. 发明授权

US06571983B1 Method and device for dispensing flat forms 有权
标题翻译：用于分配平面形式的方法和装置
公开(公告)号：US06571983B1
公开(公告)日：2003-06-03
申请号：US09856198
申请日：2001-05-17
申请人： Klaus Schumann , Peter Steinborn
发明人： Klaus Schumann , Peter Steinborn
IPC分类号： G07F1166
CPC分类号： B26D7/18 , B26F1/22 , B26F1/384 , B26F1/44 , B26F3/002 , B26F2001/4481 , B29C2793/0036 , B65C1/025 , B65C9/0006 , B65C9/18 , B65C9/1865 , B65C9/1896 , B65H35/0006 , B65H37/005
摘要： The invention relates to a method for dispensing flat forms, such as labels, stickers, transdermal therapeutic systems, flat medicaments for oral application, etc, in a controlled manner. According to said method, the outer contour of the flat form (103) is punched out from a strip-shaped starting material and connecting bridges (105) hold the flat form (103) and the edge of the punched layer together. These connecting bridges (105) break when the flat forms are dispensed via a deflector edge (106). The inventive method can be advantageously used for packing individual flat forms in primary packaging. The invention also relates to a specialised punching device used in the method.
摘要翻译：本发明涉及以受控的方式分配扁平形式如标签，贴纸，透皮治疗系统，用于口服应用的扁平药物等的方法。根据所述方法，平板形式（103）的外轮廓从带状起始材料冲出，并且连接桥（105）将平坦形式（103）和冲压层的边缘保持在一起。当扁平形式经由偏转器边缘（106）分配时，这些连接桥（105）断裂。本发明的方法可有利地用于在一次包装中包装单个平面形式。本发明还涉及在该方法中使用的专门的冲压装置。

9. 发明授权

US06187322B1 Process and a device for the production of a flat administration form comprising a preparation which contains pharmaceutical active substances 失效
标题翻译：方法和用于生产扁平给药形式的装置，其包含含有药物活性物质的制剂
公开(公告)号：US06187322B1
公开(公告)日：2001-02-13
申请号：US08682513
申请日：1996-08-22
申请人： Thomas Hille , Ludwig Grader , Klaus Schumann
发明人： Thomas Hille , Ludwig Grader , Klaus Schumann
IPC分类号： A61F1300
CPC分类号： A61K9/70
摘要： The present invention relates to a process and a device for the production of a flat administration form comprising a preparation that contains pharmaceutical active substances. The flowable preparation is conveyed to an applicator unit (12) by means of a metering pump, and flows through a distribution chamber (2) having a distribution plate (3) provided with passages (4). This application device (12) transfers the preparation onto a layer of the flat administration form (6,11) which is therefor contacted with the distribution plate (3) for a short time.
摘要翻译：本发明涉及用于制备扁平给药形式的方法和装置，其包含含有药物活性物质的制剂。可流动的制剂通过计量泵输送到施用器单元（12），并流过具有通道（4）的分配板（3）的分配室（2）。该施加装置（12）将制剂转移到平坦管理形式（6,11）的层上，以便与分配板（3）短时间接触。

10. 发明申请

US20110146466A1 APPARATUS AND METHOD FOR CUTTING AND PUNCHING PRODUCTS 审中-公开
标题翻译：切割和冲压产品的装置和方法
公开(公告)号：US20110146466A1
公开(公告)日：2011-06-23
申请号：US12971838
申请日：2010-12-17
申请人： Wolfgang Matthes , Klaus Schumann , Roger Sonntag
发明人： Wolfgang Matthes , Klaus Schumann , Roger Sonntag
IPC分类号： B26D9/00 , B26D1/09
CPC分类号： B26D1/09 , B26D9/00 , B26D2007/0081 , B26F1/14 , B26F2001/407 , Y10T83/0586 , Y10T83/869
摘要： An apparatus for the simultaneous three-sided trimming of products includes first and second cutting stations and a third processing station in which perforating or shaping punching operations can be carried out on the product at the same time as edge trimming in the preceding stations. A method for the final processing of bound or stitched products made from paper sheets is also provided.
摘要翻译：用于产品的同时三面修剪的装置包括第一和第二切割台和第三处理台，其中可以在与先前站中的边缘修剪同时在产品上执行穿孔或成形冲压操作。还提供了由纸张制成的装订或缝制产品的最终加工方法。

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